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Volumn 3, Issue 2, 2014, Pages 403-425

Causes and consequences of age-related changes in DNA methylation: A role for ROS?

Author keywords

Aging; DNA methylation; Mechanisms; Methylcytosine; Reactive oxygen species

Indexed keywords


EID: 84902955442     PISSN: None     EISSN: 20797737     Source Type: Journal    
DOI: 10.3390/biology3020403     Document Type: Review
Times cited : (50)

References (146)
  • 1
    • 0002235236 scopus 로고
    • On the Nature of the Aging Process
    • Szilard, L. On the Nature of the Aging Process. Proc. Natl. Acad. Sci. USA 1959, 45, 30-45.
    • (1959) Proc. Natl. Acad. Sci. USA , vol.45 , pp. 30-45
    • Szilard, L.1
  • 2
    • 73649150958 scopus 로고
    • The Maintenance of the Accuracy of Protein Synthesis and Its Relevance to Aging
    • Orgel, L.E. The Maintenance of the Accuracy of Protein Synthesis and Its Relevance to Aging. Proc. Natl. Acad. USA. 1963, 49, 517-521.
    • (1963) Proc. Natl. Acad. USA , vol.49 , pp. 517-521
    • Orgel, L.E.1
  • 6
    • 84879537717 scopus 로고    scopus 로고
    • Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan
    • Johansson, A.; Enroth, S.; Gyllensten, U. Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan. PLoS One 2013, 8, e67378.
    • (2013) PLoS One , vol.8
    • Johansson, A.1    Enroth, S.2    Gyllensten, U.3
  • 7
    • 84893368571 scopus 로고    scopus 로고
    • Taylor, J.A. Genome-Wide Age-Related DNA Methylation Changes in Blood and Other Tissues Relate to Histone Modification, Expression and Cancer
    • Xu, Z.; Taylor, J.A. Genome-Wide Age-Related DNA Methylation Changes in Blood and Other Tissues Relate to Histone Modification, Expression and Cancer. Carcinogen 2014, 35, 356-364.
    • (2014) Carcinogen , vol.35 , pp. 356-364
    • Xu, Z.1
  • 9
    • 84892613108 scopus 로고    scopus 로고
    • Age-Related DNA Methylation in Normal Breast Tissue and Its Relationship with Invasive Breast Tumor Methylation
    • Johnson, K.C.; Koestler, D.C.; Cheng, C.; Christensen, B.C. Age-Related DNA Methylation in Normal Breast Tissue and Its Relationship with Invasive Breast Tumor Methylation. Epigenetics 2013, 9, 268-275.
    • (2013) Epigenetics , vol.9 , pp. 268-275
    • Johnson, K.C.1    Koestler, D.C.2    Cheng, C.3    Christensen, B.C.4
  • 11
    • 84860572791 scopus 로고    scopus 로고
    • Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population
    • Bell, J.T.; Tsai, P.-C.; Yang, T.-P.; Pidsley, R.; Nisbet, J.; Glass, D.; Mangino, M.; Zhai, G.; Zhang, F.; Valdes, A. et al. Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population. PLoS Genet. 2012, 8, e1002629.
    • (2012) PLoS Genet , vol.8
    • Bell, J.T.1    Tsai, P.-C.2    Yang, T.-P.3    Pidsley, R.4    Nisbet, J.5    Glass, D.6    Mangino, M.7    Zhai, G.8    Zhang, F.9    Valdes, A.10
  • 12
    • 77049308856 scopus 로고
    • Aging: A Theory Based on Free Radical and Radiation Chemistry
    • Harman, D. Aging: A Theory Based on Free Radical and Radiation Chemistry. J Gerontol. 1956, 11, 298-300.
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 13
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative Stress, Caloric Restriction, and Aging
    • Sohal, R.S.; Weindruch, R. Oxidative Stress, Caloric Restriction, and Aging. Science 1996, 273, 59-63.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 15
    • 57249103576 scopus 로고    scopus 로고
    • Epigenetic Changes Induced by Reactive Oxygen Species in Hepatocellular Carcinoma: Methylation of the E-Cadherin Promoter
    • Lim, S.-O.; Gu, J.-M.; Kim, M.S.; Kim, H.-.; Park, Y.N.; Park, C.K.; Cho, J.W.; Park, Y.M.; Jung, G. Epigenetic Changes Induced by Reactive Oxygen Species in Hepatocellular Carcinoma: Methylation of the E-Cadherin Promoter. Gastroenterology 2008, 135, 2128-2140.
    • (2008) Gastroenterology , vol.135 , pp. 2128-2140
    • Lim, S.-O.1    Gu, J.-M.2    Kim, M.S.3    Kim, H.4    Park, Y.N.5    Park, C.K.6    Cho, J.W.7    Park, Y.M.8    Jung, G.9
  • 16
    • 80255140418 scopus 로고    scopus 로고
    • Reactive Oxygen Species Downregulate Catalase Expression via Methylation of a CpG Island in the Oct-1 Promoter
    • Quan, X.; Lim, S.-O.; Jung, G. Reactive Oxygen Species Downregulate Catalase Expression via Methylation of a CpG Island in the Oct-1 Promoter. FEBS Lett. 2011, 585, 3436-3441.
    • (2011) FEBS Lett , vol.585 , pp. 3436-3441
    • Quan, X.1    Lim, S.-O.2    Jung, G.3
  • 17
    • 0022000776 scopus 로고
    • Fraction of the Mouse Genome That Is Derived from Islands of Nonmethylated, CpG-Rich DNA
    • Bird, A.P.; Taggart, M.; Frommer, M.; Miller, O.J.; Macleod, D. A Fraction of the Mouse Genome That Is Derived from Islands of Nonmethylated, CpG-Rich DNA. Cell 1985, 40, 91-99.
    • (1985) Cell , vol.40 , pp. 91-99
    • Bird, A.P.1    Taggart, M.2    Frommer, M.3    Miller, O.J.4    Macleod, D.A.5
  • 18
    • 0033601073 scopus 로고    scopus 로고
    • Methylation-Induced Repression-Belts, Braces, and Chromatin
    • Bird, A.P.; Wolffe, A.P. Methylation-Induced Repression-Belts, Braces, and Chromatin. Cell 1999, 99, 451-454.
