The neurotoxic potential of engineered nanomaterials

NeuroToxicology

Volumn 33, Issue 4, 2012, Pages 902-910

  Boyes, William K ^a   Chen, Rui ^b   Chen, Chunying ^b   Yokel, Robert A ^c  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Biodistribution; Blood brain barrier; Cerium oxide (ceria); Copper; Pharmacokinetics; Phototoxicity; Titanium dioxide (titania)

Indexed keywords

COPPER NANOPARTICLE; ENGINEERED NANOMATERIAL; FULLERENE DERIVATIVE; FULLEROL; GOLD NANOPARTICLE; NANOMATERIAL; NANOPARTICLE; REACTIVE OXYGEN METABOLITE; TITANIUM DIOXIDE NANOPARTICLE; UNCLASSIFIED DRUG;

ABSORPTION; ANALYSIS; ARTICLE; BIOTRANSFORMATION; BRAIN LEVEL; ELEMENTAL ANALYSIS; EXCRETION; EXPOSURE; EYE TOXICITY; HUMAN; LD 50; NANOTOXICOLOGY; NEUROTOXICITY; NONHUMAN; NOSE TO BRAIN TRANSPORT; OLFACTORY BULB; OLFACTORY EPITHELIUM; PARTICLE SIZE; PHOTOCATALYSIS; PHOTOTOXICITY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; SOLUBILITY; TISSUE DISTRIBUTION; TOXICOKINETICS;

BIOTRANSFORMATION; BRAIN; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; HUMANS; NANOSTRUCTURES; NEUROTOXICITY SYNDROMES; RETINA; RISK ASSESSMENT; RISK FACTORS; TISSUE DISTRIBUTION; TOXICOLOGY; VISCERA;

EID: 84864501817     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2011.12.013     Document Type: Article

References (79)

