White cell count and platelet count associate with histological alcoholic hepatitis in jaundiced harmful drinkers

BMC Gastroenterology

Volumn 13, Issue 1, 2013, Pages

  Hardy, Timothy ^a,b   Wells, Christopher ^a   Kendrick, Stuart ^a   Hudson, Mark ^a   Day, Christopher P ^b   Burt, Alastair D ^b   Masson, Steven ^a   Stewart, Stephen F ^a,c  

^a FREEMAN HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Accuracy; Alcoholic hepatitis; Biochemical markers; Biopsy; Diagnosis

Indexed keywords

ADULT; ALCOHOL LIVER DISEASE; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; JAUNDICE; LEUKOCYTE COUNT; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; THROMBOCYTE COUNT;

ADULT; AGED; ALCOHOLISM; ALGORITHMS; AREA UNDER CURVE; BIOLOGICAL MARKERS; BIOPSY; CASE-CONTROL STUDIES; FEMALE; HEPATITIS, ALCOHOLIC; HUMANS; JAUNDICE; LEUKOCYTE COUNT; LIVER; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PLATELET COUNT; ROC CURVE; STATISTICS, NONPARAMETRIC;

EID: 84875305045     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-13-55     Document Type: Article

References (18)

1. MacSween RN, Burt AD. Histologic spectrum of alcoholic liver disease. Semin Liver Dis 1986, 6:221-232. 10.1055/s-2008-1040605, 3022386.
2. Lucey MR, Mathurin P, Morgan TR. Alcoholic hepatitis. New Engl J Med 2009, 360:2758-2769. 10.1056/NEJMra0805786, 19553649.
3. MacSween RN. Alcoholic liver disease: morphological manifestations. Review by an international group. Lancet 1981, 1:707-711.
4. Ishak KG, Zimmerman HJ, Ray MB. Alcoholic liver disease: pathologic, pathogenetic and clinical aspects. Alcohol Clin Exp Res 1991, 15:45-66. 10.1111/j.1530-0277.1991.tb00518.x, 2059245.
5. Chedid A, Mendenhall CL, Gartside P. Prognostic factors in alcoholic liver disease. VA cooperative study group. Am J Gastroenterology 1991, 86:210-216.
6. Mookerjee RP, Lackner C, Stauber R, Stadlbauer V, Deheragoda A, Jalan R. The role of liver biopsy in the diagnosis and prognosis of patients with acute deterioration of alcoholic cirrhosis. J Hepatol 2011, 55:1103-1111. 10.1016/j.jhep.2011.02.021, 21376092.
7. Gamble P, Colapinto RF, Stronell RD. Transjugular liver biopsy: a review of 461 biopsies. Radiology 1985, 157:589-593.
8. Velt PM, Choy OG, Shimkin PM. Transjugular liver biopsy in high risk patients with hepatic disease. Radiology 1984, 153:91-93.
9. Vlavianos P, Bird G, Portmann B. Transjugular liver biopsy: use in a selected high risk population. Eur J Gastroenterol Hepatol 1991, 3:469-472.
10. Maddrey WC, Boitnott JK, Bedine MS. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology 1978, 75:193-199.
11. Forrest EH, Evans CD, Stewart S. Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score. Gut 2005, 54:1174-1179. 10.1136/gut.2004.050781, 1774903, 16009691.
12. Stewart S, Prince M, Bassendine M. A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis. J Hepatol 2007, 47(2):277-283. 10.1016/j.jhep.2007.03.027, 17532088.
13. Pugh RN, Murray-Lyon IM, Dawson JL. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973, 60(8):646-649. 10.1002/bjs.1800600817, 4541913.
14. Ramond M-J, Poynard T, Rueff B. A Randomised trial of prednisolone in patients with severe alcoholic hepatitis. New Engl J Med 1992, 326:507-512. 10.1056/NEJM199202203260802, 1531090.
15. Carithers RL, Herlong F, Diehl AM. Methylprednisolone therapy in patients with severe alcoholic hepatitis. Ann Intern Med 1989, 110:685-690.
16. O'Shea RS, Dasarathy S, McCullough AJ,. Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology Alcoholic liver disease. Hepatology 2010, 51:307-328. 10.1002/hep.23258, 20034030, Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology.
17. Alcohol use disorders: diagnosis and clinical management of alcohol-related physical complications. Clinical guideline 100 (Accessed Jan 2011) http://www.nice.org.uk/nicemedia/live/12995/48989/48989.pdf.
18. Clinical Practical Guidelines EASL. Management of alcoholic liver disease. J Hepatol 2012, 57:399-420.