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Volumn 92, Issue 10, 2014, Pages 1025-1034

Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia

Author keywords

Chronic complications; Diabetes; Hyperglycaemia; Hypoxia inducible factor; Pathogenic mechanisms

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1;

EID: 84931825050     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-014-1166-x     Document Type: Review
Times cited : (44)

References (100)
  • 1
    • 84860279257 scopus 로고    scopus 로고
    • The pathogenesis of early retinal changes of diabetic retinopathy
    • COI: 1:STN:280:DC%2BC38vhvFejtQ%3D%3D
    • Arden GB, Sivaprasad S (2012) The pathogenesis of early retinal changes of diabetic retinopathy. Documenta ophthalmologica Adv in ophthalmol 124:15–26
    • (2012) Documenta ophthalmologica Adv in ophthalmol , vol.124 , pp. 15-26
    • Arden, G.B.1    Sivaprasad, S.2
  • 3
    • 61849161619 scopus 로고    scopus 로고
    • Reduced oxygenation in diabetic rat kidneys measured by T2* weighted magnetic resonance micro-imaging
    • PID: 19227472
    • Edlund J, Hansell P, Fasching A, Liss P, Weis J, Glickson JD, Palm F (2009) Reduced oxygenation in diabetic rat kidneys measured by T2* weighted magnetic resonance micro-imaging. Adv Exp Med Biol 645:199–204
    • (2009) Adv Exp Med Biol , vol.645 , pp. 199-204
    • Edlund, J.1    Hansell, P.2    Fasching, A.3    Liss, P.4    Weis, J.5    Glickson, J.D.6    Palm, F.7
  • 4
    • 53649085571 scopus 로고    scopus 로고
    • Ozagrel reverses streptozotocin-induced constriction of arterioles in rat retina
    • PID: 18718478, COI: 1:CAS:528:DC%2BD1cXht1Kgsr3P
    • Lee S, Morgan GA, Harris NR (2008) Ozagrel reverses streptozotocin-induced constriction of arterioles in rat retina. Microvasc Res 76:217–223
    • (2008) Microvasc Res , vol.76 , pp. 217-223
    • Lee, S.1    Morgan, G.A.2    Harris, N.R.3
  • 5
    • 44949232374 scopus 로고    scopus 로고
    • Neurovascular control and neurogenic inflammation in diabetes
    • PID: 18442183
    • Schaper NC, Huijberts M, Pickwell K (2008) Neurovascular control and neurogenic inflammation in diabetes. Diabetes Metab Res Rev 24(Suppl 1):S40–44
    • (2008) Diabetes Metab Res Rev , vol.24 , pp. S40-S44
    • Schaper, N.C.1    Huijberts, M.2    Pickwell, K.3
  • 6
    • 76149143129 scopus 로고    scopus 로고
    • Diabetic angiopathy, the complement system and the tumor necrosis factor superfamily
    • PID: 20098449, COI: 1:CAS:528:DC%2BC3cXpslCqsw%3D%3D
    • Flyvbjerg A (2010) Diabetic angiopathy, the complement system and the tumor necrosis factor superfamily. Nat Rev Endocrinol 6:94–101
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 94-101
    • Flyvbjerg, A.1
  • 7
    • 46349110918 scopus 로고    scopus 로고
    • Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells
    • PID: 18439413, COI: 1:CAS:528:DC%2BD1cXnsFCmu7c%3D
    • Friederich M, Fasching A, Hansell P, Nordquist L, Palm F (2008) Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells. Biochim Biophys Acta 1777:935–940
    • (2008) Biochim Biophys Acta , vol.1777 , pp. 935-940
    • Friederich, M.1    Fasching, A.2    Hansell, P.3    Nordquist, L.4    Palm, F.5
  • 8
    • 77954345078 scopus 로고    scopus 로고
    • Oxygen homeostasis
    • PID: 20836033, COI: 1:CAS:528:DC%2BC3cXmtVSrtr4%3D
    • Semenza GL (2010) Oxygen homeostasis. Wiley Interdiscip Rev Syst Biol Med 2:336–361
    • (2010) Wiley Interdiscip Rev Syst Biol Med , vol.2 , pp. 336-361
    • Semenza, G.L.1
  • 9
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • PID: 9113979, COI: 1:CAS:528:DyaK2sXjtVyitbY%3D
    • Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 94:4273–4278
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 10
    • 84655161946 scopus 로고    scopus 로고
    • HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression
    • COI: 1:CAS:528:DC%2BC3MXhs1aisbzM
    • Keith B, Johnson RS, Simon MC (2012) HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 12:9–22
    • (2012) Nat Rev Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 11
    • 80555135912 scopus 로고    scopus 로고
    • Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1alpha
    • PID: 22055192
    • Le Moan N, Houslay DM, Christian F, Houslay MD, Akassoglou K (2011) Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1alpha. Mol Cell 44:476–490
    • (2011) Mol Cell , vol.44 , pp. 476-490
    • Le Moan, N.1    Houslay, D.M.2    Christian, F.3    Houslay, M.D.4    Akassoglou, K.5
