Distribution of mRNAs encoding the peroxisome proliferator-activated receptor α, β, and γ and the retinoid X receptor α, β, and γ in rat central nervous system

Journal of Neurochemistry

Volumn 70, Issue 4, 1998, Pages 1366-1375

  Cullingford, Tim E ^a   Bhakoo, Kishore ^b   Peuchen, Stefan ^a   Dolphin, Colin T ^c   Patel, Ritesh ^a   Clark, John B ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Astrocyte; Brain; Cerebellar granule neuron; Peroxisome proliferator activated receptor; Retinoid X receptor; RNase protection assay

Indexed keywords

COMPLEMENTARY DNA; COMPLEMENTARY RNA; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RETINOID X RECEPTOR; RIBONUCLEASE;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN; CENTRAL NERVOUS SYSTEM; CEREBELLUM; DNA SEQUENCE; GENE EXPRESSION; GRANULE CELL; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0031930111     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70041366.x     Document Type: Article

References (69)

1. Aldridge T. C., Tugwood J. D., and Green S. (1995) Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. Biochem. J. 306, 473-479.
2. Amri E. Z., Bonino F., Ailhaud G., Abumrad N. A., and Grimaldi P. A. (1995) Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. J. Biol. Chem. 270, 2367-2371.
3. Auestad N., Korsak R. A., Morrow J. W., and Edmond J. (1991) Fatty acid oxidation and ketogenesis by astrocytes in primary culture J. Neurochem. 56, 1376-1386.
4. Bardot O., Aldridge T. C., Latruffe N., and Green S. (1993) PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene. Biochem. Biophys. Res. Commun. 192, 37-45.
5. Bhakoo K. K., Williams I. T., Williams S. R., Gadian D. G., and Noble M. D. (1996) Proton nuclear magnetic resonance spectroscopy of primary cells derived from nervous tissue. J. Neurochem. 66, 1254-1263.
6. Bissonnette R. P., Brunner T., Lazarchik S. B., Yoo N. J., Boehm M. F., Green D. R., and Heyman R. A. (1995) 9-cis Retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of fas ligand and requires retinoic acid receptor and retinoid X receptor activation. Mol. Cell. Biol. 15, 5576-5585.
7. Bottenstein J. H. and Sato G. H. (1979) Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc. Natl. Acad. Sci. USA 76, 514-517.
8. Bourre J. M., Durand G., Pascal G., and Youyou A. (1989) Brain cell and tissue recovery in rats made deficient in n-3 fatty acids by alteration of dietary fat. J. Nutr. 119, 15-22.
9. Braissant O., Foufelle F., Scotto C., Dauça M., and Wahli W. (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α, -β and -γ in the adult rat. Endocrinology 137, 354-366.
10. Chambon P., Mader S., Garnier J.-M., Staub A., Chen J.-Y., Zacharewsi T., Saunders M., Nakshatri H., Lyons R., Kastner P., and Leid M. (1992) Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 68, 377-395.
11. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
12. Cullingford T. E., Clark J. B., and Phillips I. R. (1994) The pyruvate dehydrogenase complex: cloning of the rat somatic E1α subunit and its coordinate expression with the mRNAs for the E1β, E2, and E3 catalytic subunits in developing rat brain. J. Neurochem. 62, 1682-1690.
13. Cullingford T. E., Dolphin C. T., Bhakoo K., Peuchen S., Canevari L., and Clark J. B. (1998) Molecular cloning of rat mitochondrial 3-hydroxy-3-methylglutaryl CoA lyase and detection of the corresponding mRNA and of those encoding the remaining enzymes comprising the ketogenic HMG-CoA cycle in CNS of suckling rat. Biochem. J. 329, 373-381.
14. Delion S., Chalon S., Guilloteau D., Besnard J.-C., and Durand G. (1996) α-Linolenic acid dietary deficiency alters age-related changes of dopaminergic and serotoninergic neurotransmission in the rat frontal cortex. J. Neurochem. 66, 1582-1591.
15. DiRenzo J., Soderstrom M., Kurokawa R., Ogliastro M. H., Ricote M., Ingrey S., Horlein A., Rosenfeld M. G., and Glass C. K. (1997) Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors. Mol. Cell. Biol. 17, 2166-2176.
16. Dolphin C. T., Cullingford T. E., Shephard E. A., Smith R. L., and Phillips I. R. (1996) Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FMO4. Eur. J. Biochem. 235, 683-689.
17. Don R. H., Cox P. T., Wainwright B. J., Baker K., and Mattick J. S. (1991) 'Touchdown' PCR to circumvent spurious priming during gene amplification. Nucleic Acids Res. 19, 4008.
18. Forman B. M., Chen J., and Evans R. M. (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc. Natl. Acad. Sci. USA 94, 4312-4317.
