-
1
-
-
77953229115
-
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
-
Lieber MR, (2010) The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway. Annual Review of Biochemistry 79. doi: 10.1146/annurev.biochem.052308.093131
-
(2010)
Annual Review of Biochemistry
, vol.79
-
-
Lieber, M.R.1
-
2
-
-
72949119310
-
Complex landscapes of somatic rearrangement in human breast cancer genomes
-
Stephens PJ, McBride DJ, Lin M-L, Varela I, Pleasance ED, et al. (2009) Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature 462: 1005–1010. doi: 10.1038/nature08645 20033038
-
(2009)
Nature
, vol.462
, pp. 1005-1010
-
-
Stephens, P.J.1
McBride, D.J.2
Lin, M.-L.3
Varela, I.4
Pleasance, E.D.5
-
3
-
-
84875980851
-
Microhomology-mediated mechanisms underlie non-recurrent disease-causing microdeletions of the FOXL2 gene or its regulatory domain
-
Verdin H, D′Haene B, Beysen D, Novikova Y, Menten B, et al. (2013) Microhomology-mediated mechanisms underlie non-recurrent disease-causing microdeletions of the FOXL2 gene or its regulatory domain. PLoS Genet 9: e1003358. doi: 10.1371/journal.pgen.1003358 23516377
-
(2013)
PLoS Genet
, vol.9
, pp. e1003358
-
-
Verdin, H.1
D′Haene, B.2
Beysen, D.3
Novikova, Y.4
Menten, B.5
-
4
-
-
0024397105
-
Short, direct repeats at the breakpoints of deletions of the retinoblastoma gene
-
Canning S, Dryja TP, (1989) Short, direct repeats at the breakpoints of deletions of the retinoblastoma gene. Proc Natl Acad Sci U S A 86: 5044–5048. doi: 10.1073/pnas.86.13.5044 2740342
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 5044-5048
-
-
Canning, S.1
Dryja, T.P.2
-
5
-
-
84896717088
-
Is non-homologous end-joining really an inherently error-prone process?
-
Betermier M, Bertrand P, Lopez BS, (2014) Is non-homologous end-joining really an inherently error-prone process? PLoS Genet 10: e1004086. doi: 10.1371/journal.pgen.1004086 24453986
-
(2014)
PLoS Genet
, vol.10
, pp. e1004086
-
-
Betermier, M.1
Bertrand, P.2
Lopez, B.S.3
-
6
-
-
54849404458
-
MMEJ repair of double-strand breaks (director′s cut): deleted sequences and alternative endings
-
McVey M, Lee SE, (2008) MMEJ repair of double-strand breaks (director′s cut): deleted sequences and alternative endings. Trends in Genetics 24: 529–538. doi: 10.1016/j.tig.2008.08.007 18809224
-
(2008)
Trends in Genetics
, vol.24
, pp. 529-538
-
-
McVey, M.1
Lee, S.E.2
-
7
-
-
79956215808
-
Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways
-
Mladenov E, Iliakis G, (2011) Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways. Mutat Res 711: 61–72. doi: 10.1016/j.mrfmmm.2011.02.005 21329706
-
(2011)
Mutat Res
, vol.711
, pp. 61-72
-
-
Mladenov, E.1
Iliakis, G.2
-
8
-
-
84900439412
-
Alternative end-joining pathway(s): bricolage at DNA breaks
-
Frit P, Barboule N, Yuan Y, Gomez D, Calsou P, (2014) Alternative end-joining pathway(s): bricolage at DNA breaks. DNA Repair (Amst) 17: 81–97. doi: 10.1016/j.dnarep.2014.02.007 24613763
-
(2014)
DNA Repair (Amst)
, vol.17
, pp. 81-97
-
-
Frit, P.1
Barboule, N.2
Yuan, Y.3
Gomez, D.4
Calsou, P.5
-
9
-
-
0037188898
-
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations
-
Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, et al. (2002) Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 109: 811–821. doi: 10.1016/S0092-8674(02)00770-5 12110179
-
(2002)
Cell
, vol.109
, pp. 811-821
-
-
Zhu, C.1
Mills, K.D.2
Ferguson, D.O.3
Lee, C.4
Manis, J.5
-
10
-
-
2942525595
-
Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells
-
Guirouilh-Barbat J, Huck S, Bertrand P, Pirzio L, Desmaze C, et al. (2004) Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. Mol Cell 14: 611–623. doi: 10.1016/j.molcel.2004.05.008 15175156
-
(2004)
Mol Cell
, vol.14
, pp. 611-623
-
-
Guirouilh-Barbat, J.1
Huck, S.2
Bertrand, P.3
Pirzio, L.4
Desmaze, C.5
-
11
-
-
77950462986
-
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation
-