  • 12
    • 66749129781 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1
    • PID: 19498162, COI: 1:CAS:528:DC%2BD1MXms12gurk%3D
    • Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, Gerard RD, Garcia JA (2009) Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 324:1289–1293
    • (2009) Science , vol.324 , pp. 1289-1293
    • Dioum, E.M.1    Chen, R.2    Alexander, M.S.3    Zhang, Q.4    Hogg, R.T.5    Gerard, R.D.6    Garcia, J.A.7
  • 15
    • 84878542447 scopus 로고    scopus 로고
    • Deciphering the emerging role of SUMO conjugation in the hypoxia-signaling cascade
    • PID: 23362194
    • Nunez-O’Mara A, Berra E (2013) Deciphering the emerging role of SUMO conjugation in the hypoxia-signaling cascade. Biol Chem 394:459–469
    • (2013) Biol Chem , vol.394 , pp. 459-469
    • Nunez-O’Mara, A.1    Berra, E.2
  • 16
    • 79952137486 scopus 로고    scopus 로고
    • miR-210: more than a silent player in hypoxia
    • PID: 21360638, COI: 1:CAS:528:DC%2BC3MXisV2jsrc%3D
    • Devlin C, Greco S, Martelli F, Ivan M (2011) miR-210: more than a silent player in hypoxia. IUBMB Life 63:94–100
    • (2011) IUBMB Life , vol.63 , pp. 94-100
    • Devlin, C.1    Greco, S.2    Martelli, F.3    Ivan, M.4
  • 17
    • 63449103705 scopus 로고    scopus 로고
    • Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
    • PID: 19255431, COI: 1:CAS:528:DC%2BD1MXjslChu7w%3D
    • Xia X, Lemieux ME, Li W, Carroll JS, Brown M, Liu XS, Kung AL (2009) Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci U S A 106:4260–4265
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4260-4265
    • Xia, X.1    Lemieux, M.E.2    Li, W.3    Carroll, J.S.4    Brown, M.5    Liu, X.S.6    Kung, A.L.7
  • 18
    • 0014014125 scopus 로고
    • Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes
    • PID: 5907911, COI: 1:CAS:528:DyaF28XntVarug%3D%3D
    • Gabbay KH, Merola LO, Field RA (1966) Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes. Science 151:209–210
    • (1966) Science , vol.151 , pp. 209-210
    • Gabbay, K.H.1    Merola, L.O.2    Field, R.A.3
  • 19
    • 0026469097 scopus 로고
    • Complications: neuropathy, pathogenetic considerations
    • PID: 1464245, COI: 1:STN:280:DyaK3s%2FpvFOktg%3D%3D
    • Greene DA, Sima AA, Stevens MJ, Feldman EL, Lattimer SA (1992) Complications: neuropathy, pathogenetic considerations. Diabetes Care 15:1902–1925
    • (1992) Diabetes Care , vol.15 , pp. 1902-1925
    • Greene, D.A.1    Sima, A.A.2    Stevens, M.J.3    Feldman, E.L.4    Lattimer, S.A.5
  • 20
    • 48449094505 scopus 로고    scopus 로고
    • Polyol pathway mediates iron-induced oxidative injury in ischemic-reperfused rat heart
    • PID: 18549825, COI: 1:CAS:528:DC%2BD1cXpslWku7s%3D
    • Tang WH, Wu S, Wong TM, Chung SK, Chung SS (2008) Polyol pathway mediates iron-induced oxidative injury in ischemic-reperfused rat heart. Free Radic Biol Med 45:602–610
    • (2008) Free Radic Biol Med , vol.45 , pp. 602-610
    • Tang, W.H.1    Wu, S.2    Wong, T.M.3    Chung, S.K.4    Chung, S.S.5
  • 21
    • 0028304845 scopus 로고
    • Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes
    • PID: 8040253, COI: 1:CAS:528:DyaK2cXltlWnt7g%3D
    • Giardino I, Edelstein D, Brownlee M (1994) Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes. J Clin Invest 94:110–117
    • (1994) J Clin Invest , vol.94 , pp. 110-117
    • Giardino, I.1    Edelstein, D.2    Brownlee, M.3
  • 22
    • 78649753203 scopus 로고    scopus 로고
    • The chaperone-dependent ubiquitin ligase CHIP targets HIF-1alpha for degradation in the presence of methylglyoxal
    • PID: 21124777, COI: 1:CAS:528:DC%2BC3cXhsFaqu7nP
    • Bento CF, Fernandes R, Ramalho J, Marques C, Shang F, Taylor A, Pereira P (2010) The chaperone-dependent ubiquitin ligase CHIP targets HIF-1alpha for degradation in the presence of methylglyoxal. PLoS ONE 5:e15062
    • (2010) PLoS ONE , vol.5 , pp. e15062
    • Bento, C.F.1    Fernandes, R.2    Ramalho, J.3    Marques, C.4    Shang, F.5    Taylor, A.6    Pereira, P.7
  • 23
    • 44849131121 scopus 로고    scopus 로고
    • Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice
    • PID: 18227068, COI: 1:CAS:528:DC%2BD1cXksFagur4%3D
    • Ceradini DJ, Yao D, Grogan RH, Callaghan MJ, Edelstein D, Brownlee M, Gurtner GC (2008) Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice. J Biol Chem 283:10930–10938
    • (2008) J Biol Chem , vol.283 , pp. 10930-10938
