Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver

Gastroenterology

Volumn 146, Issue 3, 2014, Pages 801-811

  Yin, Huquan ^a   Hu, Ming ^a   Liang, Xiaomei ^a   Ajmo, Joanne M ^a   Li, Xiaoling ^b   Bataller, Ramon ^c,d   Odena, Gemma ^c   Stevens Jr , Stanley M ^e   You, Min ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^e UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Alcoholic Fatty Liver; Inflammation; Lipid Metabolism; Signal Transduction

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; LACTIC ACID; LIPIN 1ALPHA; LIPIN 1BETA; MALONALDEHYDE; MESSENGER RNA; PROTEIN; PROTEIN SFRS10; PYRUVIC ACID; SIRTUIN 1; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT C4; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL LIVER CIRRHOSIS; ALCOHOL LIVER DISEASE; ALCOHOL METABOLISM; ALCOHOLIC FATTY LIVER; ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; ENDOPLASMIC RETICULUM STRESS; GENE DELETION; HUMAN; HUMAN TISSUE; INFLAMMATION; LIPID METABOLISM; LIPID PEROXIDATION; LIVER CELL; LIVER FIBROSIS; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA SPLICING; SIGNAL TRANSDUCTION;

ALCOHOLIC FATTY LIVER; INFLAMMATION; LIPID METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; ETHANOL; FATTY LIVER, ALCOHOLIC; HEPATOCYTES; HUMANS; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; OXIDATIVE STRESS; PHOSPHATIDATE PHOSPHATASE; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; SIRTUIN 1;

EID: 84894348922     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.11.008     Document Type: Article

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