Simsek D, Jasin M, (2010) Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation. Nat Struct Mol Biol 17: 410–416. doi: 10.1038/nsmb.1773 20208544
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 410-416
-
-
Simsek, D.1
Jasin, M.2
-
12
-
-
46249131123
-
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
-
Bennardo N, Cheng A, Huang N, Stark JM, (2008) Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair. PLoS Genet 4: e1000110. doi: 10.1371/journal.pgen.1000110 18584027
-
(2008)
PLoS Genet
, vol.4
, pp. e1000110
-
-
Bennardo, N.1
Cheng, A.2
Huang, N.3
Stark, J.M.4
-
13
-
-
0242468933
-
Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences
-
Ma JL, Kim EM, Haber JE, Lee SE, (2003) Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol Cell Biol 23: 8820–8828. doi: 10.1128/MCB.23.23.8820-8828.2003 14612421
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8820-8828
-
-
Ma, J.L.1
Kim, E.M.2
Haber, J.E.3
Lee, S.E.4
-
14
-
-
84900298762
-
Non-homologous end joining often uses microhomology: implications for alternative end joining
-
Pannunzio NR, Li S, Watanabe G, Lieber MR, (2014) Non-homologous end joining often uses microhomology: implications for alternative end joining. DNA Repair (Amst) 17: 74–80. doi: 10.1016/j.dnarep.2014.02.006 24613510
-
(2014)
DNA Repair (Amst)
, vol.17
, pp. 74-80
-
-
Pannunzio, N.R.1
Li, S.2
Watanabe, G.3
Lieber, M.R.4
-
15
-
-
0035893363
-
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
-
Pierce AJ, Hu P, Han M, Ellis N, Jasin M, (2001) Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev 15: 3237–3242. doi: 10.1101/gad.946401 11751629
-
(2001)
Genes Dev
, vol.15
, pp. 3237-3242
-
-
Pierce, A.J.1
Hu, P.2
Han, M.3
Ellis, N.4
Jasin, M.5
-
16
-
-
6344234817
-
Genetic steps of mammalian homologous repair with distinct mutagenic consequences
-
Stark JM, Pierce AJ, Oh J, Pastink A, Jasin M, (2004) Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol 24: 9305–9316. doi: 10.1128/MCB.24.21.9305-9316.2004 15485900
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9305-9316
-
-
Stark, J.M.1
Pierce, A.J.2
Oh, J.3
Pastink, A.4
Jasin, M.5
-
17
-
-
68249138694
-
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells
-
Rass E, Grabarz A, Plo I, Gautier J, Bertrand P, et al. (2009) Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat Struct Mol Biol 16: 819–824. doi: 10.1038/nsmb.1641 19633668
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 819-824
-
-
Rass, E.1
Grabarz, A.2
Plo, I.3
Gautier, J.4
Bertrand, P.5
-
18
-
-
84877321963
-
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells
-
Truong LN, Li Y, Shi LZ, Hwang PY, He J, et al. (2013) Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc Natl Acad Sci U S A 110: 7720–7725. doi: 10.1073/pnas.1213431110 23610439
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 7720-7725
-
-
Truong, L.N.1
Li, Y.2
Shi, L.Z.3
Hwang, P.Y.4
He, J.5
-
19
-
-
68249135624
-
Multiple functions of MRN in end-joining pathways during isotype class switching
-
Dinkelmann M, Spehalski E, Stoneham T, Buis J, Wu Y, et al. (2009) Multiple functions of MRN in end-joining pathways during isotype class switching. Nat Struct Mol Biol 16: 808–813. doi: 10.1038/nsmb.1639 19633670
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 808-813
-
-
Dinkelmann, M.1
Spehalski, E.2
Stoneham, T.3
Buis, J.4
Wu, Y.5
-
20
-
-
68249146431
-
Role of mammalian Mre11 in classical and alternative nonhomologous end joining
-
Xie A, Kwok A, Scully R, (2009) Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat Struct Mol Biol 16: 814–818. doi: 10.1038/nsmb.1640 19633669
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 814-818
-
-
Xie, A.1
Kwok, A.2
Scully, R.3
-
21
-
-
73349098442
-
Limiting the persistence of a chromosome break diminishes its mutagenic potential
-
Bennardo N, Gunn A, Cheng A, Hasty P, Stark JM, (2009) Limiting the persistence of a chromosome break diminishes its mutagenic potential. PLoS Genet 5: e1000683. doi: 10.1371/journal.pgen.1000683 19834534
-
(2009)
PLoS Genet
, vol.5
