Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells

Journal of Experimental Medicine

Volumn 211, Issue 6, 2014, Pages 1011-1018

  Nguyen, Thuy Vy ^a,b,c   Riou, Lydia ^b,d   Aoufouchi, Saïd ^a,b   Rosselli, Filippo ^a,b,c  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c Programme Equipe Labellisées Ligue Contre le Cancer   (France)

^d INSTITUT DE RADIOBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ANTIBODY; FANCONI ANEMIA GROUP A PROTEIN; IMMUNOGLOBULIN;

ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CHROMOSOME FRAGILITY; CONFORMATIONAL TRANSITION; DNA END JOINING REPAIR; DNA RECOMBINATION; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVATION; FANCONI ANEMIA; IMMUNOGLOBULIN GENE; LOSS OF FUNCTION MUTATION; MISMATCH REPAIR; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; SOMATIC HYPERMUTATION;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; FANCONI ANEMIA COMPLEMENTATION GROUP A PROTEIN; FANCONI ANEMIA COMPLEMENTATION GROUP G PROTEIN; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN SWITCH REGION; MICE, 129 STRAIN; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTS HOMOLOG 2 PROTEIN; POINT MUTATION; POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 84901785539     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20131637     Document Type: Article

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