    • (1999) Cell , vol.99 , pp. 451-454
    • Bird, A.P.1    Wolffe, A.P.2
  • 19
    • 33847304609 scopus 로고    scopus 로고
    • Gene Body-Specific Methylation on the Active X Chromosome
    • Hellman, A.; Chess, A. Gene Body-Specific Methylation on the Active X Chromosome. Science 2007, 315, 1141-1143.
    • (2007) Science , vol.315 , pp. 1141-1143
    • Hellman, A.1    Chess, A.2
  • 20
    • 43749098985 scopus 로고    scopus 로고
    • Methylation Landscapes: Provocative Insights from Epigenomics
    • Suzuki, M.M.; Bird, A. DNA Methylation Landscapes: Provocative Insights from Epigenomics. Nat. Rev. Genet. 2008, 9, 465-476.
    • (2008) Nat. Rev. Genet , vol.9 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.D.N.A.2
  • 21
    • 0030885667 scopus 로고    scopus 로고
    • DNA Methylation Inhibits Elongation but Not Initiation of Transcription in Neurospora Crassa
    • Rountree, M.R.; Selker, E.U. DNA Methylation Inhibits Elongation but Not Initiation of Transcription in Neurospora Crassa. Genes Dev. 1997, 11, 2383-2395.
    • (1997) Genes Dev , vol.11 , pp. 2383-2395
    • Rountree, M.R.1    Selker, E.U.2
  • 23
    • 0030840954 scopus 로고    scopus 로고
    • Cytosine Methylation and the Ecology of Intragenomic Parasites
    • Yoder, J.A.; Walsh, C.P.; Bestor, T.H. Cytosine Methylation and the Ecology of Intragenomic Parasites. Trends Genet. 1997, 13, 335-340.
    • (1997) Trends Genet , vol.13 , pp. 335-340
    • Yoder, J.A.1    Walsh, C.P.2    Bestor, T.H.3
  • 25
    • 67650090496 scopus 로고    scopus 로고
    • Lineage-Specific DNA Methylation in T Cells Correlates with Histone Methylation and Enhancer Activity
    • Schmidl, C.; Klug, M.; Boeld, T.J.; Andreesen, R.; Hoffmann, P.; Edinger, M.; Rehli, M. Lineage-Specific DNA Methylation in T Cells Correlates with Histone Methylation and Enhancer Activity. Genome Res. 2009, 19, 1165-1174.
    • (2009) Genome Res , vol.19 , pp. 1165-1174
    • Schmidl, C.1    Klug, M.2    Boeld, T.J.3    Andreesen, R.4    Hoffmann, P.5    Edinger, M.6    Rehli, M.7
  • 28
    • 68749117667 scopus 로고    scopus 로고
    • DNMT3B Interacts with Constitutive Centromere Protein CENP-C to Modulate DNA Methylation and the Histone Code at Centromeric Regions
    • Gopalakrishnan, S.; Sullivan, B.A.; Trazzi, S.; della Valle, G.; Robertson, K.D. DNMT3B Interacts with Constitutive Centromere Protein CENP-C to Modulate DNA Methylation and the Histone Code at Centromeric Regions. Hum. Mol. Genet. 2009, 18, 3178-3193.
    • (2009) Hum. Mol. Genet , vol.18 , pp. 3178-3193
    • Gopalakrishnan, S.1    Sullivan, B.A.2    Trazzi, S.3    della Valle, G.4    Robertson, K.D.5
  • 29
    • 0023701018 scopus 로고
    • Cloning and Sequencing of a cDNA Encoding DNA Methyltransferase of Mouse Cells
    • Bestor, T.; Laudano, A.; Mattaliano, R.; Ingram, V. Cloning and Sequencing of a cDNA Encoding DNA Methyltransferase of Mouse Cells. J. Mol. Biol. 1988, 203, 971-983.
    • (1988) J. Mol. Biol , vol.203 , pp. 971-983
    • Bestor, T.1    Laudano, A.2    Mattaliano, R.3    Ingram, V.4
  • 30
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and Characterization of a Family of Novel Mammalian DNA (cytosine-5) Methyltransferases
    • Okano, M.; Xie, S.; Li, E. Cloning and Characterization of a Family of Novel Mammalian DNA (cytosine-5) Methyltransferases. Nat. Genet. 1998, 19, 219-220.
    • (1998) Nat. Genet , vol.19 , pp. 219-220
    • Okano, M.1    Xie, S.2    Li, E.3
  • 31
    • 0033615717 scopus 로고    scopus 로고
    • DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
    • Okano, M.; Bell, D.W.; Haber, D.A.; Li, E. DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development. Cell 1999, 99, 247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 32
    • 0042132027 scopus 로고    scopus 로고
    • Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b
    • Chen, T.; Ueda, Y.; Dodge, J.E.; Wang, Z.; Li, E. Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b. Mol. Cell. Biol. 2003, 23, 5594-5605.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 5594-5605
    • Chen, T.1    Ueda, Y.2    Dodge, J.E.3    Wang, Z.4    Li, E.5
  • 33
    • 0026697174 scopus 로고
    • Activation of Mammalian DNA Methyltransferase by Cleavage of a Zn Binding Regulatory Domain
    • Bestor, T.H. Activation of Mammalian DNA Methyltransferase by Cleavage of a Zn Binding Regulatory Domain. EMBO J. 1992, 11, 2611-2617.
    • (1992) EMBO J , vol.11 , pp. 2611-2617
    • Bestor, T.H.1
  • 34
    • 0026439115 scopus 로고
    • A Targeting Sequence Directs DNA Methyltransferase to Sites of DNA Replication in Mammalian Nuclei
    • Leonhardt, H.; Page, A.W.; Weier, H.-U.; Bestor, T.H. A Targeting Sequence Directs DNA Methyltransferase to Sites of DNA Replication in Mammalian Nuclei. Cell 1992, 71, 865-873.
    • (1992) Cell , vol.71 , pp. 865-873
    • Leonhardt, H.1    Page, A.W.2    Weier, H.-U.3    Bestor, T.H.4
  • 35
    • 17144369504 scopus 로고    scopus 로고
    • Mechanism of Stimulation of Catalytic Activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-Methyltransferases by Dnmt3L
    • Gowher, H.; Liebert, K.; Hermann, A.; Xu, G.; Jeltsch, A. Mechanism of Stimulation of Catalytic Activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-Methyltransferases by Dnmt3L. J. Biol. Chem. 2005, 280, 13341-13348.