, pp. e1000683
-
-
Bennardo, N.1
Gunn, A.2
Cheng, A.3
Hasty, P.4
Stark, J.M.5
-
22
-
-
82755183606
-
Correct End Use during End Joining of Multiple Chromosomal Double Strand Breaks Is Influenced by Repair Protein RAD50, DNA-dependent Protein Kinase DNA-PKcs, and Transcription Context
-
Gunn A, Bennardo N, Cheng A, Stark JM, (2011) Correct End Use during End Joining of Multiple Chromosomal Double Strand Breaks Is Influenced by Repair Protein RAD50, DNA-dependent Protein Kinase DNA-PKcs, and Transcription Context. J Biol Chem 286: 42470–42482. doi: 10.1074/jbc.M111.309252 22027841
-
(2011)
J Biol Chem
, vol.286
, pp. 42470-42482
-
-
Gunn, A.1
Bennardo, N.2
Cheng, A.3
Stark, J.M.4
-
23
-
-
36549060102
-
Human CtIP promotes DNA end resection
-
Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, et al. (2007) Human CtIP promotes DNA end resection. Nature 450: 509–514. doi: 10.1038/nature06337 17965729
-
(2007)
Nature
, vol.450
, pp. 509-514
-
-
Sartori, A.A.1
Lukas, C.2
Coates, J.3
Mistrik, M.4
Fu, S.5
-
24
-
-
34548401682
-
Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining
-
Lee K, Lee SE, (2007) Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining. Genetics 176: 2003–2014. doi: 10.1534/genetics.107.076539 17565964
-
(2007)
Genetics
, vol.176
, pp. 2003-2014
-
-
Lee, K.1
Lee, S.E.2
-
25
-
-
84885838052
-
A role for BLM in double-strand break repair pathway choice: prevention of CtIP/Mre11-mediated alternative nonhomologous end-joining
-
Grabarz A, Guirouilh-Barbat J, Barascu A, Pennarun G, Genet D, et al. (2013) A role for BLM in double-strand break repair pathway choice: prevention of CtIP/Mre11-mediated alternative nonhomologous end-joining. Cell Rep 5: 21–28. doi: 10.1016/j.celrep.2013.08.034 24095737
-
(2013)
Cell Rep
, vol.5
, pp. 21-28
-
-
Grabarz, A.1
Guirouilh-Barbat, J.2
Barascu, A.3
Pennarun, G.4
Genet, D.5
-
26
-
-
84869996067
-
RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1
-
Munoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, et al. (2012) RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1. J Biol Chem 287: 40618–40628. doi: 10.1074/jbc.M112.410951 23055523
-
(2012)
J Biol Chem
, vol.287
, pp. 40618-40628
-
-
Munoz, M.C.1
Laulier, C.2
Gunn, A.3
Cheng, A.4
Robbiani, D.F.5
-
27
-
-
77951057068
-
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
-
Bothmer A, Robbiani DF, Feldhahn N, Gazumyan A, Nussenzweig A, et al. (2010) 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med 207: 855–865. doi: 10.1084/jem.20100244 20368578
-
(2010)
J Exp Med
, vol.207
, pp. 855-865
-
-
Bothmer, A.1
Robbiani, D.F.2
Feldhahn, N.3
Gazumyan, A.4
Nussenzweig, A.5
-
28
-
-
84876877091
-
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
-
Escribano-Diaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, et al. (2013) A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol Cell 49: 872–883. doi: 10.1016/j.molcel.2013.01.001 23333306
-
(2013)
Mol Cell
, vol.49
, pp. 872-883
-
-
Escribano-Diaz, C.1
Orthwein, A.2
Fradet-Turcotte, A.3
Xing, M.4
Young, J.T.5
-
29
-
-
84892743776
-
Break-induced replication repair of damaged forks induces genomic duplications in human cells
-
Costantino L, Sotiriou SK, Rantala JK, Magin S, Mladenov E, et al. (2014) Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science 343: 88–91. doi: 10.1126/science.1243211 24310611
-
(2014)
Science
, vol.343
, pp. 88-91
-
-
Costantino, L.1
Sotiriou, S.K.2
Rantala, J.K.3
Magin, S.4
Mladenov, E.5
-
30
-
-
84879887310
-
Break-induced replication: functions and molecular mechanism
-
Malkova A, Ira G, (2013) Break-induced replication: functions and molecular mechanism. Curr Opin Genet Dev 23: 271–279. doi: 10.1016/j.gde.2013.05.007 23790415
-
(2013)
Curr Opin Genet Dev
, vol.23
, pp. 271-279
-
-
Malkova, A.1
Ira, G.2
-
31
-
-
84863798373
-
Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways
-
Sears CR, Turchi JJ, (2012) Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways. J Biol Chem 287: 24263–24272. doi: 10.1074/jbc.M112.344911 22621925