    • Ceradini, D.J.1    Yao, D.2    Grogan, R.H.3    Callaghan, M.J.4    Edelstein, D.5    Brownlee, M.6    Gurtner, G.C.7
  • 25
    • 9444296528 scopus 로고    scopus 로고
    • Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function
    • PID: 15561954, COI: 1:CAS:528:DC%2BD2cXhtVOls7bN
    • Catrina SB, Okamoto K, Pereira T, Brismar K, Poellinger L (2004) Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function. Diabetes 53:3226–3232
    • (2004) Diabetes , vol.53 , pp. 3226-3232
    • Catrina, S.B.1    Okamoto, K.2    Pereira, T.3    Brismar, K.4    Poellinger, L.5
  • 26
    • 77955835661 scopus 로고    scopus 로고
    • Methylglyoxal-induced imbalance in the ratio VEGF/Ang-2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction
    • PID: 20562294, COI: 1:CAS:528:DC%2BC3cXhtlGjt7jP
    • Bento CF, Fernandes R, Matafome P, Sena C, Seica R, Pereira P (2010) Methylglyoxal-induced imbalance in the ratio VEGF/Ang-2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction. Exp Physiol 95:955–70
    • (2010) Exp Physiol , vol.95 , pp. 955-970
    • Bento, C.F.1    Fernandes, R.2    Matafome, P.3    Sena, C.4    Seica, R.5    Pereira, P.6
  • 27
    • 0035941358 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression by advanced glycation end products
    • PID: 11571295, COI: 1:STN:280:DC%2BD3MnmslKhuw%3D%3D
    • Treins C, Giorgetti-Peraldi S, Murdaca J, Van Obberghen E (2001) Regulation of vascular endothelial growth factor expression by advanced glycation end products. J Biol Chem 276:43836–43841
    • (2001) J Biol Chem , vol.276 , pp. 43836-43841
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Van Obberghen, E.4
  • 28
    • 37549011413 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates neuronal expression of the receptor for advanced glycation end products following hypoxia/ischemia
    • PID: 17942394, COI: 1:CAS:528:DC%2BD2sXhsVSgtr%2FI
    • Pichiule P, Chavez JC, Schmidt AM, Vannucci SJ (2007) Hypoxia-inducible factor-1 mediates neuronal expression of the receptor for advanced glycation end products following hypoxia/ischemia. J Biol Chem 282:36330–36340
    • (2007) J Biol Chem , vol.282 , pp. 36330-36340
    • Pichiule, P.1    Chavez, J.C.2    Schmidt, A.M.3    Vannucci, S.J.4
  • 31
    • 77649189113 scopus 로고    scopus 로고
    • Hypoxia and the expression of HIF-1alpha and HIF-2alpha in the retina of streptozotocin-injected mice and rats
    • PID: 20005221, COI: 1:CAS:528:DC%2BC3cXitVaqsrs%3D
    • Wright WS, McElhatten RM, Messina JE, Harris NR (2010) Hypoxia and the expression of HIF-1alpha and HIF-2alpha in the retina of streptozotocin-injected mice and rats. Exp Eye Res 90:405–412
    • (2010) Exp Eye Res , vol.90 , pp. 405-412
    • Wright, W.S.1    McElhatten, R.M.2    Messina, J.E.3    Harris, N.R.4
  • 32
    • 0030729851 scopus 로고    scopus 로고
    • High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria
    • PID: 9369223, COI: 1:CAS:528:DyaK2sXms1eksro%3D
    • Korshunov SS, Skulachev VP, Starkov AA (1997) High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett 416:15–18
    • (1997) FEBS Lett , vol.416 , pp. 15-18
    • Korshunov, S.S.1    Skulachev, V.P.2    Starkov, A.A.3
  • 34
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    • PID: 16517405
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3:177–185
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 36
    • 33947724515 scopus 로고    scopus 로고
    • HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    • PID: 17418790, COI: 1:CAS:528:DC%2BD2sXkvVeltLg%3D
    • Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL (2007) HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129:111–122
    • (2007) Cell , vol.129 , pp. 111-122
    • Fukuda, R.1    Zhang, H.2    Kim, J.W.3    Shimoda, L.4    Dang, C.V.5    Semenza, G.L.6
  • 37
    • 70349478990 scopus 로고    scopus 로고
    • MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
    • PID: 19808020, COI: 1:CAS:528:DC%2BD1MXhsFKltL3E
    • Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J (2009) MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 10:273–284
    • (2009) Cell Metab , vol.10 , pp. 273-284
    • Chan, S.Y.1    Zhang, Y.Y.2    Hemann, C.3    Mahoney, C.E.4    Zweier, J.L.5    Loscalzo, J.6
  • 38
    • 77951238575 scopus 로고    scopus 로고
    • Mitochondrial regulation of oxygen sensing
    • PID: 20204741, COI: 1:CAS:528:DC%2BC3cXhsFyjtrvO
    • Chandel NS (2010) Mitochondrial regulation of oxygen sensing. Adv Exp Med Biol 661:339–354
