Enteral nutrition with or without N-acetylcysteine in the treatment of severe acute alcoholic hepatitis: A randomized multicenter controlled trial

Journal of Hepatology

Volumn 53, Issue 6, 2010, Pages 1117-1122

  Moreno, Christophe ^a   Langlet, Philippe ^b   Hittelet, Axel ^a   Lasser, Luc ^b   Degré, Delphine ^a   Evrard, Sylvie ^a   Colle, Isabelle ^c   Lemmers, Arnaud ^a   Devière, Jacques ^a   Le Moine, Olivier ^a  

^a ERASME HOSPITAL   (Belgium)

^b BRUGMANN UNIVERSITY HOSPITAL   (Belgium)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Alcoholic hepatitis; Enteral nutrition; N acetylcysteine; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; LYSOMUCIL; PLACEBO; UNCLASSIFIED DRUG;

ACUTE HEPATITIS; ADULT; ALCOHOL LIVER DISEASE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG MEGADOSE; ENTERIC FEEDING; FEMALE; HEPATORENAL SYNDROME; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NUTRITIONAL SUPPORT; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

ACETYLCYSTEINE; ADULT; COMBINED MODALITY THERAPY; ENTERAL NUTRITION; FEMALE; FREE RADICAL SCAVENGERS; HEPATITIS, ALCOHOLIC; HEPATORENAL SYNDROME; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; OXIDATIVE STRESS; SINGLE-BLIND METHOD;

EID: 78049470733     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.05.030     Document Type: Article

References (43)