-
(2012)
J Biol Chem
, vol.287
, pp. 24263-24272
-
-
Sears, C.R.1
Turchi, J.J.2
-
32
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
-
Bunting SF, Callen E, Wong N, Chen HT, Polato F, et al. (2010) 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 141: 243–254. doi: 10.1016/j.cell.2010.03.012 20362325
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
Callen, E.2
Wong, N.3
Chen, H.T.4
Polato, F.5
-
33
-
-
84862776819
-
BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
-
Bunting SF, Callen E, Kozak ML, Kim JM, Wong N, et al. (2012) BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. Mol Cell 46: 125–135. doi: 10.1016/j.molcel.2012.02.015 22445484
-
(2012)
Mol Cell
, vol.46
, pp. 125-135
-
-
Bunting, S.F.1
Callen, E.2
Kozak, M.L.3
Kim, J.M.4
Wong, N.5
-
34
-
-
77953879925
-
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway
-
Pace P, Mosedale G, Hodskinson MR, Rosado IV, Sivasubramaniam M, et al. (2010) Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science 329: 219–223. doi: 10.1126/science.1192277 20538911
-
(2010)
Science
, vol.329
, pp. 219-223
-
-
Pace, P.1
Mosedale, G.2
Hodskinson, M.R.3
Rosado, I.V.4
Sivasubramaniam, M.5
-
35
-
-
77954310242
-
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia
-
Adamo A, Collis SJ, Adelman CA, Silva N, Horejsi Z, et al. (2010) Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol Cell 39: 25–35. doi: 10.1016/j.molcel.2010.06.026 20598602
-
(2010)
Mol Cell
, vol.39
, pp. 25-35
-
-
Adamo, A.1
Collis, S.J.2
Adelman, C.A.3
Silva, N.4
Horejsi, Z.5
-
36
-
-
80052168685
-
The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings
-
Helleday T, (2011) The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings. Mol Oncol 5: 387–393. doi: 10.1016/j.molonc.2011.07.001 21821475
-
(2011)
Mol Oncol
, vol.5
, pp. 387-393
-
-
Helleday, T.1
-
37
-
-
84888130820
-
The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining
-
Mansour WY, Borgmann K, Petersen C, Dikomey E, Dahm-Daphi J, (2013) The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining. DNA Repair (Amst) 12: 1134–1142. doi: 10.1016/j.dnarep.2013.10.005
-
(2013)
DNA Repair (Amst)
, vol.12
, pp. 1134-1142
-
-
Mansour, W.Y.1
Borgmann, K.2
Petersen, C.3
Dikomey, E.4
Dahm-Daphi, J.5
-
38
-
-
11244280890
-
Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
-
Audebert M, Salles B, Calsou P, (2004) Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem 279: 55117–55126. doi: 10.1074/jbc.M404524200 15498778
-
(2004)
J Biol Chem
, vol.279
, pp. 55117-55126
-
-
Audebert, M.1
Salles, B.2
Calsou, P.3
-
39
-
-
33845657443
-
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
-
Wang M, Wu W, Wu W, Rosidi B, Zhang L, et al. (2006) PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res 34: 6170–6182. doi: 10.1093/nar/gkl840 17088286
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 6170-6182
-
-
Wang, M.1
Wu, W.2
Wu, W.3
Rosidi, B.4
Zhang, L.5
-
40
-
-
33745855438
-
Bortezomib: efficacy comparisons in solid tumors and hematologic malignancies
-
Caravita T, de Fabritiis P, Palumbo A, Amadori S, Boccadoro M, (2006) Bortezomib: efficacy comparisons in solid tumors and hematologic malignancies. Nat Clin Pract Oncol 3: 374–387. doi: 10.1038/ncponc0555 16826218
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 374-387
-
-
Caravita, T.1
de Fabritiis, P.2
Palumbo, A.3
Amadori, S.4
Boccadoro, M.5
-
41
-
-
84862161278
-
Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin
-
Jacquemont C, Simon JA, D′Andrea AD, Taniguchi T, (2012) Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin. Mol Cancer 11: 26. doi: 10.1186/1476-4598-11-26 22537224
-
(2012)
Mol Cancer
, vol.11
, pp. 26
-
-
Jacquemont, C.1
Simon, J.A.2
D′Andrea, A.D.3
Taniguchi, T.4
-
42
-
-
84868592402
-
I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks
-
Gunn A, Stark JM, (2012) I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks. Methods Mol Biol 920: 379–391. doi: 10.1007/978-1-61779-998-3_27 22941618
