메뉴 건너뛰기




Volumn 37, Issue 8, 2012, Pages 1718-1729

Gemfibrozil, a lipid lowering drug, inhibits the activation of primary human microglia via peroxisome proliferator-activated receptor β

Author keywords

CD11b; Gemfibrozil; Human microglia; PPAR ; Proinflammatory molecules

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD11B ANTIGEN; CLOFIBRATE; GEMFIBROZIL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 84864329655     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0781-6     Document Type: Article
Times cited : (24)

References (60)
  • 1
    • 0033061409 scopus 로고    scopus 로고
    • Increased peroxisomal fatty acid beta-oxidation and enhanced expression of peroxisome proliferator-activated receptor-alpha in diabetic rat liver
    • Asayama K, Sandhir R, Sheikh FG, Hayashibe H, Nakane T, Singh I (1999) Increased peroxisomal fatty acid beta-oxidation and enhanced expression of peroxisome proliferator-activated receptor-alpha in diabetic rat liver. Mol Cell Biochem 194:227-234
    • (1999) Mol Cell Biochem , vol.194 , pp. 227-234
    • Asayama, K.1    Sandhir, R.2    Sheikh, F.G.3    Hayashibe, H.4    Nakane, T.5    Singh, I.6
  • 3
    • 0033525535 scopus 로고    scopus 로고
    • Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects
    • Berger J, Leibowitz MD, Doebber TW et al (1999) Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem 274:6718-6725
    • (1999) J Biol Chem , vol.274 , pp. 6718-6725
    • Berger, J.1    Leibowitz, M.D.2    Doebber, T.W.3
  • 4
    • 0034057069 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in the cardiovascular system
    • Bishop-Bailey D (2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br J Pharmacol 129:823-834
    • (2000) Br J Pharmacol , vol.129 , pp. 823-834
    • Bishop-Bailey, D.1
  • 5
    • 77954152480 scopus 로고    scopus 로고
    • Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses
    • Brahmachari S, Jana A, Pahan K (2009) Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. J Immunol 183:5917-5927
    • (2009) J Immunol , vol.183 , pp. 5917-5927
    • Brahmachari, S.1    Jana, A.2    Pahan, K.3
  • 6
    • 0033856825 scopus 로고    scopus 로고
    • PPAR agonists as direct modulators of the vessel wall in cardiovascular disease
    • Buchan KW, Hassall DG (2000) PPAR agonists as direct modulators of the vessel wall in cardiovascular disease. Med Res Rev 20:350-366
    • (2000) Med Res Rev , vol.20 , pp. 350-366
    • Buchan, K.W.1    Hassall, D.G.2
  • 7
    • 0037207510 scopus 로고    scopus 로고
    • TNFalpha downregulates PPAR delta expression in oligodendrocyte progenitor cells: Implications for demyelinating diseases
    • Cimini A, Bernardo A, Cifone MG, Di Marzio L, Di Loreto S (2003) TNFalpha downregulates PPAR delta expression in oligodendrocyte progenitor cells: implications for demyelinating diseases. Glia 41:3-14
    • (2003) Glia , vol.41 , pp. 3-14
    • Cimini, A.1    Bernardo, A.2    Cifone, M.G.3    Di Marzio, L.4    Di Loreto, S.5
  • 8
    • 0038605118 scopus 로고    scopus 로고
    • Role of very-late antigen-4 (VLA-4) in myelin basic protein-primed T cell contactinduced expression of proinflammatory cytokines in microglial cells
    • Dasgupta S, Jana M, Liu X, Pahan K (2003) Role of very-late antigen-4 (VLA-4) in myelin basic protein-primed T cell contactinduced expression of proinflammatory cytokines in microglial cells. J Biol Chem 278:22424-22431
    • (2003) J Biol Chem , vol.278 , pp. 22424-22431
    • Dasgupta, S.1    Jana, M.2    Liu, X.3    Pahan, K.4
  • 9
    • 3142774208 scopus 로고    scopus 로고
    • Antineuroinflammatory effect of NF-kappaB essential modifierbinding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis
    • Dasgupta S, Jana M, Zhou Y, Fung YK, Ghosh S, Pahan K (2004) Antineuroinflammatory effect of NF-kappaB essential modifierbinding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis. J Immunol 173:1344-1354
    • (2004) J Immunol , vol.173 , pp. 1344-1354
    • Dasgupta, S.1    Jana, M.2    Zhou, Y.3    Fung, Y.K.4    Ghosh, S.5    Pahan, K.6
  • 10
    • 34748917549 scopus 로고    scopus 로고
    • Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha
    • Dasgupta S, Roy A, Jana M, Hartley DM, Pahan K (2007) Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha. Mol Pharmacol 72:934-946
    • (2007) Mol Pharmacol , vol.72 , pp. 934-946
    • Dasgupta, S.1    Roy, A.2    Jana, M.3    Hartley, D.M.4    Pahan, K.5
  • 11
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1
    • Delerive P, De Bosscher K, Besnard S et al (1999) Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. J Biol Chem 274: 32048-32054
    • (1999) J Biol Chem , vol.274 , pp. 32048-32054
    • Delerive, P.1    De Bosscher, K.2    Besnard, S.3
  • 12
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20:649-688
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 13
    • 34247588060 scopus 로고    scopus 로고
    • PPAR beta agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y
    • Di Loreto S, D'Angelo B, D'Amico MA et al (2007) PPAR beta agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y. J Cell Physiol 211:837-847
    • (2007) J Cell Physiol , vol.211 , pp. 837-847
    • Di Loreto, S.1    D'angelo, B.2    D'amico, M.A.3
  • 15
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
    • Forman BM, Chen J, Evans RM (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci USA 94:4312-4317
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 16
    • 0027155807 scopus 로고
    • Diffuse microgliosis associated with cerebral atrophy in the acquired immunodeficiency syndrome
    • Gelman BB (1993) Diffuse microgliosis associated with cerebral atrophy in the acquired immunodeficiency syndrome. Ann Neurol 34:65-70
    • (1993) Ann Neurol , vol.34 , pp. 65-70
    • Gelman, B.B.1
  • 17
    • 0032771055 scopus 로고    scopus 로고
    • Regulation of inducible gene expression by the transcription factor NF-kappaB
    • Ghosh S (1999) Regulation of inducible gene expression by the transcription factor NF-kappaB. Immunol Res 19:183-189
    • (1999) Immunol Res , vol.19 , pp. 183-189
    • Ghosh, S.1
  • 18
    • 54949147176 scopus 로고    scopus 로고
    • New regulators of NF-kappaB in inflammation
    • Ghosh S, Hayden MS (2008) New regulators of NF-kappaB in inflammation. Nat Rev Immunol 8:837-848
    • (2008) Nat Rev Immunol , vol.8 , pp. 837-848
    • Ghosh, S.1    Hayden, M.S.2
  • 19
    • 64249165203 scopus 로고    scopus 로고
    • Transcriptional modulation of the immune response by peroxisome proliferators-activated receptor-{alpha} agonists in autoimmune disease
    • Gocke AR, Hussain RZ, Yang Y et al (2009) Transcriptional modulation of the immune response by peroxisome proliferators-activated receptor-{alpha} agonists in autoimmune disease. J Immunol 182:4479-4487
    • (2009) J Immunol , vol.182 , pp. 4479-4487
    • Gocke, A.R.1    Hussain, R.Z.2    Yang, Y.3
  • 20
    • 55949111070 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor beta/delta in the brain: Facts and hypothesis
    • Hall MG, Quignodon L, Desvergne B (2008) Peroxisome proliferator- activated receptor beta/delta in the brain: facts and hypothesis. PPAR Res 2008:780452
    • (2008) PPAR Res , vol.2008 , pp. 780452
    • Hall, M.G.1    Quignodon, L.2    Desvergne, B.3
  • 21
    • 53149124406 scopus 로고    scopus 로고
    • Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures
    • Horvath RJ, Nutile-McMenemy N, Alkaitis MS, Deleo JA (2008) Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures. J Neurochem 107:557-569
    • (2008) J Neurochem , vol.107 , pp. 557-569
    • Horvath, R.J.1    Nutile-Mcmenemy, N.2    Alkaitis, M.S.3    Deleo, J.A.4
  • 22
    • 0035371445 scopus 로고    scopus 로고
    • Effect of gemfibrozil on the composition and oxidation properties of very-low-density lipoprotein and high-density lipoprotein in patients with hypertriglyceridemia
    • Hsu HC, Lee YT, Yeh HT, Chen MF (2001) Effect of gemfibrozil on the composition and oxidation properties of very-low-density lipoprotein and high-density lipoprotein in patients with hypertriglyceridemia. J Lab Clin Med 137:414-421
    • (2001) J Lab Clin Med , vol.137 , pp. 414-421
    • Hsu, H.C.1    Lee, Y.T.2    Yeh, H.T.3    Chen, M.F.4
  • 23
    • 10944272619 scopus 로고    scopus 로고
    • Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease
    • Jana A, Pahan K (2004) Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease. J Biol Chem 279:51451-51459
    • (2004) J Biol Chem , vol.279 , pp. 51451-51459
    • Jana, A.1    Pahan, K.2
  • 24
    • 35748940962 scopus 로고    scopus 로고
    • Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of i kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia
    • Jana M, Jana A, Liu X, Ghosh S, Pahan K (2007) Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia. J Immunol 179:4142-4152
    • (2007) J Immunol , vol.179 , pp. 4142-4152
    • Jana, M.1    Jana, A.2    Liu, X.3    Ghosh, S.4    Pahan, K.5
  • 25
    • 35848933478 scopus 로고    scopus 로고
    • A simplified method for isolating highly purified neurons, oligodendrocytes, astrocytes, and microglia from the same human fetal brain tissue
    • Jana M, Jana A, Pal U, Pahan K (2007) A simplified method for isolating highly purified neurons, oligodendrocytes, astrocytes, and microglia from the same human fetal brain tissue. Neurochem Res 32:2015-2022
    • (2007) Neurochem Res , vol.32 , pp. 2015-2022
    • Jana, M.1    Jana, A.2    Pal, U.3    Pahan, K.4
  • 26
    • 0035977001 scopus 로고    scopus 로고
    • Ligation of CD40 stimulates the induction of nitric-oxide synthase in microglial cells
    • Jana M, Liu X, Koka S, Ghosh S, Petro TM, Pahan K (2001) Ligation of CD40 stimulates the induction of nitric-oxide synthase in microglial cells. J Biol Chem 276:44527-44533
    • (2001) J Biol Chem , vol.276 , pp. 44527-44533
    • Jana, M.1    Liu, X.2    Koka, S.3    Ghosh, S.4    Petro, T.M.5    Pahan, K.6
  • 27
    • 23744496026 scopus 로고    scopus 로고
    • Redox regulation of cytokine-mediated inhibition of myelin gene expression in human primary oligodendrocytes
    • Jana M, Pahan K (2005) Redox regulation of cytokine-mediated inhibition of myelin gene expression in human primary oligodendrocytes. Free Radic Biol Med 39:823-831
    • (2005) Free Radic Biol Med , vol.39 , pp. 823-831
    • Jana, M.1    Pahan, K.2
  • 28
    • 59249089569 scopus 로고    scopus 로고
    • IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages
    • Jana M, Pahan K (2009) IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages. Mol Immunol 46:773-783
    • (2009) Mol Immunol , vol.46 , pp. 773-783
    • Jana, M.1    Pahan, K.2
  • 29
    • 66549113544 scopus 로고    scopus 로고
    • Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70
    • Jana M, Pahan K (2009) Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70. Immunology 127:312-325
    • (2009) Immunology , vol.127 , pp. 312-325
    • Jana, M.1    Pahan, K.2
  • 30
    • 0347756655 scopus 로고    scopus 로고
    • Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA
    • Kelly D, Campbell JI, King TP, Grant G, Jansson EA, Coutts AG, Pettersson S, Conway S (2004) Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat Immunol 5:104-112
    • (2004) Nat Immunol , vol.5 , pp. 104-112
    • Kelly, D.1    Campbell, J.I.2    King, T.P.3    Grant, G.4    Jansson, E.A.5    Coutts, A.G.6    Pettersson, S.7    Conway, S.8
  • 32
    • 0036644961 scopus 로고    scopus 로고
    • Cytokines, chemokines, and cytokine receptors in human microglia
    • Lee YB, Nagai A, Kim SU (2002) Cytokines, chemokines, and cytokine receptors in human microglia. J Neurosci Res 69:94-103
    • (2002) J Neurosci Res , vol.69 , pp. 94-103
    • Lee, Y.B.1    Nagai, A.2    Kim, S.U.3
  • 33
    • 0029731662 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology
    • Lemberger T, Desvergne B, Wahli W (1996) Peroxisome proliferator- activated receptors: a nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12:335-363
    • (1996) Annu Rev Cell Dev Biol , vol.12 , pp. 335-363
    • Lemberger, T.1    Desvergne, B.2    Wahli, W.3
  • 34
    • 0034121698 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma-dependent repression of the inducible nitric oxide synthase gene
    • Li M, Pascual G, Glass CK (2000) Peroxisome proliferatoractivated receptor gamma-dependent repression of the inducible nitric oxide synthase gene. Mol Cell Biol 20:4699-4707