    • (2005) J. Biol. Chem , vol.280 , pp. 13341-13348
    • Gowher, H.1    Liebert, K.2    Hermann, A.3    Xu, G.4    Jeltsch, A.5
  • 36
    • 0029876208 scopus 로고    scopus 로고
    • Structure and Function of S-Adenosylmethionine Synthetase: Crystal Structures of S-Adenosylmethionine Synthetase with ADP, BrADP, and PPi at 28 Angstroms Resolution
    • Takusagawa, F.; Kamitori, S.; Markham, G.D. Structure and Function of S-Adenosylmethionine Synthetase: Crystal Structures of S-Adenosylmethionine Synthetase with ADP, BrADP, and PPi at 28 Angstroms Resolution. Biochem. 1996, 35, 2586-2596.
    • (1996) Biochem , vol.35 , pp. 2586-2596
    • Takusagawa, F.1    Kamitori, S.2    Markham, G.D.3
  • 38
    • 0016692220 scopus 로고
    • X Inactivation, Differentiation, and DNA Methylation
    • Riggs, A.D. X Inactivation, Differentiation, and DNA Methylation. Cytogenet. Genome Res. 1975, 14, 9-25.
    • (1975) Cytogenet. Genome Res , vol.14 , pp. 9-25
    • Riggs, A.D.1
  • 39
    • 0019318994 scopus 로고
    • DNA Methylation and Gene Function
    • Razin, A.; Riggs, A. DNA Methylation and Gene Function. Science 1980, 210, 604-610.
    • (1980) Science , vol.210 , pp. 604-610
    • Razin, A.1    Riggs, A.2
  • 40
    • 0020699979 scopus 로고
    • Hypomethylation Distinguishes Genes of Some Human Cancers from Their Normal Counterparts
    • Feinberg, A.P.; Vogelstein, B. Hypomethylation Distinguishes Genes of Some Human Cancers from Their Normal Counterparts. Nature 1983, 301, 89-92.
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 41
    • 0028001087 scopus 로고
    • Methylation of the Oestrogen Receptor CpG Island Links Ageing and Neoplasia in Human Colon
    • Issa, J.P.; Ottaviano, Y.L.; Celano, P.; Hamilton, S.R.; Davidson, N.E.; Baylin, S.B. Methylation of the Oestrogen Receptor CpG Island Links Ageing and Neoplasia in Human Colon. Nat. Genet. 1994, 7, 536-540.
    • (1994) Nat. Genet , vol.7 , pp. 536-540
    • Issa, J.P.1    Ottaviano, Y.L.2    Celano, P.3    Hamilton, S.R.4    Davidson, N.E.5    Baylin, S.B.6
  • 42
    • 0032401808 scopus 로고    scopus 로고
    • Aging and DNA Methylation in Colorectal Mucosa and Cancer
    • Ahuja, N.; Li, Q.; Mohan, A.L.; Baylin, S.B.; Issa, J.-P.J. Aging and DNA Methylation in Colorectal Mucosa and Cancer. Cancer Res. 1998, 58, 5489-5494.
    • (1998) Cancer Res , vol.58 , pp. 5489-5494
    • Ahuja, N.1    Li, Q.2    Mohan, A.L.3    Baylin, S.B.4    Issa, J.-P.J.5
  • 43
    • 49949108971 scopus 로고    scopus 로고
    • Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease
    • Wang, S.-C.; Oelze, B.; Schumacher, A. Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease. PLoS One 2008, 3, e2698.
    • (2008) PLoS One , vol.3
    • Wang, S.-C.1    Oelze, B.2    Schumacher, A.3
  • 45
    • 0029557798 scopus 로고
    • Induction of Oxidative DNA Damage by Ferric Iron in Mammalian Cells
    • Hartwig, A.; Schlepegrell, R. Induction of Oxidative DNA Damage by Ferric Iron in Mammalian Cells. Carcinogenesis 1995, 16, 3009-3013.
    • (1995) Carcinogenesis , vol.16 , pp. 3009-3013
    • Hartwig, A.1    Schlepegrell, R.2
  • 46
    • 0037093531 scopus 로고    scopus 로고
    • The Mitochondrial Protein Frataxin Prevents Nuclear Damage
    • Karthikeyan, G.; Lewis, K.; Resnick, M.A. The Mitochondrial Protein Frataxin Prevents Nuclear Damage. Hum. Mol. Genet. 2002, 11, 1351-1362.
    • (2002) Hum. Mol. Genet , vol.11 , pp. 1351-1362
    • Karthikeyan, G.1    Lewis, K.2    Resnick, M.A.3
  • 47
    • 0035870282 scopus 로고    scopus 로고
    • p16INK4a and Histology-Specific Methylation of CpG Islands by Exposure to Tobacco Smoke in Non-Small Cell Lung Cancer
    • Kim, D.-H.; Nelson, H.H.; Wiencke, J.K.; Zheng, S.; Christiani, D.C.; Wain, J.C.; Mark, E.J.; Kelsey, K.T. p16INK4a and Histology-Specific Methylation of CpG Islands by Exposure to Tobacco Smoke in Non-Small Cell Lung Cancer. Cancer Res. 2001, 61, 3419-3424.
    • (2001) Cancer Res , vol.61 , pp. 3419-3424
    • Kim, D.-H.1    Nelson, H.H.2    Wiencke, J.K.3    Zheng, S.4    Christiani, D.C.5    Wain, J.C.6    Mark, E.J.7    Kelsey, K.T.8
  • 51
    • 58249098396 scopus 로고    scopus 로고
    • Quantitative Analysis of DNA Methylation Profiles in Lung Cancer Identifies Aberrant DNA Methylation of Specific Genes and Its Association with Gender and Cancer Risk Factors
    • Vaissière, T.; Hung, R.J.; Zaridze, D.; Moukeria, A.; Cuenin, C.; Fasolo, V.; Ferro, G.; Paliwal, A.; Hainaut, P.; Brennan, P. et al. Quantitative Analysis of DNA Methylation Profiles in Lung Cancer Identifies Aberrant DNA Methylation of Specific Genes and Its Association with Gender and Cancer Risk Factors. Cancer Res. 2009, 69, 243-252.