    • (2010) Adv Exp Med Biol , vol.661 , pp. 339-354
    • Chandel, N.S.1
  • 39
    • 24144467846 scopus 로고    scopus 로고
    • ROS: really involved in oxygen sensing
    • PID: 16054083, COI: 1:CAS:528:DC%2BD2MXlslajs7Y%3D
    • Kaelin WG Jr (2005) ROS: really involved in oxygen sensing. Cell Metab 1:357–358
    • (2005) Cell Metab , vol.1 , pp. 357-358
    • Kaelin, W.G.1
  • 40
    • 33745006163 scopus 로고    scopus 로고
    • Nitric oxide inhibits HIF-1alpha protein accumulation under hypoxic conditions: implication of 2-oxoglutarate and iron
    • PID: 16310922, COI: 1:CAS:528:DC%2BD28XmtVOlu7Y%3D
    • Kozhukhar AV, Yasinska IM, Sumbayev VV (2006) Nitric oxide inhibits HIF-1alpha protein accumulation under hypoxic conditions: implication of 2-oxoglutarate and iron. Biochimie 88:411–418
    • (2006) Biochimie , vol.88 , pp. 411-418
    • Kozhukhar, A.V.1    Yasinska, I.M.2    Sumbayev, V.V.3
  • 41
    • 28844462418 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme
    • PID: 16356120, COI: 1:CAS:528:DC%2BD2MXhtlWht7%2FJ
    • Pacher P, Szabo C (2005) Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme. Antioxid Redox Signal 7:1568–1580
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1568-1580
    • Pacher, P.1    Szabo, C.2
  • 42
    • 70349205438 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF
    • PID: 19656264, COI: 1:CAS:528:DC%2BD1MXht1ertLnF
    • Martinez-Romero R, Canuelo A, Martinez-Lara E, Javier Oliver F, Cardenas S, Siles E (2009) Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF. J Neurochem 111:150–159
    • (2009) J Neurochem , vol.111 , pp. 150-159
    • Martinez-Romero, R.1    Canuelo, A.2    Martinez-Lara, E.3    Javier Oliver, F.4    Cardenas, S.5    Siles, E.6
  • 43
    • 84864323177 scopus 로고    scopus 로고
    • Novel links between HIFs, type 2 diabetes, and metabolic syndrome
    • PID: 22766319, COI: 1:CAS:528:DC%2BC38XpvVOqtb4%3D
    • Girgis CM, Cheng K, Scott CH, Gunton JE (2012) Novel links between HIFs, type 2 diabetes, and metabolic syndrome. Trends Endocrinol Metab 23:372–380
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 372-380
    • Girgis, C.M.1    Cheng, K.2    Scott, C.H.3    Gunton, J.E.4
  • 45
    • 77958508121 scopus 로고    scopus 로고
    • Adipose tissue-specific inhibition of hypoxia-inducible factor 1(alpha) induces obesity and glucose intolerance by impeding energy expenditure in mice
    • PID: 20716529, COI: 1:CAS:528:DC%2BC3cXht12nu7zE
    • Zhang X, Lam KS, Ye H, Chung SK, Zhou M, Wang Y, Xu A (2010) Adipose tissue-specific inhibition of hypoxia-inducible factor 1(alpha) induces obesity and glucose intolerance by impeding energy expenditure in mice. J Biol Chem 285:32869–32877
    • (2010) J Biol Chem , vol.285 , pp. 32869-32877
    • Zhang, X.1    Lam, K.S.2    Ye, H.3    Chung, S.K.4    Zhou, M.5    Wang, Y.6    Xu, A.7
  • 47
    • 80053408653 scopus 로고    scopus 로고
    • Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice
    • PID: 21873554, COI: 1:CAS:528:DC%2BC3MXhtl2is7zN
    • Jiang C, Qu A, Matsubara T, Chanturiya T, Jou W, Gavrilova O, Shah YM, Gonzalez FJ (2011) Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice. Diabetes 60:2484–2495
    • (2011) Diabetes , vol.60 , pp. 2484-2495
    • Jiang, C.1    Qu, A.2    Matsubara, T.3    Chanturiya, T.4    Jou, W.5    Gavrilova, O.6    Shah, Y.M.7    Gonzalez, F.J.8
  • 48
    • 84856628731 scopus 로고    scopus 로고
    • Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD + system
    • PID: 22302938, COI: 1:CAS:528:DC%2BC38XitlWgtLg%3D
    • Krishnan J, Danzer C, Simka T, Ukropec J, Walter KM, Kumpf S, Mirtschink P, Ukropcova B, Gasperikova D, Pedrazzini T et al (2012) Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD + system. Genes Dev 26:259–270
    • (2012) Genes Dev , vol.26 , pp. 259-270
    • Krishnan, J.1    Danzer, C.2    Simka, T.3    Ukropec, J.4    Walter, K.M.5    Kumpf, S.6    Mirtschink, P.7    Ukropcova, B.8    Gasperikova, D.9    Pedrazzini, T.10
  • 52
    • 77950344913 scopus 로고    scopus 로고
    • Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha
    • PID: 20009089, COI: 1:CAS:528:DC%2BC3cXjslegtbc%3D
    • Heinis M, Simon MT, Ilc K, Mazure NM, Pouyssegur J, Scharfmann R, Duvillie B (2010) Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha. Diabetes 59:662–669
    • (2010) Diabetes , vol.59 , pp. 662-669
    • Heinis, M.1    Simon, M.T.2    Ilc, K.3    Mazure, N.M.4    Pouyssegur, J.5    Scharfmann, R.6    Duvillie, B.7
