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Volumn 37, Issue 4, 2002, Pages 448-455

Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: A randomized controlled pilot study

Author keywords

Apoptosis; Cytokine; Maddrey's score; Tolerance; Transvenous liver biopsy

Indexed keywords

BILIRUBIN; INFLIXIMAB; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; PLACEBO; PREDNISONE; PROTHROMBIN; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; ANTIRHEUMATIC AGENT; MONOCLONAL ANTIBODY;

EID: 0036784414     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(02)00230-1     Document Type: Article
Times cited : (189)

References (41)
  • 2
    • 0014014699 scopus 로고
    • Prognosis in the acute disease of alcoholic patients
    • Hardison WG, Lee FI. Prognosis in the acute disease of alcoholic patients. N Engl J Med 1966;275:61-66.
    • (1966) N Engl J Med , vol.275 , pp. 61-66
    • Hardison, W.G.1    Lee, F.I.2
  • 3
    • 0019463397 scopus 로고
    • Alcoholic liver disease: Morphological manifestations. Review by an international group
    • International group. Alcoholic liver disease: morphological manifestations. Review by an international group. Lancet 1981;1:707-711.
    • (1981) Lancet , vol.1 , pp. 707-711
  • 4
    • 0032993223 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha-mediator of apotosis and cell proliferation of hepatocytes
    • Plümpe J, Streetz K. Manns MP, Trautwein C. Tumour necrosis factor alpha-mediator of apotosis and cell proliferation of hepatocytes. Ital J Gastroenterol Hepatol 1999;31:235-243.
    • (1999) Ital J Gastroenterol Hepatol , vol.31 , pp. 235-243
    • Plümpe, J.1    Streetz, K.2    Manns, M.P.3    Trautwein, C.4
  • 5
    • 0027488676 scopus 로고
    • Role of tumor necrosis factor-alpha in disease states and inflammation
    • Strieter RM, Kunkel SL, Bone RC. Role of tumor necrosis factor-alpha in disease states and inflammation. Crit Care Med 1993;21:112-116.
    • (1993) Crit Care Med , vol.21 , pp. 112-116
    • Strieter, R.M.1    Kunkel, S.L.2    Bone, R.C.3
  • 6
    • 0032803868 scopus 로고    scopus 로고
    • Cytokines: Overview
    • Maher JJ. Cytokines: overview. Sem Liver Dis 1999;19:109-115.
    • (1999) Sem Liver Dis , vol.19 , pp. 109-115
    • Maher, J.J.1
  • 7
    • 0035112937 scopus 로고    scopus 로고
    • Endotoxin, endotoxin-neutralizing capacity, sCD14, sICAM-1, and cytokines in patients with various degrees of alcoholic liver disease
    • Urbaschek R, McCuskey RS, Rudi V, Becker KP, Stickel F, Urbaschek B, et al. Endotoxin, endotoxin-neutralizing capacity, sCD14, sICAM-1, and cytokines in patients with various degrees of alcoholic liver disease. Alcohol Clin Exp Res 2001;25:261-268.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 261-268
    • Urbaschek, R.1    McCuskey, R.S.2    Rudi, V.3    Becker, K.P.4    Stickel, F.5    Urbaschek, B.6
  • 10
    • 0026542939 scopus 로고
    • Is the intercellular adhesion molecule-1/leukocyte function associated antigen 1 pathway of leukocyte adhesion involved in the tissue damage of alcoholic hepatitis?
    • Burra P, Hubscher SG, Shaw J, Elias E, Adams DH. Is the intercellular adhesion molecule-1/leukocyte function associated antigen 1 pathway of leukocyte adhesion involved in the tissue damage of alcoholic hepatitis? Gut 1992;33:268-271.
    • (1992) Gut , vol.33 , pp. 268-271
    • Burra, P.1    Hubscher, S.G.2    Shaw, J.3    Elias, E.4    Adams, D.H.5