1. 2 based thin films. FEMS Microbiol Lett 2002, 211:183-188.
2. Bai W., Zhang Z., Tian W., He X., Ma Y., Zhao Y., et al. Toxicity of zinc oxide nanoparticles to zebrafish embryo: a physicochemical study of toxicity mechanism. J Nanopart Res 2010, 12:1645-1654.
3. Ballou B., Lagerholm B.C., Ernst L.A., Bruchez M.P., Waggoner A.S. Noninvasive imaging of quantum dots in mice. Bioconjug Chem 2004, 15:79-86.
4. Bodian D., Howe H.A. Experimental studies on intraneuronal spread of poliomyelitis virus. Bull Johns Hopkins Hosp 1941, 69:248-267.
5. Brenneman K.A., Wong B.A., Buccellato M.A., Costa E.R., Gross E.A., Dorman D.C. Direct olfactory transport of inhaled manganese ((54)MnCl(2)) to the rat brain: toxicokinetic investigations in a unilateral nasal occlusion model. Toxicol Appl Pharmacol 2000, 169:238-248.
6. Brouwer D. Exposure to manufactured nanoparticles in different workplaces. Toxicology 2010, 269:120-127.
7. Brunner T.J., Wick P., Manser P., Spohn P., Grass R.N., Limbach L.K., et al. In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility. Environ Sci Technol 2006, 40:4374-4381.
8. Chen Y-S., Hung Y-C., Lin L-W., Liau I., Hong M-Y., Huang G.S. Size-dependent impairment of cognition in mice caused by the injection of gold nanoparticles. Nanotechnology 2010, 21:485102.
9. Chen Z., Meng H., Xing G., Chen C., Zhao Y., Jia G., et al. Acute toxicological effects of copper nanoparticles in vivo. Toxicol Lett 2006, 163:109-120.
10. Cherukuri P., Gannon C.J., Leeuw T.K., Schmidt H.K., Smalley R.E., Curley S.A., et al. Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. Proc Natl Acad Sci U S A 2006, 103:18882-18886.
11. Cho M., Cho W.S., Choi M., Kim S.J., Han B.S., Kim S.H., et al. The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles. Toxicol Lett 2009, 189:177-183.
12. Cho W.S., Cho M., Jeong J., Choi M., Cho H.Y., Han B.S., et al. Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles. Toxicol Appl Pharmacol 2009, 236:16-24.
13. Choi H.S., Liu W., Misra P., Tanaka E., Zimmer J.P., Itty Ipe B., et al. Renal clearance of quantum dots. Nat Biotechnol 2007, 25:1165-1170.
14. Dan M., Wu P., Grulke E.A., Graham U.M., Unrine J.M., Yokel R.A. Ceria engineered nanomaterial distribution in and clearance from blood: size matters. Nanomedicine 2012, 7:95-110.
15. De Jong W.H., Hagens W.I., Krystek P., Burger M.C., Sips A.J., Geertsma R.E. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 2008, 29:1912-1919.
16. de Lorenzo A.J.D. The olfactory neuron and the blood-brain barrier. Taste and smell in vertebrates 1970, 151-176. Churchill, London. G. Wolstenholme, J. Knight (Eds.).
17. Deng Z.J., Mortimer G., Schiller T., Musumeci A., Martin D., Minchin R.F. Differential plasma protein binding to metal oxide nanoparticles. Nanotechnology 2009, 20. 455101/455101-455101/455109.
18. Derfus A.M., Chan W.C.W., Bhatia S.N. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 2004, 4:11-18.
19. Elder A., Gelein R., Silva V., Feikert T., Opanashuk L., Carter J., et al. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect 2006, 114:1172-1178.
20. Fabian E., Landsiedel R., Ma-Hock L., Wiench K., Wohlleben W., van Ravenzwaay B. Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. Arch Toxicol 2008, 82:151-157.
21. Fischer H.C., Liu L., Pang K.S., Chan W.C.W. Pharmacokinetics of nanoscale quantum dots: in vivo distribution, sequestration, and clearance in the rat. Adv Funct Mater 2006, 16:1299-1305.
22. Fujishima A., Rao T.N., Tryk D.A. Titanium dioxide photocatalysis. J Photochem Photobiol C: Photochem Rev 2000, 1:1-21.
23. Geiser M., Rothen-Rutishauser B., Kapp N., Schurch S., Kreyling W., Schulz H., et al. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 2005, 113:1555-1560.
24. Hagens W.I., Oomen A.G., de Jong W.H., Cassee F.R., Sips A.J. What do we (need to) know about the kinetic properties of nanoparticles in the body. Regul Toxicol Pharmacol 2007, 49:217-229.
25. Hardas S.S., Butterfield D.A., Sultana R., Tseng M.T., Dan M., Florence R.L., et al. Brain distribution and toxicological evaluation of a systemically delivered engineered nanoscale ceria. Toxicol Sci 2010, 116:562-576.