  • 55
    • 61949412026 scopus 로고    scopus 로고
    • A role for von Hippel-Lindau protein in pancreatic beta-cell function
    • PID: 19033400, COI: 1:CAS:528:DC%2BD1MXhslersbc%3D
    • Puri S, Cano DA, Hebrok M (2009) A role for von Hippel-Lindau protein in pancreatic beta-cell function. Diabetes 58:433–441
    • (2009) Diabetes , vol.58 , pp. 433-441
    • Puri, S.1    Cano, D.A.2    Hebrok, M.3
  • 58
    • 84863474509 scopus 로고    scopus 로고
    • Acute hypoxia induces apoptosis of pancreatic beta-cell by activation of the unfolded protein response and upregulation of CHOP
    • PID: 22695615, COI: 1:STN:280:DC%2BC38jhsFamuw%3D%3D
    • Zheng X, Wang X, Ma Z, Gupta Sunkari V, Botusan I, Takeda T, Bjorklund A, Inoue M, Catrina SB, Brismar K et al (2012) Acute hypoxia induces apoptosis of pancreatic beta-cell by activation of the unfolded protein response and upregulation of CHOP. Cell Death Dis 3:e322
    • (2012) Cell Death Dis , vol.3 , pp. e322
    • Zheng, X.1    Wang, X.2    Ma, Z.3    Gupta Sunkari, V.4    Botusan, I.5    Takeda, T.6    Bjorklund, A.7    Inoue, M.8    Catrina, S.B.9    Brismar, K.10
  • 60
    • 84862528769 scopus 로고    scopus 로고
    • Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes
    • Persson MF, Franzen S, Catrina SB, Dallner G, Hansell P, Brismar K, Palm F (2012) Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes. Diabetologia
    • (2012) Diabetologia
    • Persson, M.F.1    Franzen, S.2    Catrina, S.B.3    Dallner, G.4    Hansell, P.5    Brismar, K.6    Palm, F.7
  • 63
    • 77953688069 scopus 로고    scopus 로고
    • High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein
    • PID: 20375990, COI: 1:CAS:528:DC%2BC3cXnsVyhs7Y%3D
    • Isoe T, Makino Y, Mizumoto K, Sakagami H, Fujita Y, Honjo J, Takiyama Y, Itoh H, Haneda M (2010) High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein. Kidney Int 78(1):48–59
    • (2010) Kidney Int , vol.78 , Issue.1 , pp. 48-59
    • Isoe, T.1    Makino, Y.2    Mizumoto, K.3    Sakagami, H.4    Fujita, Y.5    Honjo, J.6    Takiyama, Y.7    Itoh, H.8    Haneda, M.9
  • 64
    • 33750866706 scopus 로고    scopus 로고
    • Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone
    • PID: 17003339, COI: 1:CAS:528:DC%2BD28XhtVGlsrbN
    • Makino H, Miyamoto Y, Sawai K, Mori K, Mukoyama M, Nakao K, Yoshimasa Y, Suga S (2006) Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone. Diabetes 55:2747–2756
    • (2006) Diabetes , vol.55 , pp. 2747-2756
    • Makino, H.1    Miyamoto, Y.2    Sawai, K.3    Mori, K.4    Mukoyama, M.5    Nakao, K.6    Yoshimasa, Y.7    Suga, S.8
  • 65
    • 84939898507 scopus 로고    scopus 로고
    • Effect of pioglitazone on diabetic nephropathy and expression of HIF-1alpha and VEGF in the renal tissues of type 2 diabetic rats
    • Xu X, Chen P, Zheng Q, Wang Y, Chen W (2011) Effect of pioglitazone on diabetic nephropathy and expression of HIF-1alpha and VEGF in the renal tissues of type 2 diabetic rats. Diabetes Res Clin Pract 60:981–92
    • (2011) Diabetes Res Clin Pract , vol.60 , pp. 981-992
    • Xu, X.1    Chen, P.2    Zheng, Q.3    Wang, Y.4    Chen, W.5
  • 66
    • 84866594039 scopus 로고    scopus 로고
    • Glucotoxicity induces glucose-6-phosphatase catalytic unit expression by acting on the interaction of HIF-1alpha with CREB-binding protein
    • PID: 22787137, COI: 1:CAS:528:DC%2BC38XhsVent7fL
    • Gautier-Stein A, Soty M, Chilloux J, Zitoun C, Rajas F, Mithieux G (2012) Glucotoxicity induces glucose-6-phosphatase catalytic unit expression by acting on the interaction of HIF-1alpha with CREB-binding protein. Diabetes 61:2451–2460
    • (2012) Diabetes , vol.61 , pp. 2451-2460
    • Gautier-Stein, A.1    Soty, M.2    Chilloux, J.3    Zitoun, C.4    Rajas, F.5    Mithieux, G.6
  • 67
    • 33646358954 scopus 로고    scopus 로고
    • High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway
    • PID: 16597689, COI: 1:CAS:528:DC%2BD28XkvVKrsbk%3D
    • Katavetin P, Miyata T, Inagi R, Tanaka T, Sassa R, Ingelfinger JR, Fujita T, Nangaku M (2006) High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway. J Am Soc Nephrol 17:1405–1413
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1405-1413
    • Katavetin, P.1    Miyata, T.2    Inagi, R.3    Tanaka, T.4    Sassa, R.5    Ingelfinger, J.R.6    Fujita, T.7    Nangaku, M.8
  • 68
    • 42949165144 scopus 로고    scopus 로고
    • Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model
