Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis

American Journal of Pathology

Volumn 179, Issue 5, 2011, Pages 2177-2188

  Theilig, Franziska ^a,b   Enke, Anne Kathrin ^a   Scolari, Brigitte ^a   Polzin, Danny ^b   Bachmann, Sebastian ^b   Koesters, Robert ^c  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PLATELET DERIVED GROWTH FACTOR B; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGLOMERULAR BASEMENT MEMBRANE GLOMERULONEPHRITIS; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME DEFICIENCY; FIBROBLAST; GENE INACTIVATION; GLOMERULONEPHRITIS; KIDNEY DISEASE; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PODOCYTE; PRIORITY JOURNAL;

ANIMALS; ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE; AUTOANTIBODIES; CAPILLARIES; CELL PROLIFERATION; DISEASE PROGRESSION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; KIDNEY GLOMERULUS; KIDNEY TUBULES, PROXIMAL; MALE; MICE; MICE, KNOCKOUT; NEOVASCULARIZATION, PHYSIOLOGIC; PROTO-ONCOGENE PROTEINS C-SIS; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VON HIPPEL-LINDAU DISEASE; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 80054976363     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.07.012     Document Type: Article

References (43)

1. D.H. Kang, A.H. Joly, S.W. Oh, C. Hugo, D. Kerjaschki, K.L. Gordon, M. Mazzali, J.A. Jefferson, J. Hughes, K.M. Madsen, G.F. Schreiner, and R.J. Johnson Impaired angiogenesis in the remnant kidney model: i Potential role of vascular endothelial growth factor and thrombospondin-1 J Am Soc Nephrol 12 2001 1434 1447
2. W. Kriz, and M. LeHir Pathways to nephron loss starting from glomerular diseases-insights from animal models Kidney Int 67 2005 404 419
3. M. Nangaku Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure J Am Soc Nephrol 17 2006 17 25
4. K.U. Eckardt, W.M. Bernhardt, A. Weidemann, C. Warnecke, C. Rosenberger, M.S. Wiesener, and C. Willam Role of hypoxia in the pathogenesis of renal disease Kidney Int Suppl 99 2005 S46 S51
5. L.G. Fine, C. Orphanides, and J.T. Norman Progressive renal disease: the chronic hypoxia hypothesis Kidney Int Suppl 65 1998 S74 S78
6. S.N. Heyman, M. Khamaisi, S. Rosen, and C. Rosenberger Renal parenchymal hypoxia, hypoxia response and the progression of chronic kidney disease Am J Nephrol 28 2008 998 1006
7. L.G. Fine, and J.T. Norman Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics Kidney Int 74 2008 867 872
8. G.L. Semenza Intratumoral hypoxia, radiation resistance, and HIF-1 Cancer Cell 5 2004 405 406
9. D.F. Higgins, K. Kimura, W.M. Bernhardt, N. Shrimanker, Y. Akai, B. Hohenstein, Y. Saito, R.S. Johnson, M. Kretzler, C.D. Cohen, K.U. Eckardt, M. Iwano, and V.H. Haase Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition J Clin Invest 117 2007 3810 3820
10. T. Tanaka, I. Kojima, T. Ohse, J.R. Ingelfinger, S. Adler, T. Fujita, and M. Nangaku Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model Lab Invest 85 2005 1292 1307
11. T. Tanaka, M. Matsumoto, R. Inagi, T. Miyata, I. Kojima, T. Ohse, T. Fujita, and M. Nangaku Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis Kidney Int 68 2005 2714 2725
12. S. Ohtomo, M. Nangaku, Y. Izuhara, S. Takizawa, C.Y. Strihou, and T. Miyata Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model Nephrol Dial Transplant 23 2008 1166 1172
13. M. Traykova-Brauch, K. Schonig, O. Greiner, T. Miloud, A. Jauch, M. Bode, D.W. Felsher, A.B. Glick, D.J. Kwiatkowski, H. Bujard, J. Horst, M. von Knebel Doeberitz, F.K. Niggli, W. Kriz, H.J. Grone, and R. Koesters An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice Nat Med 14 2008 979 984
14. K. Schonig, F. Schwenk, K. Rajewsky, and H. Bujard Stringent doxycycline dependent control of CRE recombinase in vivo Nucleic Acids Res 30 2002 e134
15. V.H. Haase, J.N. Glickman, M. Socolovsky, and R. Jaenisch Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor Proc Natl Acad Sci U S A 98 2001 1583 1588
16. F. Theilig, W. Kriz, T. Jerichow, P. Schrade, B. Hahnel, T. Willnow, M. Le Hir, and S. Bachmann Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulointerstitial injury J Am Soc Nephrol 18 2007 1824 1834
17. F. Theilig, M. Bostanjoglo, H. Pavenstadt, C. Grupp, G. Holland, I. Slosarek, A.M. Gressner, M. Russwurm, D. Koesling, and S. Bachmann Cellular distribution and function of soluble guanylyl cyclase in rat kidney and liver J Am Soc Nephrol 12 2001 2209 2220
18. L.J. Ma, S. Nakamura, J.S. Whitsitt, C. Marcantoni, J.M. Davidson, and A.B. Fogo Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1 Kidney Int 58 2000 2425 2436