  • 11
    • 0035173872 scopus 로고    scopus 로고
    • Rapid changes in alcoholic hepatitis histology under steroids: Correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood
    • Spahr L, Rubbia-Brandt L, Pugin J, Giostra E, Frossard JL, Borisch B, et al. Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood. J Hepatol 2001;35:582-589.
    • (2001) J Hepatol , vol.35 , pp. 582-589
    • Spahr, L.1    Rubbia-Brandt, L.2    Pugin, J.3    Giostra, E.4    Frossard, J.L.5    Borisch, B.6
  • 13
    • 0026026639 scopus 로고
    • Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients
    • Khoruts A, Stahnke L, McClain C, Logan G, Allen JI. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology 1991;13:267-276.
    • (1991) Hepatology , vol.13 , pp. 267-276
    • Khoruts, A.1    Stahnke, L.2    McClain, C.3    Logan, G.4    Allen, J.I.5
  • 14
    • 0035113898 scopus 로고    scopus 로고
    • Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis
    • Ziol M, Tepper M, Lohez M, Arcangeli G, Ganne N, Christidis C, et al. Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis. J Hepatol 2001;34:254-260.
    • (2001) J Hepatol , vol.34 , pp. 254-260
    • Ziol, M.1    Tepper, M.2    Lohez, M.3    Arcangeli, G.4    Ganne, N.5    Christidis, C.6
  • 16
    • 0025278936 scopus 로고
    • Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis
    • Felver ME, Mezey E, McGuire M, Mitchell MC, Herlong HF, Veech GA, et al. Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis. Alcohol Clin Exp Res 1990;14:255-259.
    • (1990) Alcohol Clin Exp Res , vol.14 , pp. 255-259
    • Felver, M.E.1    Mezey, E.2    McGuire, M.3    Mitchell, M.C.4    Herlong, H.F.5    Veech, G.A.6
  • 18
    • 0034014905 scopus 로고    scopus 로고
    • Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: Relationship to severity of liver disturbance
    • Fujimoto M, Uemura M, Nakatani Y, Tsujita S, Hoppo K, Tamagawa T, et al. Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relationship to severity of liver disturbance. Alcohol Clin Exp Res 2000;24:48S-54S.
    • (2000) Alcohol Clin Exp Res , vol.24
    • Fujimoto, M.1    Uemura, M.2    Nakatani, Y.3    Tsujita, S.4    Hoppo, K.5    Tamagawa, T.6
  • 20
    • 0024521973 scopus 로고
    • Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial
    • Carithers RL, Herlong F, Diehl AM, Shaw EW, Combes B, Fallon HJ, et al. Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial. Ann Intern Med 1989;110:685-690.
    • (1989) Ann Intern Med , vol.110 , pp. 685-690
    • Carithers, R.L.1    Herlong, F.2    Diehl, A.M.3    Shaw, E.W.4    Combes, B.5    Fallon, H.J.6
  • 21
    • 0036105350 scopus 로고    scopus 로고
    • Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): Individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH
    • Mathurin P, Mendenhall CL, Carithers RL, Ramond MJ, Maddrey WC, Garstide P, et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH. J Hepatol 2002;36:480-487.
    • (2002) J Hepatol , vol.36 , pp. 480-487
    • Mathurin, P.1    Mendenhall, C.L.2    Carithers, R.L.3    Ramond, M.J.4    Maddrey, W.C.5    Garstide, P.6
  • 22
    • 0342368653 scopus 로고    scopus 로고
    • Blood neutrophil functions and cytokine release in severe alcoholic hepatitis: Effect of corticosteroids
    • Taïeb J, Mathurin P, Elbim C, Cluzel P, Arce-Vicioso M, Bernard B, et al. Blood neutrophil functions and cytokine release in severe alcoholic hepatitis: effect of corticosteroids. J Hepatol 2000;32:579-586.