    • PID: 17967803, COI: 1:CAS:528:DC%2BD1cXjs12lsLY%3D
    • Ohtomo S, Nangaku M, Izuhara Y, Takizawa S, Strihou CY, Miyata T (2008) Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model. Nephrol Dial Transplant 23:1166–1172
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 1166-1172
    • Ohtomo, S.1    Nangaku, M.2    Izuhara, Y.3    Takizawa, S.4    Strihou, C.Y.5    Miyata, T.6
  • 69
    • 80054976363 scopus 로고    scopus 로고
    • Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis
    • PID: 21925138, COI: 1:CAS:528:DC%2BC3MXhsFCmu7zN
    • Theilig F, Enke AK, Scolari B, Polzin D, Bachmann S, Koesters R (2011) Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis. Am J Pathol 179:2177–88
    • (2011) Am J Pathol , vol.179 , pp. 2177-2188
    • Theilig, F.1    Enke, A.K.2    Scolari, B.3    Polzin, D.4    Bachmann, S.5    Koesters, R.6
  • 70
    • 20944446740 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha is involved in the attenuation of experimentally induced rat glomerulonephritis
    • PID: 15775723, COI: 1:CAS:528:DC%2BD2MXkt1ShtL0%3D
    • Kudo Y, Kakinuma Y, Mori Y, Morimoto N, Karashima T, Furihata M, Sato T, Shuin T, Sugiura T (2005) Hypoxia-inducible factor-1alpha is involved in the attenuation of experimentally induced rat glomerulonephritis. Nephron Exp Nephrol 100:e95–103
    • (2005) Nephron Exp Nephrol , vol.100 , pp. e95-e103
    • Kudo, Y.1    Kakinuma, Y.2    Mori, Y.3    Morimoto, N.4    Karashima, T.5    Furihata, M.6    Sato, T.7    Shuin, T.8    Sugiura, T.9
  • 71
    • 84885005460 scopus 로고    scopus 로고
    • Deal watch: astraZeneca bets on FibroGen’s anaemia drug
    • PID: 24080688
    • Flight MH (2013) Deal watch: astraZeneca bets on FibroGen’s anaemia drug. Nat Rev Drug Discov 12:730
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 730
    • Flight, M.H.1
  • 72
    • 84867539657 scopus 로고    scopus 로고
    • HIF-1alpha in the heart: a double agent?
    • PID: 22673235
    • Hashmi S, Al-Salam S (2012) HIF-1alpha in the heart: a double agent? Cardiol Rev 20:268–73
    • (2012) Cardiol Rev , vol.20 , pp. 268-273
    • Hashmi, S.1    Al-Salam, S.2
  • 73
    • 0033602795 scopus 로고    scopus 로고
    • Glycometabolic state at admission: important risk marker of mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction: long-term results from the diabetes and insulin-glucose infusion in acute myocardial infarction (DIGAMI) study
    • PID: 10338454, COI: 1:CAS:528:DyaK1MXjvVKmtrw%3D
    • Malmberg K, Norhammar A, Wedel H, Ryden L (1999) Glycometabolic state at admission: important risk marker of mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction: long-term results from the diabetes and insulin-glucose infusion in acute myocardial infarction (DIGAMI) study. Circulation 99:2626–2632
    • (1999) Circulation , vol.99 , pp. 2626-2632
    • Malmberg, K.1    Norhammar, A.2    Wedel, H.3    Ryden, L.4
  • 74
    • 0025900699 scopus 로고
    • In-hospital prognosis of patients with fasting hyperglycemia after first myocardial infarction
    • PID: 1954815
    • O’Sullivan JJ, Conroy RM, Robinson K, Hickey N, Mulcahy R (1991) In-hospital prognosis of patients with fasting hyperglycemia after first myocardial infarction. Diabetes Care 14:758–760
    • (1991) Diabetes Care , vol.14 , pp. 758-760
    • O’Sullivan, J.J.1    Conroy, R.M.2    Robinson, K.3    Hickey, N.4    Mulcahy, R.5
  • 76
    • 84880401475 scopus 로고    scopus 로고
    • N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1alpha/HO-1 signaling in diabetic rats
    • PID: 23874823, COI: 1:CAS:528:DC%2BC3sXht1WmtLrJ
    • Mao X, Wang T, Liu Y, Irwin MG, Ou JS, Liao XL, Gao X, Xu Y, Ng KF, Vanhoutte PM et al (2013) N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1alpha/HO-1 signaling in diabetic rats. PLoS ONE 8:e68949
    • (2013) PLoS ONE , vol.8 , pp. e68949
    • Mao, X.1    Wang, T.2    Liu, Y.3    Irwin, M.G.4    Ou, J.S.5    Liao, X.L.6    Gao, X.7    Xu, Y.8    Ng, K.F.9    Vanhoutte, P.M.10
  • 77
    • 66049097308 scopus 로고    scopus 로고
    • Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy
    • PID: 19490906, COI: 1:CAS:528:DC%2BD1MXps1ensro%3D
    • Krishnan J, Suter M, Windak R, Krebs T, Felley A, Montessuit C, Tokarska-Schlattner M, Aasum E, Bogdanova A, Perriard E et al (2009) Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy. Cell Metab 9:512–524
    • (2009) Cell Metab , vol.9 , pp. 512-524
