Down-regulated lysosomal processing improved pegylated lipopolyplex-mediated gene transfection

Journal of Gene Medicine

Volumn 15, Issue 5, 2013, Pages 182-192

  Bai, Jing ^a,b   Liu, Yujie ^a   Sun, Wenqiang ^a   Chen, Jian ^a   Miller, Andrew D ^b,c   Xu, Yuhong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Gene transfection; Lipopolyplex; Omeprazole; PEGylation; Proton pump inhibitor; Vacuolar H+ ATPase

Indexed keywords

DNA; LIPID; LIPID MU DNA; LUCIFERASE; MACROGOL; NANOPARTICLE; OMEPRAZOLE; PEPTIDE; PLASMID DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL ORGANELLE; CELL PH; CELL VIABILITY; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DOWN REGULATION; FLOW CYTOMETRY; GEL ELECTROPHORESIS; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LYSOSOME; MALE; MOUSE; NONHUMAN; PHOTON CORRELATION SPECTROSCOPY; PREMEDICATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; TUMOR XENOGRAFT;

ANIMALS; CELL LINE; CELL LINE, TUMOR; DNA; DOWN-REGULATION; GENETIC VECTORS; HUMANS; LIPOSOMES; LYSOSOMES; MALE; MICE; MICE, NUDE; NANOPARTICLES; POLYETHYLENE GLYCOLS; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 84878257703     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.2707     Document Type: Article

References (31)

1. Moghimi SM, Szebeni J. Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog Lipid Res 2003; 42: 463-478.
2. Torchilin VP, Omelyanenko VG, Papisov MI, et al. Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity. Biochim Biophys Acta 1994; 1195: 11-20.
3. Li SD, Huang L. Gene therapy progress and prospects: non-viral gene therapy by systemic delivery. Gene Ther 2006; 13: 1313-1319.
4. Mishra S, Webster P, Davis ME. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur J Cell Biol 2004; 83: 97-111.
5. Remaut K, Lucas B, Braeckmans K, Demeester J, De Smedt SC. Pegylation of liposomes favours the endosomal degradation of the delivered phosphodiester oligonucleotides. J Control Release 2007; 117: 256-266.
6. Romberg B, Hennink WE, Storm G. Sheddable coatings for long-circulating nanoparticles. Pharm Res 2008; 25: 55-71.
7. Masson C, Garinot M, Mignet N, et al. pH-sensitive PEG lipids containing orthoester linkers: new potential tools for nonviral gene delivery. J Control Release 2004; 99: 423-434.
8. Li W, Huang Z, MacKay JA, Grube S, Szoka FC Jr. Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery. J Gene Med 2005; 7: 67-79.
9. Hatakeyama H, Akita H, Kogure K, et al. Development of a novel systemic gene delivery system for cancer therapy with a tumour-specific cleavable PEG-lipid. Gene Ther 2007; 14: 68-77.
10. Akinc A, Thomas M, Klibanov AM, Langer R. Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med 2005; 7: 657-663.
11. Khalil IA, Kogure K, Akita H, Harashima H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol Rev 2006; 58: 32-45.
12. Moore NM, Sheppard CL, Sakiyama-Elbert SE. Characterization of a multifunctional PEG-based gene delivery system containing nuclear localization signals and endosomal escape peptides. Acta Biomater 2009; 5: 854-864.
13. Bowman EJ, Siebers A, Altendorf K. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci USA 1988; 85: 7972-7976.
14. Drose S, Altendorf K. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. J Exp Biol 1997; 200: 1-8.
15. Fass E, Shvets E, Degani I, Hirschberg K, Elazar Z. Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes. J Biol Chem 2006; 281: 36303-36316.
16. Mousavi SA, Kjeken R, Berg TO, Seglen PO, Berg T, Brech A. Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy. Biochim Biophys Acta 2001; 1510: 243-257.
17. Clague MJ, Urbe S, Aniento F, Gruenberg J. Vacuolar ATPase activity is required for endosomal carrier vesicle formation. J Biol Chem 1994; 269: 21-24.
18. Lambers CB, Lind T, Moberg S, Jansen JB, Olbe L. Omeprazole in Zollinger-Ellison syndrome. Effects of a single dose and of long-term treatment in patients resistant to histamine H2-receptor antagonists. N Engl J Med 1984; 310: 758-761.
19. De Milito A, Iessi E, Logozzi M, et al. Proton pump inhibitors induce apoptosis of human B-cell tumours through a caspase-independent mechanism involving reactive oxygen species. Cancer Res 2007; 67: 5408-5417.
20. Mattsson JP, Vaananen K, Wallmark B, Lorentzon P. Omeprazole and bafilomycin, two proton pump inhibitors: differentiation of their effects on gastric, kidney and bone H(+)-translocating ATPases. Biochim Biophys Acta 1991; 1065: 261-268.
21. Moriyama Y, Patel V, Ueda I, Futai M. Evidence for a common binding site for omeprazole and N-ethylmaleimide in subunit A of chromaffin granule vacuolar-type H(+)-ATPase. Biochem Biophys Res Commun 1993; 196: 699-706.
22. Lee CM, Tannock IF. Inhibition of endosomal sequestration of basic anticancer drugs: influence on cytotoxicity and tissue penetration. Br J Cancer 2006; 94: 863-869.
23. Bai J, Zhou Z, Tang H, Song S, Peng J, Xu Y. Impact of PEGylation on biodistribution and tumour accumulation of Lipid-Mu peptide-DNA. J Liposome Res 2013; 23: 1-10.
24. Tagawa T, Manvell M, Brown N, et al. Characterization of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu and plasmid DNA. Gene Ther 2002; 9: 564-576.
25. Ishida T, Iden DL, Allen TM. A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs. FEBS Lett 1999; 460: 129-133.
26. Uster PS, Allen TM, Daniel BE, Mendez CJ, Newman MS, Zhu GZ. Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time. FEBS Lett 1996; 386: 243-246.
27. Kostarelos K, Miller AD. Synthetic, self-assembly ABCD nanoparticles; a structural paradigm for viable synthetic non-viral vectors. Chem Soc Rev 2005; 34: 970-994.
28. Li S, Huang L. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Ther 1997; 4: 891-900.
29. Udelnow A, Kreyes A, Ellinger S, et al. Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells. PLoS One 2011; 6: e20143.
30. Song LY, Ahkong QF, Rong Q, et al. Characterization of the inhibitory effect of PEG-lipid conjugates on the intracellular delivery of plasmid and antisense DNA mediated by cationic lipid liposomes. Biochim Biophys Acta 2002; 1558: 1-13.
31. Deshpande MC, Davies MC, Garnett MC, et al. The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes. J Control Release 2004; 97: 143-156.