Alcohol and lipid metabolism

Journal of Gastroenterology and Hepatology (Australia)

Volumn 21, Issue SUPPL. 3, 2006, Pages

  Crabb, David W ^a,c   Liangpunsakul, Suthat ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RICHARD L ROUDEBUSH VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c Emerson Hall ^*  (United States)

Author keywords

Ethanol; Fatty liver; Kinase; Transcription factor

Indexed keywords

4 METHYLPYRAZOLE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETALDEHYDE; ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A OXIDASE; ADENOSINE MONOPHOSPHATE DEPENDENT PROTEIN KINASE; ADENYLATE KINASE; ALCOHOL; ALCOHOL DEHYDROGENASE; APOLIPOPROTEIN B; CARNITINE PALMITOYLTRANSFERASE; CHOLESTEROL; CYCLOOXYGENASE 2; FATTY ACID; FATTY ACID BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIRINIXIC ACID; PROTEIN KINASE; RETINOID X RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; TUBERIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALCOHOL METABOLISM; ALCOHOLIC FATTY LIVER; CHOLESTEROL SYNTHESIS; CONFERENCE PAPER; ENZYME INHIBITION; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; GENE ACTIVATION; GLYCOLYSIS; HEPATOMA CELL; IN VIVO STUDY; KNOCKOUT MOUSE; LIPID METABOLISM; LIVER CELL CULTURE; METABOLIC REGULATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SYSTEMATIC REVIEW;

EID: 33747626296     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2006.04582.x     Document Type: Conference Paper

References (41)

1. Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990; 347: 645-50.
2. Bocos C, Gottlicher M, Gearing K et al. Fatty acid activation of peroxisome proliferator-activated receptor (PPAR). J. Steroid Biochem. Mol. Biol. 1995; 53: 1-6.
3. Lee CH, Olson P, Evans RM. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 2003; 144: 2201-7.
4. Aoyama T, Peters JM, Iritani N et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα). J. Biol. Chem. 1998; 273: 5678-84.
5. Costet P, Legendre C, More J, Edgar A, Galtier P, Pineau T. Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J. Biol. Chem. 1998; 273: 29 577-85.
6. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J. Clin. Invest. 1999; 103: 1489-98.
7. Ip E, Farrell GC, Robertson G, Hall P, Kirsch R, Leclercq I. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Hepatology 2003; 38: 123-32.
8. Ma X, Baraona E, Lieber CS. Alcohol consumption enhances fatty acid omega-oxidation, with a greater increase in male than in female rats. Hepatology 1993; 18: 1247-53.
9. Pignon JP, Bailey NC, Baraona E, Lieber CS. Fatty acid-binding protein: a major contributor to the ethanol-induced increase in liver cytosolic proteins in the rat. Hepatology 1987; 7: 865-71.
10. Everett L, Galli A, Crabb D. The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease. Liver 2000; 20: 191-9.
11. Rabinowitz JL, Staeffen J, Hall CL, Brand JG. A probable defect in the beta-oxidation of lipids in rats fed alcohol for 6 months. Alcohol 1991; 8: 241-6.
12. Wan YY, Cai Y, Li J et al. Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice. Hepatol. Res. 2000; 19: 117-30.
13. Nakajima T, Kamijo Y, Tanaka N et al. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Hepatology 2004; 40: 972-80.
14. Galli A, Pinaire J, Fischer M, Dorris R, Crabb DW. The transcriptional activation of peroxisome proliferator-activated receptor α is inhibited by ethanol metabolism: novel mechanism for the development of ethanol-induced fatty liver. J. Biol. Chem. 2001; 276: 68-7.
15. Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. The acute phase response is associated with retinoid X receptor repression in rodent liver. J. Biol. Chem. 2000; 275: 16 390-9.
16. Fischer M, You M, Matsumoto M, Crabb DW. Peroxisome proliferator- activated receptor alpha (PPARα) agonist treatment reverses PPARα dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J. Biol. Chem. 2003; 278: 27 997-8004.
17. Spritz N, Lieber CS. Decrease of ethanol-induced fatty liver by ethyl alpha-p-chlorophenoxyisobutyrate. P. Soc. Exp. Biol. Med. 1966; 121: 147-9.
18. Tsutsumi A, Takase S. Effect of fenofibrate on fatty liver in rats treated with alcohol. Alcohol. Clin. Exp. Res. 2001; 25: 75S-9S.
19. Sugimoto T, Yamashita S, Ishigami M et al. Decreased microsomal triglyceride transfer protein activity contributes to initiation of alcoholic liver steatosis in rats. J. Hepatol. 2002; 36: 157-62.
20. Ameen C, Edvardsson U, Ljungberg A et al. Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver. J. Biol. Chem. 2005; 280: 1224-9.
21. Nanji AA, Dannenberg AJ, Jokelainen K, Bass NM. Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation. J. Pharmacol. Exp. Ther. 2004; 310: 417-24.
22. Lieber CS, Spritz N, DeCarli LM. Role of dietary, adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver. J. Clin. Invest. 1966; 45: 51-62.
23. Siler SQ, Neese RA, Hellerstein MK. De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption. Am. J. Clin. Nutr. 1999; 70: 928-36.
24. Carrasco MP, Marco C, Segovia JL. Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes. Life Sci. 2001; 68: 1295-304.
25. Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Invest. 1997; 99: 838-45.
26. Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 2002; 109: 1125-31.
27. Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J. Clin. Invest. 1996; 98: 1575-84.
28. You M, Fischer M, Deeg MA, Crabb DW. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J. Biol. Chem. 2002; 277: 29 342-2947.
29. Lluis JM, Colell A, Garcia-Ruiz C, Kaplowitz N, Fernandez-Checa JC. Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology 2003; 124: 708-24.
30. Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 2003; 124: 1488-99.
31. You M, Matsumoto M, Pacold CM, Cho WK, Crabb DW. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 2004; 127: 1798-808.
32. Lin HZ, Yang SQ, Chuckaree C, Kuhajda F, Ronnet G, Diehl AM. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat. Med. 2000; 6: 998-1003.
33. Zhou G, Myers R, Li Y et al. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 2001; 108: 1167-74.
34. Galli A, Price D, Crabb D. High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells. Hepatology 1999; 29: 1164-70.
35. Wan YJ, Morimoto M, Thurman RG, Bojes HK, French SW. Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease. Life Sci. 1995; 56: 307-17.
36. Juge-Aubry CE, Hammar E, Siegrist-Kaiser C et al. Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain. J. Biol. Chem. 1999; 274: 10 505-10.
37. Lazennec G, Canaple L, Saugy D, Wahli W. Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. Mol. Endocrinol. 2000; 14: 1962-75.
38. Munday MR, Hemingway CJ. The regulation of acetyl-CoA carboxylase: a potential target for the action of hypolipidemic agents. Adv. Enzyme Regul. 1999; 39: 205-34.
39. Lu SC, Tsukamoto H, Mato JM. Role of abnormal methionine metabolism in alcoholic liver injury. Alcohol 2002; 27: 155-62.
40. Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 2003; 112: 91-100.
41. Yamauchi T, Kamon J, Minokoshi Y et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 2002; 8: 1288-95.