    • Krishnan, J.1    Suter, M.2    Windak, R.3    Krebs, T.4    Felley, A.5    Montessuit, C.6    Tokarska-Schlattner, M.7    Aasum, E.8    Bogdanova, A.9    Perriard, E.10
  • 78
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials
    • PID: 17848652, COI: 1:CAS:528:DC%2BD2sXhtVGmtL3J
    • Lincoff AM, Wolski K, Nicholls SJ, Nissen SE (2007) Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA 298:1180–1188
    • (2007) JAMA , vol.298 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 79
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • PID: 17517853, COI: 1:CAS:528:DC%2BD2sXms1SisrY%3D
    • Nissen SE, Wolski K (2007) Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 356:2457–2471
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 81
    • 77954608736 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of HIF-1(alpha) prevents deterioration of glycolytic pathway and cardiac remodeling in streptozotocin-induced diabetic mice
    • PID: 20566749, COI: 1:CAS:528:DC%2BC3cXpslCrsr4%3D
    • Xue W, Cai L, Tan Y, Thistlethwaite P, Kang YJ, Li X, Feng W (2010) Cardiac-specific overexpression of HIF-1(alpha) prevents deterioration of glycolytic pathway and cardiac remodeling in streptozotocin-induced diabetic mice. Am J Pathol 177:97–105
    • (2010) Am J Pathol , vol.177 , pp. 97-105
    • Xue, W.1    Cai, L.2    Tan, Y.3    Thistlethwaite, P.4    Kang, Y.J.5    Li, X.6    Feng, W.7
  • 82
    • 39749087544 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury
    • PID: 18287886, COI: 1:CAS:528:DC%2BD1cXit1yhtbk%3D
    • Natarajan R, Salloum FN, Fisher BJ, Kukreja RC, Fowler AA 3rd (2008) Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury. J Cardiovasc Pharmacol 51:178–187
    • (2008) J Cardiovasc Pharmacol , vol.51 , pp. 178-187
    • Natarajan, R.1    Salloum, F.N.2    Fisher, B.J.3    Kukreja, R.C.4    Fowler, A.A.5
  • 83
    • 77954165358 scopus 로고    scopus 로고
    • Modified multipotent stromal cells with epidermal growth factor restore vasculogenesis and blood flow in ischemic hind-limb of type II diabetic mice
    • PID: 20440273, COI: 1:CAS:528:DC%2BC3cXotFeisbg%3D
    • Amin AH, Abd Elmageed ZY, Nair D, Partyka MI, Kadowitz PJ, Belmadani S, Matrougui K (2010) Modified multipotent stromal cells with epidermal growth factor restore vasculogenesis and blood flow in ischemic hind-limb of type II diabetic mice. Lab Invest 90:985–96
    • (2010) Lab Invest , vol.90 , pp. 985-996
    • Amin, A.H.1    Abd Elmageed, Z.Y.2    Nair, D.3    Partyka, M.I.4    Kadowitz, P.J.5    Belmadani, S.6    Matrougui, K.7
  • 84
    • 72449157983 scopus 로고    scopus 로고
    • Decreased mobilization of endothelial progenitor cells contributes to impaired neovascularization in diabetes
    • PID: 19558529, COI: 1:CAS:528:DC%2BD1MXhsVSkur%2FP
    • Kang LN, Chen Q, Wang L, Gao L, Meng K, Chen JH, Ferro A, Xu B (2009) Decreased mobilization of endothelial progenitor cells contributes to impaired neovascularization in diabetes. Clin Exp Pharmacol Physiol 36:E47–E56
    • (2009) Clin Exp Pharmacol Physiol , vol.36 , pp. E47-E56
    • Kang, L.N.1    Chen, Q.2    Wang, L.3    Gao, L.4    Meng, K.5    Chen, J.H.6    Ferro, A.7    Xu, B.8
  • 85
    • 73249140173 scopus 로고    scopus 로고
    • Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice
    • PID: 19841279, COI: 1:CAS:528:DC%2BD1MXhsVKmtLvM
    • Sarkar K, Fox-Talbot K, Steenbergen C, Bosch-Marce M, Semenza GL (2009) Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice. Proc Natl Acad Sci U S A 106:18769–18774
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 18769-18774
    • Sarkar, K.1    Fox-Talbot, K.2    Steenbergen, C.3    Bosch-Marce, M.4    Semenza, G.L.5
  • 87
    • 50949099761 scopus 로고    scopus 로고
    • The role of HIF-1 in hypoxic response in the skeletal muscle
    • PID: 18269201
    • Mason S, Johnson RS (2007) The role of HIF-1 in hypoxic response in the skeletal muscle. Adv Exp Med Biol 618:229–244
    • (2007) Adv Exp Med Biol , vol.618 , pp. 229-244
    • Mason, S.1    Johnson, R.S.2
  • 89
    • 0034326273 scopus 로고    scopus 로고
    • Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
    • PID: 11085544, COI: 1:CAS:528:DC%2BD3cXotV2ltr4%3D
    • Elson DA, Ryan HE, Snow JW, Johnson R, Arbeit JM (2000) Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res 60:6189–6195
    • (2000) Cancer Res , vol.60 , pp. 6189-6195
    • Elson, D.A.1    Ryan, H.E.2    Snow, J.W.3    Johnson, R.4    Arbeit, J.M.5
  • 90
