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Volumn 124, Issue 1, 2012, Pages 15-26

The pathogenesis of early retinal changes of diabetic retinopathy

Author keywords

Dark adaptation; Diabetic retinopathy; Oxidative stress hypoxia; Rods; VEGF

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; PHOSPHODIESTERASE; REACTIVE OXYGEN METABOLITE;

EID: 84860279257     PISSN: 00124486     EISSN: 15732622     Source Type: Journal    
DOI: 10.1007/s10633-011-9305-y     Document Type: Article
Times cited : (75)

References (100)
  • 4
    • 54949157448 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives
    • Madsen-Bouterse SA, Kowluru RA (2008) Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Rev Endocr Metab Disord 9:315-327
    • (2008) Rev Endocr Metab Disord , vol.9 , pp. 315-327
    • Madsen-Bouterse, S.A.1    Kowluru, R.A.2
  • 5
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge W (2002) Free radicals and the physiological control of cell function. Physiol Rev 83:47-95 (Pubitemid 34654215)
    • (2002) Physiological Reviews , vol.82 , Issue.1 , pp. 47-95
    • Droge, W.1
  • 6
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: A unifying mechanism
    • DOI 10.2337/diabetes.54.6.1615
    • Brownlee M (2005) The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54:1615-1625 (Pubitemid 40770750)
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1615-1625
    • Brownlee, M.1
  • 7
    • 34247394257 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy
    • Kowluru RA, Chan P-S (2007) Oxidative stress and diabetic retinopathy. Exp Diabetes Res 43603
    • (2007) Exp Diabetes Res , vol.43 , pp. 603
    • Kowluru, R.A.1    Chan, P.-S.2
  • 8
    • 33645964980 scopus 로고    scopus 로고
    • Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy
    • DOI 10.1167/iovs.05-1276
    • Kowluru RA, Atasi L, Ho YS (2006) Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci 47:1594-1599 (Pubitemid 46780770)
    • (2006) Investigative Ophthalmology and Visual Science , vol.47 , Issue.4 , pp. 1594-1599
    • Kowluru, R.A.1    Atasi, L.2    Ho, Y.-S.3
  • 9
    • 0030770396 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: A potential role for vascular endothelial growth factor in the progression of nonproliferative diabetic retinopathy
    • Clermont AC, Aiello LP, Mori F, Aiello LM, Bursell SE (1997) Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: a potential role for vascular endothelial growth factor in the progression of non-proliferative diabetic retinopathy. Am J Ophthalmol 124:433-446 (Pubitemid 27425869)
    • (1997) American Journal of Ophthalmology , vol.124 , Issue.4 , pp. 433-446
    • Clermont, A.C.1    Aiello, L.P.2    Mori, F.3    Aiello, L.M.4    Bursell, S.-E.5
  • 12
    • 0029915447 scopus 로고    scopus 로고
    • Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia
    • Kern TS, Engerman RL (1996) Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia. Arch Ophthalmol 114: 306-310 (Pubitemid 26086737)
    • (1996) Archives of Ophthalmology , vol.114 , Issue.3 , pp. 306-310
    • Kern, T.S.1    Engerman, R.L.2
  • 13
    • 48249091745 scopus 로고    scopus 로고
    • Hyperglycaemiainduced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators
    • Busik JV, Mohr S, Grant MB (2008) Hyperglycaemiainduced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators. Diabetes 57:1952-1965
    • (2008) Diabetes , vol.57 , pp. 1952-1965
    • Busik, J.V.1    Mohr, S.2    Grant, M.B.3
  • 16
    • 0031919598 scopus 로고    scopus 로고
    • Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy
    • DOI 10.2337/diabetes.47.5.815
    • Lieth E, Barber AJ, Xu B, Dice C, Ratz MJ, Tanase D, Strother JM (1998) Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Diabetes 47:815-820 (Pubitemid 28201813)
    • (1998) Diabetes , vol.47 , Issue.5 , pp. 815-820
    • Lieth, E.1    Barber, A.J.2    Xu, B.3    Dice, C.4    Ratz, M.J.5    Tanase, D.6    Strother, J.M.7
  • 18
    • 33750365346 scopus 로고
    • Uber die Klassifizierung tierischer Gewebe nach ihremStoffwechsel
    • Warburg O (1927) Uber die Klassifizierung tierischer Gewebe nach ihremStoffwechsel. BiochemZ 184:484-488
    • (1927) BiochemZ , vol.184 , pp. 484-488
    • Warburg, O.1
  • 19
    • 0005647520 scopus 로고
    • Dark adaptation and reduced oxygen tension
    • McFarland RA, Evans JN (1939) Dark adaptation and reduced oxygen tension. Am J Physiol 127:37-50
    • (1939) Am J Physiol , vol.127 , pp. 37-50
    • McFarland, R.A.1    Evans, J.N.2
  • 20
    • 0002059199 scopus 로고
    • The effects of variations in the concentration of oxygen and of glucose on dark adaptation
    • McFarland RA, Forbes WH (1940) The effects of variations in the concentration of oxygen and of glucose on dark adaptation. J Gen Physiol 24:69-98
    • (1940) J Gen Physiol , vol.24 , pp. 69-98
    • McFarland, R.A.1    Forbes, W.H.2
  • 22
    • 0030657964 scopus 로고    scopus 로고
    • II. Improved dark adaptation after carotid endarterectomy: Evidence of a long-term ischemic penumbra?
    • Havelius U, Bergqvist D, Hindfelt B et al (1997) Improved dark adaptation after carotid endarterectomy. Evidence of a long-term ischaemic penumbra. Neurology 49:1360-1364 (Pubitemid 27495643)
    • (1997) Neurology , vol.49 , Issue.5 , pp. 1360-1364
    • Havelius, U.1    Bergqvist, D.2    Hindfelt, B.3    Krakau, T.4
  • 23
    • 0030707576 scopus 로고    scopus 로고
    • I. Impaired dark adaptation in symptomatic carotid artery disease
    • Havelius U, Bergqvist D, Falke P, Hindfelt B, Krakau T (1997) Impaired dark adaptation in symptomatic carotid artery disease. Neurology 49:1353-1359 (Pubitemid 27495642)
    • (1997) Neurology , vol.49 , Issue.5 , pp. 1353-1359
    • Havelius, U.1    Bergqvist, D.2    Falke, P.3    Hindfelt, B.4    Krakau, T.5
  • 24
  • 25
    • 0023023438 scopus 로고
    • Effects of light and darkness on oxygen distribution and consumption in the cat retina
    • DOI 10.1085/jgp.88.4.521
    • Linsenmeier RA (1986) The effect of light and darkness on oxygen distribution and consumption in the cat retina. J Gen Physiol 88:521-542 (Pubitemid 17172465)
    • (1986) Journal of General Physiology , vol.88 , Issue.4 , pp. 521-542
    • Linsenmeier, R.A.1
  • 29
    • 0035136729 scopus 로고    scopus 로고
    • Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease
    • DOI 10.1016/S1350-9462(00)00027-6, PII S1350946200000276
    • Yu DY, Cringle SJ (2001) Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog Ret Eye Res 20:175-208 (Pubitemid 32153715)
