A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition

Nature Medicine

Volumn 19, Issue 10, 2013, Pages 1331-1337

  Wei, Kevin ^a   Piecewicz, Stephanie M ^a   McGinnis, Lisa M ^a   Taniguchi, Cullen M ^a   Wiegand, Stanley J ^b   Anderson, Keith ^b   Chan, Carol W M ^a   Mulligan, Kimberly X ^c   Kuo, David ^a   Yuan, Jenny ^a   Vallon, Mario ^a   Morton, Lori C ^b   Lefai, Etienne ^d   Simon, M Celeste ^e   Maher, Jacquelyn J ^f   Mithieux, Gilles ^d   Rajas, Fabienne ^d   Annes, Justin P ^a   McGuinness, Owen P ^c   Thurston, Gavin ^b   Giaccia, Amato J ^a   Kuo, Calvin J ^a   more..

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITÉ DE LYON   (France)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AD SFLT 1; AFLIBERCEPT; ANTIDIABETIC AGENT; GLYCOGEN; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY B20.4.1.1; MONOCLONAL ANTIBODY DC101; UNCLASSIFIED DRUG; VASCULOTROPIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; INSULIN RECEPTOR SUBSTRATE; IRS2 PROTEIN, MOUSE; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE TOLERANCE; GLYCOGEN METABOLISM; HUMAN; INSULIN METABOLISM; INSULIN SENSITIVITY; LIVER ISCHEMIA; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DIABETES MELLITUS, TYPE 2; LIVER; METABOLISM; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

MUS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DIABETES MELLITUS, TYPE 2; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; LIVER; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84887432293     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3295     Document Type: Article

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