Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: Relation to severity of liver disturbance

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 4 SUPPL., 2000, Pages

  Fujimoto, Masao ^a   Uemura, Masahito ^a   Nakatani, Yoshihiro ^a   Tsujita, Shigenobu ^a   Hoppo, Kazushige ^a   Tamagawa, Taikoo ^a   Kitano, Hiroyuki ^a   Kikukawa, Masaji ^a   Ann, Tatsuichi ^a   Ishii, Yoshinobu ^a   Kojima, Hideyuki ^a   Sakurai, Shinya ^a   Tanaka, Rieko ^a   Namisaki, Tadashi ^a   Noguchi, Ryuichi ^a   Higashino, Tadashi ^a   Kikuchi, Eiryo ^a   Nishimura, Kimio ^a   Takaya, Akira ^a   Fukui, Hiroshi ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Alcoholic Hepatitis; Cytokines; Endotoxin; Lipopolysaccharide Binding Protein; Prognosis

Indexed keywords

ALCOHOL; BILIRUBIN; BINDING PROTEIN; CYTOKINE; ENDOTOXIN; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE;

ACUTE PHASE RESPONSE; ADULT; AGED; ALCOHOL LIVER DISEASE; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ENDOTOXEMIA; FEMALE; HUMAN; INFLAMMATION; LIVER FAILURE; MALE; NEUTROPHIL; PRIORITY JOURNAL; PROGNOSIS;

EID: 0034014905     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2000.tb00012.x     Document Type: Conference Paper

References (37)

