Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease

American Journal of Pathology

Volumn 163, Issue 4, 2003, Pages 1301-1311

  Roskams, Tania ^a   Yang, Shi Qi ^b   Koteish, Aymen ^b   Durnez, Anne ^a   DeVos, Rita ^a   Huang, Xiawen ^b   Achten, Ruth ^a   Verslype, Chris ^a   Diehl, Anna Mae ^b,c  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE;

ALCOHOL LIVER CIRRHOSIS; ANIMAL CELL; ARTICLE; CANCER RISK; CELL ACTIVATION; CELL COUNT; CELL CYCLE; CELL PROLIFERATION; CELL REGENERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FATTY LIVER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; MALE; MITOSIS INHIBITION; NONHUMAN; OVAL CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; STEM CELL;

EID: 0042033294     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63489-X     Document Type: Article

References (37)

1. Thorgeirsson SS, Factor VM, Snyderwine EG: Transgenic mouse models in carcinogenesis research and testing. Toxicol Lett 2000, 112-113:553-555
2. Evarts RP, Nagy P, Marsden E, Thorgeirsson SS: A precursor-product relationship exists between oval cells and hepatocytes in rat liver. Carcinogenesis 1987, 8:1737-1740
3. Sell S, Dunsford HA: Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma. Am J Pathol 1989, 134:1347-1363
4. Libbrecht L, Meerman L, Kuipers F, Roskams T, Desmet V, Jansen P: Liver pathology and hepatocarcinogenesis in a long-term mouse model of erythropoietic protoporphyria. J Pathol 2003, 199:191-200
5. Hsia CC, Evarts RP, Nakatsukasa H, Marsden ER, Thorgeirsson SS: Occurrence of oval-type cells in hepatitis B virus-associated human hepatocarcinogenesis. Hepatology 1992, 16:1327-1333
6. Ruck P, Xiao JC, Pietsch T, Von Schweinitz D, Kaiserling E: Hepatic stem-like cells in hepatoblastoma: expression of cytokeratin 7, albumin and oval cell associated antigens detected by OV-1 and OV-6. Histopathology 1997, 31:324-329
7. Roskams T, De Vos R, Van Eyken P, Myazaki H, Van Damme B, Desmet V: Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man. J Hepatol 1998, 29:455-463
8. Crosby HA, Hubscher S, Fabris L, Joplin R, Sell S, Kelly D, Strain AJ: Immunocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6. Am J Pathol 1998, 152:771-779
9. Libbrecht L, Desmet V, Van Damme B, Roskams T: Deep intralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: can 'progenitor cells' migrate? J Pathol 2000, 192:373-378
10. Libbrecht L, Desmet V, Van Damme B, Roskams T: The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells. J Hepatol 2000, 33:76-84
11. Ohlson LC, Koroxenidou L, Hallstrom IP: Inhibition of in vivo rat liver regeneration by 2-acetylaminofluorene affects the regulation of cell cycle-related proteins. Hepatology 1998, 27:691-696
12. Lindeman B, Skarpen E, Oksvold MP, Huitfeldt HS: The carcinogen 2-acetylaminofluorene inhibits activation and nuclear, accumulation of cyclin-dependent kinase 2 in growth-induced rat liver. Mol Carcinog 2000, 27:190-199
13. Mehta K, Van Thiel DH, Shah N, Mobarhan S: Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants. Nutr Rev 2002, 60:289-293
14. Tsukamoto H, Lu SC: Current concepts in the pathogenesis of alcoholic liver injury. FASEB J 2001, 15:1335-1349
15. Crary GS, Albrecht JH: Expression of cyclin-dependent kinase inhibitor p21 in human liver. Hepatology 1998, 28:738-743
16. Wands JR, Carter EA, Bucher NL, Isselbacher KJ: Inhibition of hepatic regeneration in rats by acute and chronic ethanol intoxication. Gastroenterology 1979, 77:528-531
17. Selzner M, Clavien PA: Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway. Hepatology 2000, 31:35-42
18. Yang SQ, Lin HZ, Mandal AK, Huang J, Diehl AM: Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. Hepatology 2001, 34:694-706
19. Tarsetti F, Lenzi R, Salvi R, Schuler E, Rijhsinghani K, Lenzen R, Tavoloni N: Liver carcinogenesis associated with feeding of ethionine in a choline-free diet: evidence against a role of oval cells in the emergence of hepatocellular carcinoma. Hepatology 1993, 18:596-603
20. Dragani TA, Manenti G, Galliani G, Della Porta G: Promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in mouse hepatocarcinogenesis. Carcinogenesis 1985, 6:225-228
21. Higgins G, Andersen R: Experimental pathology of liver: restoration of liver of white rat following partial surgical removal. Arch Pathol 1931, 12:186-202
22. Lee FY, Li Y, Zhu H, Yang S, Lin HZ, Trush M, Diehl AM: Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver. Hepatology 1999, 29:677-687
23. Akhurst B, Croager EJ, Farley-Roche CA, Ong JK, Dumble ML, Knight B, Yeoh GC: A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver. Hepatology 2001, 34:519-522
24. Sell S: Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of liver injury. Hepatology 1998, 27:317-331
25. Yang S, Zhu H, Li Y, Lin H, Gabrielson K, Trush MA, Diehl AM: Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophys 2000, 378:259-268
26. Hissin PJ, Hilf R: A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 1976, 74:214-226
27. Flohe L, Otting F: Superoxide dismutase assays. Methods Enzymol 1984, 105:93-104
28. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR: Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999, 94:2467-2474
29. Roskams T, Desmet V: Ductular reaction and its diagnostic significance. Semin Diagn Pathol 1998, 15:259-269
30. Koteish A, Yang S, Lin H, Huang, Diehl AM: Ethanol induces redox-sensitive cell-cycle inhibitors and inhibits liver regeneration after partial hepatectomy. Alcohol Clin Exp Res 2002, 26:1710-1718
31. Lowes KN, Brennan BA, Yeoh GC, Olynyk JK: Oval cell numbers in human chronic liver diseases are directly related to disease severity. Am J Pathol 1999, 154:537-541
32. French SW, Ruebner BH, Mezey E, Tamura T, Halsted CH: Effect of chronic ethanol feeding on hepatic mitochondria in the monkey. Hepatology 1983, 3:34-40
33. Yeldandi AV, Rao MS, Reddy JK: Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis. Mutat Res 2000, 448:159-177
34. Torbenson M, Yang SQ, Liu HZ, Huang J, Gage W, Diehl AM: STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers. Am J Pathol 2002, 161:155-161
35. De Vos R, Desmet V: Ultrastructural characteristics of novel epithelial cell types identified in human pathological liver specimens with chronic ductular reaction. Am J Pathol 1992, 140:1441-1450
36. Ros J, Libbrecht L, Geuken M, Jansen P, Roskams T: High expression of MDR1, MRP1 and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver disease. J Pathol 2003, 200:553-560
37. Renes J, de Vries EE, Hooiveld GJ, Krikken I, Jansen PL, Muller M: Multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation product 4-hydroxynonenal. Biochem J 2000, 350:555-561