Remodeling the Proteostasis Network to Rescue Glucocerebrosidase Variants by Inhibiting ER-Associated Degradation and Enhancing ER Folding

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Wang, Fan ^a   Segatori, Laura ^a,b  

^a Rice University   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSYLCERAMIDASE; LACIDIPINE;

APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CELL ACTIVITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; FIBROBLAST; GENE SEQUENCE; HUMAN; HUMAN CELL; LYSOSOME; NUCLEOTIDE SEQUENCE; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; PROTEIN UNFOLDING; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

CALCIUM; CELL DEATH; CYTOPROTECTION; CYTOSOL; DIHYDROPYRIDINES; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; FIBROBLASTS; GAUCHER DISEASE; GENE SILENCING; GLUCOSYLCERAMIDASE; HEAT-SHOCK PROTEINS; HOMEOSTASIS; HUMANS; LYSOSOMES; MUTANT PROTEINS; MUTATION; PROTEIN FOLDING; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; UNFOLDED PROTEIN RESPONSE; UP-REGULATION;

EID: 84876435491     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061418     Document Type: Article

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