Antineuroinflammatory effect of NF-κB essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis

Journal of Immunology

Volumn 173, Issue 2, 2004, Pages 1344-1354

  Dasgupta, Subhajit ^a   Jana, Malabendu ^a   Zhou, You ^b   Fung, Yiu K ^a   Ghosh, Sankar ^c   Pahan, Kalipada ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MUTANT PROTEIN; MYELIN BASIC PROTEIN; NUCLEAR FACTOR KAPPA B ESSENTIAL MODIFIER BINDING DOMAIN PEPTIDE; PEPTIDE; PEPTIDE DERIVATIVE; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INVASION; CELL SPECIFICITY; CEREBELLUM; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DRUG SCREENING; FEMALE; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; IN VIVO STUDY; INFLAMMATION; LYMPH NODE CELL; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; SPINAL CORD; SYMPTOM; T LYMPHOCYTE; TH1 CELL; TH2 CELL; WILD TYPE;

EID: 3142774208     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.2.1344     Document Type: Article

References (24)

1. Martin, R., H. F. McFarland, and D. E. McFarlin. 1992. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 10:153.
2. Tuohy, V. K., R. A. Sobel, and M. B. Less. 1988. Myelin proteolipid protein-induced experimental allergic encephalomyelitis. J. Immunol. 140:1868.
3. Benveniste, E. N. 1997. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J. Mol. Med. 75:165.
4. Du, C., M. W. Khalil, and S. Sriram. 2001. Administration of dehydroepiandrosterone suppresses experimental allergic encephalomyelitis in SJL/J mice. J. Immunol. 167:7094.
5. Parkinson, J. F., B. Mitrovic, and J. E. Merrill. 1997. The role of nitric oxide in multiple sclerosis. J. Mol. Med. 75:174.
6. Ghosh, S. 1999. Regulation of inducible gene expression by the transcription factor NF-κB. Immunol. Res. 19:183.
7. Hilliard, B., E. B. Samoilova, T. S. Liu, A. Rostami, and Y. Chen. 1999. Experimental autoimmune encephalomyelitis in NF-κB-deficient mice: roles of NF-κB in the activation and differentiation of autoreactive T cells. J. Immunol. 163:2937.
8. Pahan, K., and M. Schmid. 2000. Activation of NF-κB in the spinal cord of experimental allergic encephalomyelitis. Neurosci. Lett. 287:17.
9. Wooten, M. W. 1999. Function for NF-κB in neuronal survival: regulation by atypical protein kinase C. J. Neurosci. Res. 58:607.
10. Mattson, M. P., C. Culmsee, Z. Yu, and S. Camandola. 2000. Roles of NF-κB in neuronal survival and plasticity. J. Neurochem. 74:443.
11. May, M. J., F. D'Acquisto, L. A. Madge, J. Glockner, J. S. Pober, and S. Ghosh. 2000. Selective inhibition of NF-κB activation by a peptide that blocks the interaction of NEMO with the IκB kinase complex. Science 289:1550.
12. Dasgupta, S., Y. Zhou, M. Jana, N. L. Banik, and K. Pahan. 2003. Sodium phenylacetate inhibits the adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps. J. Immunol. 170:3874.
13. Dasgupta, S., M. Jana, X. Liu, and K. Pahan. 2002. Myelin basic protein (MBP)-primed T cells induce nitric oxide synthase in microglial cells: implications to multiple sclerosis. J. Biol. Chem. 277:39327.
14. Paxinos, G., and K. B. J. Franklin. 2001. The Mouse Brain in Stereotaxic Coordinates. Academic, New York.
15. Pahan, K., F. G. Sheikh, A. M. S. Namboodiri, and I. Singh. 1998. N-Acetyl cysteine inhibits induction of NO production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells, and astrocytes. Free Radical Biol. Med. 24:39.
16. Weil, R., K. Schwamborn, A. Alcover, C. Bessia, V. Di Bartolo, and A. Israel. 2003. Induction of the NF-κB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor. Immunity 18:13.
17. Weller, R. O., B. Engelhardt, and M. J. Phillips. 1996. Lymphocyte targeting of the CNS: a review of afferent and efferent CNS-immune pathways. Brain Pathol. 6:275.
18. Thiel, V. E., and K. L. Audus. 2001. Nitric oxide and blood-brain barrier integrity. Antioxid. Redox Signal. 3:273.
19. Hurst, R. D., S. Azam, A. Hurst, and J. B. Clark. 2001. Nitric-oxide-induced inhibition of glyceraldehyde-3-phosphate dehydrogenase may mediate reduced endothelial cell monolayer integrity in an in vitro model blood-brain barrier. Brain Res. 894:181.
20. Pahan, K., F. G. Sheikh, X. Liu, S. Hilger, M. McKinney, and T. M. Petro. 2001. Interleukin-12 p40 induces nitric oxide synthase and activates NF-κB in microglial cells. J. Biol. Chem. 276:7899.
21. Jana, M., X. Liu, S. Koka, S. Ghosh, T. M. Petro, and K. Pahan. 2001. Ligation of CD40 stimulates the induction of nitric oxide synthase in microglial cells. J. Biol. Chem. 276:44527.
22. Liu, H., A. J. MacKenzie-Graham, K. Palaszynski, S. Liva, and R. R. Voskuhl. 2001. Classic myelin basic proteins are expressed in lymphoid tissue macrophages. J. Neuroimmunol. 116:83.
23. Martino, G., and H. P. Hartung. 1992. Immunopathogenesis of multiple sclerosis: the role of T cells. Curr. Opin. Neurol. 12:309.
24. Liu, B., and J. S. Hong. 2003. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 304:1.