A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism

Science

Volumn 333, Issue 6038, 2011, Pages 87-90

  Marschner, Katrin ^a   Kollmann, Katrin ^a   Schweizer, Michaela ^a   Braulke, Thomas ^a   Pohl, Sandra ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; MANNOSE 6 PHOSPHATE; N ACETYLGLUCOSAMINYLTRANSFERASE; PROTEINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN;

CATALYSIS; ENZYME ACTIVITY; IDENTIFICATION KEY; MEMBRANE; METABOLISM; PHENOTYPE; STEROL;

ANIMAL CELL; ARTICLE; BIOGENESIS; CHOLESTEROL METABOLISM; CONTROLLED STUDY; ENZYME MECHANISM; LYSOSOME; MUCOLIPIDOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CHO CELLS; CHOLESTEROL; CHONDROCYTES; CRICETINAE; CRICETULUS; ENZYME PRECURSORS; HELA CELLS; HUMANS; LIPID METABOLISM; LYSOSOMES; MANNOSEPHOSPHATES; MICE; MORPHOGENESIS; MUCOLIPIDOSES; N-ACETYLGALACTOSAMINE-4-SULFATASE; OSTEOGENESIS; PROPROTEIN CONVERTASES; PROTEIN SUBUNITS; RNA, SMALL INTERFERING; SERINE ENDOPEPTIDASES; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 79959853238     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1205677     Document Type: Article

References (25)

1. T. Braulke, J. S. Bonifacino, Biochim. Biophys. Acta 1793, 605 (2009).
2. M. Bao, J. L. Booth, B. J. M. Elmendorf, W. M. Canfield, J. Biol. Chem. 271, 31437 (1996).
3. S. Tiede et al., Nat. Med. 11, 1109 (2005).
4. M. Kudo et al., J. Biol. Chem. 280, 36141 (2005).
5. K. H. Paik et al., Hum. Mutat. 26, 308 (2005).
6. S. Kornfeld, W. S. Sly, in The Metabolic and Molecular Bases of Inherited Disease, C. R. Scriver et al., Eds. (McGraw-Hill, New York, 2001), pp. 3421-3452.
7. M. Kudo, W. M. Canfield, J. Biol. Chem. 281, 11761 (2006).
8. K. Kollmann et al., Eur. J. Cell Biol. 89, 117 (2010).
9. S. Pohl et al., J. Biol. Chem. 285, 23936 (2010).
10. A. Elagoz, S. Benjannet, A. Mammarbassi, L. Wickham, N. G. Seidah, J. Biol. Chem. 277, 11265 (2002).
11. N. G. Seidah et al., Proc. Natl. Acad. Sci. U.S.A. 96, 1321 (1999).
12. J. Sakai, A. Nohturfft, J. L. Goldstein, M. S. Brown, J. Biol. Chem. 273, 5785 (1998).
13. M. S. Brown, J. L. Goldstein, Proc. Natl. Acad. Sci. U.S.A. 96, 11041 (1999).
14. J. M. Rojek, A. M. Lee, N. Nguyen, C. F. Spiropoulou, S. Kunz, J. Virol. 82, 6045 (2008).
15. J. Stirling, P. O'Hare, Mol. Biol. Cell 17, 413 (2006).
16. R. B. Rawson, D. Cheng, M. S. Brown, J. L. Goldstein, J. Biol. Chem. 273, 28261 (1998).
17. J. Sakai et al., Mol. Cell 2, 505 (1998).
18. S. Müller-Loennies, G. Galliciotti, K. Kollmann, M. Glatzel, T. Braulke, Am. J. Pathol. 177, 240 (2010).
19. K. Schlombs, T. Wagner, J. Scheel, Proc. Natl. Acad. Sci. U.S.A. 100, 14024 (2003).
20. D. Patra et al., J. Cell Biol. 179, 687 (2007).
21. S. U. Walkley, M. T. Vanier, Biochim. Biophys. Acta 1793, 726 (2009).
22. R. A. Saul, V. Proud, H. A. Taylor, J. G. Leroy, J. Spranger, Am. J. Med. Genet. A 135A, 328 (2005).
23. N. G. Seidah, A. Prat, J. Mol. Med. 85, 685 (2007).
24. J. L. Hawkins et al., J. Pharmacol. Exp. Ther. 326, 801 (2008).
25. J. M. Rojek et al., J. Virol. 84, 573 (2010).