    • (2000) Mol Cell Biol , vol.20 , pp. 4699-4707
    • Li, M.1    Pascual, G.2    Glass, C.K.3
  • 36
    • 0037131393 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia
    • Liu X, Jana M, Dasgupta S, Koka S, He J, Wood C, Pahan K (2002) Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia. J Biol Chem 277: 39312-39319
    • (2002) J Biol Chem , vol.277 , pp. 39312-39319
    • Liu, X.1    Jana, M.2    Dasgupta, S.3    Koka, S.4    He, J.5    Wood, C.6    Pahan, K.7
  • 37
    • 11144357288 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha agonists as therapy for autoimmune disease
    • Lovett-Racke AE, Hussain RZ, Northrop S et al (2004) Peroxisome proliferator-activated receptor alpha agonists as therapy for autoimmune disease. J Immunol 172:5790-5798
    • (2004) J Immunol , vol.172 , pp. 5790-5798
    • Lovett-Racke, A.E.1    Hussain, R.Z.2    Northrop, S.3
  • 38
    • 0026619875 scopus 로고
    • Apparent anterograde transport of basic fibroblast growth factor in the rat nigrostriatal dopamine system
    • McGeer EG, Singh EA, McGeer PL (1992) Apparent anterograde transport of basic fibroblast growth factor in the rat nigrostriatal dopamine system. Neurosci Lett 148:31-33
    • (1992) Neurosci Lett , vol.148 , pp. 31-33
    • McGeer, E.G.1    Singh, E.A.2    McGeer, P.L.3
  • 40
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • McGeer PL, McGeer EG (1995) The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Rev 21:195-218
    • (1995) Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 41
    • 0345118108 scopus 로고    scopus 로고
    • Immunolocalization of peroxisome proliferator-activated receptors and retinoid 9 receptors in the adult rat CNS
    • Moreno S, Farioli-Vecchioli S, Ceru MP (2004) Immunolocalization of peroxisome proliferator-activated receptors and retinoid 9 receptors in the adult rat CNS. Neuroscience 123:131-145
    • (2004) Neuroscience , vol.123 , pp. 131-145
    • Moreno, S.1    Farioli-Vecchioli, S.2    Ceru, M.P.3
  • 42
    • 0037195866 scopus 로고    scopus 로고
    • Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes
    • Pahan K, Jana M, Liu X, Taylor BS, Wood C, Fischer SM (2002) Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes. J Biol Chem 277: 45984-45991
    • (2002) J Biol Chem , vol.277 , pp. 45984-45991
    • Pahan, K.1    Jana, M.2    Liu, X.3    Taylor, B.S.4    Wood, C.5    Fischer, S.M.6
  • 43
    • 25844473319 scopus 로고    scopus 로고
    • Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis
    • Polak PE, Kalinin S, Dello Russo C et al (2005) Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis. J Neuroimmunol 168:65-75
    • (2005) J Neuroimmunol , vol.168 , pp. 65-75
    • Polak, P.E.1    Kalinin, S.2    Dello Russo, C.3
  • 44
    • 34547603895 scopus 로고    scopus 로고
    • PPARs and molecular mechanisms of transrepression
    • Ricote M, Glass CK (2007) PPARs and molecular mechanisms of transrepression. Biochim Biophys Acta 1771:926-935
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 926-935
    • Ricote, M.1    Glass, C.K.2
  • 45
    • 33744960217 scopus 로고    scopus 로고
    • Up-regulation of microglial CD11b expression by nitric oxide
    • Roy A, Fung YK, Liu X, Pahan K (2006) Up-regulation of microglial CD11b expression by nitric oxide. J Biol Chem 281: 14971-14980
    • (2006) J Biol Chem , vol.281 , pp. 14971-14980
    • Roy, A.1    Fung, Y.K.2    Liu, X.3    Pahan, K.4
  • 46
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans affairs high-density lipoprotein cholesterol intervention trial study group
    • Rubins HB, Robins SJ, Collins D et al (1999) Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans affairs high-density lipoprotein cholesterol intervention trial study group. N Engl J Med 341:410-418
    • (1999) N Engl J Med , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3
  • 47
    • 38449119486 scopus 로고    scopus 로고
    • MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65
    • Saha RN, Jana M, Pahan K (2007) MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65. J Immunol 179:7101-7109
    • (2007) J Immunol , vol.179 , pp. 7101-7109
