Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: A critical role for IL-6/STAT3

Hepatology

Volumn 61, Issue 2, 2015, Pages 692-702

  Xu, Ming Jiang ^a,b   Feng, Dechun ^a   Wu, Hailong ^c   Wang, Hua ^a   Chan, Yvonne ^d   Kolls, Jay ^e   Borregaard, Niels ^f   Porse, Bo ^g,h,i   Berger, Thorsten ^j   Mak, Tak W ^j   Cowland, Jack B ^f   Kong, Xiaoni ^a,c,k   Gao, Bin ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^f Rigshospitalet   (Denmark)

^g UNIVERSITY OF COPENHAGEN   (Denmark)

^h UNIVERSITY OF COPENHAGEN   (Denmark)

ⁱ University of Copenhagen   (Denmark)

^j PRINCESS MARGARET HOSPITAL   (Canada)

^k SHANGHAI JIAO TONG UNIVERSITY   (China)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; STAT3 PROTEIN; ACUTE PHASE PROTEIN; LCN2 PROTEIN, MOUSE; LIPOCALIN; ONCOPROTEIN; STAT3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; BACTERIAL LOAD; BACTERIAL TRANSLOCATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ESCHERICHIA COLI INFECTION; GENE EXPRESSION; INFECTION SENSITIVITY; INTESTINE; KLEBSIELLA PNEUMONIAE INFECTION; LIVER; LIVER CELL; LIVER REGENERATION; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; ANIMAL; BLOOD; C57BL MOUSE; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; LIVER RESECTION; METABOLISM; SECRETION (PROCESS);

ACUTE-PHASE PROTEINS; ANIMALS; BACTERIAL INFECTIONS; ESCHERICHIA COLI; HEPATECTOMY; HEPATOCYTES; INTERLEUKIN-6; KLEBSIELLA PNEUMONIAE; LIPOCALINS; LIVER REGENERATION; MICE, INBRED C57BL; ONCOGENE PROTEINS; RECEPTORS, INTERLEUKIN-6; STAT3 TRANSCRIPTION FACTOR;

EID: 84921509612     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27447     Document Type: Article

References (35)

1. Gao B, Jeong WI, Tian Z. Liver: an organ with predominant innate immunity. Hepatology 2008;47:729-736.
2. Cowland JB, Borregaard N. Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics 1997;45:17-23.
3. Wu H, Santoni-Rugiu E, Ralfkiaer E, Porse BT, Moser C, Høiby N, et al. Lipocalin 2 is protective against E. coli pneumonia. Respir Res 2010;11:96.
4. Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 1993;268:10425-10432.
5. Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. Biochim Biophys Acta 2012;1826:129-169.
6. Zhao P, Elks CM, Stephens JM. The induction of lipocalin-2 expression in vivo and in vitro. J Biol Chem 2014.
7. Li C, Chan YR. Lipocalin 2 regulation and its complex role in inflammation and cancer. Cytokine 2011;56:435-441.
8. Sultan S, Pascucci M, Ahmad S, Malik IA, Bianchi A, Ramadori P, et al. Lipocalin-2 is a major acute-phase protein in a rat and mouse model of sterile abscess. Shock 2012;37:191-196.
9. Warszawska JM, Gawish R, Sharif O, Sigel S, Doninger B, Lakovits K, et al. Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest 2013.
10. Zhao P, Stephens JM. STAT1, NF-kappaB and ERKs play a role in the induction of lipocalin-2 expression in adipocytes. Mol Metab 2013;2:161-170.
11. Cowland JB, Muta T, Borregaard N. IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta. J Immunol 2006;176:5559-5566.
12. Goetz DH, Holmes MA, Borregaard N, Bluhm ME, Raymond KN, Strong RK. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 2002;10:1033-1043.
13. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004;432:917-921.
14. Berger T, Togawa A, Duncan GS, Elia AJ, You-Ten A, Wakeham A, et al. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci U S A 2006;103:1834-1839.
15. Chan YR, Liu JS, Pociask DA, Zheng M, Mietzner TA, Berger T, et al. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol 2009;182:4947-4956.
16. Wang YP, Yu GR, Lee MJ, Lee SY, Chu IS, Leem SH, et al. Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular carcinoma through the epidermal growth factor (TGF-beta1)/Lcn2/Twist1 pathway. Hepatology 2013;58:1349-1361.
17. Zhang Y, Foncea R, Deis JA, Guo H, Bernlohr DA, Chen X. Lipocalin 2 expression and secretion is highly regulated by metabolic stress, cytokines, and nutrients in adipocytes. PLoS One 2014;9:e96997.
18. Belcher JM, Sanyal AJ, Peixoto AJ, Perazella MA, Lim J, Thiessen-Philbrook H, et al. Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology 2014;60:622-632.
19. Guo H, Bazuine M, Jin D, Huang MM, Cushman SW, Chen X. Evidence for the regulatory role of lipocalin 2 in high-fat diet-induced adipose tissue remodeling in male mice. Endocrinology 2013;154:3525-3538.
20. Klausen P, Niemann CU, Cowland JB, Krabbe K, Borregaard N. On mouse and man: neutrophil gelatinase associated lipocalin is not involved in apoptosis or acute response. Eur J Haematol 2005;75:332-340.
21. Cramer EP, Glenthoj A, Hager M, Juncker-Jensen A, Engelholm LH, Santoni-Rugiu E, et al. No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer. PLoS One 2012;7:e39646.
22. Lai HS, Wu YM, Lai SL, Lin WH. Lipocalin-2 gene expression during liver regeneration after partial hepatectomy in rats. Int J Surg 2013;11:314-318.
23. Zhang J, Wu Y, Zhang Y, Leroith D, Bernlohr DA, Chen X. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol 2008;22:1416-1426.
24. Horiguchi N, Wang L, Mukhopadhyay P, Park O, Jeong WI, Lafdil F, et al. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 2008;134:1148-1158.
25. Yin S, Wang H, Park O, Wei W, Shen J, Gao B. Enhanced liver regeneration in IL-10-deficient mice after partial hepatectomy via stimulating inflammatory response and activating hepatocyte STAT3. Am J Pathol 2011;178:1614-1621.
26. Wang X, Andersson R, Soltesz V, Bengmark S. Bacterial translocation after major hepatectomy in patients and rats. Arch Surg 1992;127:1101-1106.
27. Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 2008;14:275-281.
28. Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA, et al. Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe 2009;5:476-486.
29. Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, et al. Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest 2012;122:1758-1763.
30. Wang H, Lafdil F, Kong X, Gao B. Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target. Int J Biol Sci 2011;7:536-550.
31. Borkham-Kamphorst E, van de Leur E, Zimmermann HW, Karlmark KR, Tihaa L, Haas U, et al. Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis. Biochim Biophys Acta 2013;1832:660-673.
32. Srinivasan G, Aitken JD, Zhang B, Carvalho FA, Chassaing B, Shashidharamurthy R, et al. Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. J Immunol 2012;189:1911-1919.
33. Kienzl-Wagner K, Moschen AR, Geiger S, Bichler A, Aigner F, Brandacher G, et al. The role of lipocalin-2 in liver regeneration. Liver Int 2014.
34. Albrecht JH, Poon RY, Ahonen CL, Rieland BM, Deng C, Crary GS. Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver. Oncogene 1998;16:2141-2150.
35. Lehmann K, Tschuor C, Rickenbacher A, Jang JH, Oberkofler CE, Tschopp O, et al. Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regeneration. Gastroenterology 2012;143:1609-1619 e4.