Long-term outcome in patients with severe alcoholic hepatitis can be reliably determined using an in vitro measure of steroid sensitivity

Hepatology

Volumn 61, Issue 3, 2015, Pages 1099-1099

  Dhanda, Ashwin D ^a,b   di Mambro, Alex J ^c   Hunt, Vicky L ^b   Mccune, C Anne ^b   Dayan, Colin M ^d   Dick, Andrew D ^a   Lee, Richard W J ^a   Collins, Peter L ^b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^c GLOUCESTERSHIRE ROYAL HOSPITAL   (United Kingdom)

^d CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; PREDNISOLONE; STEROID;

ALCOHOL LIVER DISEASE; BILIRUBIN BLOOD LEVEL; BLOOD CLOTTING DISORDER; DISEASE SEVERITY; DRUG SENSITIVITY; HUMAN; IN VITRO STUDY; JAUNDICE; LETTER; LONG TERM CARE; MORTALITY; PREDICTION; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SEVERE ALCOHOLIC HEPATITIS; STEROID THERAPY; SURVIVAL; TREATMENT OUTCOME; FEMALE; HEPATITIS, ALCOHOLIC; MALE; MIDDLE AGED;

FEMALE; HEPATITIS, ALCOHOLIC; HUMANS; MALE; MIDDLE AGED; PREDNISOLONE; ROC CURVE;

EID: 84923455758     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27211     Document Type: Letter

References (3)

1. Louvet A, Naveau S, Abdelnour M, Ramond MJ, Diaz E, Fartoux L, et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology 2007;45:1348-1354.
2. di Mambro AJ, Parker R, McCune A, Gordon F, Dayan CM, Collins P. In vitro steroid resistance correlates with outcome in severe alcoholic hepatitis. Hepatology 2011;53:1316-1322.
3. Hearing SD, Norman M, Smyth C, Foy C, Dayan CM. Wide variation in lymphocyte steroid sensitivity among healthy human volunteers. J Clin Endocrinol Metab 1999;84:4149-4154.