Microsomal ethanol-oxidizing system (MEOS): The first 30 years (1968- 1998) - A review

Alcoholism: Clinical and Experimental Research

Volumn 23, Issue 6, 1999, Pages 991-1007

  Lieber, Charles S ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acetaldehyde; Cytochrome P 450CYP2E1; Ethanol Metabolism; Liver Injury; Oxidative Stress

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; CARBON TETRACHLORIDE; CYTOCHROME P450; DIMETHYLNITROSAMINE; DIMETHYLNITROSAMINE DEMETHYLASE; GLUTATHIONE; KETONE; PARACETAMOL; PHOSPHATIDYLCHOLINE; SOLVENT;

ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ALCOHOL METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; DETOXIFICATION; ENZYME ACTIVITY; FATTY ACID METABOLISM; GLUCONEOGENESIS; LIVER FIBROSIS; LIVER INJURY; LIVER MICROSOME; LIVER TOXICITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW;

EID: 0033053587     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1999.tb04217.x     Document Type: Review

References (240)

1. Adas F, Betthou F, Picart D, Lozac'h P, Beauge F, Amet Y (1998) Involvement of cytochrome P-450 2E1 in the (omega-1)-hydroxylation of oleic acid in human and rat liver microsomes. J Lipid Res 39:1210-1219.
2. Albano E, Tomasi A, Ingelman-Sundberg M (1994) Spin trapping of alcohol derived radicals in microsomes and reconstituted systems by electron spin resonance. Methods Enzymol 223:117-127.
3. Aleynik SI, Leo MA, Aleynik MK, Lieber CS (1997a) Polyenylphosphatidylcholine prevents carbontetrachloride induced lipid peroxidation while it attenuates liver injury and fibrosis. J Hepatol 26:554-561.
4. Aleynik SI, Leo MA, Takeshige U, Aleynik M, Lieber CS (1997b) Dilinoleoylphosphatidylcholine (DLPC) is the active antioxidant of polyenylphosphatidylcholine (PPC). Gastroenterology 112:1209.
5. Aleynik MK, Leo MA, Aleynik SI, Lieber CS (1998) Polyenylphosphatidylcholine opposes the increase of cytochrome P-4502E1 by ethanol and corrects its iron-induced decrease. Alcohol Clin Exp Res 23:96-100.
6. Amet Y, Berthou F, Goasduff T, Salaun JP, Le Breton L, Menez JF (1994) Evidence that cytochrome P-450 2E1 is involved in the (ù-1)-hydroxylation of lauric acid in rat liver microsomes. Biochem Biophys Res Commun 203:1168-1174.
7. Asai H, Imaoka S, Kuroki T, Monna T, Funae Y (1996) Microsomal ethanol oxidizing system activity by human hepatic cytochrome P-450s. J Pharmacol Exp Ther 277:1004-1009.
8. Badger TM, Huang J, Ronis M, Lumpkin CK (1993) Induction of cytochrome P-450 2E1 during chronic ethanol exposure occurs via transcription of the CYP 2E1 gene when blood alcohol concentrations are high. Biochem Biophys Res Commun 190:780-785.
9. Badger TM, Korourian S, Hakkak R, Ronis MJJ, Shelnutt SR, Ingelman-Sundberg M, Waldron J (1998) Carbohydrate deficiency as a possible factor in ethanol-induced hepatic necrosis. Alcohol Clin Exp Res 22: 742.
10. Baraona E, Leo MA, Borowsky SA, Lieber CS (1977) Pathogenesis of alcohol-induced accumulation of protein in the liver. J Clin Invest 60:546-554.
11. Baraona E, Lieber CS (1998) Alcohol and lipids, in Recent Developments in Alcoholism (Galanter M ed) pp 97-134, Plenum Publishing Corp, New York, NY.
12. Behrens UH, Hoerner M, Lasker JM, Lieber CS (1988) Formation of acetaldehyde adducts with ethanol-inducible P-450IIE1 in vivo. Biochem Biophys Res Commun 154:584-590.
13. Bellward GD, Chang T, Rodrigues JH, McNeil JH, Maines S, Ryan DE, Levin W, Thomas PE (1987) Hepatic cytochrome P-450j induction in the spontaneously diabetic BB rat. Mol Pharmacol 33:140-143.
14. Beskid M, Bialck J, Dzieniszewski J, Sadowski J, Tlalka J (1980) Effect of combined phenylbutazone and ethanol administration on rat liver. Exp Pathol 18:487-491.
15. Bhagwat SV, Boyd MR, Ravindranath V (1995) Brain mitochondrial cytochromes P 450:xenobiotic metabolism, presence of multiple forms and their selective inducibility. Arch Biochem Biophys 320:73-83.
16. Boleda MD, Saubi N, Farres J, Pares X (1993) Physiological substrates for rat alcohol dehydrogenase classes: Aldehydes of lipid peroxidation, ù-hydroxy fatty acids, and retinoids. Arch Biochem Biophys 307:85-90.
17. Botto F, Seree E, Khyari SE, DeSousa G, Massacrier A, Placidi M, Cau P, Pellet W, Rahmani R, Barra Y (1994) Tissue-specific expression and methylation of the human CYP2E1 gene. Biochem Pharmacol 48:1095-1103.
18. Burnett DA, Lysenko N, Manning JA, Ockner RK (1979) Utilization of long chain fatty acids by rat liver: Studies of the role of fatty acid binding protein. Gastroenterology 77:241-249.
19. Carr LG, Hartleroad JY, Liang YB, Mendenhall C, Moritz T, Thomasson H (1995) Polymorphism at the P-450IIE1 locus is not associated with alcoholic liver disease in caucasian men. Alcohol Clin Exp Res 19:182-184.
20. Carriere V, Berthou F, Baird S, Belloc C, Beaune P, De Waziers I (1996) Human cytochrome P-450 2E1 (CYP2E1): From genotype to phenotype. Pharmacogenetics 6:203-211.
21. Carroccio A, Wu D, Cederbaum AI (1994) Ethanol increases content and activity of human cytochrome P-4502E1 in a transduced HepG2 cell line. Biochem Biophys Res Commun 203:727-733.
22. Casazza JP, Felver ME, Veech RL (1984) The metabolism of acetone in rat. J Biol Chem 259:231-236.
23. Casazza JP, Fu JL (1985) Measurement of acetol in serum. Anal Biochem 148:344-348.
24. Casazza JP, Veech RL (1985) The production of 1, 2 propanediol in ethanol treated rats. Biochem Biophys Res Commun 129:426-430.