-
(2012)
Methods Mol Biol
, vol.920
, pp. 379-391
-
-
Gunn, A.1
Stark, J.M.2
-
43
-
-
78649707827
-
ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks
-
Bennardo N, Stark JM, (2010) ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks. PLoS Genet 6: e1001194. doi: 10.1371/journal.pgen.1001194 21079684
-
(2010)
PLoS Genet
, vol.6
, pp. e1001194
-
-
Bennardo, N.1
Stark, J.M.2
-
44
-
-
78650995499
-
An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway
-
Zhang Y, Jasin M, (2011) An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway. Nat Struct Mol Biol 18: 80–84. doi: 10.1038/nsmb.1940 21131978
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 80-84
-
-
Zhang, Y.1
Jasin, M.2
-
45
-
-
46749106037
-
Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24
-
Kim JM, Kee Y, Gurtan A, D′Andrea AD, (2008) Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood 111: 5215–5222. doi: 10.1182/blood-2007-09-113092 18174376
-
(2008)
Blood
, vol.111
, pp. 5215-5222
-
-
Kim, J.M.1
Kee, Y.2
Gurtan, A.3
D′Andrea, A.D.4
-
46
-
-
0033569684
-
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
-
Pierce AJ, Johnson RD, Thompson LH, Jasin M, (1999) XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev 13: 2633–2638. doi: 10.1101/gad.13.20.2633 10541549
-
(1999)
Genes Dev
, vol.13
, pp. 2633-2638
-
-
Pierce, A.J.1
Johnson, R.D.2
Thompson, L.H.3
Jasin, M.4
-
47
-
-
84884141940
-
BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids
-
Chandramouly G, Kwok A, Huang B, Willis NA, Xie A, et al. (2013) BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids. Nat Commun 4: 2404. doi: 10.1038/ncomms3404 23994874
-
(2013)
Nat Commun
, vol.4
, pp. 2404
-
-
Chandramouly, G.1
Kwok, A.2
Huang, B.3
Willis, N.A.4
Xie, A.5
-
48
-
-
33747889217
-
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair
-
Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S, (2006) Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst) 5: 1021–1029. doi: 10.1016/j.dnarep.2006.05.022 16807135
-
(2006)
DNA Repair (Amst)
, vol.5
, pp. 1021-1029
-
-
Sonoda, E.1
Hochegger, H.2
Saberi, A.3
Taniguchi, Y.4
Takeda, S.5
-
49
-
-
84872578210
-
Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
-
Kottemann MC, Smogorzewska A, (2013) Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature 493: 356–363. doi: 10.1038/nature11863 23325218
-
(2013)
Nature
, vol.493
, pp. 356-363
-
-
Kottemann, M.C.1
Smogorzewska, A.2
-
50
-
-
38049187905
-
Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends
-
Guirouilh-Barbat J, Rass E, Plo I, Bertrand P, Lopez BS, (2007) Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends. Proceedings of the National Academy of Sciences 104: 20902–20907. doi: 10.1073/pnas.0708541104 18093953
-
(2007)
Proceedings of the National Academy of Sciences
, vol.104
, pp. 20902-20907
-
-
Guirouilh-Barbat, J.1
Rass, E.2
Plo, I.3
Bertrand, P.4
Lopez, B.S.5
-
51
-
-
68149110347
-
Ku86 represses lethal telomere deletion events in human somatic cells
-
Wang Y, Ghosh G, Hendrickson EA, (2009) Ku86 represses lethal telomere deletion events in human somatic cells. Proc Natl Acad Sci U S A 106: 12430–12435. doi: 10.1073/pnas.0903362106 19581589
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 12430-12435
-
-
Wang, Y.1
Ghosh, G.2
Hendrickson, E.A.3
-
52
-
-
12844286052
-
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair
-
Nakanishi K, Yang YG, Pierce AJ, Taniguchi T, Digweed M, et al. (2005) Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A 102: 1110–1115. doi: 10.1073/pnas.0407796102 15650050
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 1110-1115
-
-
Nakanishi, K.1
Yang, Y.G.2
Pierce, A.J.3
Taniguchi, T.4
Digweed, M.5
-
53
-
-
79953778192
-
Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication
-
Nakanishi K, Cavallo F, Perrouault L, Giovannangeli C, Moynahan ME, et al. (2011) Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication. Nat Struct Mol Biol 18: 500–503. doi: 10.1038/nsmb.2029 21423196