    • (2009) Cancer Res , vol.69 , pp. 243-252
    • Vaissière, T.1    Hung, R.J.2    Zaridze, D.3    Moukeria, A.4    Cuenin, C.5    Fasolo, V.6    Ferro, G.7    Paliwal, A.8    Hainaut, P.9    Brennan, P.10
  • 52
    • 33846619807 scopus 로고    scopus 로고
    • Global DNA Methylation Level in Whole Blood as a Biomarker in Head and Neck Squamous Cell Carcinoma. Cancer Epidemiol
    • Hsiung, D.T.; Marsit, C.J.; Houseman, E.A.; Eddy, K.; Furniss, C.S.; McClean, M.D.; Kelsey, K.T. Global DNA Methylation Level in Whole Blood as a Biomarker in Head and Neck Squamous Cell Carcinoma. Cancer Epidemiol. Biomarkers Prev. 2007, 16, 108-114.
    • (2007) Biomarkers Prev , vol.16 , pp. 108-114
    • Hsiung, D.T.1    Marsit, C.J.2    Houseman, E.A.3    Eddy, K.4    Furniss, C.S.5    McClean, M.D.6    Kelsey, K.T.7
  • 54
    • 68149163598 scopus 로고    scopus 로고
    • The Presence of Aberrant DNA Methylation in Noncancerous Esophageal Mucosae in Association with Smoking History: A Target for Risk Diagnosis and Prevention of Esophageal Cancers
    • Oka, D.; Yamashita, S.; Tomioka, T.; Nakanishi, Y.; Kato, H.; Kaminishi, M.; Ushijima, T. The Presence of Aberrant DNA Methylation in Noncancerous Esophageal Mucosae in Association with Smoking History: A Target for Risk Diagnosis and Prevention of Esophageal Cancers. Cancer 2009, 115, 3412-3426.
    • (2009) Cancer , vol.115 , pp. 3412-3426
    • Oka, D.1    Yamashita, S.2    Tomioka, T.3    Nakanishi, Y.4    Kato, H.5    Kaminishi, M.6    Ushijima, T.7
  • 58
    • 2442656662 scopus 로고    scopus 로고
    • Mitochondrial-Derived Free Radicals Mediate Asbestos-Induced Alveolar Epithelial Cell Apoptosis
    • Panduri, V.; Weitzman, S.A.; Chandel, N.S.; Kamp, D.W. Mitochondrial-Derived Free Radicals Mediate Asbestos-Induced Alveolar Epithelial Cell Apoptosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004, 286, 1220-1227.
    • (2004) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.286 , pp. 1220-1227
    • Panduri, V.1    Weitzman, S.A.2    Chandel, N.S.3    Kamp, D.W.4
  • 59
    • 0015319592 scopus 로고
    • The Biologic Clock: The Mitochondria
    • Harman, D. The Biologic Clock: The Mitochondria? J. Am. Geriatr. Soc. 1972, 20, 145-147.
    • (1972) J. Am. Geriatr. Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 62
    • 59049086591 scopus 로고    scopus 로고
    • The Overexpression of Major Antioxidant Enzymes Does Not Extend the Lifespan of Mice
    • Pérez, V.I.; Van Remmen, H.; Bokov, A.; Epstein, C.J.; Vijg, J.; Richardson, A. The Overexpression of Major Antioxidant Enzymes Does Not Extend the Lifespan of Mice. Aging Cell 2009, 8, 73-75.
    • (2009) Aging Cell , vol.8 , pp. 73-75
    • Pérez, V.I.1    van Remmen, H.2    Bokov, A.3    Epstein, C.J.4    Vijg, J.5    Richardson, A.6
  • 63
    • 0026023219 scopus 로고
    • Hydrogen Peroxide Release by Mitochondria Increases during Aging
    • Sohal, R.S.; Sohal, B.H. Hydrogen Peroxide Release by Mitochondria Increases during Aging. Mech. Ageing Dev. 1991, 57, 187-202.
    • (1991) Mech. Ageing Dev , vol.57 , pp. 187-202
    • Sohal, R.S.1    Sohal, B.H.2
  • 66
    • 80053124673 scopus 로고    scopus 로고
    • Taking a "Good" Look at Free Radicals in the Aging Process
    • Hekimi, S.; Lapointe, J.; Wen, Y. Taking a "Good" Look at Free Radicals in the Aging Process. Trends Cell Biol. 2011, 21, 569-576.
    • (2011) Trends Cell Biol , vol.21 , pp. 569-576
    • Hekimi, S.1    Lapointe, J.2    Wen, Y.3
  • 67
    • 0028973482 scopus 로고
    • 2 for Platelet-Derived Growth Factor Signal Transduction
    • Sundaresan, M.; Yu, Z.-X.; Ferrans, V.J.; Irani, K.; Finkel, T. Requirement for Generation of H2O2 for Platelet-Derived Growth Factor Signal Transduction. Science 1995, 270, 296-299.
    • (1995) Science , vol.270 , pp. 296-299
    • Sundaresan, M.1    Yu, Z.-X.2    Ferrans, V.J.3    Irani, K.4    Finkel, T.5
  • 68
    • 15144343374 scopus 로고    scopus 로고
    • Epidermal Growth Factor (EGF)-Induced Generation of Hydrogen Peroxide. Role in EGF Receptor-Mediated Tyrosine Phosphorylation
    • Bae, Y.S.; Kang, S.W.; Seo, M.S.; Baines, I.C.; Tekle, E.; Chock, P.B.; Rhee, S.G. Epidermal Growth Factor (EGF)-Induced Generation of Hydrogen Peroxide. Role in EGF Receptor-Mediated Tyrosine Phosphorylation. J. Biol. Chem. 1997, 272, 217-221.
    • (1997) J. Biol. Chem , vol.272 , pp. 217-221
    • Bae, Y.S.1    Kang, S.W.2    Seo, M.S.3    Baines, I.C.4    Tekle, E.5    Chock, P.B.6    Rhee, S.G.7
  • 72
    • 34247186472 scopus 로고    scopus 로고
    • Reactive Oxygen Species Are Essential for Autophagy and Specifically Regulate the Activity of Atg4
    • Scherz-Shouval, R.; Shvets, E.; Fass, E.; Shorer, H.; Gil, L.; Elazar, Z. Reactive Oxygen Species Are Essential for Autophagy and Specifically Regulate the Activity of Atg4. EMBO J. 2007, 26, 1749-1760.