19. S. Hakroush, M.J. Moeller, F. Theilig, B. Kaissling, T.P. Sijmonsma, M. Jugold, A.L. Akeson, M. Traykova-Brauch, H. Hosser, B. Hahnel, H.J. Grone, R. Koesters, and W. Kriz Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease Am J Pathol 175 2009 1883 1895
20. M. Le Hir, and V. Besse-Eschmann A novel mechanism of nephron loss in a murine model of crescentic glomerulonephritis Kidney Int 63 2003 591 599
21. L. Gunaratnam, and J.V. Bonventre HIF in kidney disease and development J Am Soc Nephrol 20 2009 1877 1887
22. S.C. Clifford, and E.R. Maher Von Hippel-Lindau disease: clinical and molecular perspectives Adv Cancer Res 82 2001 85 105
23. C.J. Hu, L.Y. Wang, L.A. Chodosh, B. Keith, and M.C. Simon Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation Mol Cell Biol 23 2003 9361 9374
24. V. Eremina, M. Sood, J. Haigh, A. Nagy, G. Lajoie, N. Ferrara, H.P. Gerber, Y. Kikkawa, J.H. Miner, and S.E. Quaggin Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases J Clin Invest 111 2003 707 716
25. E. Liu, M. Morimoto, S. Kitajima, T. Koike, Y. Yu, H. Shiiki, M. Nagata, T. Watanabe, and J. Fan Increased expression of vascular endothelial growth factor in kidney leads to progressive impairment of glomerular functions J Am Soc Nephrol 18 2007 2094 2104
26. G.L. Semenza Regulation of vascularization by hypoxia-inducible factor 1 Ann N Y Acad Sci 1177 2009 2 8
27. S. Germain, C. Monnot, L. Muller, and A. Eichmann Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding Curr Opin Hematol 17 2010 245 251
28. Y. Horita, M. Miyazaki, T. Koji, N. Kobayashi, M. Shibuya, M.S. Razzaque, M. Cheng, Y. Ozono, S. Kohno, and T. Taguchi Expression of vascular endothelial growth factor and its receptors in rats with protein-overload nephrosis Nephrol Dial Transplant 13 1998 2519 2528
29. C.S. Haas, V. Campean, A. Kuhlmann, A. Dimmler, U. Reulbach, C. Forster, T. Aigner, T. Acker, K. Plate, and K. Amann Analysis of glomerular VEGF mRNA and protein expression in murine mesangioproliferative glomerulonephritis Virchows Arch 450 2007 81 92
30. B. Klanke, M. Simon, W. Rockl, H.A. Weich, H. Stolte, and H.J. Grone Effects of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) on haemodynamics and permselectivity of the isolated perfused rat kidney Nephrol Dial Transplant 13 1998 875 885
31. H.M. Lafferty, D.L. Garcia, H.G. Rennke, J.L. Troy, S. Anderson, and B.M. Brenner Anemia ameliorates progressive renal injury in experimental DOCA-salt hypertension J Am Soc Nephrol 1 1991 1180 1185
32. C. Rosenberger, S. Mandriota, J.S. Jurgensen, M.S. Wiesener, J.H. Horstrup, U. Frei, P.J. Ratcliffe, P.H. Maxwell, S. Bachmann, and K.U. Eckardt Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys J Am Soc Nephrol 13 2002 1721 1732
33. D.H. Kang, J. Hughes, M. Mazzali, G.F. Schreiner, and R.J. Johnson Impaired angiogenesis in the remnant kidney model: II Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function J Am Soc Nephrol 12 2001 1448 1457
34. K. Sison, V. Eremina, H. Baelde, W. Min, M. Hirashima, I.G. Fantus, and S.E. Quaggin Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 Signaling J Am Soc Nephrol 21 2010 1691 1701
35. A. Bohle, S. Mackensen-Haen, and M. Wehrmann Significance of postglomerular capillaries in the pathogenesis of chronic renal failure Kidney Blood Press Res 19 1996 191 195
36. B.D. Humphreys, S.L. Lin, A. Kobayashi, T.E. Hudson, B.T. Nowlin, J.V. Bonventre, M.T. Valerius, A.P. McMahon, and J.S. Duffield Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis Am J Pathol 176 2010 85 97
37. Z.D. Li, J.P. Bork, B. Krueger, E. Patsenker, A. Schulze-Krebs, E.G. Hahn, and D. Schuppan VEGF induces proliferation, migration, and TGF-beta1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase Biochem Biophys Res Commun 334 2005 1049 1060
38. B. Hinz Formation and function of the myofibroblast during tissue repair J Invest Dermatol 127 2007 526 537
39. J. Floege, F. Eitner, and C.E. Alpers A new look at platelet-derived growth factor in renal disease J Am Soc Nephrol 19 2008 12 23
40. S.B. Nicholas, J. Liu, J. Kim, Y. Ren, A.R. Collins, L. Nguyen, and W.A. Hsueh Critical role for osteopontin in diabetic nephropathy Kidney Int 77 2010 588 600
41. L. Yang, T.Y. Besschetnova, C.R. Brooks, J.V. Shah, and J.V. Bonventre Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury Nat Med 16 2010 535 543
42. K.A. Kirkby, and C.A. Adin Products of heme oxygenase and their potential therapeutic applications Am J Physiol Renal Physiol 290 2006 F563 F571
43. J.H. Kie, M.H. Kapturczak, A. Traylor, A. Agarwal, and N. Hill-Kapturczak Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosis J Am Soc Nephrol 19 2008 1681 1691