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 500-503
-
-
Nakanishi, K.1
Cavallo, F.2
Perrouault, L.3
Giovannangeli, C.4
Moynahan, M.E.5
-
54
-
-
84887010498
-
Genome engineering using the CRISPR-Cas9 system
-
Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, et al. (2013) Genome engineering using the CRISPR-Cas9 system. Nat Protoc 8: 2281–2308. doi: 10.1038/nprot.2013.143 24157548
-
(2013)
Nat Protoc
, vol.8
, pp. 2281-2308
-
-
Ran, F.A.1
Hsu, P.D.2
Wright, J.3
Agarwala, V.4
Scott, D.A.5
-
55
-
-
0030858967
-
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
-
Gu Y, Jin S, Gao Y, Weaver DT, Alt FW, (1997) Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci U S A 94: 8076–8081. doi: 10.1073/pnas.94.15.8076 9223317
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 8076-8081
-
-
Gu, Y.1
Jin, S.2
Gao, Y.3
Weaver, D.T.4
Alt, F.W.5
-
56
-
-
80755187806
-
Double-strand break end resection and repair pathway choice
-
Symington LS, Gautier J, (2011) Double-strand break end resection and repair pathway choice. Annu Rev Genet 45: 247–271. doi: 10.1146/annurev-genet-110410-132435 21910633
-
(2011)
Annu Rev Genet
, vol.45
, pp. 247-271
-
-
Symington, L.S.1
Gautier, J.2
-
57
-
-
84869485349
-
DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network
-
Karanja KK, Cox SW, Duxin JP, Stewart SA, Campbell JL, (2012) DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network. Cell Cycle 11: 3983–3996. doi: 10.4161/cc.22215 22987153
-
(2012)
Cell Cycle
, vol.11
, pp. 3983-3996
-
-
Karanja, K.K.1
Cox, S.W.2
Duxin, J.P.3
Stewart, S.A.4
Campbell, J.L.5
-
58
-
-
84900559537
-
Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells
-
Karanja KK, Lee EH, Hendrickson EA, Campbell JL, (2014) Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells. Cell Cycle 13: 1540–1550. doi: 10.4161/cc.28476 24626199
-
(2014)
Cell Cycle
, vol.13
, pp. 1540-1550
-
-
Karanja, K.K.1
Lee, E.H.2
Hendrickson, E.A.3
Campbell, J.L.4
-
59
-
-
84862688195
-
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
-
Duxin JP, Moore HR, Sidorova J, Karanja K, Honaker Y, et al. (2012) Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem 287: 21980–21991. doi: 10.1074/jbc.M112.359018 22570476
-
(2012)
J Biol Chem
, vol.287
, pp. 21980-21991
-
-
Duxin, J.P.1
Moore, H.R.2
Sidorova, J.3
Karanja, K.4
Honaker, Y.5
-
60
-
-
84861880476
-
Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection
-
Peng G, Dai H, Zhang W, Hsieh HJ, Pan MR, et al. (2012) Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection. Cancer Res 72: 2802–2813. doi: 10.1158/0008-5472.CAN-11-3152 22491672
-
(2012)
Cancer Res
, vol.72
, pp. 2802-2813
-
-
Peng, G.1
Dai, H.2
Zhang, W.3
Hsieh, H.J.4
Pan, M.R.5
-
61
-
-
84866627047
-
A high-throughput, flow cytometry-based method to quantify DNA-end resection in mammalian cells
-
Forment JV, Walker RV, Jackson SP, (2012) A high-throughput, flow cytometry-based method to quantify DNA-end resection in mammalian cells. Cytometry A 81: 922–928. doi: 10.1002/cyto.a.22155 22893507
-
(2012)
Cytometry A
, vol.81
, pp. 922-928
-
-
Forment, J.V.1
Walker, R.V.2
Jackson, S.P.3
-
62
-
-
84879763829
-
DNA2, a new player in telomere maintenance and tumor suppression
-
Chai W, Zheng L, Shen B, (2013) DNA2, a new player in telomere maintenance and tumor suppression. Cell Cycle 12: 1985–1986. doi: 10.4161/cc.25306 23759580
-
(2013)
Cell Cycle
, vol.12
, pp. 1985-1986
-
-
Chai, W.1
Zheng, L.2
Shen, B.3
-
63
-
-
34547628200
-
Proteasome function is required for DNA damage response and fanconi anemia pathway activation
-
Jacquemont C, Taniguchi T, (2007) Proteasome function is required for DNA damage response and fanconi anemia pathway activation. Cancer Res 67: 7395–7405. doi: 10.1158/0008-5472.CAN-07-1015 17671210
-
(2007)
Cancer Res
, vol.67
, pp. 7395-7405
-
-
Jacquemont, C.1
Taniguchi, T.2
-
64
-
-
84888349734
-
Synthetic lethality between CCNE1 amplification and loss of BRCA1