    • (2001) Progress in Retinal and Eye Research , vol.20 , Issue.2 , pp. 175-208
    • Yu, D.-Y.1    Cringle, S.J.2
  • 32
    • 0014782201 scopus 로고
    • Dark current and photocurrent in retinal rods
    • Hagins WA, Penn RD, Yoshikami S (1970) Dark current and photocurrent in retinal rods. Biophys J 10:380-412
    • (1970) Biophys J , vol.10 , pp. 380-412
    • Hagins, W.A.1    Penn, R.D.2    Yoshikami, S.3
  • 33
    • 0033179607 scopus 로고    scopus 로고
    • Molecular mechanisms of vertebrate photoreceptor light adaptation
    • DOI 10.1016/S0959-4388(99)80062-2
    • Pugh ENJ, Nikonov S, Lamb TD (1999) Molecular mechanisms of vertebrate photoreceptor light adaptation. Curr Opin Neurobiol 9:410-418 (Pubitemid 29389447)
    • (1999) Current Opinion in Neurobiology , vol.9 , Issue.4 , pp. 410-418
    • Pugh Jr., E.N.1    Nikonov, S.2    Lamb, T.D.3
  • 37
    • 0031696332 scopus 로고    scopus 로고
    • Choriocapillaris degeneration and related pathologic changes in human diabetic eyes
    • Cao J, McLeod S, Merges CA, Lutty GA (1998) Choriocapillaris degeneration and related pathologic changes in human diabetic eyes. Arch Ophthalmol 116:589-597 (Pubitemid 28414572)
    • (1998) Archives of Ophthalmology , vol.116 , Issue.5 , pp. 589-597
    • Cao, J.1    McLeod, D.S.2    Merges, C.A.3    Lutty, G.A.4
  • 38
    • 0037044901 scopus 로고    scopus 로고
    • Blood-brain barrier integrity is unaltered in human brain cortex with diabetes mellitus
    • DOI 10.1016/S0006-8993(02)03294-8, PII S0006899302032948
    • Dai J, Vrensen GF, Schlingemann RO (2002) Blood-brain barrier integrity is unaltered in human brain cortex with diabetes mellitus. Brain Res 954:311-316 (Pubitemid 35284672)
    • (2002) Brain Research , vol.954 , Issue.2 , pp. 311-316
    • Dai, J.1    Vrensen, G.F.J.M.2    Schlingemann, R.O.3
  • 39
    • 0029595275 scopus 로고
    • Does occupational exposure to argon laser radiation decrease colour contrast sensitivity in UK ophthalmologists?
    • Arden GB, Hall MJ (1995) Does occupational exposure to argon laser radiation decrease colour contrast sensitivity in UK ophthalmologists? Eye 9:686-696 (Pubitemid 26018192)
    • (1995) Eye , vol.9 , Issue.6 , pp. 686-696
    • Arden, G.B.1    Hall, M.J.2
  • 41
    • 4243465559 scopus 로고    scopus 로고
    • Dark adaptation is impaired in diabetics before photopic visual losses can be seen
    • Hollyfield et al. (ed) Ch. 29. Kluwer Academic, Plenumn
    • Arden GB, Wolf JE, Collier J, Wolff C, Rosenberg M (1999) Dark adaptation is impaired in diabetics before photopic visual losses can be seen. In: Hollyfield et al. (ed) Retinal degenerative diseases and experimental therapy, Ch. 29. Kluwer Academic, Plenumn, pp 305-316
    • (1999) Retinal Degenerative Diseases and Experimental Therapy , pp. 305-316
    • Arden, G.B.1    Wolf, J.E.2    Collier, J.3    Wolff, C.4    Rosenberg, M.5
  • 42
    • 0037193804 scopus 로고    scopus 로고
    • Effect of darkness on inner retinal hypoxia in diabetes
    • DOI 10.1016/S0140-6736(02)09265-6
    • Drasdo N, Chiti Z, Owens DR, North RV (2002) Effect of darkness on inner retinal hypoxia in diabetes. Lancet 359(9325):2251-2253 (Pubitemid 34717982)
    • (2002) Lancet , vol.359 , Issue.9325 , pp. 2251-2253