1. E. Mezey Treatment of alcoholic liver disease Semin Liver Dis 13 1993 210 216
2. Alcoholic liver disease: morphological manifestations. Review by an international group. Lancet 1981;1:707-711.
3. H.R. Lesesne, E.M. Bozymski, and H.J. Fallon Treatment of acute alcoholic hepatitis with encephalopathy. Comparison of prednisolone with caloric supplements Gastroenterology 74 1978 169 173
4. W. Depew, T. Boyer, M. Omata, A. Redeker, and T. Reynolds Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy Gastroenterology 78 1980 524 529
5. M.J. Ramond, T. Poynard, B. Rueff, P. Mathurin, C. Théodore, and J.C. Chaput A randomized trial of prednisolone in patients with severe alcoholic hepatitis N Engl J Med 326 1992 507 512
6. S. Tome, and M.R. Lucey Review article: current management of alcoholic liver disease Aliment Pharmacol Ther 19 2004 707 714
7. P. Mathurin, C.L. Mendenhall, R.L. Carithers Jr., M.J. Ramond, W.C. Maddrey, and P. Garstide Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH J Hepatol 36 2002 480 487
8. A. Dey, and A.I. Cederbaum Alcohol and oxidative liver injury Hepatology 43 2006 S63 S74
9. S.R. Paredes, P.A. Kozicki, H. Kukuda, M.V. Rossetti, and A.M. Batlle S-Adenosyl-l-methionine: its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication Alcohol 4 1987 81 85
10. J.C. Fernandez-Checa, M. Ookhtens, and N. Kaplowitz Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol J Clin Invest 80 1987 57 62
11. J.C. Fernandez-Checa, M. Ookhtens, and N. Kaplowitz Effect of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration J Clin Invest 83 1989 1247 1252
12. P. Peristeris, B.D. Clark, S. Gatti, R. Faggioni, A. Mantovani, and M. Mengozzi N-Acetylcysteine and glutathione as inhibitors of tumor necrosis factor production Cell Immunol 140 1992 390 399
13. B. San-Miguel, M. Alvarez, J.M. Culebras, J. González-Gallego, and M.J. Tuñón N-Acetyl-cysteine protects liver from apoptotic death in an animal model of fulminant hepatic failure Apoptosis 11 2006 1945 1957
14. S.R. DiCecco, and N. Francisco-Ziller Nutrition in alcoholic liver disease Nutr Clin Pract 21 2006 245 254
15. E. Cabré, P. Rodríguez-Iglesias, J. Caballería, J.C. Quer, J.L. Sánchez-Lombraña, and A. Parés Short- and long-term outcome of severe alcohol-induced hepatitis treated with steroids or enteral nutrition: a multicenter randomized trial Hepatology 32 2000 36 42
16. V. Arroyo, P. Gins, A.L. Gerbes, F.J. Dudley, P. Gentilini, and G. Laffi Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. International Ascites Club Hepatology 23 1996 164 176
17. H. Tsukamoto, and S.C. Lu Current concepts in the pathogenesis of alcoholic liver injury FASEB J 15 2001 1335 1345
18. G.E. Arteel Oxidants and antioxidants in alcohol-induced liver disease Gastroenterology 124 2003 778 790
19. A.I. Cederbaum Introduction-serial review: alcohol, oxidative stress and cell injury Free Radic Biol Med 31 2001 1524 1526
20. H. Ishii, I. Kurose, and S. Kato Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress J Gastroenterol Hepatol 12 1997 S272 S282
21. N.R. Di Luzio, and A.D. Hartman Role of lipid peroxidation in the pathogenesis of the ethanol-induced fatty liver Fed Proc 26 1967 1436 1442
22. C. Garcia-Ruiz, A. Morales, A. Ballesta, J. Rodes, N. Kaplowitz, and J.C. Fernandez-Checa Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes J Clin Invest 94 1994 193 201
23. A. Colell, C. Garcia-Ruiz, M. Miranda, E. Ardite, M. Mari, and A. Morales Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor Gastroenterology 115 1998 1541 1551
24. A.A. Nanji, E.K. Yang, F. Fogt, S.M. Sadrzadeh, and A.J. Dannenberg Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease J Pharmacol Exp Ther 277 1996 1694 1700
25. Y. Iimuro, B.U. Bradford, and S. Yamashina The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat Hepatology 31 2000 391 398
26. M.D. Wheeler, H. Kono, and M. Yin Delivery of the Cu/Zn superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats Gastroenterology 120 2001 1241 1250
27. M. Phillips, H. Curtis, B. Portmann, N. Donaldson, A. Bomford, and J. O'Grady Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis - a randomized clinical trial J Hepatol 44 2006 784 790
28. E. Mezey, J.J. Potter, L. Rennie-Tankersley, J. Caballeria, and A. Pares A randomized placebo controlled trial of vitamin E for alcoholic hepatitis J Hepatol 40 2004 40 46
29. S. Stewart, M. Prince, M. Bassendine, M. Hudson, O. James, and D. Jones A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis J Hepatol 47 2007 277 283
30. S.W. French, and H. Tsukamoto Animal models for alcoholic liver disease Hepatology 10 1989 898 899
31. T. Gustot, A. Lemmers, C. Moreno, N. Nagy, E. Quertinmont, and C. Nicaise Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver Hepatology 43 2006 989 1000
32. C.S. Lieber, and L.M. DeCarli Alcoholic liver injury: experimental models in rats and baboons Adv Exp Med Biol 59 1975 379 393
33. S. Naveau, S. Chollet-Martin, S. Dharancy, P. Mathurin, P. Jouet, and M.A. Piquet Foie-Alcool group of the Association Franaise pour l'Etude du Foie. A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis Hepatology 39 2004 1390 1397
34. N.C. Boetticher, C.J. Peine, P. Kwo, G.A. Abrams, T. Patel, and B. Aqel A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis Gastroenterology 135 2008 1953 1960
35. L. Spahr, L. Rubbia-Brandt, J.L. Frossard, E. Giostra, A.L. Rougemont, and J. Pugin Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study J Hepatol 37 2002 448 455
36. C.J. McClain, and D.A. Cohen Increased tumor necrosis factor production by monocytes in alcoholic hepatitis Hepatology 9 1989 349 351
37. M. Yin, M.D. Wheeler, H. Kono, B.U. Bradford, R.M. Gallucci, and M.I. Luster Essential role of tumor necrosis alpha in alcohol-induced liver injury in mice Gastroenterology 117 1999 942 952
38. A. Colell, C. García-Ruiz, A. Morales, A. Ballesta, M. Ookhtens, and J. Rodés Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-l-methionine Hepatology 26 1997 699 708
39. P. Mathurin, M. Abdelnour, M.J. Ramond, N. carbonell, L. Fartoux, and L. Serfaty Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone Hepatology 38 2003 1363 1369
40. S. Holt, D. Goodier, R. Marley, D. Patch, A. Burroughs, and B. Fernando Improvement in renal function in hepatorenal syndrome with N-acetylcysteine Lancet 353 1999 294 295
41. E. Nguyen-Khac, T. Thevenot, M.A. Piquet, D. Chatelain, B. Tramier, and F. Dewael Treatment of severe acute alcoholic hepatitis (AAH) with corticoids plus N-acetyl cysteine (C-NAC) versus corticoids (C): planed interim analysis of a multicentre, controlled, randomized trial J Hepatol 48 2008 A38
42. E. Akriviadis, R. Botla, W. Briggs, S. Han, T. Reynolds, and O. Shakil Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial Gastroenterology 119 2000 1637 1648
43. A. Louvet, S. Naveau, M. Abdelnour, M.J. Ramond, E. Diaz, and L. Fartoux The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids Hepatology 45 2007 1348 1354