25. Cederbaum AI (1989a) Introduction: Role of lipid peroxidation and oxidative stress in alcohol toxicity. Free Radic Biol Med 7:537-539.
26. Cederbaum AI (1989b) Oxygen radical generation by microsomes: Role of iron and implications for alcohol metabolism and toxicity. Free Radic Biol Med 7:559-567.
27. Cederbaum AI, Dicker E, Rubin E, Cohen G (1977) The effect of dimethylsulfoxide and other hydroxyl radical scavengers on the oxidation of ethanol by rat liver microsomes. Biochem Biophys Res Commun 78:1254-1262.
28. Chance B (1947) An intermediate compound in the catalase-hydrogen reaction. Acta Chem Scand 1:236-267.
29. Chen L, Lee M, Hong J-Y, Huang W, Wang E, Yang CS (1994) Relationship between cytochrome P-450 2E1 and acetone catabolism in rats as studied with diallyl sulfide as an inhibitor. Biochem Pharmacol 48:2199-2205.
30. Cohen PA, Mak KM, Rosman AS, Kessova I, Mishin VM, Kovisto T, Lieber CS (1997) Immunohistochemical determination of hepatic cytochrome P-4502E1 in formalin-fixed, paraffin-embedded sections. Alcohol Clin Exp Res 21:1057-1062.
31. Conney AH (1967) Pharmacological implications of microsomal enzyme induction. Pharmacol Rev 19:317-366.
32. Crabb DW (1995) Ethanol oxidizing enzymes: Roles in alcohol metabolism and alcoholic liver disease. Prog Liver Dis 13:151-172.
33. Dai Y, Rashba-Step J, Cederbaum AI (1993) Stable expression of human cytochrome P-4502E1 in HepG2 cells: Characterization of catalytic activities and production of reactive oxygen intermediates. Biochemistry 32:6928-6937.
34. DeWaziers I, Garlatti M, Bouguet J, Beaune PH, Barouki R (1995) Insulin down-regulates cytochrome P-450 2B and 2E expression at the posttranscriptional level in the rat hepatoma cell line. Mol Pharmacol 47:474-479.
35. Dicker E, Cederbaum AI (1988) Increased oxygen radical dependent inactivation of metabolic enzymes by liver microsomes after chronic ethanol consumption. FASEB J 2:2901-2906.
36. Diehl AM, Bisgaard HC, Kren BT, Steer CJ (1991) Ethanol interferes with regeneration-associated changes in biotransforming enzymes: A potential mechanism underlying ethanol's carcinogenicity? Hepatology 13:722-727.
37. Ding X, Coon MJ (1988) Induction of cytochrome P-450 isozyme 3a (P-450IIE1) in rabbit olfactory mucosa by ethanol and acetone. Drug Metab Dispos 18:742-745.
38. ALC] in rabbit nasal and kidney microsomes and evidence for differential induction by alcohol. Mol Pharmacol 30:370-378.
39. DiPadova C, Worner TM, Julkunen RJK, Lieber CS (1987) The effect of abstinence on the blood acetaldehyde response to a test dose of alcohol in alcoholics. Alcohol Clin Exp Res 11:559-561.
40. Dong Z, Hong J, Ma Q, Li DC, Bullock J, Gonzalez FJ, Park SS, Gelboin HV, Yang CS (1988) Mechanism of induction of cytochrome P-450ac (P-450J) in chemically induced and spontaneously diabetic rats. Arch Biochem Biophys 263:29-35.
41. Dupont I, Lucas D, Clot P, Menez C, Albano E (1998) Cytochrome P-4502E1 inducibility and hydroxyethyl radical formation among alcoholics. J Hepatology 28:564-571.
42. Eliasson E, Johansson I, Ingelman-Sundberg M (1988) Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures. Biochem Biophys Res Commun 150:436-443.
43. Eliasson E, Mkrtchian S, Ingelman-Sundberg M (1992) Hormone- and substrate-regulated intracellular degradation of cytochrome P-450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes. J Biol Chem 267:15765-15769.
44. Eriksson CJP, Fukunaga T, Sarkola T, Linholm H, Ahola L (1996) Estrogen-related acetaldehyde elevation in women during alcohol intoxication. Alcohol Clin Exp Res 20:1192-1195
45. Espina N, Lima V, Lieber CS, Garro AJ (1988) In vitro and in vivo inhibitory effect of ethanol and acetaldehyde on O6-methylguanine transferase. Carcinogenesis 9:761-766.
46. Fabry TL, Lieber CS (1979) The photochemical action spectrum of the microsomal ethanol oxidizing system. Alcohol Clin Exp Res 3:219-222.
47. Farinati F, Zhou Z, Bellah J, Lieber CS, Garro AJ (1985) Effect of chronic ethanol consumption on activation of nitrosopyrrolidine to a mutagen by rat upper alimentary tract, lung and hepatic tissue. Drug Metab Dispos 13:210-214.
48. French S, Morimoto M, Reitz R, Koop D, Klopfenstein B, Estes K, Clot P, Ingelman-Sundberg M, Albano E (1997) Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats. J Nutr 127(Suppl 5):907S-911S.
49. Frezza M, DiPadova C, Pozzato G, Terpin M, Baraona E, Lieber CS (1990) High blood alcohol levels in women: Role of decreased gastric alcohol dehydrogenase activity and first pass metabolism. N Engl J Med 322:95-99.
50. Garro AJ, Seitz HK, Lieber CS (1981) Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption. Cancer Res 41:120-124.
51. Gebhardt AC, Lucas D, Menez JF, Seitz HK (1997) Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans. Hepatology 26:957-961.
52. George J, Liddle C, Murray M, Byth K, Farrell GC (1995) Pretranslational regulation of P-450 genes is responsible for disease specific changes of individual P-450 enzymes among patients with cirrhosis. Biochem Pharmacol 49:873-881.
53. Guengerich FP, Turvy CG (1991) Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples. J Pharmacol Exp Ther 256:1189-1194.
54. Hakkak R, Korourian S, Ronis MJ, Ingelman-Sundberg M, Badger TM (1996a) Effects of diet and ethanol on the expression and localization of cytochromes P-450 2E1 and P-450 2C7 in the colon of male rats. Biochem Pharmacol 51:61-69.
55. Hakkak R, Korourian S, Ronis MJ, Badger TM (1996b) Effects of diet and ethanol treatment on azoxymethane-induced liver and gastrointestinal neoplasia of male rats. Cancer Lett 107:257-264.