    • 51449105857 scopus 로고    scopus 로고
    • Age-dependent impairment of HIF-1alpha expression in diabetic mice: correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells
    • PID: 18506785, COI: 1:CAS:528:DC%2BD1cXht1eltrnM
    • Liu L, Marti GP, Wei X, Zhang X, Zhang H, Liu YV, Nastai M, Semenza GL, Harmon JW (2008) Age-dependent impairment of HIF-1alpha expression in diabetic mice: correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. J Cell Physiol 217:319–327
    • (2008) J Cell Physiol , vol.217 , pp. 319-327
    • Liu, L.1    Marti, G.P.2    Wei, X.3    Zhang, X.4    Zhang, H.5    Liu, Y.V.6    Nastai, M.7    Semenza, G.L.8    Harmon, J.W.9
  • 92
    • 84879601468 scopus 로고    scopus 로고
    • Deferoxamine enhances neovascularization and accelerates wound healing in diabetic rats via the accumulation of hypoxia-inducible factor-1alpha
    • Hou Z, Nie C, Si Z, Ma Y (2013) Deferoxamine enhances neovascularization and accelerates wound healing in diabetic rats via the accumulation of hypoxia-inducible factor-1alpha. Diabetes Res Clin Pract
    • (2013) Diabetes Res Cl
    • Hou, Z.1    Nie, C.2    Si, Z.3    Ma, Y.4
  • 93
    • 0030010417 scopus 로고    scopus 로고
    • Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy
    • PID: 8603873, COI: 1:STN:280:DyaK287otFCntA%3D%3D
    • Bursell SE, Clermont AC, Kinsley BT, Simonson DC, Aiello LM, Wolpert HA (1996) Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy. Invest Ophthalmol Vis Sci 37:886–897
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 886-897
    • Bursell, S.E.1    Clermont, A.C.2    Kinsley, B.T.3    Simonson, D.C.4    Aiello, L.M.5    Wolpert, H.A.6
  • 95
    • 78049232810 scopus 로고    scopus 로고
    • A comparison of hypoxia-inducible factor-alpha in surgically exised neovascular membranes of patients with diabetes compared with epiretinal membranes in nondiabetic patients
    • Lim JI, Spee C, Hinton DR (2010) A comparison of hypoxia-inducible factor-alpha in surgically exised neovascular membranes of patients with diabetes compared with epiretinal membranes in nondiabetic patients. Retina
    • (2010) Retina
    • Lim, J.I.1    Spee, C.2    Hinton, D.R.3
  • 96
    • 4444317558 scopus 로고    scopus 로고
    • Altered insulin signaling in retinal tissue in diabetic states
    • PID: 15201286, COI: 1:CAS:528:DC%2BD2cXntFSnt7w%3D
    • Kondo T, Kahn CR (2004) Altered insulin signaling in retinal tissue in diabetic states. J Biol Chem 279:37997–38006
    • (2004) J Biol Chem , vol.279 , pp. 37997-38006
    • Kondo, T.1    Kahn, C.R.2
  • 97
    • 48649089571 scopus 로고    scopus 로고
    • Expression of erythropoietin and its receptor in the human retina: a comparative study of diabetic and nondiabetic subjects
    • PID: 18332162
    • Garcia-Ramirez M, Hernandez C, Simo R (2008) Expression of erythropoietin and its receptor in the human retina: a comparative study of diabetic and nondiabetic subjects. Diabetes Care 31:1189–1194
    • (2008) Diabetes Care , vol.31 , pp. 1189-1194
    • Garcia-Ramirez, M.1    Hernandez, C.2    Simo, R.3
  • 98
    • 0037008770 scopus 로고    scopus 로고
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
    • PID: 12032158, COI: 1:CAS:528:DC%2BD38XlvFKgtL0%3D
    • Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van Obberghen E (2002) Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 277:27975–27981
    • (2002) J Biol Chem , vol.277 , pp. 27975-27981
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Semenza, G.L.4    Van Obberghen, E.5
  • 99
    • 0036196081 scopus 로고    scopus 로고
    • Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF
    • COI: 1:CAS:528:DC%2BD38Xit1Gnsrs%3D
    • Poulaki V, Qin W, Joussen AM, Hurlbut P, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP (2002) Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. JClinInvest 109:805–815
    • (2002) JClinInvest , vol.109 , pp. 805-815
    • Poulaki, V.1    Qin, W.2    Joussen, A.M.3    Hurlbut, P.4    Wiegand, S.J.5    Rudge, J.6    Yancopoulos, G.D.7    Adamis, A.P.8
  • 100
    • 79953286300 scopus 로고    scopus 로고
    • Role of HIF-1alpha in maternal hyperglycemia-induced embryonic vasculopathy
    • Yang P, Reece EA (2011) Role of HIF-1alpha in maternal hyperglycemia-induced embryonic vasculopathy. Am J Obstet Gynecol 204(332):e331–337
    • (2011) Am J Obstet Gynecol , vol.204 , Issue.332 , pp. e331-e337
    • Yang, P.1    Reece, E.A.2


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