-
Etemadmoghadam D, Weir BA, Au-Yeung G, Alsop K, Mitchell G, et al. (2013) Synthetic lethality between CCNE1 amplification and loss of BRCA1. Proc Natl Acad Sci U S A 110: 19489–19494. doi: 10.1073/pnas.1314302110 24218601
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 19489-19494
-
-
Etemadmoghadam, D.1
Weir, B.A.2
Au-Yeung, G.3
Alsop, K.4
Mitchell, G.5
-
65
-
-
84857781943
-
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response
-
Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ, (2012) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol 14: 318–328. doi: 10.1038/ncb2426 22344029
-
(2012)
Nat Cell Biol
, vol.14
, pp. 318-328
-
-
Adamson, B.1
Smogorzewska, A.2
Sigoillot, F.D.3
King, R.W.4
Elledge, S.J.5
-
66
-
-
84875224166
-
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination
-
Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, et al. (2013) Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol 20: 317–325. doi: 10.1038/nsmb.2499 23377543
-
(2013)
Nat Struct Mol Biol
, vol.20
, pp. 317-325
-
-
Tang, J.1
Cho, N.W.2
Cui, G.3
Manion, E.M.4
Shanbhag, N.M.5
-
67
-
-
36049024402
-
Accurate homologous recombination is a prominent double-strand break repair pathway in mammalian chromosomes and is modulated by mismatch repair protein Msh2
-
Smith JA, Bannister LA, Bhattacharjee V, Wang Y, Waldman BC, et al. (2007) Accurate homologous recombination is a prominent double-strand break repair pathway in mammalian chromosomes and is modulated by mismatch repair protein Msh2. Mol Cell Biol 27: 7816–7827. doi: 10.1128/MCB.00455-07 17846123
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7816-7827
-
-
Smith, J.A.1
Bannister, L.A.2
Bhattacharjee, V.3
Wang, Y.4
Waldman, B.C.5
-
68
-
-
3042546122
-
Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1
-
Sugawara N, Goldfarb T, Studamire B, Alani E, Haber JE, (2004) Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1. Proc Natl Acad Sci U S A 101: 9315–9320. doi: 10.1073/pnas.0305749101 15199178
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9315-9320
-
-
Sugawara, N.1
Goldfarb, T.2
Studamire, B.3
Alani, E.4
Haber, J.E.5
-
69
-
-
24944497114
-
The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells
-
Yang YG, Herceg Z, Nakanishi K, Demuth I, Piccoli C, et al. (2005) The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells. Carcinogenesis 26: 1731–1740. doi: 10.1093/carcin/bgi134 15905196
-
(2005)
Carcinogenesis
, vol.26
, pp. 1731-1740
-
-
Yang, Y.G.1
Herceg, Z.2
Nakanishi, K.3
Demuth, I.4
Piccoli, C.5
-
70
-
-
84901044867
-
The role of the human psoralen 4 (hPso4) protein complex in replication stress and homologous recombination
-
Abbas M, Shanmugam I, Bsaili M, Hromas R, Shaheen M, (2014) The role of the human psoralen 4 (hPso4) protein complex in replication stress and homologous recombination. J Biol Chem 289: 14009–14019. doi: 10.1074/jbc.M113.520056 24675077
-
(2014)
J Biol Chem
, vol.289
, pp. 14009-14019
-
-
Abbas, M.1
Shanmugam, I.2
Bsaili, M.3
Hromas, R.4
Shaheen, M.5
-
71
-
-
28844509443
-
The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links
-
Zhang N, Kaur R, Lu X, Shen X, Li L, et al. (2005) The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. J Biol Chem 280: 40559–40567. doi: 10.1074/jbc.M508453200 16223718
-
(2005)
J Biol Chem
, vol.280
, pp. 40559-40567
-
-
Zhang, N.1
Kaur, R.2
Lu, X.3
Shen, X.4
Li, L.5
-
72
-
-
84876861783
-
FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions
-
Wang Y, Leung JW, Jiang Y, Lowery MG, Do H, et al. (2013) FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. Mol Cell 49: 997–1009. doi: 10.1016/j.molcel.2012.12.010 23333308
-
(2013)
Mol Cell
, vol.49
, pp. 997-1009
-
-
Wang, Y.1
Leung, J.W.2
Jiang, Y.3
Lowery, M.G.4
Do, H.5
-
73
-
-
0035937735
-
Deficient DNA end joining activity in extracts from fanconi anemia fibroblasts
-