    • (2000) J Hepatol , vol.32 , pp. 579-586
    • Taïeb, J.1    Mathurin, P.2    Elbim, C.3    Cluzel, P.4    Arce-Vicioso, M.5    Bernard, B.6
  • 23
    • 0033524159 scopus 로고    scopus 로고
    • Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial
    • Maini R, St Clair EW, Breedveld F, Furst D, Kalden J, Weisman M, et al. Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. Lancet 1999;354:1932-1939.
    • (1999) Lancet , vol.354 , pp. 1932-1939
    • Maini, R.1    St Clair, E.W.2    Breedveld, F.3    Furst, D.4    Kalden, J.5    Weisman, M.6
  • 25
    • 0032923705 scopus 로고    scopus 로고
    • Tumor necrosis factor α antibody (Infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis
    • Baert FJ, D'Haens GR, Peeters M, Hiele MI, Schaible TF, Shealy D, et al. Tumor necrosis factor α antibody (Infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis. Gastroenterology 1999;116:22-28.
    • (1999) Gastroenterology , vol.116 , pp. 22-28
    • Baert, F.J.1    D'Haens, G.R.2    Peeters, M.3    Hiele, M.I.4    Schaible, T.F.5    Shealy, D.6
  • 26
    • 0035068351 scopus 로고    scopus 로고
    • Infliximab for Crohn's disease in clinical practice at the Mayo Clinic: The first 100 patients
    • Ricart E, Panaccione R, Loftus EV, Tremaine WJ, Sandborn WJ. Infliximab for Crohn's disease in clinical practice at the Mayo Clinic: the first 100 patients. Am J Gastroenterol 2001;96:722-729.
    • (2001) Am J Gastroenterol , vol.96 , pp. 722-729
    • Ricart, E.1    Panaccione, R.2    Loftus, E.V.3    Tremaine, W.J.4    Sandborn, W.J.5
  • 27
    • 0034881694 scopus 로고    scopus 로고
    • Mortality associated with infliximab
    • Lankarani KB. Mortality associated with infliximab (letter). J Clin Gastroenterol 2001;33:255-256.
    • (2001) J Clin Gastroenterol , vol.33 , pp. 255-256
    • Lankarani, K.B.1
  • 28
    • 0030716183 scopus 로고    scopus 로고
    • Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat
    • Iimuro Y, Gallucci RM, Luster MI, Kono H, Thurman RG. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 1997;26:1530-1537.
    • (1997) Hepatology , vol.26 , pp. 1530-1537
    • Iimuro, Y.1    Gallucci, R.M.2    Luster, M.I.3    Kono, H.4    Thurman, R.G.5
  • 29
    • 0020000749 scopus 로고
    • Transvenous liver biopsy. An experience based on 1000 hepatic tissue samplings with this procedure
    • Lebrec D, Goldfarb G, Degott C, Rueff B, Benhamou JP. Transvenous liver biopsy. An experience based on 1000 hepatic tissue samplings with this procedure. Gastroenterology 1982;83:338-340.
    • (1982) Gastroenterology , vol.83 , pp. 338-340
    • Lebrec, D.1    Goldfarb, G.2    Degott, C.3    Rueff, B.4    Benhamou, J.P.5
  • 30
    • 0034765504 scopus 로고    scopus 로고
    • Pharmacokinetics considerations in the treatment of inflammatory bowel diseases
    • Schwab M, Klotz U. Pharmacokinetics considerations in the treatment of inflammatory bowel diseases. Clin Pharmacokinet 2001;40:723-751.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 723-751
    • Schwab, M.1    Klotz, U.2
  • 31
    • 0018756343 scopus 로고
    • Cytochemical diagnosis of acute myelomonocytic leukemia
    • Tavassoli M, Shaklai M, Crosby WH. Cytochemical diagnosis of acute myelomonocytic leukemia. Am J Clin Pathol 1979;72:59-62.
    • (1979) Am J Clin Pathol , vol.72 , pp. 59-62
    • Tavassoli, M.1    Shaklai, M.2    Crosby, W.H.3
  • 32