1. Abe H, Ishii K, Aso S, Nakano H, Kawahara T, Kumashiro R, Tanikawa K (1987) Clinical and pathological studies in severe alcoholic hepatitis. Acta Hepatologica Japonica 28:297-304.
2. Andus T, Geiger T, Hirano T, Northoff H, Ganter U, Bauer J, Kishimoto T, Heinrich PC (1987) Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-β2) regulates β-fibrinogen and albumin mRNA levels in Fao-9 cells. FEBS Lett 221:18-22.
3. Arai M (1986) Effect of ethanol on the intestinal uptake of endotoxin. Nippon Shokakibyo Gakka Zasshi 83:1060.
4. Arai M, Nakano S, Okuno F, Hirao Y, Sujita K, Kobayashi T, Ishii H, Tsuchiya M (1989) Endotoxin induced hypercoagulability: A possible aggravating factor of alcoholic liver disease. Hepatology 9:846-851.
5. Bird G (1994) Interleukin-8 in alcoholic liver disease. Acta Gastroenterol Belg 57:255-259.
6. Bird GL, Sheron N, Goka AK, Alexander GJ, Williams RS (1990) Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med 112:917-920.
7. Bode C, Fukui H, Bode JC (1993) "Hidden" endotoxin in plasma of patients with alcoholic liver disease. Eur J Gastroenterol Hepatol 5:257-262.
8. Bode C, Kugler V, Bode JC (1987) Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J Hepatol 4:8-14.
9. Bode C, Schäfer C, Bode JC (1998) The role of gut-derived bacterial toxins (endotoxin) for the development of alcoholic liver disease in man, in Gut and the Liver (Blum HE, Bode C, Bode JC, Sartor RB eds), pp 281-298. Kluwer Academic, Dordrecht.
10. Fujimoto M, Uemura M, Kojima H, Ishii Y, Ann T, Sakurai S, Okuda K, Noguchi R, Adachi S, Kitano H, Hoppo K, Higashino T, Takaya A, Fukui H, Nara Liver Study Group (1999) Prognostic factors in severe alcoholic liver injury. Alcohol Clin Exp Res 23:33s-38s.
11. Fukui H, Brauner B, Bode JC, Bode C (1991) Plasma endotoxin concentration in patients with alcoholic and non-alcoholic liver disease. J Hepatol 12:162-169.
12. Fukui H, Kitano H, Morimura M, Kikuchi E, Matsumoto M, Tsujita S, Kinoshita K, Matsumoto M, Okamoto Y, Tsujii T (1993a) Metabolic fate of endotoxin and blood tumor necrosis factor levels in rats with acute and chronic alcoholic loading. Alcohol Alcohol 28:65-70.
13. Fukui H, Kitano H, Tsujii T, Morimura M, Kikuchi E, Matsumoto M, Tsujita S, Kikukawa M, Nagamoto I, Nakatani T, Okamoto Y (1993b) Effect of alcohol on the function of Kupffer cells and splenic macrophages in rats. Alcohol Alcohol 28:53-57.
14. Fukui H, Matsumoto M, Tsujita S, Kikuchi E, Takaya A, Kojima H, Matsumura M, Tsujii T (1994) Plasma endotoxin concentration and endotoxin binding capacity of plasma acute phase protein in cirrhotics with variceal bleeding: A analysis by new methods. J Gastroenterol Hepatol 9:582-586.
15. Fukui H, Tsujita S, Matsumoto M, Kitano H, Kinoshita K, Kikuchi E, Okamoto Y, Tsujii T (1995) Endotoxin inactivating action of plasma in patients with liver cirrhosis. Liver 15:104-109.
16. Gauldie J, Richards C, Harnish D, Lansdorp P, Baumann H (1987) Interferon β2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cell. Proc Natl Acad Sci USA 84:7251-7255.
17. Gupta S, Slaughter S, Akiriviadis EA, Valenzuela R, Deodhar SD (1995) Serial measurement of serial c-reactive protein facilitates evaluation in alcoholic hepatitis. Hepatogastroenterology 42:516-521.
18. Hill DB, Marsano L, Cohen D, Allen J, Shedlofsky S, McClain CJ (1992) Increased plasma interleukin-6 concentrations in alcoholic hepatitis. J Lab Clin Med 119:547-552.
19. Hill DB, Marsano LS, McClain CJ (1993) Increased plasma interleukin-8 concentrations in alcoholic hepatitis. Hepatology 18:576-580.
20. Huang YS, Chan CY, Wu JC, Pai CH, Chao Y, Lee SD (1996) Serum levels of interleukin-8 in alcoholic liver disease: Relationship with disease stage, biochemical parameters and survival. J Hepatol 24:377-384.
21. Ishii K, Furudera S, Kumashiro R, Seo J, Koga Y, Sata M, Tanikawa K (1994) Role of serum interleukin-8 and intercellular adhesion molecule-1 in the severity of alcoholic hepatitis. Alcohol Alcohol (Suppl 1) 29:81-85.
22. Khoruts A, Stahnke L, McClain CJ, Logan G, Allen JI (1991) Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology 13:267-276.
23. Kitano H, Fukui H, Okamoto Y, Kikuchi E, Matsumoto M, Kikukawa M, Morimura M, Tsujita S, Nagamoto I, Nakatani T, Akira T, Tsujii T (1996a) Role of albumin and high-density lipoprotein as endotoxin-binding proteins in rats with acute and chronic alcohol loading. Alcohol Clin Exp Res 20:73A-76A.
24. Kitano H, Fukui H, Okamoto Y, Kikuchi E, Matsumoto M, Kikukawa M, Morimura M, Tsujita S, Nagamoto I, Nakatani Y, Nakatani T, Tsujii T (1996b) Protective mechanism of high-density lipoprotein against endotoxemia in chronic alcohol ingestion. Alcohol Clin Exp Res 20:356A-359A.
25. Matsumoto T, Onji M, Horiike N, Ohta Y (1993) Assay of serum interleukin-8 levels in patients with alcoholic hepatitis. Alcohol Alcohol 28(Suppl 1A):99-102.
26. Nanji AA, Khettry U, Sadrzadeh SM, Yamanaka T (1993) Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4, and thromboxane B2. Am J Pathol 142:367-373.
27. Nolan JP (1981) Endotoxin, reticuloendothelial function, and liver injury. Hepatology 1:458-465.
28. Nolan JP (1989) Intestinal endotoxins as mediators of hepatic injury - An idea whose time has come again. Hepatology 10:887-891.
29. Schäfer C, Parlesak A, Carroll J, Bode JC, Bode C (1996) Endotoxin plasma levels and endotoxin binding factors in patients with alcoholic liver disease. Alcohol Clin Exp Res 20:127.
30. Schumann RR, Leong SR, Flaggs GW, Gray PW, Wright SD, Mathison JC, Tobias PS, Ulevitch RJ (1990) Structure and function of lipopolysaccharide binding protein. Science (Wash. DC) 249:1429-1431.
31. Sheron N, Bird G, Goka J, Alexander G, Williams R (1991) Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis. Clin Exp Immunol 84:449-453.
32. Sheron N, Bird G, Koskinas J, Portmann B, Ceska M, Lindley I, Williams R (1993) Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration. Hepatology 18:41-46.
33. Takada A, and the Japanese Study Group for Alcoholic Liver Disease (1993) A new diagnostic criteria of alcoholic liver disease. Acta Hepatologica Japonica 34:888-896.
34. Tanikawa K (1995) Cytokines and adhesion molecules in the liver, in Cytokines and the Liver (Decker K, Gerok W eds), pp 37-45. Kluwer Academic, Dordrecht.
35. Thurman RG, Bradford BU, Knecht KT, Iimuro Y, Arteel GE, Yin M, Conner HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT, Brenner D, Kadiiska M (1998) Endotoxin, Kupffer cells and alcoholic liver injury, in Gut and the Liver (Blum HE, Bode C, Bode JC, Sartor RB eds), pp 222-240. Kluwer Academic, Dordrecht.
36. Watson RR, Borgs P, Witte M, McCuskey RS, Lantz C, Johnson MI, Mufti SI, Earnest DL (1994) Alcohol, immunomodulation, and disease. Alcohol Alcohol 29:131-139.
37. Wurfel MM, Haliman E, Wright SD (1995) Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein. J Exp Med 181:1743-1754.