    • (2007) EMBO J , vol.26 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 73
    • 75149165994 scopus 로고    scopus 로고
    • Update on the Oxidative Stress Theory of Aging: Does Oxidative Stress Play a Role in Aging or Healthy Aging? Free Radic
    • Salmon, A.B.; Richardson, A.; Pérez, V.I. Update on the Oxidative Stress Theory of Aging: Does Oxidative Stress Play a Role in Aging or Healthy Aging? Free Radic. Biol. Med. 2010, 48, 642-655.
    • (2010) Biol. Med , vol.48 , pp. 642-655
    • Salmon, A.B.1    Richardson, A.2    Pérez, V.I.3
  • 74
    • 32444433202 scopus 로고    scopus 로고
    • Free Radicals, Metals and Antioxidants in Oxidative Stress-Induced Cancer
    • Valko, M.; Rhodes, C.J.; Moncol, J.; Izakovic, M.; Mazur, M. Free Radicals, Metals and Antioxidants in Oxidative Stress-Induced Cancer. Chem. Biol. Interact. 2006, 160, 1-40.
    • (2006) Chem. Biol. Interact , vol.160 , pp. 1-40
    • Valko, M.1    Rhodes, C.J.2    Moncol, J.3    Izakovic, M.4    Mazur, M.5
  • 75
    • 0020188453 scopus 로고
    • Oxidase and Oxygenase Function of the Microsomal Cytochrome P450 Monooxygenase System
    • Kuthan, H.; Ullrich, V. Oxidase and Oxygenase Function of the Microsomal Cytochrome P450 Monooxygenase System. Eur. J. Biochem. 1982, 126, 583-588.
    • (1982) Eur. J. Biochem , vol.126 , pp. 583-588
    • Kuthan, H.1    Ullrich, V.2
  • 76
    • 0013897667 scopus 로고
    • Peroxisomes (microbodies and Related Particles)
    • De Duve, C.; Baudhuin, P. Peroxisomes (microbodies and Related Particles). Physiol. Rev. 1966, 46, 323-357.
    • (1966) Physiol. Rev , vol.46 , pp. 323-357
    • de Duve, C.1    Baudhuin, P.2
  • 78
    • 0014773829 scopus 로고
    • The Monocyte in Cellular Immunity
    • Mackaness, G.B. The Monocyte in Cellular Immunity. Semin. Hematol. 1970, 7, 172-184.
    • (1970) Semin. Hematol , vol.7 , pp. 172-184
    • Mackaness, G.B.1
  • 79
    • 0020324680 scopus 로고
    • Mechanisms of Target Recognition and Destruction in Macrophage-Mediated Tumor Cytotoxicity
    • Adams, D.O.; Johnson, W.J.; Marino, P.A. Mechanisms of Target Recognition and Destruction in Macrophage-Mediated Tumor Cytotoxicity. Fed. Proc. 1982, 41, 2212-2221.
    • (1982) Fed. Proc , vol.41 , pp. 2212-2221
    • Adams, D.O.1    Johnson, W.J.2    Marino, P.A.3
  • 81
    • 0029439509 scopus 로고
    • Oxidative Stress: The Paradox of Aerobic Life
    • Davies, K. Oxidative Stress: The Paradox of Aerobic Life. Biochem. Soc. Synmp. 1995, 61, 1-31.
    • (1995) Biochem. Soc. Synmp , vol.61 , pp. 1-31
    • Davies, K.1
  • 83
    • 0026502997 scopus 로고
    • Study on the Mutagenicity of Brandy with the Ara Test
    • Ariza, R.R.; Serrano, A.; Pueyo, C. Study on the Mutagenicity of Brandy with the Ara Test. Mutagenesis 1992, 7, 77-81.
    • (1992) Mutagenesis , vol.7 , pp. 77-81
    • Ariza, R.R.1    Serrano, A.2    Pueyo, C.3
  • 85
    • 0030869103 scopus 로고    scopus 로고
    • Identification of Possible Reactive Oxygen Species Involved in Ultraviolet Radiation-Induced Oxidative DNA Damage
    • Zhang, X.; Rosenstein, B.S.; Wang, Y.; Lebwohl, M.; Wei, H. Identification of Possible Reactive Oxygen Species Involved in Ultraviolet Radiation-Induced Oxidative DNA Damage. Free Radic. Biol. Med. 1997, 23, 980-985.
    • (1997) Free Radic. Biol. Med , vol.23 , pp. 980-985
    • Zhang, X.1    Rosenstein, B.S.2    Wang, Y.3    Lebwohl, M.4    Wei, H.5
  • 86
    • 0035872421 scopus 로고    scopus 로고
    • Ionizing Radiation-Induced, Mitochondria-Dependent Generation of Reactive Oxygen/Nitrogen
    • Leach, J.K.; Van Tuyle, G.; Lin, P.-S.; Schmidt-Ullrich, R.; Mikkelsen, R.B. Ionizing Radiation-Induced, Mitochondria-Dependent Generation of Reactive Oxygen/Nitrogen. Cancer Res. 2001, 61, 3894-3901.
    • (2001) Cancer Res , vol.61 , pp. 3894-3901
    • Leach, J.K.1    van Tuyle, G.2    Lin, P.-S.3    Schmidt-Ullrich, R.4    Mikkelsen, R.B.5
  • 88
    • 0036260697 scopus 로고    scopus 로고
    • Cellular Response to Oxidative Stress: Signaling for Suicide and Survival
    • Martindale, J.L.; Holbrook, N.J. Cellular Response to Oxidative Stress: Signaling for Suicide and Survival. J. Cell. Physiol. 2002, 192, 1-15.
    • (2002) J. Cell. Physiol , vol.192 , pp. 1-15
    • Martindale, J.L.1    Holbrook, N.J.2
  • 89
    • 0034633602 scopus 로고    scopus 로고
    • Hydrogen Peroxide: A Key Messenger That Modulates Protein Phosphorylation through Cysteine Oxidation
    • Rhee, S.G.; Bae, Y.S.; Lee, S.R.; Kwon, J. Hydrogen Peroxide: A Key Messenger That Modulates Protein Phosphorylation through Cysteine Oxidation. Sci. STKE 2000, 53, pe1.