19. Gearing K. L., Gottlicher M., Teboul M., Widmark E., and Gustafsson J.-A. (1993) Interaction of the peroxisome proliferator activated receptor and retinoid X receptor. Proc. Natl. Acad. Sci. USA 90, 1440-1444.
20. Gottlicher M., Widmark E., Li Q., and Gustafsson J. A. (1992) Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 89, 4653-4657.
21. Green S. (1995) PPAR: a mediator of peroxisome proliferator action. Mutat. Res. 333, 101-109.
22. Greene M. E., Blumberg B., McBride O. W., Yi H. F., Kronquist K., Kwan K., Hsieh L., Greene G., and Nimer S. D. (1995) Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr. 4, 281-282.
23. Harmon M. A., Boehm M. F., Heyman R. A., and Mangelsdorf D. J. (1995) Activation of mammalian retinoid X receptors by the insect growth regulator methoprene. Proc. Natl. Acad. Sci. USA 92, 6157-6160.
24. Hembree J. R., Agarwal C., Beard R. L., Chandraratna R. A., and Eckert R. (1996) Retinoid X receptor-specific retinoids inhibit the ability of retinoic acid receptor-specific retinoids to increase the level of insulin-like growth factor binding protein-3 in human ectocervical epithelial cells. Cancer Res. 56, 1794-1799.
25. Horn V., Minucci S., Ogryzko V. V., Adamson E. D., Howard B. H., Levin A. A., and Ozato K. (1996) RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells. FASEB J. 10, 1071-1077.
26. Issemann I. and Green S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347, 645-649.
27. Jow L. and Mukherjee R. (1995) The human peroxisome proliferator-activated receptor PPAR subtype NUC1 represses the activation of hPPAR alpha and thyroid hormone receptors. J. Biol. Chem. 270, 3836-3840.
28. Kainu T., Wikström A.-C., Gustafsson J.-Å., and Pelto-Huikko M. (1994) Localization of the peroxisome proliferator-activated receptor in the brain. Neuroreport 5, 2481-2485.
29. Kastner P., Mark M., and Chambon P. (1995) Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83, 859-869.
30. Keller H., Dreyer C., Medin J., Mahfoudi A., Ozato K., and Wahli W. (1993) Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc. Natl. Acad. Sci. USA 90, 2160-2164.
31. Kitareewan S., Burka L. T., Tomer K. B., Parker C. E., Deterding L. J., Stevens R. D., Forman B. M., Mais D. E., Heyman R. A., McMorris T., and Weinberger C. (1996) Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR. Mol. Biol. Cell 7, 1153-1166.
32. Kliewer S. A., Forman B. A., Blumberg B., Ong E. S., Borgmeyer D. J., Mangelsdorf D. J., Umesono K., and Evans R. M. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA 91, 7355-7359.
33. Kliewer S. A., Sundseth S. S., Jones S. A., Brown P. J., Wisely G. B., Koble C. S., Devchand P., Wahli W., Willson T. M., Lenhard J. M., and Lehmann J. M. (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc. Natl. Acad. Sci. USA 94, 4318-4323.
34. Krey G., Braissant O., L'Horset F., Kalkhoven E., Perroud M., Parker M. G., and Wahli W. (1997) Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 11, 779-791.
35. Lee S. S., Pineau T., Drago J., Lee E. J., Owens J. W., Kroetz D. L., Fernandez-Salguero P. M., Westphal H., and Gonzalez F. J. (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15, 3012-3022.
36. Lee S. Y. and Rasheed S. (1990) A simple procedure for maximum yield of high-quality plasmid DNA. Biotechniques 9, 676-679.
37. Lemberger T., Saladin R., Vazquez M., Assimacopoulos F., Staels B., Desvergne B., Wahli W., and Auwerx J. (1996) Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm. J. Biol. Chem. 19, 1764-1769.
38. Lemotte P. K., Keidel S., and Apfel C. M. (1996) Phytanic acid is a retinoid X receptor ligand. Eur. J. Biochem. 236, 328-333.
39. Little P. F. R. and Jackson I. J. (1987) Application of plasmids containing promoters specific for phage-encoded RNA polymerase, in DNA Cloning; A Practical Approach, Vol. 3 (Glover D. M., ed), pp. 1-18. IRL Press, Oxford.
40. Liu Q. and Linney E. (1993) The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms. Mol. Endocrinol. 7, 651-658.
41. MacDonald P. N., Bok D., and Ong D. E. (1990) Localization of cellular retinol-binding protein and retinol-binding protein in cells comprising the blood-brain barrier of rat and human. Proc. Natl. Acad. Sci. USA 87, 4265-4269.
42. Mangelsdorf D. J., Borgmeyer U., Heyman R. A., Zhou J. Y., Ong E. S., Oro A. E., Kakizuka A., and Evans R. M. (1992) Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 6, 329-344.