56. Hansson T, Tindberg N, Ingelman-Sunberg M, Köhler C (1990) Regional distribution of ethanol-inducible cytochrome P-450 IIEI in the rat central nervous system. Neurosci 34:451-463.
57. Hasumura Y, Teschke R, Lieber CS (1974) Increased carbon tetrachloride hepatotoxicity, and its mechanism, after chronic ethanol consumption. Gastroenterology 66:226-234.
58. Hasumura Y, Teschke R, Lieber CS (1975) Acetaldehyde oxidation by hepatic mitochondria: Its decrease after chronic ethanol consumption. Science 189:727-729.
59. Hayashi S, Watanabe J, Kaname K (1991) Genetic polymorphism in the 5′-flanking region change transcriptional regulation of the human cytochrome P-450IIE1 gene. J Biochem 110:559-565.
60. Hetu C, Dumont A, Joly JG (1983) Effect of chronic ethanol administration on bromobenzene liver toxicity in the rat. Toxicol Appl Pharmacol 67:166-167.
61. Hirvonen A, Husgafvel-Pursiainen K, Anttila S, Karjalainen A, Vainio H (1993) The human CYP2E1 gene and lung cancer: Dra I and Rsa I restriction fragment length polymorphisms in a Finnish study population. Carcinogenesis 14:85-88.
62. Hoivik DJ, Manautou JE, Tveit A, Hart SG, Khairallah EA, Cohen SD (1995) Gender-related differences in susceptibility to acetaminophen-induced protein arylation and nephrotoxicity in the CD-1 mouse. Toxicol Appl Pharmacol 130:257-271.
63. Hong JY, Ning SM, Ma BL, Lee MJ, Pan JM, Yang CS (1990) Roles of pituitary hormones in the regulation of hepatic cytochrome P-450IIE1 in rats and mice. Arch Biochem Biophys 281:132-138.
64. Ingelman-Sundberg M, Johansson I (1984) Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450. J Biol Chem 259:6447-6458.
65. Ingelman-Sundberg M, Johansson I, Penttila KE, Glaumann H, Lindros KO (1988) Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver. Biochem Biophys Res Commun 157:55-60.
66. Iseri OA, Gottlieb LS, Lieber CS (1966) The ultrastructure of fatty liver induced by prolonged ethanol ingestion. Am J Pathol 48:535-555.
67. Isselbacher KJ, Carter EA (1970) Ethanol oxidation by liver microsomes: Evidence against a separate and distinct enzyme system. Biochem Biophys Res Commun 39:530-537.
68. Jayyosi Z, Knoble D, Mue M, Erick J, Thomas PE, Kelley N (1995) Cytochrome P-450 2E1 is not the sole catalyst of chlorzoxazone 22 hydroxylation in rat liver microsomes. J Pharmacol Exp Ther 273:1156-1161.
69. Jiang Y, Kuo CL, Pernecky SJ, Piper WN (1998) The detection of cytochrome P-450 2E1 and its catalytic activity in rat testis. Biochem Biophys Res Commun 246:578-583.
70. Johansson E, Eliasson E, Ingelman-Sundberg M (1991) Hormone controlled phosphorylation and degradation of CYP2B1 and CYP2E1 in isolated rat hepatocytes. Biochem Biophys Res Commun 174:37-42.
71. Johansson IJ, Eliasson E, Norsten C, Ingelman-Sundberg M (1986) Hydroxylation of acetone by ethanol- and acetone-inducible cytochrome P-450 in liver microsomes and reconstituted membranes. FEBS Lett 196:59-64.
72. Johansson IJ, Ingelman-Sundberg M (1988) Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes. Cancer Res 48:5387-5390.
73. Jones BM, Jones MK (1976) Male and female intoxication levels for three alcohol doses or do women really get higher than men? Alcohol Tech Rep 5:544-583.
74. Kaikaus RM, Chan WK, Ortiz de Montellano PR, Bass NM (1993) Mechanisms of regulation of liver fatty acid-binding protein. Mol Cell Biochem 123:93-100.
75. Kalant H, LeBlanc AE, Gibbins RJ (1971) Tolerance to and dependence on some nonopiate psychotropic drugs. Pharmacol Rev 23:135-191.
76. Keilin D, Hartree EF (1945) Properties of catalase: Catalysis of coupled oxidation of alcohols. Biochem J 39:293-301.
77. Kessova IG, DeCarli LM, Lieber CS (1998) Inducibility of cytochromes P-4502E1 & P-4501A1 in rat pancreas. Alcohol Clin Exp Res 22:501-504.
78. Khani SC, Zaphiropoulos PG, Fujita VS, Porter TD, Koop DR, Coon MJ (1987) cDNA and derived amino acid sequence of ethanol-inducible rabbit liver cytochrome P-450 isozyme 3a (P-450ALC). Proc Natl Acad Sci 84:638.
79. Kharasch ED, Thummel KE (1993) Identification of cytochrome P-450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology 79:795-807.
80. Kikkawa F, Nawa A, Oguchi H, Kawai M, Maeda O, Suganuma N, Aoyama T, Tomoda Y (1994) Positive correlation between cytochrome P-4502E1 mRNA level and serum estradiol level in human uterine endometrium. Oncology 51:52-58.
81. Kim ND, Kwak MK, Kim SG (1997) Inhibition of cytochrome P-450 2E1 expression by 2-(allylthio) pyrazine, a potential chemoprotective agent: Hepatoprotective effects. Biochem Pharmacol 53:261-269.
82. Kim SG, Novak RF (1990) Induction of rat hepatic P-450IIE1 (CYP 2E1) by pyridine: Evidence for a role of protein synthesis in the absence of transcriptional activation. Biochem Biophys Res Commun 166:1072-1079.
83. Kim SG, Shehin SE, States JC, Novak RF (1990) Evidence for increased translational efficiency in the induction of P-450IIE1 by solvents: Analysis of P-450IIE1 mRNA polyribosomal distribution. Biochem Biophys Res Commun 172:767-774.
84. Knecht KT, Thurman RG, Mason PR (1993) Role of superoxide and trace transition metals in the production of □-hydroxyethyl radical from ethanol by microsomes from alcohol dehydrogenase-deficient deermice. Arch Biochem Biophys 303:339-348.
85. Koivisto T, Mishin VM, Mak KM, Cohen PA, Lieber CS (1996) Induction of cytochrome P-4502E1 by ethanol in rat Kupffer cells. Alcohol Clin Exp Res 20:207-212.