    • Drasdo, N.1    Chiti, Z.2    Owens, D.R.3    North, R.V.4
  • 43
    • 0025268188 scopus 로고
    • Electrophysiological changes in juvenile diabetics without retinopathy
    • Juen S, Kieselbach GF (1990) Electrophysiological changes in juvenile diabetics without retinopathy. Arch Ophthalmol 1083:372-375 (Pubitemid 20100685)
    • (1990) Archives of Ophthalmology , vol.108 , Issue.3 , pp. 372-375
    • Juen, S.1    Kieselbach, G.F.2
  • 44
    • 0031031010 scopus 로고    scopus 로고
    • Partial reversal of protan and tritan colour defects with inhaled oxygen in insulin dependent diabetic subjects
    • Dean FM, Arden GB, Dornhorst A (1997) Partial reversal of protan and tritan colour defects with inhaled oxygen in insulin dependent diabetic subjects. Br J Ophthalmol 81:27-30 (Pubitemid 27068159)
    • (1997) British Journal of Ophthalmology , vol.81 , Issue.1 , pp. 27-30
    • Dean, F.M.1
  • 47
    • 0035136729 scopus 로고    scopus 로고
    • Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease
    • DOI 10.1016/S1350-9462(00)00027-6, PII S1350946200000276
    • Yu DY, Cringle SJ (2001) Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog Retin Eye Res 20:175-208 (Pubitemid 32153715)
    • (2001) Progress in Retinal and Eye Research , vol.20 , Issue.2 , pp. 175-208
    • Yu, D.-Y.1    Cringle, S.J.2
  • 49
    • 0037309999 scopus 로고    scopus 로고
    • Effect of acute hyperglycemia on oxygen and oxidative metabolism in the intact cat retina
    • DOI 10.1167/iovs.02-0432
    • Padnick-Silver L, Linsenmeier RA (2003) Effect of acute hyperglycemia on oxygen and oxidative metabolism in the intact cat retina. Invest Ophthalmol Vis Sci 44:745-750 (Pubitemid 36159724)
    • (2003) Investigative Ophthalmology and Visual Science , vol.44 , Issue.2 , pp. 745-750
    • Padnick-Silver, L.1    Linsenmeier, R.A.2
  • 50
    • 0035086992 scopus 로고    scopus 로고
    • The absence of diabetic retinopathy in patients with retinitis pigmentosa: Implications for pathophysiology and possible treatment
    • DOI 10.1136/bjo.85.3.366
    • Arden GB (2001) Absence of diabetic retinopathy in patients with retinitis pigmentosa: implications for pathophysiology and possible treatment. Brit J Ophthalmol 85:366-370 (Pubitemid 32250774)
    • (2001) British Journal of Ophthalmology , vol.85 , Issue.3 , pp. 366-370
    • Arden, G.B.1
  • 52
    • 0023019090 scopus 로고
    • Retinitis pigmentosa and retinal neovascularization
    • Uliss AE, Gregor ZJ, Bird AC (1986) Retinitis pigmentosa and retinal neovascularization. Ophthalmology 93:1599-1603 (Pubitemid 17216938)
    • (1986) Ophthalmology , vol.93 , Issue.12 , pp. 1599-1603
    • Uliss, A.E.1    Gregor, Z.J.2    Bird, A.C.3
  • 53
    • 33745646315 scopus 로고    scopus 로고
    • Ocular Oxygenation and the Treatment of Diabetic Retinopathy
    • DOI 10.1016/j.survophthal.2006.04.005, PII S0039625706000786
    • Stefansson E (2006) Ocular oxygenation and the treatment of diabetic retinopathy. Surv Ophthalmol 51:364-380 (Pubitemid 43970734)
    • (2006) Survey of Ophthalmology , vol.51 , Issue.4 , pp. 364-380
    • Stefansson, E.1
  • 54
    • 0031742026 scopus 로고    scopus 로고
    • Does mitochondrial genome mutation in subjects with maternally inherited diabetes and deafness decrease severity of diabetic retinopathy?
