Rutile TiO2 particles exert size and surface coating dependent retention and lesions on the murine brain

Toxicology Letters

Volumn 207, Issue 1, 2011, Pages 73-81

  Zhang, Lili ^a   Bai, Ru ^a   Li, Bai ^b   Ge, Cuicui ^b   Du, Jiangfeng ^b   Liu, Ying ^a   Le Guyader, Laurent ^a   Zhao, Yuliang ^a,b   Wu, Yanchuan ^c   He, Shida ^c   Ma, Yongmei ^d   Chen, Chunying ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b INSTITUTE OF HIGH ENERGY PHYSICS   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d INSTITUTE OF CHEMISTRY   (China)

Author keywords

Intranasal instillation; Murine brain; Nanomaterials; Neurotransmitter secretion; Shape; Surface modification; TiO2 nanoparticles; Toxicity

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; DOPAMINE; HOMOVANILLIC ACID; METAL NANOPARTICLE; NORADRENALIN; SEROTONIN; SILICON DIOXIDE; TITANIUM DIOXIDE; NANOPARTICLE; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DAMAGE; BRAIN REGION; BRAIN TISSUE; CELL STRUCTURE; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; HIPPOCAMPUS; HISTOPATHOLOGY; HYDROPHILICITY; HYDROPHOBICITY; MASS SPECTROMETRY; MATERIAL COATING; MOUSE; NERVE CELL; NEUROTOXICITY; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STAINING; SURFACE PROPERTY; UPREGULATION; ZETA POTENTIAL; ANIMAL; BRAIN; BRAIN DISEASE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; CYTOCHEMISTRY; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; INTRANASAL DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; RANDOMIZATION; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

MURINAE; MUS;

ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN; BRAIN DISEASES; DOPAMINE; FEMALE; HISTOCYTOCHEMISTRY; MICE; MICE, INBRED ICR; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PARTICLE SIZE; RANDOM ALLOCATION; SURFACE PROPERTIES; TITANIUM;

EID: 80053384428     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.08.001     Document Type: Article

References (51)

