Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways

Journal of Biological Chemistry

Volumn 287, Issue 29, 2012, Pages 24263-24272

  Sears, Catherine R ^a   Turchi, John J ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR EFFECTS; CIS-PLATIN; COMBINATION THERAPY; DAMAGE EFFECTS; DIRECT TREATMENT; DNA DSB; DNA SUBSTRATES; DOSE-DEPENDENT; HOST CELLS; IN-VITRO; NO REDUCTION; NON SMALL CELL LUNG CANCER; NONHOMOLOGOUS END JOINING; PLATINUM-BASED CHEMOTHERAPY; SITE-SPECIFIC; STRAND BREAKS;

CATALYSIS; CELL CULTURE; CELLS; DNA; PLATINUM COMPOUNDS; REPAIR;

MOLECULAR BIOLOGY;

CELL DNA; CISPLATIN; GREEN FLUORESCENT PROTEIN;

ARTICLE; CATALYSIS; CELL ASSAY; CELL DAMAGE; CONTROLLED STUDY; CYTOTOXICITY; DNA END JOINING REPAIR; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DOWNSTREAM DAMAGE RESPONSE; GENETIC TRANSFECTION; HOST CELL; IN VITRO STUDY; IONIZING RADIATION; PLASMID; PRIORITY JOURNAL;

CELL LINE, TUMOR; CISPLATIN; DNA BREAKS, DOUBLE-STRANDED; FLOW CYTOMETRY; HUMANS; MICROSCOPY, FLUORESCENCE; SIGNAL TRANSDUCTION;

EID: 84863798373     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.344911     Document Type: Article

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