    • DOI 10.1002/(SICI)1096-9136(1998110)15:11<946::AID-DIA707>3.0.CO;2- L
    • Holmes-Walker DJ, Mitchell P, Boyages SC (1998) Does mitochondrial genome mutation in subjects with maternally inherited diabetes and deafness decrease severity of diabetic retinopathy? Diabet Med 15:946-952 (Pubitemid 28500248)
    • (1998) Diabetic Medicine , vol.15 , Issue.11 , pp. 946-952
    • Holmes-Walker, D.J.1    Mitchell, P.2    Boyages, S.C.3
  • 55
    • 49249083583 scopus 로고    scopus 로고
    • Retinal and renal complications in patients with a mutation of mitochondrial DNA at position 3, 243 (maternally inherited diabetes and deafness) A case-control study
    • GEDIAM (Mitochondrial Diabetes French Study Group)
    • Massin P, Dubois-Laforgue D, Meas T, Laloi-Michelin M, Gin H, GEDIAM (Mitochondrial Diabetes French Study Group) (2008) Retinal and renal complications in patients with a mutation of mitochondrial DNA at position 3, 243 (maternally inherited diabetes and deafness). A case- control study. Diabetologia 51:1664-1670
    • (2008) Diabetologia , vol.51 , pp. 1664-1670
    • Massin, P.1    Dubois-Laforgue, D.2    Meas, T.3    Laloi-Michelin, M.4    Gin, H.5
  • 57
    • 67349248578 scopus 로고    scopus 로고
    • Relationship between diabetic retinopathy and sleep-disordered breathing
    • Shiba T, Sato Y, Takahashi M (2009) Relationship between diabetic retinopathy and sleep-disordered breathing. Am J Ophthalmol 147:1017-1021
    • (2009) Am J Ophthalmol , vol.147 , pp. 1017-1021
    • Shiba, T.1    Sato, Y.2    Takahashi, M.3
  • 59
    • 78149260637 scopus 로고    scopus 로고
    • The association between obstructive sleep apnea syndrome and microvascular complications in wellcontrolled diabetic patients
    • Kosseifi S, Bailey B, Price R, Roy TM, Byrd RP Jr, Peiris AN (2010) The association between obstructive sleep apnea syndrome and microvascular complications in wellcontrolled diabetic patients. Mil Med 175(11):913-916
    • (2010) Mil Med , vol.175 , Issue.11 , pp. 913-916
    • Kosseifi, S.1    Bailey, B.2    Price, R.3    Roy, T.M.4    Byrd Jr., R.P.5    Peiris, A.N.6
  • 60
    • 0036179104 scopus 로고    scopus 로고
    • Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate
    • DOI 10.1016/S0002-9394(01)01381-2, PII S0002939401013812
    • Tolentino MJ, McLeod DS, Taomoto M, Otsuji T, Adamis AP, Lutty GA (2002) Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate. Am J Ophthalmol 133:373-385 (Pubitemid 34171588)
    • (2002) American Journal of Ophthalmology , vol.133 , Issue.3 , pp. 373-385
    • Tolentino, M.J.1    McLeod, D.S.2    Taomoto, M.3    Otsuji, T.4    Adamis, A.P.5    Lutty, G.A.6
  • 61
    • 0031018867 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy
    • Amin RH, Frank RN, Kennedy A, Eliott D, Puklin JE, Abrams GW (1997) Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 38:36-47 (Pubitemid 27051522)
    • (1997) Investigative Ophthalmology and Visual Science , vol.38 , Issue.1 , pp. 36-47
    • Amin, R.H.1    Frank, R.N.2    Kennedy, A.3    Eliott, D.4    Puklin, J.E.5    Abrams, G.W.6
  • 62
    • 0032853603 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and diabetes: The agonist versus antagonist paradox
    • DOI 10.2337/diabetes.48.10.1899
    • Duh E, Aiello LP (1999) Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox. Diabetes 48:1899-1906 (Pubitemid 29458350)
    • (1999) Diabetes , vol.48 , Issue.10 , pp. 1899-1906
    • Duh, E.1    Aiello, L.P.2