1. Amurao C.V. Nanotechnology-it's a small (and scary) world after all. Occup. Health Tracker 2006, 9:3-6.
2. 2, SiC nanoparticles and multi-walled carbon nanotubes exposure in several mammalian cell types: an in vitro study. J. Nanopart. Res. 2010, 12:61-73.
3. Bhattacharya K., Cramer H., Albrecht C., Schins R., Rahman Q., Zimmermann U., Dopp E. Vanadium pentoxide-coated ultrafine titanium dioxide particles induce cellular damage and micronucleus formation in V79 cells. J. Toxicol. Environ. Health A 2008, 71:976-980.
4. Boffetta P., Soutar A., Cherrie J.W., Granath F., Anderson A., Anttila A., Blettner M., Gaborieau V., Klug S.J., Langard S., Luce D., Merletti F., Miller B., Mirabelli D., Pukkala E., Adami H.O., Weiderpass E. Mortality among workers employed in the titanium dioxide production industry in Europe. Cancer Causes Control 2004, 15:697-706.
5. Byrne J.H. Neural computation: olfactory cortex as a model for telencephalic processing. Learning & Memory 2003, Macmillan Reference USA, New York, NY, pp. 445-450. second edition.
6. Chen Z., Meng H., Yuan H., Xing G.M., Chen C.Y., Zhao F., Wang Y., Zhang C.C., Zhao Y.L. Identification of target organs of copper nanoparticles with ICP-MS technique. J. Radioanal. Nucl. Chem. 2007, 272:599-603.
7. Cooper J.R., Bloom F.E., Roth R.H. The Biochemical Basis of Neuropharmacology 1996, Oxford University Press, New York, NY.
8. 2 nanoparticles. J. Biomed. Mater. Res. A 2011, 96A(1):221-229.
9. De Lorenzo A., Darin J. The olfactory neuron and the blood-brain barrier. Taste and Smell in Vertebrates 1970, Churchill, London, pp. 151-176.
10. Donaldson K., Stone V., Tran C.L., Kreyling W., Borm P.J.A. Nanotoxicology. Occup. Environ. Med. 2004, 61:727-728.
11. Dugan L.L., Lovett E.G., Quick K.L., Lotharius J., Lin T.T., O'Malley K.L. Fullerene-based antioxidants and neuro-degenerative disorders. Parkinsonism Relat. Disord. 2001, 7:243-246.
12. Elder A., Gelein R., Silva V., Feikert T., Opanashuk L., Carter J., Potter R., Maynard A., Finkelstein J., Oberdörster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ. Health Perspect. 2006, 114(8):1172-1178.
13. Fuster J.M. Chemical neurotransmission. The Prefrontal Cortex 2008, Academic Press, San Diego, USA, p. 62. fourth edition.
14. Gao X.Y., Yin S.T., Tang M.L., Chen J.T., Yang Z.F., Zhang W.C., Chen L., Yang B., Li Z.F., Zha Y.Y., Ruan D.Y., Wang M. Effects of developmental exposure to TiO2 nanoparticles on synaptic plasticity in hippocampus dentate gyrus area: an in vivo study in anesthetized rats. Biol. Trace Elem. Res. 2011, 10.1007/s12011-011-8990-4.
15. Haxhiu M.A., Tolentino-Silva F., Pete G., Kc P., Mack S.O. Monoaminergic neurons, chemosensation and arousal. Respir. Physiol. 2001, 129:191-209.
16. Hoet P.H.M., Brüske-Hohlfeld I., Salata O.V. Nanoparticles-known and unknown health risks. J. Nanobiotechnol. 2004, 2:12.
17. Hu R.P., Zheng L., Zhang T., Gao G.D., Cui Y.L., Cheng Z., Cheng J., Hong M.M., Tang M., Hong F.S. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. J. Hazard. Mater. 2011, 191(1-3):32-40.
18. IARC IAfRoC 2006. Descriptive epidemiology group of IARC.
19. Illum L. Transport of drugs from the nasal cavity to the central nervous system. Eur. J. Pharm. Sci. 2000, 11(1):1-18.
20. Lao F., Chen L., Li W., Ge C.C., Qu Y., Sun Q.M., Zhao Y.L., Han D., Chen C.Y. Fullerene nanoparticles selectively enter oxidation-damaged cerebral microvessel endothelial cells and inhibit JNK-related apoptosis. ACS Nano 2009, 3(11):3358-3368.
21. Lao F., Li W., Han D., Qu Y., Liu Y., Zhao Y.L., Chen C.Y. Fullerene derivatives protect endothelial cells against NO-induced damage. Nanotechnology 2009, 20(22):225103-225111.
22. Liang X.J., Chen C.Y., Zhao Y.L., Jia L., Wang P.C. Biopharmaceutics and therapeutic potential of engineered nanomaterials. Curr. Drug Metab. 2008, 9(8):697-709.
23. Lin A.M., Ho L.T. Melatonin suppressed iron-induced neurodegeneration in rat brain. Free Radic. Biol. Med. 2000, 28:904-911.
24. Liu Y.X., Li W., Lao F., Liu Y., Wang L.M., Bai R., Zhao Y.L., Chen C.Y. Intracellular dynamics of cationic and anionic polystyrene nanoparticles without direct interaction with mitotic spindle and chromosomes. Biomaterials 2011, 10.1016/j.biomaterials.2011.07.037.
25. Nel A., Xia T., Mädler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311(3):622-627.
26. Oberdörster G., Oberdörster E., Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005, 113:823-839.
27. Oberdörster G., Sharp Z., Atudorei V., Elder A., Gelein R., Kreyling W., Cox C. Translocation of inhaled ultrafine particles to the brain. Inhal. Toxicol. 2004, 16(6-7):437-445.