Lundberg R, Mavinakere M, Campbell C, (2001) Deficient DNA end joining activity in extracts from fanconi anemia fibroblasts. J Biol Chem 276: 9543–9549. doi: 10.1074/jbc.M008634200 11124945
-
(2001)
J Biol Chem
, vol.276
, pp. 9543-9549
-
-
Lundberg, R.1
Mavinakere, M.2
Campbell, C.3
-
74
-
-
84901785539
-
Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells
-
Nguyen TV, Riou L, Aoufouchi S, Rosselli F, (2014) Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells. J Exp Med 211: 1011–1018. doi: 10.1084/jem.20131637 24799500
-
(2014)
J Exp Med
, vol.211
, pp. 1011-1018
-
-
Nguyen, T.V.1
Riou, L.2
Aoufouchi, S.3
Rosselli, F.4
-
75
-
-
49749093073
-
Ku80 removal from DNA through double strand break-induced ubiquitylation
-
Postow L, Ghenoiu C, Woo EM, Krutchinsky AN, Chait BT, et al. (2008) Ku80 removal from DNA through double strand break-induced ubiquitylation. J Cell Biol 182: 467–479. doi: 10.1083/jcb.200802146 18678709
-
(2008)
J Cell Biol
, vol.182
, pp. 467-479
-
-
Postow, L.1
Ghenoiu, C.2
Woo, E.M.3
Krutchinsky, A.N.4
Chait, B.T.5
-
76
-
-
3543092021
-
Pathways of apoptotic and non-apoptotic death in tumour cells
-
Okada H, Mak TW, (2004) Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer 4: 592–603. doi: 10.1038/nrc1412 15286739
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 592-603
-
-
Okada, H.1
Mak, T.W.2
-
77
-
-
84876319685
-
The Pol alpha-primase complex
-
Pellegrini L, (2012) The Pol alpha-primase complex. Subcell Biochem 62: 157–169. doi: 10.1007/978-94-007-4572-8_9 22918585
-
(2012)
Subcell Biochem
, vol.62
, pp. 157-169
-
-
Pellegrini, L.1
-
78
-
-
84870720807
-
Microhomology directs diverse DNA break repair pathways and chromosomal translocations
-
Villarreal DD, Lee K, Deem A, Shim EY, Malkova A, et al. (2012) Microhomology directs diverse DNA break repair pathways and chromosomal translocations. PLoS Genet 8: e1003026. doi: 10.1371/journal.pgen.1003026 23144625
-
(2012)
PLoS Genet
, vol.8
, pp. e1003026
-
-
Villarreal, D.D.1
Lee, K.2
Deem, A.3
Shim, E.Y.4
Malkova, A.5
-
79
-
-
56749119855
-
Identification of Holliday junction resolvases from humans and yeast
-
Ip SC, Rass U, Blanco MG, Flynn HR, Skehel JM, et al. (2008) Identification of Holliday junction resolvases from humans and yeast. Nature 456: 357–361. doi: 10.1038/nature07470 19020614
-
(2008)
Nature
, vol.456
, pp. 357-361
-
-
Ip, S.C.1
Rass, U.2
Blanco, M.G.3
Flynn, H.R.4
Skehel, J.M.5
-
80
-
-
77954838714
-
Mechanism of Holliday junction resolution by the human GEN1 protein
-
Rass U, Compton SA, Matos J, Singleton MR, Ip SC, et al. (2010) Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev 24: 1559–1569. doi: 10.1101/gad.585310 20634321
-
(2010)
Genes Dev
, vol.24
, pp. 1559-1569
-
-
Rass, U.1
Compton, S.A.2
Matos, J.3
Singleton, M.R.4
Ip, S.C.5
-
81
-
-
62449164136
-
Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination
-
Begum NA, Stanlie A, Doi T, Sasaki Y, Jin HW, et al. (2009) Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination. Proc Natl Acad Sci U S A 106: 2752–2757. doi: 10.1073/pnas.0813252106 19202054
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 2752-2757
-
-
Begum, N.A.1
Stanlie, A.2
Doi, T.3
Sasaki, Y.4
Jin, H.W.5
-
82
-
-
37549004382
-
Initiation of base excision repair of oxidative lesions in nucleosomes by the human, bifunctional DNA glycosylase NTH1
-
Prasad A, Wallace SS, Pederson DS, (2007) Initiation of base excision repair of oxidative lesions in nucleosomes by the human, bifunctional DNA glycosylase NTH1. Mol Cell Biol 27: 8442–8453. doi: 10.1128/MCB.00791-07 17923696
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8442-8453
-
-
Prasad, A.1
Wallace, S.S.2
Pederson, D.S.3
-
83
-
-
0344375083
-
Lentivirus-delivered stable gene silencing by RNAi in primary cells
-
Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, et al. (2003) Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9: 493–501. doi: 10.1261/rna.2192803 12649500
-
(2003)
RNA
, vol.9
, pp. 493-501
-
-
Stewart, S.A.1
Dykxhoorn, D.M.2
Palliser, D.3
Mizuno, H.4
Yu, E.Y.5
|