86. Koop DR (1992) Oxidative and reductive metabolism by cytochrome P-450 2E1. FASEB J 6:724-730.
87. Koop DR, Casazza JP (1985) Identification of ethanol-inducible P-450 enzyme 3a as the acetone and acetol monooxygenase of rabbit microsomes. J Biol Chem 260:13607-13612.
88. Koop DR, Chernosky A, Brass EP (1991) Identification and induction of cytochrome P-450 2E1 in rat Kupffer cells. J Pharmacol Exp Ther 258:1072-1076.
89. Koop DR, Morgan ET, Tarr GE, Coon MJ (1982) Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits. J Biol Chem 257:8472-8480.
90. Koop DR, Tierney DJ (1990) Multiple mechanisms in the regulation of ethanol-inducible cytochrome P-450IIE1. Bioessays 9:429-435.
91. Kubota S, Lasker JM, Lieber CS (1988) Molecular regulation of ethanol inducible cytochrome P-450-IIE1 in hamsters. Biochem Biophys Res Commun 150:304-310.
92. Kunitoh S, Tanaka T, Imaoka S, Funae Y, Monna Y (1993) Contribution of cytochrome P-450s to MEOS (microsomal ethanol-oxidizing system): A specific and sensitive assay of MEOS activity by HPLC with fluorescence labeling. Alcohol Alcohol 28:63-68.
93. Laethem RM, Balaxy M, Falck JR, Laethem CL, Koop DR (1993) Formation of 19(S)-, 19(R)-, and 18(R)-Hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P-4502E1. J Biol Chem 268:12912-12918.
94. Lane BP, Lieber CS (1966) Ultrastructural alterations in human hepatocytes following ingestion of ethanol with adequate diets. Am J Pathol 49:593-603.
95. Lane BP, Lieber CS (1967) Effects of butylated hydroxytoluene on the ultrastructure of rat hepatocytes. Lab Invest 16:341-348.
96. Lasker JM, Raucy J, Kubota S, Bloswick BP, Black M, Lieber CS (1987) Purification and characterization of human liver cytochrome P-450-ALC. Biochem Biophys Res Commun 148:232-238.
97. Lefevre A, Adler H, Lieber CS (1970) Effect of ethanol on ketone metabolism. J Clin Invest 49:1775-1782.
98. Li J, Kim C, Leo MA, Mak KM, Rojkind M, Lieber CS (1992) Polyun-saturated lecithin prevents acetaldehyde-mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes. Hepatology 15:373-381.
99. Lieber CS (1991) Perspectives: Do alcohol calories count? Am J Clin Nutr 54:976-982.
100. Lieber CS (1992) Medical and Nutritional Complications of Alcoholism: Mechanisms and Management. p 579, Plenum Press, New York.
101. Lieber CS (1994) Alcohol and the liver: 1994 update. Gastroenterology 106:1085-1105.
102. Lieber CS (1995) Medical disorders of alcoholism. N Engl J Med 333: 1058-1965.
103. Lieber CS (1997a) Cytochrome P-4502E1: Its physiological and pathological role. Physiol Rev 77:517-544.
104. Lieber CS (1997b) Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases, in Advances in Pharmacology (Sies H ed) pp 601-628, Academic Press, San Diego, CA.
105. Lieber CS (1998) Hepatic and other medical disorders of alcoholism: From pathogenesis to treatment. J Stud Alcohol 59:9-25.
106. Lieber CS, DeCarli LM (1968) Ethanol oxidation by hepatic microsomes: Adaptive increase after ethanol feeding. Science 162:917-918.
107. Lieber CS, DeCarli LM (1970a) Hepatic microsomal ethanol oxidizing system: In vitro characteristics and adaptive properties in vivo. J Biol Chem 245:2505-2512.
108. Lieber CS, DeCarli LM (1970b) Quantitative relationship between the amount of dietary fat and the severity of the alcoholic fatty liver. Am J Clin Nutr 23:474-478.
109. Lieber CS, DeCarli LM (1972) The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo. J Pharmacol Exp Ther 181:279-287.
110. Lieber CS, DeCarli LM (1974a) Oxidation of ethanol by hepatic microsomes of acatalasemic mice. Biochem Biophys Res Commun 60:1187-1192.
111. Lieber CS, DeCarli LM (1974b) An experimental model of alcohol feeding and liver injury in the baboon. J Med Primatol 3:153-163.
112. Lieber CS, DeCarli LM, Schmid R (1959) Effects of ethanol on fatty acid metabolism in liver slices. Biochem Biophys Res Commun 1:302-306.
113. Lieber CS, Schmid R (1961) The effect of ethanol on fatty acid metabolism: Stimulation of hepatic fatty acid synthesis in vitro. J Clin Invest 40:394-399.
114. Lieber CS, Spritz N (1966) Effects of prolonged ethanol intake in man: Role of dietary, adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver. J Clin Invest 45:1400-1411.
115. Lieber CS, Spritz N, DeCarli LM (1966) Role of dietary, adipose and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver. J Clin Invest 45:51-62.
116. Lieber CS, Lefevre A, Spritz N, Feinman L, DeCarli LM (1967) Difference in hepatic metabolism of long and medium-chain fatty acids: The role of fatty acid chain length in the production of the alcoholic fatty liver. J Clin Invest 46:1451-1460.
117. Lieber CS, Garro A, Leo MA, Mak KM, Worner TM (1986) Alcohol and cancer. Hepatology 6:1005-1019.
118. Lieber CS, Lasker JM, DeCarli LM, Saeli J, Wojtowicz T (1988) Role of acetone, dietary fat and total energy intake in induction of hepatic microsomal ethanol oxidizing system. J Pharmacol Exp Ther 247:791-795.
119. Lieber CS, Baraona E, Hernandez-Munoz R, Kubota S, Sato N, Kawano S, Matsumura T, Inatomi N (1989) Impaired oxygen utilization: A new mechanism for the hepatotoxicity of ethanol in subhuman primates. J Clin Invest 83:1682-1690.
120. Lieber CS, Robins SJ, Li J, DeCarli LM, Mak KM, Fasulo JM, Leo MA (1994) Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology 106:152-159.
121. Lieber CS, Leo MA, Aleynik S, Aleynik M, DeCarli LM (1997) Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. Alcohol Clin Exp Res 21:375-379.