    • (2000) Sci. STKE , vol.53
    • Rhee, S.G.1    Bae, Y.S.2    Lee, S.R.3    Kwon, J.4
  • 93
    • 0034603580 scopus 로고    scopus 로고
    • Age-Related Changes in Reactive Oxygen Species Production in Rat Brain Homogenates
    • Driver, A.S.; Kodavanti, P.R.S.; Mundy, W.R. Age-Related Changes in Reactive Oxygen Species Production in Rat Brain Homogenates. Neurotoxicol. Teratol. 2000, 22, 175-181.
    • (2000) Neurotoxicol. Teratol , vol.22 , pp. 175-181
    • Driver, A.S.1    Kodavanti, P.R.S.2    Mundy, W.R.3
  • 95
    • 0033817812 scopus 로고    scopus 로고
    • Free Radical Generation and Oxidative Stress with Ageing and Exercise: Differential Effects in the Myocardium and Liver
    • Bejma, J.; Ramires, P.; Ji, L.L. Free Radical Generation and Oxidative Stress with Ageing and Exercise: Differential Effects in the Myocardium and Liver. Acta Physiol. Scand. 2000, 169, 343-351.
    • (2000) Acta Physiol. Scand , vol.169 , pp. 343-351
    • Bejma, J.1    Ramires, P.2    Ji, L.L.3
  • 97
    • 79956196320 scopus 로고    scopus 로고
    • Reactive Oxygen Species (ROS)--Induced Genetic and Epigenetic Alterations in Human Carcinogenesis. Mutat
    • Ziech, D.; Franco, R.; Pappa, A.; Panayiotidis, M.I. Reactive Oxygen Species (ROS)--Induced Genetic and Epigenetic Alterations in Human Carcinogenesis. Mutat. Res. 2011, 711, 167-173.
    • (2011) Res , vol.711 , pp. 167-173
    • Ziech, D.1    Franco, R.2    Pappa, A.3    Panayiotidis, M.I.4
  • 98
    • 77249094474 scopus 로고    scopus 로고
    • Oxidative DNA Damage Impairs Global Sperm DNA Methylation in Infertile Men
    • Tunc, O.; Tremellen, K. Oxidative DNA Damage Impairs Global Sperm DNA Methylation in Infertile Men. J. Assist. Reprod. Genet. 2009, 26, 537-544.
    • (2009) J. Assist. Reprod. Genet , vol.26 , pp. 537-544
    • Tunc, O.1    Tremellen, K.2
  • 100
    • 0029001483 scopus 로고
    • DNA Adduct 8-Hydroxyl-2′-Deoxyguanosine (8-Hydroxyguanine) Affects Function of Human DNA Methyltransferase
    • Turk, P.W.; Laayoun, A.; Smith, S.S.; Weitzman, SA. DNA Adduct 8-Hydroxyl-2′-Deoxyguanosine (8-Hydroxyguanine) Affects Function of Human DNA Methyltransferase. Carcinogen. 1995, 16, 1253-1255.
    • (1995) Carcinogen , vol.16 , pp. 1253-1255
    • Turk, P.W.1    Laayoun, A.2    Smith, S.S.3    Weitzman, S.A.4
  • 101
    • 33847055935 scopus 로고    scopus 로고
    • Endogenous Cytosine Damage Products Alter the Site Selectivity of Human DNA Maintenance Methyltransferase DNMT1
    • Valinluck, V.; Sowers, L.C. Endogenous Cytosine Damage Products Alter the Site Selectivity of Human DNA Maintenance Methyltransferase DNMT1. Cancer Res. 2007, 67, 946-950.
    • (2007) Cancer Res , vol.67 , pp. 946-950
    • Valinluck, V.1    Sowers, L.C.2
  • 104
    • 66149123748 scopus 로고    scopus 로고
    • The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
    • Kriaucionis, S.; Heintz, N. The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain. Science 2009, 324, 929-930.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 106
    • 80052933429 scopus 로고    scopus 로고
    • DNA Demethylation Dynamics
    • Bhutani, N.; Burns, D.M.; Blau, H.M. DNA Demethylation Dynamics. Cell 2011, 146, 866-872.
    • (2011) Cell , vol.146 , pp. 866-872
    • Bhutani, N.1    Burns, D.M.2    Blau, H.M.3
  • 108
    • 77954362183 scopus 로고    scopus 로고
    • Examination of the Specificity of DNA Methylation Profiling Techniques towards 5-Methylcytosine and 5-Hydroxymethylcytosine
    • Jin, S.G.; Kadam, S.; Pfeifer, G.P. Examination of the Specificity of DNA Methylation Profiling Techniques towards 5-Methylcytosine and 5-Hydroxymethylcytosine. Nucleic Acids Res. 2010, 38, e125.
    • (2010) Nucleic Acids Res , vol.e125 , pp. 38
    • Jin, S.G.1    Kadam, S.2    Pfeifer, G.P.3
  • 109
    • 4043112183 scopus 로고    scopus 로고
    • Oxidative Damage to Methyl-CpG Sequences Inhibits the Binding of the Methyl-CpG Binding Domain (MBD) of Methyl-CpG Binding Protein 2 (MeCP2)
    • Valinluck, V.; Tsai, H.-H.; Rogstad, D.K.; Burdzy, A.; Bird, A.; Sowers, L.C. Oxidative Damage to Methyl-CpG Sequences Inhibits the Binding of the Methyl-CpG Binding Domain (MBD) of Methyl-CpG Binding Protein 2 (MeCP2). Nucleic Acids Res. 2004, 32, 4100-4108.
    • (2004) Nucleic Acids Res , vol.32 , pp. 4100-4108
    • Valinluck, V.1    Tsai, H.-H.2    Rogstad, D.K.3    Burdzy, A.4    Bird, A.5    Sowers, L.C.6
  • 110
    • 85016326735 scopus 로고    scopus 로고
    • New Nucleophilic Mechanisms of Ros-Dependent Epigenetic Modifications: Comparison of Aging and Cancer
    • Afanas'Ev, I. New Nucleophilic Mechanisms of Ros-Dependent Epigenetic Modifications: Comparison of Aging and Cancer. Aging Dis. 2014, 5, 52-62.