  • 63
    • 34447120906 scopus 로고    scopus 로고
    • Leukostatis and pigment epithelium-derived factor in rat models of diabetic retinopathy
    • Matsuoka M, Ogata N, Minamino K, MatsumuraM(2007) Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. Mol Vis 13:1058-1065 (Pubitemid 47034649)
    • (2007) Molecular Vision , vol.13 , pp. 1058-1065
    • Matsuoka, M.1    Ogata, N.2    Minamino, K.3    Matsumura, M.4
  • 66
    • 77956380383 scopus 로고    scopus 로고
    • Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage
    • Wang J, Xu X, Elliott MH, Zhu M, Le YZ (2010) Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage. Diabetes 59:2297-2305
    • (2010) Diabetes , vol.59 , pp. 2297-2305
    • Wang, J.1    Xu, X.2    Elliott, M.H.3    Zhu, M.4    Le, Y.Z.5
  • 67
    • 68349119150 scopus 로고    scopus 로고
    • Anti-inflammatory and antioxidant effects of SERPINA3 K in the retina
    • Zhang B, Hu Y, Ma JX (2009) Anti-inflammatory and antioxidant effects of SERPINA3 K in the retina. Invest Ophthalmol Vis Sci 50:3943-3952
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 3943-3952
    • Zhang, B.1    Hu, Y.2    Ma, J.X.3
  • 68
    • 0033838925 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1)
    • Miyamoto K, Khosrof S, Bursell SE, Moromizato Y, Aiello LP, Ogura Y, Adamis AP (2000) Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1). Am J Pathol 156:1733-1739 (Pubitemid 30646710)
    • (2000) American Journal of Pathology , vol.156 , Issue.5 , pp. 1733-1739
    • Miyamoto, K.1    Khosrof, S.2    Bursell, S.-E.3    Moromizato, Y.4    Aiello, L.P.5    Ogura, Y.6    Adamis, A.P.7
  • 69
    • 42449135678 scopus 로고    scopus 로고
    • Immunological mechanisms in the pathogenesis of diabetic retinopathy
    • Adamis AP, Berman AJ (2008) Immunological mechanisms in the pathogenesis of diabetic retinopathy. Semin Immunopathol 30:65-84
    • (2008) Semin Immunopathol , vol.30 , pp. 65-84
    • Adamis, A.P.1    Berman, A.J.2
  • 73
    • 55849126672 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and diabetic complications
    • Wirostko B, Wong TY, Simó R (2008) Vascular endothelial growth factor and diabetic complications. Prog Retin Eye Res 27:608-621
    • (2008) Prog Retin Eye Res , vol.27 , pp. 608-621
    • Wirostko, B.1    Wong, T.Y.2    Simó, R.3
  • 74
    • 55949126170 scopus 로고    scopus 로고
    • Cytokine profile of peripheral blood in type 2 diabetes mellitus patients with diabetic retinopathy
    • Lee JH, Lee W, Kwon OH, Kim JH, Kwon OW, Kim KH, Lim JB (2008) Cytokine profile of peripheral blood in type 2 diabetes mellitus patients with diabetic retinopathy. Ann Clin Lab Sci 38:361-367
    • (2008) Ann Clin Lab Sci , vol.38 , pp. 361-367
    • Lee, J.H.1    Lee, W.2    Kwon, O.H.3    Kim, J.H.4    Kwon, O.W.5    Kim, K.H.6    Lim, J.B.7
  • 75
    • 56049091016 scopus 로고    scopus 로고
    • Assessment of selected adhesion molecule and proinflammatory cytokine levels in the vitreous body of patients with type 2 diabetes - Role of the inflammatory-immune process in the pathogenesis of proliferative diabetic retinopathy
    • Adamiec-Mroczek J, Oficjalska-Młyńczak (2008) Assessment of selected adhesion molecule and proinflammatory cytokine levels in the vitreous body of patients with type 2 diabetes - role of the inflammatory-immune process in the pathogenesis of proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 246:1665-1670