122. Lindros K, Jarvelainen H (1998) A new oral low-carbohydrate alcohol liquid diet producing liver lesions: A preliminary account. Alcohol Alcohol 33:347-353.
123. Lucas D, Berthou F, Dreano Y, Lozach P, Volant A, Menez JF (1993) Comparison of levels of cytochromes P-450, CYP1A2, CYP2E1, and their related monooxygenase activities in human surgical liver samples. Alcohol Clin Exp Res 17:900-905.
124. Lucas D, Menez C, Girre C, Berthou F, Bodenez P, Joannet I, Hispard E, Bardon LG, Menez JF (1995a) Cytochrome P-450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects. Pharmacogenetics 5:298-304.
125. Lucas D, Menez C, Girre C, Bodenez P, Hispard E, Menez JF (1995b) Decrease in cytochrome P-4502E1 as assessed by the rate of chlorzoxazone hydroxylation in alcoholics during the withdrawal phase. Alcohol Clin Exp Res 19:362-366.
126. Lucas D, Farez C, Bardou LG, Vaisse J, Attali JR, Valensi P (1998) Cytochrome P-450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation. Fundam Clin Pharmacol 12: 553-558.
127. Ma X, Baraona E, Goozner BG, Lieber CS (1999) Gender differences in medium chain dicarboxylic aciduria in alcoholics. Am J Med 106:70-75.
128. Ma X, Svegliati-Baroni G, Poniachik J, Baraona E, Lieber CS (1997) Collagen synthesis by liver stellate cells is released from its normal feedback regulation by acetaldehyde-induced modification of the carboxyl-terminal propeptide of procollagen. Alcohol Clin Exp Res 21:1204-1211.
129. Ma X, Zhao J, Lieber CS (1996) Polyenylphosphatidylcholine attenuates nonalcoholic hepatic fibrosis and accelerates its regression. J Hepatology 24:604-613.
130. Ma XL, Baraona E, Lieber CS (1993) Alcohol consumption enhances fatty acid ù-oxidation, with a greater increase in male than in female rats. Hepatol 18:1247-1253.
131. Maezawa Y, Yamauchi M, Toda G (1994) Association between restriction fragment length polymorphism of the human cytochrome P-450IIE1 gene and susceptibility to alcoholic liver cirrhosis. Am J Gastroenterol 89:561-565.
132. Mathews JM, Etheridge AS, Raymer JH, Black SR, Pulliam DW, Bucher JR (1998) Selective inhibition of cytochrome P-450 2E1 in vivo and in vitro with trans-1, 2-dichloroethylene. Chem Res Toxicol 11:778-785.
133. McGehee RE, Ronis MJJ, Badger TM (1997) Regulation of the Hepatic CYP2E1 gene during chronic alcohol exposure: Lack of an ethanol response element in the proximal 5′-flanking sequence. DNA Cell Biol 16:725-736.
134. McGehee RE, Ronis MJJ, Cowherd RM, Ingelman-Sundberg M, Badger TM (1994) Characterization of cytochrome P-450 2E1 induction in a rat hepatoma FGC-4 cell model by ethanol. Biochem Pharmacol 48:1823-1833.
135. Meldolesi J (1967) On the significance of the hypertrophy of the smooth endoplasmic reticulum in liver cells after administration of drugs. Biochem Pharmacol 16:125-131.
136. Mezey E, Potter JJ, Reed WD (1973) Ethanol oxidation by a component of liver microsomes rich in cytochrome P-450. J Biol Chem 248:1183-1187.
137. Mishin V, Koivisto T, Lieber CS (1995) Respective roles of CYP2E1 and CYPA2 in chlorzoxazone and ethanol metabolism of mammalian liver microsomes. Alcohol Clin Exp Res 19:78A.
138. Mishin VM, Rosman AS, Basu P, Kessova I, Oneta CM, Lieber CS (1998) Chlorzoxazone pharmacokinetics as a marker of hepatic cytochrome P-4502E1 in humans. Am J Gastroenterol 93:2154-2161.
139. Mishra L, Sharma S, Potter JJ, Mezey E (1989) More rapid elimination of alcohol in women as compared to their male siblings. Alcohol Clin Exp Res 13:752-754.
140. Miwa GT, Levin W, Thomas PE, Lu AYH (1978) The direct oxidation of ethanol by a catalase- and alcohol dehydrogenase-free reconstituted system containing cytochrome P-450. Arch Biochem Biophys 187:464-475.
141. Morimoto M, Hagbjork AL, Nanji AA, Ingelman-Sundberg M, Lindros KO, Fu PC, Albano E, French SW (1993) Role of cytochrome P-450 2E1 in alcoholic liver disease pathogenesis. Alcohol 10:459-464.
142. Morimoto M, Hagbjork AL, Wan YJY, Fu PC, Clot P, Albano E, Ingelman-Sundberg M, French SW (1995) Modulation of experimental alcohol-induced liver disease by cytochrome P-450 2E1 inhibitors. Hepatology 21:1610-1617.
143. Nakajima T, Okino T, Sato A (1987) Kinetic studies on benzene metabolism in rat liver - possible presence of three forms of benzene metabolizing enzymes in the liver. Biochem Pharmacol 36:2799-2804.
144. Nanajima T, Ikatsu H, Okin T, Wang RS, Murayama N, Yonekura I, Sato A (1992) Enhancement of ethanol-induced lipid peroxidatioh in rat liver by lowered carbohydrate intake. Biochem Pharmacol 43:245-250.
145. Nanji AA, French SW (1989) Dietary linoleic acid is required for development of experimentally induced alcoholic liver injury. Life Sci 44: 223-227.
146. Nanji AA, Mendenhall CL, French SW (1989) Beef fat prevents alcoholic liver disease in the rat. Alcohol Clin Exp Res 13:15-19.
147. Navder K, Baraona E, Lieber CS (1997a) Polyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats. J Nutr 127:1800-1806.
148. Navder K, Baraona E, Lieber CS (1997b) Polyenylphosphatidylcholine decreases alcoholic hyperlipemia without affecting the alcohol-induced rise of HDL-cholesterol. Life Sci 61:1907-1914.
149. Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Fetereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O, Okuda K, Nebert DW (1993) The P-450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol 12:1-51.
150. Nomura F, Lieber CS (1981) Binding of acetaldehyde to rat liver microsomes: Enhancement after chronic alcohol consumption. Biochem Biophys Res Commun 100:131-137.
