S-Adenosyl-L-methionine and alcoholic liver disease in animal models: Implications for early intervention in human beings

Alcohol

Volumn 27, Issue 3, 2002, Pages 173-177

  Lieber, Charles S ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alcoholic liver injury; Baboons; Fibrosis; Mitochondria; Oxidative stress; S Adenosylmethionine

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 2E1; FREE RADICAL; GLUTAMATE DEHYDROGENASE; LIPOTROPIC AGENT; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; PROTEIN; S ADENOSYLMETHIONINE; VITAMIN;

ALCOHOL LIVER DISEASE; ALCOHOL METABOLISM; ANIMAL MODEL; ARTIFICIAL DIET; BABOON; CELL MEMBRANE; CONFERENCE PAPER; DISEASE ASSOCIATION; DISEASE COURSE; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME INDUCTION; FATTY LIVER; FEEDING; HUMAN; LIPID PEROXIDATION; LIVER LEVEL; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN DIET; SPECIES COMPARISON; VITAMIN INTAKE; ANIMAL; DISEASE MODEL; METABOLISM; REVIEW;

ANIMAL; DISEASE MODELS, ANIMAL; HUMAN; LIVER DISEASES, ALCOHOLIC; S-ADENOSYLMETHIONINE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS; HUMANS;

ANIMALIA; PAPIO; PRIMATES; RODENTIA;

EID: 0036024249     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0741-8329(02)00230-6     Document Type: Conference Paper

References (35)

1. Polyenylphosphatidylcholine opposes the increase of cytochrome P-4502E1 by ethanol and corrects its iron-induced decrease
2. Polyenylphosphatidylcholine (PPC) corrects the alcohol-induced hepatic oxidative stress by restoring S-adenosyl-L-methionine (SAMe)
3. Decreased cytochrome oxidase activity in hepatic mitochondria after chronic ethanol consumption and the possible role of decreased cytochrome aa3 content and changes in phospholipids
4. Pitfalls and problems in studies on the methylation of phosphatidylethanolamine
5. Adaptive increase in betaine-homocysteine methyltransferase activity maintains hepatic S-adenosyl-L-methionine levels in ethanol-treated rats
6. Intestinal absorption of S-adenosyl-L-methionine in humans
7. Rates of oxidation of the methionine and S-adenosylmethionine methyl carbons in isolated rat hepatocytes
8. Ethanol-induced changes in methionine metabolism in rat liver
9. Methionine metabolism in mammals. Adaptation to methionine excess
10. Plasma amino acids in patients with hepatic encephalopathy. Effects of amino acids infusions
11. A radioenzymatic method for S-adenosyl-L-methionine determination in biological fluids
12. Pathogenesis of methionine-induced toxicity
13. Choline deficiency in baboon and rat compared
14. S-Adenosylmethionine and S-adenosylhomocystein metabolism in isolated rat liver. Effects of L-methionine, L-homocystein, and adenosine
15. Evidence for impairment of transsulfuration pathway in cirrhosis
16. The plasma amino acids in patients with liver failure
17. Free amino acids in liver, plasma, and muscle of patients with cirrhosis of the liver
18. Rate of disappearance from plasma of intravenously administered methionine in patients with liver damage
19. Effect of S-adenosyl-L-methionine (SAMe) and other natural compounds in alcoholic and nonalcoholic liver injury
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21. Attenuation of alcohol-induced hepatic fibrosis by polyunsaturated lecithin
22. Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon
23. Hepatic phosphatidylethanolamine methyltransferase activity is decreased by ethanol and increased by phosphatidylcholine
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33. Chronic ethanol consumption alters rat liver plasma membranes and potentates release of alkaline phosphatase
34. Uptake of adenosylmethionine and related sulfur compounds by isolated rat liver