    • (2008) Graefes Arch Clin Exp Ophthalmol , vol.246 , pp. 1665-1670
    • Adamiec-Mroczek, J.1    Oficjalska-Młyńczak2
  • 76
    • 0028914871 scopus 로고
    • Vascular endothelial growth factor plays a role in hyperpermeability of diabetic retinal vessels
    • Murata T, Ishibashi T, Khalil A, Hata Y, Yoshikawa H, Inomata H(1995) Vascular endothelial growth factor plays a role in hyperpermeability of diabetic retinal vessels. Ophthalmic Res 27:48-52
    • (1995) Ophthalmic Res , vol.27 , pp. 48-52
    • Murata, T.1    Ishibashi, T.2    Khalil, A.3    Hata, Y.4    Yoshikawa, H.5    Inomata, H.6
  • 78
    • 0031974158 scopus 로고    scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin
    • Murohara T, Horowitz JR, Silver M, Tsurumi Y, Chen D, Sullivan A, Isner JM (1998) Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. Circulation 97:99-107 (Pubitemid 28036160)
    • (1998) Circulation , vol.97 , Issue.1 , pp. 99-107
    • Murohara, T.1    Horowitz, J.R.2    Silver, M.3    Tsurumi, Y.4    Chen, D.5    Sullivan, A.6    Isner, J.M.7
  • 81
    • 37349098832 scopus 로고    scopus 로고
    • Vitreous fluid of db/db mice exhibits alterations in angiogenic and metabolic factors consistent with early diabetic retinopathy
    • DOI 10.1159/000111151
    • Cohen MP, Hud E, Shea E, Shearman CW(2008) Vitreous fluid of db/db mice exhibits alterations in angiogenic and metabolic factors consistent with early diabetic retinopathy. Ophthalmic Res 40:5-9 (Pubitemid 350308296)
    • (2008) Ophthalmic Research , vol.40 , Issue.1 , pp. 5-9
    • Cohen, M.P.1    Hud, E.2    Shea, E.3    Shearman, C.W.4
  • 82
    • 0038243821 scopus 로고    scopus 로고
    • Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor
    • El-Remessy AB, Behzadian MA, Abou-Mohamed G, Franklin T, Caldwell RW, Caldwell RB (2003) Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor. Am J Pathol 162:1995-2004 (Pubitemid 36613056)
    • (2003) American Journal of Pathology , vol.162 , Issue.6 , pp. 1995-2004
    • El-Remessy, A.B.1    Ali Behzadian, M.2    Abou-Mohamed, G.3    Franklin, T.4    Caldwell, R.W.5    Caldwell, R.B.6
  • 83
    • 0033621686 scopus 로고    scopus 로고
    • 2, vascular endothelial growth factor and receptors in the retina of the BBZ/WOR diabetic rat
    • DOI 10.1016/S0891-5849(99)00216-6, PII S0891584999002166
    • Ellis EA, Guberski DL, Somogyi-Mann M, Grant MB (2000) Increased H2O2, vascular endothelial growth factor and receptors in the retina of the BBZ/Wor diabetic rat. Free Radic Biol Med 28:91-101 (Pubitemid 30045577)
    • (2000) Free Radical Biology and Medicine , vol.28 , Issue.1 , pp. 91-101
    • Ellis, E.A.1    Guberski, D.L.2    Somogyi-Mann, M.3    Grant, M.B.4
  • 84
    • 44949084501 scopus 로고    scopus 로고
    • Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for neovascular age-related macular degeneration
    • Vedula SS, Krzystolik MG (2008) Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for neovascular age-related macular degeneration. Cochrane Database Syst Rev CD005139
    • (2008) Cochrane Database Syst Rev
    • Vedula, S.S.1    Krzystolik, M.G.2
  • 85
    • 35548939420 scopus 로고    scopus 로고
    • The future implications and indications of anti-vascular endothelial growth factor therapy in ophthalmic practice
    • Hussain N, Ghanekar Y, Kaur I (2007) The future implications and indications of anti-vascular endothelial growth factor therapy in ophthalmic practice. Ind J Ophthalmol 55:445-450