43. Mano H., Ozawa T., Takeyama K., Yoshizawa Y., Kojima R., Kato S., and Masushige S. (1993) Thyroid hormone affects the gene expression of retinoid X receptors in the adult rat. Biochem. Biophys. Res. Commun. 191, 943-949.
44. Marcus S. L., Miyata K. S., Zhang B., Subramani S., Rachubinski R. A., and Capone J. P. (1993) Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression. Proc. Natl. Acad. Sci. USA 90, 5723-5727.
45. Martinez M. (1992) Tissue levels of polyunsaturated fatty acids during early human development. J. Pediatr. 120 (Suppl.), S129-S138.
46. Melton D. A., Krieg P. A., Rebagliati M. R., Maniatis T., Zinn K., and Green M. R. (1984) Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12, 7035-7056.
47. Mironov V. N., Van Montagu M., and Inze D. (1995) High throughput RNase protection assay. Nucleic Acids Res. 23, 3359-3360.
48. Mukherjee R., Jow L., Noonan D., and McDonnell D. P. (1994) Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J. Steroid Biochem. Mol. Biol. 51, 157-166.
49. Neuringer M., Anderson G. J., and Connor W. E. (1988) The essentiality of n-3 fatty acids for the development and function of the retina and brain. Annu. Rev. Nutr. 8, 517-541.
50. Noble M. and Murray K. (1984) Purified astrocytes promote the in vitro division of a bipotential glial progenitor cell. EMBO J. 3, 2243-2247.
51. Palmer C. N. A., Hsu M. H., Muerhoff A. S., Griffin K. J., and Johnson E. F. (1994) Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter. J. Biol. Chem. 269, 18083-18089.
52. Pardridge W. M., Sakiyama R., and Coty W. A. (1985) Restricted transport of vitamin D and A derivatives through the rat blood-brain barrier. J. Neurochem. 44, 1138-1141.
53. Peuchen S., Clark J. B., and Duchen M. R. (1996) Mechanisms of intracellular calcium regulation in adult astrocytes. Neuroscience 71, 871-883.
54. Pineau T., Hudgins W. R., Liu L., Chen L. C., Sher T., Gonzalez F. J., and Samid D. (1996) Activation of a human peroxisome proliferator-activated receptor by the antitumor agent phenylacetate and its analogs. Biochem. Pharmacol. 52, 659-667.
55. Poulos A. (1995) Very long chain fatty acids in higher animals - a review. Lipids 30, 1-14.
56. Prasanna P., Thibault A., Liu L., and Samid D. (1996) Lipid metabolism as a target for brain cancer therapy: synergistic activity of lovastatin and sodium phenylacetate against human glioma cells. J. Neurochem. 66, 710-716.
57. Rodriguez J. C., Gil-Gomez G., Hegardt F. G., and Haro D. (1994) Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J. Biol. Chem. 269, 18767-18772.
58. Roels F., de Bie S., Schtgens R. B. H., and Besley G. T. N. (1995) Diagnosis of human peroxisomal disorders. J. Inherit. Metab. Dis. 18 (Suppl. 1).
59. Sambrook J., Fritsch E. F., and Maniatis T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edit. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
60. Sanger F., Nicklen S., and Coulson A. R. (1977) DNA sequencing with chain terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467.
61. Schmidt A., Endo N., Rutledge S., Vogel R., Shinar D., and Rodan G. A. (1992) Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol. Endocrinol. 6, 1634-1641.
62. Schoonjans K., Staels B., and Auwerx J. (1996) The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim. Biophys. Acta 1302, 93-109.
63. Sharpe C. R. and Goldstone K. (1997) Retinoid receptors promote primary neurogenesis in Xenopus. Development 124, 515-523.
64. Tegtmeier F., Weber C., Heister U., Haker I., Scheller D., Nikolov R., and Holler M. (1990) Eicosanoids in rat brain during ischemia and reperfusion - correlation to DC depolarization. J. Cereb. Blood Flow Metab. 10, 358-364.
65. Tontonoz P., Hu E., Devine J., Beale E. G., and Spiegelman B. M. (1995) PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 15, 351-357.
66. Urenjak J., Williams S. R., Gadian D. G., and Noble M. (1993) Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J. Neurosci. 13, 981-989.
67. Wood J. N. and Anderton B. (1981) Monoclonal antibodies to mammalian neurofilaments. Biosci. Rep. 1, 263-268.
68. Xing G., Zhang L., Zhang L., Heynen T., Yoshikawa T., Smith M., Weiss S., and Detera-Wadleigh S. (1995) Rat PPAR delta contains a CGG triplet repeat and is prominently expressed in the thalamic nuclei. Biochem. Biophys. Res. Commun. 217, 1015-1025.
69. Zhu Y., Alvares K., Huang Q., Rao M. S., and Reddy J. K. (1993) Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J. Biol. Chem. 268, 26817-26820.