Gemfibrozil and fenofibrate, food and drug administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: Implications for late infantile batten disease therapy

Journal of Biological Chemistry

Volumn 287, Issue 46, 2012, Pages 38922-38935

  Ghosh, Arunava ^a   Corbett, Grant T ^a   Gonzalez, Frank J ^b   Pahan, Kalipada ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN CELLS; CELL TYPES; CEROID LIPOFUSCINOSIS; CO-IMMUNOPRECIPITATIONS; ENZYMATIC ACTIVITIES; FATAL DISEASE; FENOFIBRATE; FIBRATE DRUGS; GEMFIBROZILS; HETERODIMERS; IN-VITRO; MOLECULAR LEVELS; NEURONAL CELL; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; RETINOIC ACIDS; RETINOID X RECEPTOR; TRIPEPTIDYL-PEPTIDASE I; UP-REGULATION; WILD TYPES;

BIOMOLECULES; DISEASE CONTROL; DRUG THERAPY; GENE ENCODING; MAMMALS; NEURONS; PEDIATRICS; PROTEINS;

DRUG PRODUCTS;

FENOFIBRATE; GEMFIBROZIL; MESSENGER RNA; PEPTIDASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RETINOID X RECEPTOR ALPHA; TRIPEPTIDYL PEPTIDASE I; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BINDING AFFINITY; BINDING SITE; BRAIN CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG APPROVAL; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME LOCALIZATION; FETUS; FOOD AND DRUG ADMINISTRATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE;

AMINOPEPTIDASES; ANIMALS; ASTROCYTES; BRAIN; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; FENOFIBRATE; GEMFIBROZIL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; HYPOLIPIDEMIC AGENTS; LYSOSOMES; MICE; NEURONAL CEROID-LIPOFUSCINOSES; NEURONS; PPAR ALPHA; RETINOID X RECEPTOR ALPHA; SERINE PROTEASES; UP-REGULATION;

MUS;

EID: 84869025959     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.365148     Document Type: Article

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