    • (2014) Aging Dis , vol.5 , pp. 52-62
    • Afanas'Ev, I.1
  • 111
    • 0035877609 scopus 로고    scopus 로고
    • The Mechanism of DNA Cytosine-5 Methylation. Kinetic and Mutational Dissection of Hhai Methyltransferase
    • Vilkaitis, G.; Merkiene, E.; Serva, S.; Weinhold, E.; Klimasauskas, S. The Mechanism of DNA Cytosine-5 Methylation. Kinetic and Mutational Dissection of Hhai Methyltransferase. J. Biol. Chem. 2001, 276, 20924-20934.
    • (2001) J. Biol. Chem , vol.276 , pp. 20924-20934
    • Vilkaitis, G.1    Merkiene, E.2    Serva, S.3    Weinhold, E.4    Klimasauskas, S.5
  • 112
    • 79956001873 scopus 로고    scopus 로고
    • Direct Observation of Cytosine Flipping and Covalent Catalysis in a DNA Methyltransferase
    • Gerasimaite, R.; Merkiene, E.; Klimašauskas, S. Direct Observation of Cytosine Flipping and Covalent Catalysis in a DNA Methyltransferase. Nucleic Acids Res. 2011, 39, 3771-3780.
    • (2011) Nucleic Acids Res , vol.39 , pp. 3771-3780
    • Gerasimaite, R.1    Merkiene, E.2    Klimašauskas, S.3
  • 113
    • 81255162523 scopus 로고    scopus 로고
    • Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands
    • O'Hagan, H.; Wang, W.; Sen, S. Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands. Cancer Cell 2011, 20, 606-619.
    • (2011) Cancer Cell , vol.20 , pp. 606-619
    • O'Hagan, H.1    Wang, W.2    Sen, S.3
  • 114
    • 77955501963 scopus 로고    scopus 로고
    • SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
    • Fan, W.; Luo, J. SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA. Mol. Cell 2010, 39, 247-258.
    • (2010) Mol. Cell , vol.39 , pp. 247-258
    • Fan, W.1    Luo, J.2
  • 118
    • 50849104569 scopus 로고    scopus 로고
    • Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island
    • O'Hagan, H.M.; Mohammad, H.P.; Baylin, S.B. Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island. PLoS Genet. 2008, 4, e1000155.
    • (2008) PLoS Genet , vol.4
    • O'Hagan, H.M.1    Mohammad, H.P.2    Baylin, S.B.3
  • 119
    • 0029046134 scopus 로고
    • Regulation of DNA Methylation by the Ras Signaling Pathway
    • MacLeod, A.; Rouleau, J.; Szyf, M. Regulation of DNA Methylation by the Ras Signaling Pathway. J. Biol. Chem. 1995, 270, 11327-11337.
    • (1995) J. Biol. Chem , vol.270 , pp. 11327-11337
    • Macleod, A.1    Rouleau, J.2    Szyf, M.3
  • 121
    • 0033988813 scopus 로고    scopus 로고
    • DNA Methyltransferase Dnmt1 Associates with Histone Deacetylase Activity
    • Fuks, F.; Burgers, W.A.; Brehm, A.; Hughes-Davies, L.; Kouzarides, T. DNA Methyltransferase Dnmt1 Associates with Histone Deacetylase Activity. Nat. Genet. 2000, 24, 88-91.
    • (2000) Nat. Genet , vol.24 , pp. 88-91
    • Fuks, F.1    Burgers, W.A.2    Brehm, A.3    Hughes-Davies, L.4    Kouzarides, T.5
  • 122
    • 24344466882 scopus 로고    scopus 로고
    • DNA Methylation and Histone Modifications: Teaming up to Silence Genes
    • Fuks, F. DNA Methylation and Histone Modifications: Teaming up to Silence Genes. Curr. Opin. Genet. Dev. 2005, 15, 490-495.
    • (2005) Curr. Opin. Genet. Dev , vol.15 , pp. 490-495
    • Fuks, F.1
  • 124
  • 125
    • 67349190247 scopus 로고    scopus 로고
    • Linking DNA Methylation and Histone Modification: Patterns and Paradigms
    • Cedar, H.; Bergman, Y. Linking DNA Methylation and Histone Modification: Patterns and Paradigms. Nat. Rev. Genet. 2009, 10, 295-304.
    • (2009) Nat. Rev. Genet , vol.10 , pp. 295-304
    • Cedar, H.1    Bergman, Y.2
  • 126
    • 34447625911 scopus 로고    scopus 로고
    • Epigenetics and Aging: The Targets and the Marks
    • Fraga, M.F.; Esteller, M. Epigenetics and Aging: The Targets and the Marks. Trends Genet. 2007, 23, 413-418.
    • (2007) Trends Genet , vol.23 , pp. 413-418
    • Fraga, M.F.1    Esteller, M.2
  • 127
    • 43049162647 scopus 로고    scopus 로고
    • Aging by Epigenetics-A Consequence of Chromatin Damage? Exp
    • Sedivy, J.M.; Banumathy, G.; Adams, P.D. Aging by Epigenetics-A Consequence of Chromatin Damage? Exp. Cell Res. 2008, 314, 1909-1917.
    • (2008) Cell Res , vol.314 , pp. 1909-1917
    • Sedivy, J.M.1    Banumathy, G.2    Adams, P.D.3
  • 128
    • 84867907645 scopus 로고    scopus 로고
    • The Great Unravelling: Chromatin as a Modulator of the Aging Process
    • O'Sullivan, R.J.; Karlseder, J. The Great Unravelling: Chromatin as a Modulator of the Aging Process. Trends Biochem. Sci. 2012, 37, 466-476.
    • (2012) Trends Biochem. Sci , vol.37 , pp. 466-476
    • O'Sullivan, R.J.1    Karlseder, J.2
  • 131
    • 72249101937 scopus 로고    scopus 로고
    • Kang, G.H. Comparison of CpG Island Hypermethylation and Repetitive DNA Hypomethylation in Premalignant Stages of Gastric Cancer, Stratified for Helicobacter Pylori Infection
    • Park, S.-Y.; Yoo, E.J.; Cho, N.-Y.; Kim, N.; Kang, G.H. Comparison of CpG Island Hypermethylation and Repetitive DNA Hypomethylation in Premalignant Stages of Gastric Cancer, Stratified for Helicobacter Pylori Infection. J. Pathol. 2009, 219, 410-416.
