Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: Implications for lysosomal storage disorders

Journal of Biological Chemistry

Volumn 290, Issue 16, 2015, Pages 10309-10324

  Ghosh, Arunava ^a   Jana, Malabendu ^a   Modi, Khushbu ^a   Gonzalez, Frank J ^b   Sims, Katherine B ^c   Berry Kravis, Elizabeth ^a   Pahan, Kalipada ^a,d  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; COORDINATION REACTIONS; CYTOLOGY; MACHINERY; MOBILE SECURITY; WASTE MANAGEMENT;

ALL-TRANS RETINOIC ACIDS; LIPID METABOLISMS; LYSOSOMAL BIOGENESIS; LYSOSOMAL STORAGE DISORDER; MASTER REGULATORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; REPORTER ASSAY; RETINOID X RECEPTOR;

DRUG PRODUCTS;

GEMFIBROZIL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RETINOIC ACID; RETINOID X RECEPTOR ALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; PPARGC1A PROTEIN, MOUSE; PROTEIN BINDING; TCFEB PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BIOGENESIS; BRAIN CELL; CHROMATIN IMMUNOPRECIPITATION; CLN2 GENE; CONTROLLED STUDY; GENE; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LATE INFANTILE NEURONAL CEROID LIPOFUSCINOSIS; LIPID METABOLISM; LIPOFUSCINOSIS; LYSOSOME; LYSOSOME STORAGE DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SKIN FIBROBLAST; TFEB GENE; TRANSCRIPTION REGULATION; UPREGULATION; AGONISTS; ANIMAL; ASTROCYTE; AUTOPHAGY; BRAIN; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION;

ANIMALS; ASTROCYTES; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BRAIN; GEMFIBROZIL; GENE EXPRESSION REGULATION; HUMANS; LIPID METABOLISM; LYSOSOMES; MICE; NEURONS; PPAR ALPHA; PPAR GAMMA; PPAR-BETA; PRIMARY CELL CULTURE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RETINOID X RECEPTOR ALPHA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRETINOIN;

EID: 84927748765     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.610659     Document Type: Article

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