26. He X., Zhang H., Ma Y., Bai W., Zhang Z., Lu K., et al. Lung deposition and extrapulmonary translocation of nano-ceria after intratracheal instillation. Nanotechnology 2010, 21. 285103/285101-285103/285108.
27. 2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus. Chemosphere 2008, 71:1308-1316.
28. Hillyer J.F., Albrecht R.M. Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J Pharm Sci 2001, 90:1927-1936.
29. Illum L. Transport of drugs from the nasal cavity to the central nervous system. Eur J Pharm Sci 2000, 11:1-18.
30. Jacobs G.H., Fenwick J.A., Williams G.A. Cone-based vision of rats for ultraviolet and visible lights. J Exp Biol 2001, 204:2439-2446.
31. Jani P., Halbert G.W., Langridge J., Florence A.T. Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J Pharm Pharmacol 1990, 42:821-826.
32. Johnston H.J., Hutchison G., Christensen F.M., Peters S., Hankin S., Stone V. A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity. Crit Rev Toxicol 2010, 40:328-346.
33. 2 to yeast Saccharomyces cerevisiae. Toxicol In Vitro 2009, 23:1116-1122.
34. 2 in environmental engineering. Crit Rev Environ Sci Technol 2008, 38:197-226.
35. Lerman S. NMR fluorescence spectroscopy on the normal, aging, and cataractous lens. Lens Res 1983, 1:175.
36. Li N., Guo J., Liu B., Yu Y., Cui H., Mao L., et al. Determination of monoamine neurotransmitters and their metabolites in a mouse brain microdialysate by coupling high-performance liquid chromatography with gold nanoparticle-initiated chemiluminescence. Anal Chim Acta 2009, 645:48-55.
37. Lin C.H., Chang L.W., Chang H., Yang M.H., Yang C.S., Lai W.H., et al. The chemical fate of the Cd/Se/Te-based quantum dot 705 in the biological system: toxicity implications. Nanotechnology 2009, 20. 215101/215101-215101/215109.
38. Lin P., Chen J.W., Chang L.W., Wu J.P., Redding L., Chang H., et al. Computational and ultrastructural toxicology of a nanoparticle, Quantum Dot 705, in mice. Environ Sci Technol 2008, 42:6264-6270.
39. Liu Y., Gao Y., Zhang L., Wang T., Wang J., Jiao F., et al. Potential health impact on mice after nasal instillation of nano-sized copper particles and their translocation in mice. J Nanosci Nanotechnol 2009, 9:6335-6343.
40. Meng H., Chen Z., Xing G., Yuan H., Chen C., Zhao F., et al. Ultrahigh reactivity and grave nanotoxicity of copper nanoparticles. J Radioanal Nucl Chem 2007, 272:595-598.
41. Monopoli M.P., Walczyk D., Campbell A., Elia G., Lynch I., Bombelli F.B., et al. Physical-chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles. J Am Chem Soc 2011, 133:2525-2534.
42. Muneer M., Singh H.K., Bahnemann D. Semiconductor-mediated photocatalysed degradation of two selected priority organic pollutants, benzidine and 1,2-diphenylhydrazine, in aqueous suspension. Chemosphere 2002, 49:193-203.
43. Nagpal K., Singh S., Mishra D. Chitosan nanoparticles: a promising system in novel drug delivery. Chem Pharm Bull 2010, 58:1423-1430.
44. National Science and Technology Council The National Nanotechnology Initiative - Strategic Plan 2007, National Science and Technology Council, Committee on Technology and Subcommittee on Nanoscale Science Engineering and Technology, Arlington, VA.
45. Oberdörster G., Elder A., Rinderknecht A. Nanoparticles and the brain: cause for concern. J Nanosci Nanotechnol 2009, 9:4996-5007.
46. Oberdörster G., Maynard A., Donaldson K., Castranova V., Fitzpatrick J., Ausman K., et al. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy, A report from the ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group. Part Fibre Toxicol 2005, 2:1-35.
47. Oberdörster G., Sharp Z., Atudorei V., Elder A., Gelein R., Kreyling W., et al. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 2004, 16:437-445.
48. Owens D.E., Peppas N.A. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm 2006, 307:93-102.
49. Roberts J.E. Screening for ocular phototoxicity. Int J Toxicol 2002, 21:491-500.
50. Roberts J.E., Wielgus A.R., Boyes W.K., Andley U., Chignell C.F. Phototoxicity and cytotoxicity of fullerol in human lens epithelial cells. Toxicol Appl Pharmacol 2008, 228:49-58.