    • (2009) J. Pathol , vol.219 , pp. 410-416
    • Park, S.-Y.1    Yoo, E.J.2    Cho, N.-Y.3    Kim, N.4
  • 133
    • 0041924707 scopus 로고    scopus 로고
    • Aberrant Promoter Methylation Profiles of Tumor Suppressor Genes in Hepatocellular Carcinoma
    • Yang, B.; Guo, M.; Herman, J.G.; Clark, D.P. Aberrant Promoter Methylation Profiles of Tumor Suppressor Genes in Hepatocellular Carcinoma. Am. J. Pathol. 2003, 163, 1101-1107.
    • (2003) Am. J. Pathol , vol.163 , pp. 1101-1107
    • Yang, B.1    Guo, M.2    Herman, J.G.3    Clark, D.P.4
  • 134
    • 79956212196 scopus 로고    scopus 로고
    • Oxidative Stress and DNA Methylation in Prostate Cancer
    • Donkena, K.V.; Young, C.Y.F.; Tindall, D.J. Oxidative Stress and DNA Methylation in Prostate Cancer. Obstet. Gynecol. Int. 2010, 2010, 302051.
    • Obstet. Gynecol. Int , vol.2010 , Issue.30 , pp. 2010
    • Donkena, K.V.1    Young, C.Y.F.2    Tindall, D.J.3
  • 136
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal Instability and Tumors Promoted by DNA Hypomethylation
    • Eden, A.; Gaudet, F.; Waghmare, A.; Jaenisch, R. Chromosomal Instability and Tumors Promoted by DNA Hypomethylation. Science 2003, 300, 455.
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3    Jaenisch, R.4
  • 137
    • 0041736002 scopus 로고    scopus 로고
    • Drawing the Line in Progeria Syndromes
    • Hegele, R.A. Drawing the Line in Progeria Syndromes. Lancet 2003, 362, 416-417.
    • (2003) Lancet , vol.362 , pp. 416-417
    • Hegele, R.A.1
  • 140
    • 84878738557 scopus 로고    scopus 로고
    • Depleting the Methyltransferase Suv39h1 Improves DNA Repair and Extends Lifespan in a Progeria Mouse Model
    • Liu, B.; Wang, Z.; Zhang, L.; Ghosh, S.; Zheng, H.; Zhou, Z. Depleting the Methyltransferase Suv39h1 Improves DNA Repair and Extends Lifespan in a Progeria Mouse Model. Nat. Commun. 2013, 4, 2-12.
    • (2013) Nat. Commun , vol.4 , pp. 2-12
    • Liu, B.1    Wang, Z.2    Zhang, L.3    Ghosh, S.4    Zheng, H.5    Zhou, Z.6
  • 141
    • 84872007491 scopus 로고    scopus 로고
    • Aberrant DNA Methylation Profiles in the Premature Aging Disorders Hutchinson-Gilford Progeria and Werner Syndrome
    • Heyn, H.; Moran, S.; Esteller, M. Aberrant DNA Methylation Profiles in the Premature Aging Disorders Hutchinson-Gilford Progeria and Werner Syndrome. Epigenetics 2013, 8, 28-33.
    • (2013) Epigenetics , vol.8 , pp. 28-33
    • Heyn, H.1    Moran, S.2    Esteller, M.3
  • 143
    • 77954819453 scopus 로고    scopus 로고
    • C-Myb Has a Character of Oxidative Stress Resistance in Aged Human Diploid Fibroblasts: Regulates SAPK/JNK and Hsp60 Pathway Consequently
    • Lee, Y.-H.; Lee, N.-H.; Bhattarai, G.; Hwang, P.-H.; Kim, T.-I.; Jhee, E.-C.; Yi, H.-K. C-Myb Has a Character of Oxidative Stress Resistance in Aged Human Diploid Fibroblasts: Regulates SAPK/JNK and Hsp60 Pathway Consequently. Biogerontology 2010, 11, 267-274.
    • (2010) Biogerontology , vol.11 , pp. 267-274
    • Lee, Y.-H.1    Lee, N.-H.2    Bhattarai, G.3    Hwang, P.-H.4    Kim, T.-I.5    Jhee, E.-C.6    Yi, H.-K.7
  • 144
    • 0141839825 scopus 로고    scopus 로고
    • Transcriptional Control of the DNA Methyltransferases Is Altered in Aging and Neoplastically-Transformed Human Fibroblasts
    • Casillas, M.A.; Lopatina, N.; Andrews, L.G.; Tollefsbol, T.O. Transcriptional Control of the DNA Methyltransferases Is Altered in Aging and Neoplastically-Transformed Human Fibroblasts. Mol. Cell. Biochem. 2003, 252, 33-43.
    • (2003) Mol. Cell. Biochem , vol.252 , pp. 33-43
    • Casillas, M.A.1    Lopatina, N.2    Andrews, L.G.3    Tollefsbol, T.O.4
  • 145
    • 0035679346 scopus 로고    scopus 로고
    • Differential Maintenance and de Novo Methylating Activity by Three DNA Methyltransferases in Aging and Immortalized Fibroblasts
    • Lopatina, N.; Haskell, J.F.; Andrews, L.G.; Poole, J.C.; Saldanha, S.; Tollefsbol, T. Differential Maintenance and de Novo Methylating Activity by Three DNA Methyltransferases in Aging and Immortalized Fibroblasts. J. Cell. Biochem. 2002, 84, 324-334.
    • (2002) J. Cell. Biochem , vol.84 , pp. 324-334
    • Lopatina, N.1    Haskell, J.F.2    Andrews, L.G.3    Poole, J.C.4    Saldanha, S.5    Tollefsbol, T.6
  • 146
    • 84881086323 scopus 로고    scopus 로고
    • Cancer as a Dysregulated Epigenome Allowing Cellular Growth Advantage at the Expense of the Host
    • Timp, W.; Feinberg, A. Cancer as a Dysregulated Epigenome Allowing Cellular Growth Advantage at the Expense of the Host. Nat. Rev. Cancer 2013, 13, 497-510.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 497-510
    • Timp, W.1    Feinberg, A.2


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