A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts

Genes and Development

Volumn 27, Issue 8, 2013, Pages 955-969

  Ferron, Mathieu ^a,j   Settembre, Carmine ^b,c,d,e   Shimazu, Junko ^a   Lacombe, Julie ^f   Kato, Shigeaki ^g,h   Rawlings, David J ⁱ   Ballabio, Andrea ^b,c,d,e   Karsenty, Gerard ^a  

^a Columbia University ^*  (United States)

^b TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e TEXAS CHILDREN S HOSPITAL   (United States)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^g FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^h Soma Central Hospital   (Japan)

ⁱ UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^j CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

more..

Author keywords

Lysosomal biogenesis; Osteoclast; PKC ; RANKL; TFEB

Indexed keywords

OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN KINASE C BETA; TFEB PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; BONE MASS; CELL ASSAY; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE DELETION; GENE EXPRESSION REGULATION; INTRACELLULAR SIGNALING; LYSOSOME; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL LINE; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; LYSOSOMES; MICE; MICE, INBRED C57BL; OSTEOCLASTS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; RANK LIGAND; SIGNAL TRANSDUCTION;

LACUNA; MUS;

EID: 84876920718     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.213827.113     Document Type: Article

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