151. Nordmann R, Rouach H (1995) Alcool et radicaux libres: De la recherche fondamentale aux espoirs cliniques. Bull Acad Natl Med 179:1839-1853.
152. Norton ID, Apte MV, Haber PS, McCaughan GW, Pirola RC, Wilson JS (1998) Cytochrome P-450 2E1 is present in rat pancreas is induced by chronic ethanol administration. Gut 42:426-430.
153. Ohnishi K, Lieber CS (1977) Reconstitution of the microsomal ethanoloxidizing system: Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption. J Biol Chem 252:7124-7131.
154. Ohnishi K, Lieber CS (1978) Respective role of superoxide and hydroxyl radical in the activity of the reconstituted microsomal ethanol-oxidizing system. Arch Biochem Biophys 191:798-803.
155. Oinonen T, Mode A, Lobie PE, Lindros KO (1996) Zonation of cytochrome P-450 enzyme expression in rat liver: Isozyme-specific regulation by pituitary dependent hormones. Biochem Pharmacol 51:1379-1387.
156. Owen OE, Trapp VE, Skutches CL, Mozzoli MA, Hoieldtke RD, Boden G, Reichard GA Jr (1982) Acetone metabolism during diabetic keto-acidosis. Diabetes 31:242-248.
157. Peng HM, Coon MJ (1998) Regulation of rabbit cytochrome P-450 2E1 expression in HepG2 cells by insulin and thyroid hormone. Mol Pharmacol 54:740-747.
158. Persson I, Johansson I, Bergling H, Dahl ML, Seidegard J, Rylander R, Rannug A, Haberg J, Sundberg H (1993) Genetic polymorphism of cytochrome P-4502E1 in a Swedish population: Relation ship to incidence of lung cancer. FEBS Lett 319:207-211.
159. Peter R, Bocker R, Beaune PH, Iwasaki N, Guengerich FP, Yang CS (1990) Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-45011E1. Chem Res Toxicol 3:566-573.
160. Pirmohamed M, Kitteringham NR, Quest LJ, Allott RL, Green VJ, Gilmore IT, Park BK (1995) Genetic polymorphism of cytochrome P-4502E1 and risk of alcoholic liver disease in Caucasians. Pharmacogenetics 5:351-357.
161. Pirola RC, Lieber CS (1972) The energy cost of the metabolics of drugs, including ethanol. Pharmacology 7:185-196.
162. Porter TD, Khani SC, Coon MJ (1989) Induction and tissue-specific expression of rabbit cytochrome P-450IIE1 and IIE2 genes. Mol Pharmacol 36:61-65.
163. Powell H, Kitteringham NR, Pirmohamed M, Smith DA, Park BK (1998) Expression of cytochrome P-4502E1 in human liver: Assessment by MRNA, genotype and phenotype. Pharmacogenetics 8:411-421.
164. Rannug A, Alexandrie AK, Persson I, Ingelman-Sundberg M (1995) Genetic polymorphism of cytochromes P-450 1A1, 2D6 and 2E1: Regulation and texicological significance. J Occup Environ Med 37:25-36.
165. Rashba-Step J, Turro NJ, Cederbaum AI (1993) Increased NADPH- and NADH- dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol consumption. Arch Biochem Biophys 300:401-408.
166. Raucy JL, Lasker JM, Kramer JC, Salazer DE, Lieber CS, Corcoran GB (1991) Induction of P-450IIE1 in the obese rat. Mol Pharmacol 39:275-280.
167. Reichard GA Jr, Haff AC, Skutches CL, Paul P, Holroyde CP, Owen OE (1979) Plasma acetone metabolism in the fasting human. J Clin Invest 63:619-626.
168. Reichard GA Jr, Skutches CL, Hoeldke RD, Owen OW (1986) Acetone metabolism in humans during diabetic ketoacidosis. Diabetes 35:668-674.
169. Roach MK, Reese WN Jr, Creaven PJ (1969) Ethanol oxidation in the microsomal fraction of rat liver. Biochem Biophys Res Commun 36: 596-602.
170. Roberts BJ, Song B-J, Soh Y, Park SS, Shoaf SE (1995) Ethanol induces CYP2E1 by protein stabilization. J Biol Chem 270:29632-29635.
171. Ronis MJ, Huang J, Crouch J, Mercado C, Irby D, Valentine CR, Lumpkin CK, Ingelman-Sundberg M, Badger TM (1993) Cytochrome P-450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentration in rats. J Pharmacol Exp Ther 264:944-950.
172. Ross AD, Varghese G, Oporto B, Carmichael FJ, Israel Y (1995) Effect of propylthiouracil treatment on NADPH-cytochrome P-450 reductase levels, oxygen consumption and hydroxyl radical formation in liver microsomes from rats fed ethanol or acetone chronically. Biochem Pharmacol 49:979-989.
173. Ryan DE, Koop DR, Thomas PE, Coon MJ, Levin W (1986) Evidence that isoniazid and ethanol induce the same microsomal cytochrome P-450 isozyme 3a. Arch Biochem Biophys 246:633-644.
174. Ryan DE, Ramanthan L, Iida S, Thomas PE, Haniu M, Shively JE, Lieber CS, Levin, W (1985) Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid. J Biol Chem 260: 6385-6393.
175. Salaspuro MP, Lieber CS (1978) Nonuniformity of blood ethanol elimination: Its exaggeration after chronic consumption. Ann Clin Res 10: 294-297.
176. Salazar DE, Sorge CL, Corcoran GB (1988) Obesity as a risk factor for drug-induced organ injury: VI. Increased hepatic P-450 concentration and microsomal ethanol oxidizing activity in the obese overfed rat. Biochem Biophys Res Commun 157:315-320.
177. Salmela KS, Kessova IG, Tsyrlov IB, Lieber CS (1998) Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system. Alcohol Clin Exp Res 22:2125-2132.
178. Sampol E, Mirrione A, Villard PH, Piccerelle P, Scoma H, Berbis P, Barra Y, Durand A, Lacarelle B (1997) Evidence for a tissue-specific induction of cutaneous CYP2E1 by dexamethasone. Biochem Biophys Res Commun 235:557-561.
179. Sato C, Matsuda Y, Lieber CS (1981) Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat. Gastroenterology 80:140-148.
180. Schmalix WA, Barrenscheen N, Landsiedel R, Janzowski C, Eisenbrand G, Gonzalez F, Eliasson B, Ingelman-Sundberg M, Perchermeier M, Greim H (1995) Stable expression of human cytochrome P-450 2E1 in V79 Chinese hamster cells. Eur J Pharmacol 293:123-131.
181. Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E, Benjamin SB (1986) Acetaminophen hepatotoxicity in alcoholics. Ann Intern Med 104:399-404.
182. Seitz HK, Czygan P, Waldherr K, Veith S, Kommerell B (1985) Ethanol and intestinal carcinogenesis in the rat. Alcohol 2:491-494.
183. Seitz HK, Garro AJ, Lieber CS (1981) Enhanced pulmonary and intestinal activation of procarcinogens and mutagens after chronic ethanol consumption in the rat. Eur J Clin Invest 11:33-38.
184. Seree EM, Villard PH, Re JL, De Meo M, Lacarelle B, Attolini L, Dumenil G, Catalin J, Durand A, Barra Y (1996) High inducibility of mouse renal CYP2E1 gene by tobacco smoke and its possible effect on DNA single strand breaks. Biochem Biophys Res Commun 219:429-434.
185. Shevchuk O, Baraona E, Ma XL, Pignon JP, Lieber CS (1991) Gender differences in the response of hepatic fatty acids and cytosolic fatty acid-binding capacity to alcohol consumption in rats. Proc Soc Exp Biol Med 198:584-590.
186. Shimizu M, Lasker JM, Tsutsumi M, Lieber CS (1990) Immunohistochemical localization of ethanol-inducible P-450IIE1 in the rat alimentary tract. Gastroenterology 99:1044-1053.
187. Shimojo N, Ishizaki T, Imaoka S, Funae Y, Fujii S, Okuda K (1993) Changes in amounts of cytochrome P-450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozocin-induced diabetes. Biochem Pharmacol 46:621-627.
188. Siegers CP, Heidbuchel K, Younes M (1983) Influence of alcohol, dithiocarb and (+)-catechin on the hepatotoxicity and metabolism of vinylidene chloride in rats. J Appl Toxicol 3:90-95.
189. Sippel H, Oinonenn, Lindros KO (1998) Chronic low-carbohydrate ethanol diet: Further depletion of glutathione peroxidase activity in the centrilobular liver region. Alcohol Clin Exp Res 22:171A.
190. Slater TF (1984) Free-radical mechanisms in tissue injury. Biochem J 222:1-15.
191. Sohda T, Shimizu M, Okumura M (1992) Distribution in pancreas of ethanol-inducible P-4502E1 in rats fed ethanol plus high fat or low fat diet. Alc Metab Liver 1:110-113.
192. Song BJ, Gelboin HV, Park SS, Yang CS, Gonzalez FJ (1986) Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s: Transcriptional and posttranscriptional regulation of the rat enzyme. J Biol Chem 261:16689.
193. Song BJ, Matsunaga T, Hardwick J, Park SS, Veech RI, Yang CS, Gelboin HV, Gonzalez FJ (1987) Stabilization of cytochrome P-450j messenger ribonucleic acid in the diabetic rat. Mol Endocrinol 1:542-547.
194. Song BJ, Veech RI, Park SS, Gelboin HV, Gonzalez FJ (1989) Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization. J Biol Chem 264:3568.
195. Song BJ, Veech RL, Saenger P (1990) Cytochrome P-450IIE1 is elevated in lymphocytes from poorly controlled insulin-dependent diabetics. J Clin Endocrinol Metabol 71:1036-1040.
196. Sorensen TIA, Orholm M, Bentsen KD, Hoybye G, Eghoje K, Christoffersen P (1984) Prospective evaluation of alcohol abuse and alcoholic liver injury in men as predictors of development of cirrhosis. Lancet 2:241-244.
197. Speerschneider P, Dekant W (1995) Renal tumorigenicity of 1, 1-dichloroethene in mice: the role of male-specific expression of cytochrome P-450 2E1 in the renal bioactivation of 1, 1-dichloroethene. Toxicol Appl Pharmacol 130:48-56.
198. Stephens EA, Taylor JA, Kaplan N, Yang C-H, Hsieh LL, Lucier GW, Bell DA (1994) Ethnic variation in the CYP2E1 gene: Polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese. Pharmacogenetics 4:185-192.
199. Subramanian U, Ahmed AE (1995) Intestinal toxicity of acrylonitrile: In vitro metabolism by intestinal cytochrome P-450 2E1. Toxicol Appl Pharmacol 135:1-8.
200. Takagi T, Ishii H, Takahashi H, Kato S, Okuno F, Ebihara Y, Yamauchi H, Nagata Y, Tashiro M, Tsuchiya M (1983) Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: An animal model of halothane hepatitis. Pharmacol Biochem Behav 18:461-465.
201. Takahashi T, Lasker JM, Rosman AS, Lieber CS (1993) Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology 17: 236-245.
202. Tassaneeyakul W, Veronese ME, Birkett DJ, Gonzalez FJ, Miners O (1993) Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using CDNA expression and microsomal kinetic techniques. Biochem Pharmacol 46:1975-1981.
203. Tephly TR, Tinelli F, Watkins WD (1969) Alcohol metabolism: Role of microsomal oxidation in vivo. Science 166:627-628.
204. Terelius Y, Norsten-Hoog C, Cronholm T, Ingelman-Sundberg M (1991) Acetaldehyde as a substrate for ethanol-inducible cytochrome P-450 (CYP2E1). Biochem Biophys Res Commun 179:689-694.
205. Teschke R, Hasumura Y, Joly J-G, Ishii H, Lieber CS (1972) Microsomal ethanol-oxidizing system (MEOS): Purification and properties of a rat liver system free of catalase and alcohol dehydrogenase. Biochem Biophys Res Commun 49:1187-1193.
206. Teschke R, Hasumura Y, Lieber CS (1974a) Hepatic microsomal ethanol oxidizing system: Solubilization, isolation and characterization. Arch Biochem Biophys 163:404-415.
207. Teschke R, Hasumura Y, Lieber CS (1974b) NADPH dependent oxidation of methanol, ethanol, propanol and butanol by hepatic microsomes. Biochem Biophys Res Commun 60:851-857.
208. 2. Mol Pharmacol 11:841-849.
209. Teschke R, Hasumura Y, Lieber CS (1975b) Hepatic microsomal alcohol oxidizing system: Affinity for methanol, ethanol and propanol. J Biol Chem 250:7397-7404.
210. Teschke R, Matsuzaki S, Ohnishi K, DeCarli LM, Lieber CS (1977) Microsomal ethanol oxidizing system (MEOS): Current status of its characterization and its role. Alcohol Clin Exp Res 1:7-15.