    • 0025054966 scopus 로고
    • Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune murine nephritis
    • Wuthrich RP, Jevnikar AM, Takei F, Glimcher LH, Kelley VE. Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune murine nephritis. Am J Pathol 1990;136:441-450.
    • (1990) Am J Pathol , vol.136 , pp. 441-450
    • Wuthrich, R.P.1    Jevnikar, A.M.2    Takei, F.3    Glimcher, L.H.4    Kelley, V.E.5
  • 33
    • 0025295973 scopus 로고
    • Immunohistochemical study of adhesion molecules in liver inflammation
    • Volpes R, Van den Oord JJ, Desmet VJ. Immunohistochemical study of adhesion molecules in liver inflammation. Hepatology 1990;12:59-65.
    • (1990) Hepatology , vol.12 , pp. 59-65
    • Volpes, R.1    Van den Oord, J.J.2    Desmet, V.J.3
  • 34
    • 0031039603 scopus 로고    scopus 로고
    • Serum intercellular adhesion molecule-I in alcoholic liver disease and its relationship with histological disease severity
    • Douds AC, Guan Lim A, Jazrawi RP, Finlayson C, Maxwell JD. Serum intercellular adhesion molecule-I in alcoholic liver disease and its relationship with histological disease severity. J Hepatol 1997;26:280-286.
    • (1997) J Hepatol , vol.26 , pp. 280-286
    • Douds, A.C.1    Guan Lim, A.2    Jazrawi, R.P.3    Finlayson, C.4    Maxwell, J.D.5
  • 35
    • 0029989527 scopus 로고    scopus 로고
    • Serum levels of interleukin-8 in alcoholic liver disease: Relationship with disease stage, biochemical parameters and survival
    • Huang YS, Chan CY, Wu JC, Pai CH, Chao Y, Lee SD. Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival. J Hepatol 1996;24:377-384.
    • (1996) J Hepatol , vol.24 , pp. 377-384
    • Huang, Y.S.1    Chan, C.Y.2    Wu, J.C.3    Pai, C.H.4    Chao, Y.5    Lee, S.D.6
  • 37
    • 0027296643 scopus 로고
    • Increased plasma interleukin-8 concentrations in alcoholic hepatitis
    • Hill DB, Marsano LS, McClain CJ. Increased plasma interleukin-8 concentrations in alcoholic hepatitis. Hepatology 1993;18:576-580.
    • (1993) Hepatology , vol.18 , pp. 576-580
    • Hill, D.B.1    Marsano, L.S.2    McClain, C.J.3
  • 38
    • 0034958819 scopus 로고    scopus 로고
    • Effects of treatment with a fully human anti-tumour necrosis factor α monoclonal antibody on the local and systemic homeostasis of interleukin-1 and TNFα in patients with rheumatoid arthritis
    • Barrera P, Joosten LAB, den Broeder AA, van de Putte LBA, van Riel PLCM, van den Berg WB. Effects of treatment with a fully human anti-tumour necrosis factor α monoclonal antibody on the local and systemic homeostasis of interleukin-1 and TNFα in patients with rheumatoid arthritis. Ann Rheum Dis 2001;60:660-669.
    • (2001) Ann Rheum Dis , vol.60 , pp. 660-669
    • Barrera, P.1    Joosten, L.A.B.2    Den Broeder, A.A.3    Van de Putte, L.B.A.4    Van Riel, P.L.C.M.5    Van den Berg, W.B.6
  • 39
    • 0034676629 scopus 로고    scopus 로고
    • Cytokines in alcoholic and nonalcoholic steatohepatitis
    • Tilg H, Diehl AM. Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 2000;343:1467-1476.
    • (2000) N Engl J Med , vol.343 , pp. 1467-1476
    • Tilg, H.1    Diehl, A.M.2
  • 40
    • 0026021473 scopus 로고
    • Effects of cytokines on the liver
    • Andus T, Bauer J, Gerok W. Effects of cytokines on the liver. Hepatology 1991;13:364-375.
    • (1991) Hepatology , vol.13 , pp. 364-375
    • Andus, T.1    Bauer, J.2    Gerok, W.3


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