    • (2007) Ind J Ophthalmol , vol.55 , pp. 445-450
    • Hussain, N.1    Ghanekar, Y.2    Kaur, I.3
  • 86
    • 77955657984 scopus 로고    scopus 로고
    • A review of clinical trials of anti-VEGF agents for diabetic retinopathy
    • Nicholson BP, Schachat AP (2010) A review of clinical trials of anti-VEGF agents for diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 248:915-930
    • (2010) Graefes Arch Clin Exp Ophthalmol , vol.248 , pp. 915-930
    • Nicholson, B.P.1    Schachat, A.P.2
  • 87
    • 49349103253 scopus 로고    scopus 로고
    • Intravitreous anti-VEGF for diabetic retinopathy: Hopes and fears for a new therapeutic strategy
    • Simó R, Hernández C (2008) Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy. Diabetologia 51:1574-1580
    • (2008) Diabetologia , vol.51 , pp. 1574-1580
    • Simó, R.1    Hernández, C.2
  • 88
    • 77954287509 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor agents for diabetic maculopathy
    • Salam A, DaCosta J, Sivaprasad S (2010) Anti-vascular endothelial growth factor agents for diabetic maculopathy. Br J Ophthalmol 94:821-826
    • (2010) Br J Ophthalmol , vol.94 , pp. 821-826
    • Salam, A.1    Dacosta, J.2    Sivaprasad, S.3
  • 89
    • 79955000130 scopus 로고    scopus 로고
    • Treatment of diabetic retinopathy with anti-VEGF drugs
    • Waisbourd M, Goldstein M, Loewenstein A (2011) Treatment of diabetic retinopathy with anti-VEGF drugs. Acta Ophthalmol 89:203-207
    • (2011) Acta Ophthalmol , vol.89 , pp. 203-207
    • Waisbourd, M.1    Goldstein, M.2    Loewenstein, A.3
  • 90
    • 79551505801 scopus 로고    scopus 로고
    • The influence of glucose concentration and hypoxia on VEGF secretion by cultured retinal cells
    • Kennedy A, Frank RN (2011) The influence of glucose concentration and hypoxia on VEGF secretion by cultured retinal cells. Curr Eye Res 36:168-177
    • (2011) Curr Eye Res , vol.36 , pp. 168-177
    • Kennedy, A.1    Frank, R.N.2
  • 91
    • 79952606844 scopus 로고    scopus 로고
    • The optic UK lecture: Bench-to-bedside adventures of a diabetes researcher: Results past, results present
    • Frank RN (2011) The optic UK lecture: bench-to-bedside adventures of a diabetes researcher: results past, results present. Eye 25:331-341
    • (2011) Eye , vol.25 , pp. 331-341
    • Frank, R.N.1
  • 94
    • 0033852150 scopus 로고    scopus 로고
    • Hypoxic induction of vascular endothelial growth factor is markedly decreased in diabetic individuals who do not develop retinopathy
    • Marsh S, Nakhoul FM, Skorecki K, Rubin A, Miller BP, Leibu R, Levy NS, Levy AP (2000) Hypoxic induction of vascular endothelial growth factor is markedly decreased in diabetic individuals who do not develop retinopathy. Diabetes Care 23:1375-1380
    • (2000) Diabetes Care , vol.23 , pp. 1375-1380
    • Marsh, S.1    Nakhoul, F.M.2    Skorecki, K.3    Rubin, A.4    Miller, B.P.5    Leibu, R.6    Levy, N.S.7    Levy, A.P.8
  • 99
    • 80053526640 scopus 로고    scopus 로고
    • Regression of early diabetic macular oedema associated with prevention of dark - Adaptation
    • e-published Oct 20th 2011
    • Arden GB, Jyothi S, Hogg CH, Lee YF, Sivaprasad S (2011) Regression of early diabetic macular oedema associated with prevention of dark - adaptation. Eye 25. e-published Oct 20th 2011
    • (2011) Eye , vol.25
    • Arden, G.B.1    Jyothi, S.2    Hogg, C.H.3    Lee, Y.F.4    Sivaprasad, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.