211. Teschke R, Moreno F, Petrides AS (1981) Hepatic microsomal ethanol oxidizing system (MEOS): Respective roles of ethanol and carbohydrates for the enhanced activity after chronic alcohol consumption. Biochem Pharmacol 30:1745-1751.
212. Thurman RG, Brentzel HJ (1977) The role of alcohol dehydrogenase in microsomal ethanol oxidation and the adaptive increase in ethanol metabolism due to chronic treatment with ethanol. Alcohol Clin Exp Res 1:33-38.
213. Thurman RG, Ley HG, Scholz R (1972) Hepatic microsomal ethanol oxidation: Hydrogen peroxide formation and the role of catalase. Eur J Biochem 25:420-430.
214. Tindberg N, Ingelman-Sundberg M (1996) Expression, catalytic activity, and inducibility of cytochrome P-450 2E1 (CYP2E1) in the rat central nervous system. 67:2066-2073.
215. Tsukamoto H, French SW, Benson N, Delgado G, Rao GA, Larkin EC, Largman C (1985) Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology 5:224-232.
216. Tsukamoto H, Towner SJ, Ciofalo LM, French SW (1986) Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatology 6:814-822.
217. Tsutsumi M, Lasker JM, Shimizu M, Rosman AS, Lieber CS (1989) The intralobular distribution of ethanol-inducible P-450IIE1 in rat and human liver. Hepatology 10:437-446.
218. Tsutsumi M, Lasker JM, Takahashi T, Lieber CS (1993) In vivo induction of hepatic P-4502E1 by ethanol: Role of increased enzyme synthesis. Arch Biochem Biophys 304:209.
219. Tsumi M, Shimizu M, Lasker JM, Lieber, CS (1988) Intralobular distribution of ethanol-inducible cytochrome P-450IIE1 in liver. Hepatology 8:1237.
220. Tsutsumi M, Takada A, Wang JS (1994) Genetic polymorphism of cytochrome P-4502E1 related to the development of alcoholic liver disease. Gastroenterology 107:1430-1435.
221. Tsutsumi R, Leo MA, Kim C, Tsutsumi M, Lasker JM, Lowe N, Lieber CS (1990) Interaction of ethanol with enflurane metabolism and toxicity: Role of P-450IIE1. Alcohol Clin Exp Res 14:174-179.
222. Uematsu F, Ikawa S, Kikuchi H, Sagami I, Kanamara R, Abe T, Satoh K, Motomiya M, Watanabe M (1994) Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P-450IIE1) gene and susceptibility to lung cancer: Possible relevance to low smoking exposure. Pharmacogenetics 4:58-63.
223. Uematsu F, Kikuchi H, Motomiya M, Abe T, Sagami I, Ohmachi T, Wakui A, Kanamaru R, Watanabe M (1991) Association between restriction fragment length polymorphism of the human cytochrome P-450IIE1 gene and susceptibility to lung cancer. Jpn J Cancer Res 82:254-256.
224. Ueno T, Gonzalez FJ (1990) Transcriptional control of the rat hepatic CYP2E1 gene. Mol Cell Biol 10:4495-4505.
225. Vatsis KP, Schulman MP (1973) Absence of ethanol metabolism in "acatalatic" hepatic microsomes that oxidize drugs. Biochem Biophys Res Commun 52:588-594.
226. Vatsis KP, Schulman MP (1974) An unidentified constituent of ethanol oxidation in hepatic microsomes (abstract). Fed Proc 33:554.
227. Watanabe J, Hayashi S, Kawajiri K (1994) Different regulations and expression of the human CYP2E1 gene due to the Rsa I polymorphism in the 5′ flanking region. J Biochem 116:321-326.
228. Watanabe J, Yang JP, Eguchi H, Hayashi S, Imai K, Nakachi K, Kawajiri K (1995) An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population. Jpn J Cancer Res 86:245-248.
229. Weltman MD, Farrell GC, Hall P, Ingelman-Sundberg M, Liddle C (1998) Hepatic cytochrome P4502E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 27:128-133.
230. Wickramasinghe SN, Barden G, Levy L (1987) The capacity of macrophages from different murine tissues to metabolize ethanol and generate an ethanol-dependent nondialyzable cytotoxic activity in vitro. Alcohol Alcohol 22:31-39.
231. Woodcroft KJ, Novak RF (1997) Insulin effects on CYP2E1, 2B, 3A, and 4A expression in primary cultured rat hepatocytes. Chem Biol Interact 107:75-91.
232. Wrighton SA, Thomas PE, Molowa DT, Haniu M, Shively JE, Maines SL, Watkins PB, Parker G, Mendez-Picon G, Levin W, Guzelian PS (1986) Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase. Biochemistry 25:6731-6735.
233. Wu Y, Salmela K, Lieber CS (1998) Microsomal acetaldehyde oxidation is negligible in the presence of ethanol. Alcohol Clin Exp Res 22:1165-1169.
234. Yamazaki H, Guo Z, Guengerich FP (1995) Selectivity of cytochrome P-4502E1 in chlorzoxazone 6-hydroxylation. Drug Metab Dispos 23: 438-440.
235. Yang CS, Yoo J-S, Ishizaki H, Hong J (1990) Cytochrome P-450IIE1: Roles in nitrosamine metabolism and mechanisms of regulation. Drug Metab Rev 22:147-159.
236. Yonekura I, Nakano M, Sato A (1993) Effects of carbohydrate intake on the blood ethanol level and alcoholic fatty liver damage in rats. Hepatology 17:97-101.
237. Yoo J, Ning SM, Pantuck CB, Pantuck EJ, Yang CS (1991) Regulation of hepatic microsomal cytochrome P-450 2E1 level by dietary lipids and carbohydrates in rats. J Nutr 121:959-965.
238. Zangar RC, Novak RF (1997) Effects of fatty acids and ketone bodies on cytochromes P-450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes. Arch Biochem Biophys 337:217-224.
239. Zerilli A, Lucas D, Amet Y, Beauge F, Volant A, Floch HH, Berthou F, Menez JF (1995) Cytochrome P-450 2E1 in rat liver, kidney and lung microsomes after chronic administration of ethanol either orally or by inhalation. Alcohol Alcohol 30:357-365.
240. Ziegler DM (1972) Discussion in Microsomes and Drug Oxidations (Estabrook RW, Gillette RJ and Lieberman KC eds) p 458, Williams & Wilkins, Baltimore, MD.