메뉴 건너뛰기




Volumn 60, Issue 10, 2011, Pages 2484-2495

Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; HYPOXIA INDUCIBLE FACTOR 1; SUPPRESSOR OF CYTOKINE SIGNALING 3;

EID: 80053408653     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0174     Document Type: Article
Times cited : (233)

References (41)
  • 1
    • 47849121225 scopus 로고    scopus 로고
    • Hypoxia in adipose tissue: A basis for the dysregulation of tissue function in obesity?
    • Trayhurn P, Wang B, Wood IS. Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr 2008;100:227-235
    • (2008) Br J Nutr , vol.100 , pp. 227-235
    • Trayhurn, P.1    Wang, B.2    Wood, I.S.3
  • 2
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • DOI 10.1152/ajpendo.00435.2007
    • Ye J, Gao Z, Yin J, He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 2007;293:E1118-E1128 (Pubitemid 47535846)
    • (2007) American Journal of Physiology - Endocrinology and Metabolism , vol.293 , Issue.4
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 3
    • 63249093556 scopus 로고    scopus 로고
    • Hypoxia decreases insulin signaling pathways in adipocytes
    • Regazzetti C, Peraldi P, Grémeaux T, et al. Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes 2009;58:95-103
    • (2009) Diabetes , vol.58 , pp. 95-103
    • Regazzetti, C.1    Peraldi, P.2    Grémeaux, T.3
  • 4
    • 67650717659 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-3alpha functions as an accelerator of 3T3-L1 adipose differentiation
    • Hatanaka M, Shimba S, Sakaue M, et al. Hypoxia-inducible factor-3alpha functions as an accelerator of 3T3-L1 adipose differentiation. Biol Pharm Bull 2009;32:1166-1172
    • (2009) Biol Pharm Bull , vol.32 , pp. 1166-1172
    • Hatanaka, M.1    Shimba, S.2    Sakaue, M.3
  • 5
    • 4644368368 scopus 로고    scopus 로고
    • EPAS1 promotes adipose differentiation in 3T3-L1 cells
    • DOI 10.1074/jbc.M400840200
    • Shimba S, Wada T, Hara S, Tezuka M. EPAS1 promotes adipose differentiation in 3T3-L1 cells. J Biol Chem 2004;279:40946-40953 (Pubitemid 39287694)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.39 , pp. 40946-40953
    • Shimba, S.1    Wada, T.2    Hara, S.3    Tezuka, M.4
  • 6
    • 58149500277 scopus 로고    scopus 로고
    • Emerging role of adipose tissue hypoxia in obesity and insulin resistance
    • Lond
    • Ye J. Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) 2009;33:54-66
    • (2009) Int J Obes , vol.33 , pp. 54-66
    • Ye, J.1
  • 9
    • 0033777202 scopus 로고    scopus 로고
    • Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha
    • Tomita S, Sinal CJ, Yim SH, Gonzalez FJ. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol Endocrinol 2000;14:1674-1681
    • (2000) Mol Endocrinol , vol.14 , pp. 1674-1681
    • Tomita, S.1    Sinal, C.J.2    Yim, S.H.3    Gonzalez, F.J.4
  • 12
    • 0033623531 scopus 로고    scopus 로고
    • Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice
    • Gavrilova O, Marcus-Samuels B, Reitman ML. Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice. Diabetes 2000;49:1910-1916
    • (2000) Diabetes , vol.49 , pp. 1910-1916
    • Gavrilova, O.1    Marcus-Samuels, B.2    Reitman, M.L.3
  • 13
    • 77950202899 scopus 로고    scopus 로고
    • G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis
    • Chen M, Chen H, Nguyen A, et al. G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis. Cell Metab 2010;11:320-330
    • (2010) Cell Metab , vol.11 , pp. 320-330
    • Chen, M.1    Chen, H.2    Nguyen, A.3
  • 14
    • 76049086229 scopus 로고    scopus 로고
    • PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization
    • Sugii S, Olson P, Sears DD, et al. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci USA 2009;106:22504-22509
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 22504-22509
    • Sugii, S.1    Olson, P.2    Sears, D.D.3
  • 15
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • DOI 10.1038/414799a
    • Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001;414:799-806 (Pubitemid 34000783)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 16
    • 68949159760 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue
    • Halberg N, Khan T, Trujillo ME, et al. Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 2009;29:4467-4483
    • (2009) Mol Cell Biol , vol.29 , pp. 4467-4483
    • Halberg, N.1    Khan, T.2    Trujillo, M.E.3
  • 18
    • 0035930605 scopus 로고    scopus 로고
    • SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice
    • Emanuelli B, Peraldi P, Filloux C, et al. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem 2001;276:47944-47949
    • (2001) J Biol Chem , vol.276 , pp. 47944-47949
    • Emanuelli, B.1    Peraldi, P.2    Filloux, C.3
  • 19
    • 4544256147 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling
    • DOI 10.1074/jbc.M403886200
    • Shi H, Tzameli I, Bjørbaek C, Flier JS. Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. J Biol Chem 2004;279:34733-34740 (Pubitemid 39318104)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.33 , pp. 34733-34740
    • Shi, H.1    Tzameli, I.2    Bjorbaek, C.3    Flier, J.S.4
  • 20
    • 3142782772 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
    • DOI 10.1038/nm1072
    • Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 2004;10:734-738 (Pubitemid 38937639)
    • (2004) Nature Medicine , vol.10 , Issue.7 , pp. 734-738
    • Howard, J.K.1    Cave, B.J.2    Oksanen, L.J.3    Tzameli, I.4    Bjoorbaek, C.5    Flier, J.S.6
  • 21
    • 33847364944 scopus 로고    scopus 로고
    • Effects of pioglitazone on suppressor of cytokine signaling 3 expression: Potential mechanisms for its effects on insulin sensitivity and adiponectin expression
    • DOI 10.2337/db06-1039
    • Kanatani Y, Usui I, Ishizuka K, et al. Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression. Diabetes 2007;56:795-803 (Pubitemid 46348484)
    • (2007) Diabetes , vol.56 , Issue.3 , pp. 795-803
    • Kanatani, Y.1    Usui, I.2    Ishizuka, K.3    Bukhari, A.4    Fujisaka, S.5    Urakaze, M.6    Haruta, T.7    Kishimoto, T.8    Naka, T.9    Kobayashi, M.10
  • 23
    • 60849121937 scopus 로고    scopus 로고
    • Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue
    • Yin J, Gao Z, He Q, Zhou D, Guo Z, Ye J. Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab 2009;296:E333-E342
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Yin, J.1    Gao, Z.2    He, Q.3    Zhou, D.4    Guo, Z.5    Ye, J.6
  • 24
    • 33845325476 scopus 로고    scopus 로고
    • Adipocyte differentiation from the inside out
    • DOI 10.1038/nrm2066, PII NRM2066
    • Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 2006;7:885-896 (Pubitemid 44871415)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.12 , pp. 885-896
    • Rosen, E.D.1    MacDougald, O.A.2
  • 25
    • 63349110943 scopus 로고    scopus 로고
    • Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation
    • van Eijk M, Aten J, Bijl N, et al. Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation. PLoS ONE 2009;4:e4723
    • (2009) PLoS ONE , vol.4
    • Van Eijk, M.1    Aten, J.2    Bijl, N.3
  • 26
    • 0036198010 scopus 로고    scopus 로고
    • Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: A mechanism for regulation of adipogenesis by hypoxia
    • DOI 10.1016/S1534-5807(02)00131-4
    • Yun Z, Maecker HL, Johnson RS, Giaccia AJ. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell 2002;2:331-341 (Pubitemid 34266118)
    • (2002) Developmental Cell , vol.2 , Issue.3 , pp. 331-341
    • Yun, Z.1    Maecker, H.L.2    Johnson, R.S.3    Giaccia, A.J.4
  • 31
    • 63749109585 scopus 로고    scopus 로고
    • Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: Role of local versus bone marrow-derived endothelial cells
    • Tam J, Duda DG, Perentes JY, Quadri RS, Fukumura D, Jain RK. Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells. PLoS ONE 2009;4:e4974
    • (2009) PLoS ONE , vol.4
    • Tam, J.1    Duda, D.G.2    Perentes, J.Y.3    Quadri, R.S.4    Fukumura, D.5    Jain, R.K.6
  • 33
    • 74949138985 scopus 로고    scopus 로고
    • Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
    • Wueest S, Rapold RA, Schumann DM, et al. Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest 2010;120:191-202
    • (2010) J Clin Invest , vol.120 , pp. 191-202
    • Wueest, S.1    Rapold, R.A.2    Schumann, D.M.3
  • 34
    • 77953200528 scopus 로고    scopus 로고
    • Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism
    • Kumar A, Lawrence JC Jr, Jung DY, et al. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes 2010;59:1397-1406
    • (2010) Diabetes , vol.59 , pp. 1397-1406
    • Kumar, A.1    Lawrence Jr., J.C.2    Jung, D.Y.3
  • 35
    • 2942628012 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
    • DOI 10.1128/MCB.24.12.5434-5446.2004
    • Ueki K, Kondo T, Kahn CR. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 2004;24:5434-5446 (Pubitemid 38738176)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.12 , pp. 5434-5446
    • Ueki, K.1    Kondo, T.2    Kahn, C.R.3
  • 39
    • 33644782904 scopus 로고    scopus 로고
    • Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance
    • Shi H, Cave B, Inouye K, Bjørbaek C, Flier JS. Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. Diabetes 2006;55:699-707 (Pubitemid 43343226)
    • (2006) Diabetes , vol.55 , Issue.3 , pp. 699-707
    • Shi, H.1    Cave, B.2    Inouye, K.3    Bjorbaek, C.4    Flier, J.S.5
  • 40
    • 2942735492 scopus 로고    scopus 로고
    • The molecular mechanism linking muscle fat accumulation to insulin resistance
    • DOI 10.1079/PNS2004351
    • Hulver MW, Dohm GL. The molecular mechanism linking muscle fat accumulation to insulin resistance. Proc Nutr Soc 2004;63:375-380 (Pubitemid 38787493)
    • (2004) Proceedings of the Nutrition Society , vol.63 , Issue.2 , pp. 375-380
    • Hulver, M.W.1    Dohm, G.L.2
  • 41
    • 33744953147 scopus 로고    scopus 로고
    • Rosiglitazone controls fatty acid cycling in human adipose tissue by means of glyceroneogenesis and glycerol phosphorylation
    • DOI 10.1074/jbc.M512943200
    • Leroyer SN, Tordjman J, Chauvet G, et al. Rosiglitazone controls fatty acid cycling in human adipose tissue by means of glyceroneogenesis and glycerol phosphorylation. J Biol Chem 2006;281:13141-13149 (Pubitemid 43855225)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.19 , pp. 13141-13149
    • Leroyer, S.N.1    Tordjman, J.2    Chauvet, G.3    Quette, J.4    Chapron, C.5    Forest, C.6    Antoine, B.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.