28. Oberdörster G., Utell M.J. Ultrafine particles in the urban air: to the respiratory tract and beyond?. Environ. Health Perspect. 2002, 110A:440-441.
29. Qiu Y., Liu Y., Wang L.M., Xu L.G., Bai R., Ji Y.L., Wu X.C., Zhao Y.L., Li Y.F., Chen C.Y. Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods. Biomaterials 2010, 31:7606-7619.
30. Qu Y., Li W., Zhou Y.L., Liu X.F., Zhang L.L., Wang L.M., Li Y.F., Iida A., Tang Z.Y., Zhao Y.L., Chai Z.F., Chen C.Y. Full Assessment of Fate and Physiological Behavior of Quantum Dots Utilizing Caenorhabditis elegans as a Model Organism. Nano Lett. 2011, 10.1021/nl201391e.
31. Ressler K.J., Nemeroff C.B. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress. Anxiety 2000, 12(Suppl. 1):2-19.
32. Roberts J.R., Chapman R.S., Tirumala V.R., Karim A., Chen B.T., Schwegler-Berry D., Stefaniak A.B., Leonard S.S., Antonini J.M. Toxicological evaluation of lung responses after intratracheal exposure to non-dispersed titanium dioxide nanorods. J. Toxicol. Env. Heal. A Current Issues 2011, 74(12):790-810.
33. 2 nanoparticles induces pulmonary neutrophilia in mice. Toxicol. Sci. 2010, 113:422-433.
34. Sayer C.M., Wahi P.A., Kurian P.A., Liu Y., West J.L., Ausman K.D., Warheit D.B., Colvin V.L. Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicol. Sci. 2006, 92:174-185.
35. Semmler M., Seitz J., Erbe F., Mayer P., Heyder J., Oberdörster G., Kreyling W.G. Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organs. Inhal. Toxicol. 2004, 16(6-7):453-459.
36. Sharma R.P., Coulombe R.A., Srisuchart B. Effects of dietary vanadium exposure on levels of regional brain neurotransmitters and their metabolites. Biochem. Pharmacol. 1986, 35:461-465.
37. Shimizu M., Tainaka H., Oba T., Mizuo K., Umezawa M., Takeda K. Maternal exposure to nanoparticulate titanium dioxide during theprenatal period alters gene expression related to brain development in the mouse. Part Fibre Toxicol. 2009, 6:20.
38. Suzuki T., Oshio S., Iwata M., Saburi H., Odagiri T., Udagawa T., Sugawara I., Umezawa M., Takeda K. In utero exposure to a low concentration of diesel exhaust affects spontaneous locomotor activity and monoaminergic system in male mice. Part. Fibre Toxicol. 2010, 7.
39. Takahashi Y., Mizuo K., Shinkai Y., Oshio S., Takeda K. Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cotex and neostriatum of mice. J. Toxicol. Sci. 2010, 35(5):749-756.
40. Tamminga C.A. The neurobiology of cognition in schizophrenia. J. Clin. Psychiatry 2006, 67:e11.
41. 3 particles into the brain: micro-distribution, chemical states, and histopathological observation. Biol. Trace Elem. Res. 2007, 118:233-243.
42. Wang B., Feng W.Y., Zhu M.T., Wang Y., Wang M., Gu Y.Q., Ouyang H., Wang H.J., Li M., Zhao Y.L., Chai Z.F., Wang H.F. Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice. J. Nanopart. Res. 2009, 11:41-53.
43. Wang J.X., Zhou G.Q., Chen C.Y., Yu H.W., Wang T.C., Ma Y.M., Jia G., Gao Y.X., Li B., Sun J., Jiao F., Zhao Y.L., Chai Z.F. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol. Lett. 2007, 168:176-185.
44. 2 nanoparticles in the anatase and rutile crystal phases. Toxicol. Lett. 2008, 183:72-80.
45. 2 nanoparticles. Toxicology 2008, 254:82-90.
46. Wang L.M., Liu Y., Li W., Jiang X., Ji Y.L., Wu X.C., Xu L.G., Qiu Y., Zhao K., Wei T.T., Li Y.F., Zhao Y., Chen C.Y. Selective targeting of gold nanorods at the mitochondria of cancer cells: implications for cancer therapy. Nano Lett. 2011, 11:772-780.
47. Watanabe M., Okada M., Kudo Y., Tonori Y., Niitsuya M., Sato T., Aizawa Y., Kotani M. Differences in the effects of fibrous and particulate titanium dioxide on alveolar macrophages of fischer 344 rats. J. Toxicol. Environ. Health A 2002, 65(15):1047-1060.
48. Win-Shwe T.T., Mitsushima D., Yamamoto S., Fukushima A., Funabashi T., Kobayashi T., Fujimaki H. Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticles exposure. Toxicol. Appl. Pharm. 2008, 226:192-198.
49. Yamashita K., Yoshioka Y., Higashisaka K., Mimura K., Morishita Y., Nozaki M., Yoshida T., Ogura T., Nabeshi H., Nagano K., Abe Y., Kamada H., Monobe Y., Imazawa T., Aoshima H., Shishido K., Kawai Y., Mayumi T., Tsunoda S.-i., Itoh N., Yoshikawa T., Yanagihara I., Saito S., Tsutsumi Y. Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat. Nanotechnol. 2011, 6(5):321-328.
50. Yin J.J., Lao F., Fu P.P., Wamer W.G., Zhao Y.L., Wang P.C., Qiu Y., Sun B., Xing G.M., Dong J.Q., Liang X.J., Chen C.Y. The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials. Biomaterials 2009, 30(4):611-621.
51. Zhao Y.L., Xing G.M., Chai Z.F. Nanotoxicology: are carbon nanotubes safe?. Nat. Nanotechnol. 2008, 3:191-192.