    • Saha, R.N.1    Jana, M.2    Pahan, K.3
  • 48
    • 0035108316 scopus 로고    scopus 로고
    • PPAR delta agonists stimulate oligodendrocyte differentiation in tissue culture
    • Saluja I, Granneman JG, Skoff RP (2001) PPAR delta agonists stimulate oligodendrocyte differentiation in tissue culture. Glia 33:191-204
    • (2001) Glia , vol.33 , pp. 191-204
    • Saluja, I.1    Granneman, J.G.2    Skoff, R.P.3
  • 49
    • 0037022592 scopus 로고    scopus 로고
    • The peroxisome proliferators-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling
    • Shi Y, Hon M, Evans RM (2002) The peroxisome proliferators-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci USA 99: 2613-2618
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2613-2618
    • Shi, Y.1    Hon, M.2    Evans, R.M.3
  • 50
    • 0035053973 scopus 로고    scopus 로고
    • Cyclopentenone prostaglandins: New insights on biological activities and cellular targets
    • Straus DS, Glass CK (2001) Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev 21:185-210
    • (2001) Med Res Rev , vol.21 , pp. 185-210
    • Straus, D.S.1    Glass, C.K.2
  • 51
    • 41949123156 scopus 로고    scopus 로고
    • PPARdelta-mediated anti-inflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis
    • Takata Y, Liu J, Yin F et al (2008) PPARdelta-mediated anti-inflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis. Proc Natl Acad Sci USA 105:4277-4282
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 4277-4282
    • Takata, Y.1    Liu, J.2    Yin, F.3
  • 52
    • 0026708978 scopus 로고
    • Brain macrophages: Evaluation of microglia and their functions
    • Thomas WE (1992) Brain macrophages: evaluation of microglia and their functions. Brain Res Rev 17:61-74
    • (1992) Brain Res Rev , vol.17 , pp. 61-74
    • Thomas, W.E.1
  • 53
    • 0028923898 scopus 로고
    • Complement and cytokine gene expression in cultured microglial derived from postmortem human brains
    • Walker DG, Kim SU, McGeer PL (1995) Complement and cytokine gene expression in cultured microglial derived from postmortem human brains. J Neurosci Res 40:478-493
    • (1995) J Neurosci Res , vol.40 , pp. 478-493
    • Walker, D.G.1    Kim, S.U.2    McGeer, P.L.3
  • 56
    • 0027939931 scopus 로고
    • Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
    • Xie QW, Kashiwabara Y, Nathan C (1994) Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 269:4705-4708
    • (1994) J Biol Chem , vol.269 , pp. 4705-4708
    • Xie, Q.W.1    Kashiwabara, Y.2    Nathan, C.3
  • 57
    • 33746079214 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha and retinoid × receptor agonists inhibit inflammatory responses of astrocytes
    • Xu J, Chavis JA, Racke MK, Drew PD (2006) Peroxisome proliferator- activated receptor-alpha and retinoid × receptor agonists inhibit inflammatory responses of astrocytes. J Neuroimmunol 176:95-105
    • (2006) J Neuroimmunol , vol.176 , pp. 95-105
    • Xu, J.1    Chavis, J.A.2    Racke, M.K.3    Drew, P.D.4
  • 58
    • 25444528680 scopus 로고    scopus 로고
    • Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid × receptor inhibit inflammatory responses of microglia
    • Xu J, Storer PD, Chavis JA, Racke MK, Drew PD (2005) Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid × receptor inhibit inflammatory responses of microglia. J Neurosci Res 81:403-411
    • (2005) J Neurosci Res , vol.81 , pp. 403-411
    • Xu, J.1    Storer, P.D.2    Chavis, J.A.3    Racke, M.K.4    Drew, P.D.5
  • 59
    • 0037648909 scopus 로고    scopus 로고
    • Gemfibrozil reduces release of tumor necrosis factor-alpha in peripheral blood mononuclear cells from healthy subjects and patients with coronary heart disease. Clin Chim Acta
    • Zhao SP, Ye HJ, Zhou HN, Nie S, Li QZ (2003) Gemfibrozil reduces release of tumor necrosis factor-alpha in peripheral blood mononuclear cells from healthy subjects and patients with coronary heart disease. Clin Chim Acta, Int J Clin Chem 332:61-67
    • (2003) Int J Clin Chem , vol.332 , pp. 61-67
    • Zhao, S.P.1    Ye, H.J.2    Zhou, H.N.3    Nie, S.4    Li, Q.Z.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.