51. Rothen-Rutishauser B.M., Schurch S., Haenni B., Kapp N., Gehr P. Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques. Environ Sci Technol 2006, 40:4353-4359.
52. Sanders K., Degn L.L., Mundy W.R., Zucker R., Dreher K., Zhao B., et al. In vitro phototoxicity and hazard identification of nano-scale titanium dioxide. Toxicol Appl Pharmacol 2011, 10.1016/j.taap.2011.10.023.
53. Schmidt J., Vogelsberger W. Aqueous long-term solubility of titania nanoparticles and titanium(IV) hydrolysis in a sodium chloride system studied by adsorptive stripping voltammetry. J Solution Chem 2009, 38:1267-1282.
54. Seipenbusch M., Binder A., Kasper G. Temporal evolution of nanoparticle aerosols in workplace exposure. Ann Occup Hyg 2008, 52:707-716.
55. Semmler-Behnke M., Kreyling W.G., Lipka J., Fertsch S., Wenk A., Takenaka S., et al. Biodistribution of 1.4- and 18-nm gold particles in rats. Small 2008, 4:2108-2111.
56. Seyfoddin A., Shaw J., Al-Kassas R. Solid lipid nanoparticles for ocular drug delivery. Drug Deliv 2010, 17:467-489.
57. Sonavane G., Tomoda K., Makino K. Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size. Colloids Surf B Biointerfaces 2008, 66:274-280.
58. Takeda K., Suzuki K-i, Ishihara A., Kubo-Irie M., Fujimoto R., Tabata M., et al. Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems. J Health Sci 2009, 55:95-102.
59. 2 nanoparticles in aquatic ecotoxicity tests. Environ Sci Technol 2009, 43:4537-4546.
60. 2 and quartz. Toxicol Lett 2009, 186:152-159.
61. Walczyk D., Bombelli F.B., Monopoli M.P., Lynch I., Dawson K.A. What the cell sees in bionanoscience. J Am Chem Soc 2010, 132:5761-5768.
62. 3 particles into the brain: micro-distribution, chemical states, and histopathological observation. Biol Trace Elem Res 2007, 118:233-243.
63. 2 nanoparticles in the anatase and rutile crystal phases. Toxicol Lett 2008, 183:72-80.
64. 2 nanoparticles. Toxicology 2008, 254:82-90.
65. Wang J., Zhou G., Chen C., Yu H., Wang T., Ma Y., et al. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 2007, 168:176-185.
66. Wielgus A.R., Zhao B., Chignell C.F., Hu D-N., Roberts J.E. Phototoxicity and cytotoxicity of fullerol in human retinal pigment epithelial cells. Toxicol Appl Pharmacol 2010, 242:79-90.
67. 2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett 2009, 191:1-8.
68. Xia T., Kovochich M., Liong M., Madler L., Gilbert B., Shi H., et al. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2008, 2:2121-2134.
69. Yamashita K., Yoshioka Y., Higashisaka K., Mimura K., Morishita Y., Nozaki M., et al. Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat Nanotechnol 2011, 6:321-328.
70. Yang R.S., Chang L.W., Wu J.P., Tsai M.H., Wang H.J., Kuo Y.C., et al. Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment. Environ Health Perspect 2007, 115:1339-1343.
71. 2 thin film and the associated biological toxicity to zebrafish (Danio rerio) during and after photocatalysis. Water Res 2006, 40:1906-1914.
72. Yokel RA, Au TC, MacPhail R, Hardas SS, Butterfield DA, Sultana R, et al. Distribution, elimination and biopersistence to 90 days of a systemically-introduced 30nm ceria engineered nanomaterial in rats; submitted for publication.
73. Yokel R.A., Florence R.L., Unrine J.M., Tseng M.T., Graham U.M., Wu P., et al. Biodistribution and oxidative stress effects of a systemically-introduced commercial ceria engineered nanomaterial. Nanotoxicology 2009, 3:234-248.
74. Yokel R.A., MacPhail R.C. Engineered nanomaterials: exposures, hazards and risk prevention. J Occup Med Toxicol 2011, 6:1-27.
75. 2 particles exert size and surface coating dependent retention and lesions on the murine brain. Toxicol Lett 2011, 207:73-81.
76. Zhang L, Bai R, Liu Y, Meng L, Li B, Wang L, et al. The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles. Nanotoxicology, , in press. doi:10.3109/17435390.2011.590906.
77. Zhang L.W., Monteiro-Riviere N.A. Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin. Skin Pharmacol Physiol 2008, 21:166-180.
78. Zhu M.T., Feng W.Y., Wang Y., Wang B., Wang M., Ouyang H., et al. Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment. Toxicol Sci 2009, 107:342-351.
79. 2 nanoparticles in cells by flow cytometry. Cytometry A 2010, 77A:677-685.