The Pol α -Primase Complex

Subcellular Biochemistry

Volumn 62, Issue , 2012, Pages 157-169

  Pellegrini, Luca ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Pol ; Primase; primer

Indexed keywords

ARCHAEAL PROTEIN; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE BETA; DNA DIRECTED DNA POLYMERASE GAMMA; DNA PRIMASE; IRON SULFUR PROTEIN; MULTIENZYME COMPLEX; PRIMER DNA; RNA; RNA PRIMERS;

ANIMAL; ARCHAEON; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; REVIEW;

ANIMALS; ARCHAEA; ARCHAEAL PROTEINS; DNA POLYMERASE I; DNA POLYMERASE II; DNA POLYMERASE III; DNA PRIMASE; DNA PRIMERS; HUMANS; IRON-SULFUR PROTEINS; MULTIENZYME COMPLEXES; RNA;

EID: 84876319685     PISSN: 03060225     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-007-4572-8_9     Document Type: Article

References (42)

1. Agarkar VB, Babayeva ND, Pavlov YI, Tahirov TH (2011) Crystal structure of the C-terminal domain of human DNA primase large subunit: implications for the mechanism of the primasepolymerase α switch. Cell Cycle 10(6): 926-931.
2. Aravind L, Koonin EV (1998) Phosphoesterase domains associated with DNA polymerases of diverse origins. Nucleic Acids Res 26(16): 3746-3752.
3. Augustin MA, Huber R, Kaiser JT (2001) Crystal structure of a DNA-dependent RNA polymerase (DNA primase). Nat Struct Biol 8(1): 57-61.
4. Baranovskiy AG, Babayeva ND, Liston VG, Rogozin IB, Koonin EV, Pavlov YI, Vassylyev DG, Tahirov TH (2008) X-ray structure of the complex of regulatory subunits of human DNA polymerase δ. Cell Cycle 7(19): 3026-3036.
5. Brissett NC, Pitcher RS, Juarez R, Picher AJ, Green AJ, Dafforn TR, Fox GC, Blanco L, Doherty AJ (2007) Structure of a NHEJ polymerase-mediated DNA synaptic complex. Science 318(5849): 456-459.
6. Burgers PM (2009) Polymerase dynamics at the eukaryotic DNA replication fork. J Biol Chem 284(7): 4041-4045.
7. Conaway RC, Lehman IR (1982) A DNA primase activity associated with DNA polymerase alpha from Drosophila melanogaster embryos. Proc Natl Acad Sci USA 79(8): 2523-2527.
8. Copeland WC, Wang TS (1993) Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication. J Biol Chem 268(35): 26179-26189.
9. Corn JE, Pease PJ, Hura GL, Berger JM (2005) Crosstalk between primase subunits can act to regulate primer synthesis in trans. Mol Cell 20(3): 391.
10. Dua R, Levy DL, Campbell JL (1998) Role of the putative zincfinger domain of Saccharomyces cerevisiae DNA polymerase ε in DNA replication and the S/M checkpoint pathway. J Biol Chem 273(45): 30046-30055.
11. Eki T, Enomoto T, Masutani C, Miyajima A, Takada R, Murakami Y, Ohno T, Hanaoka F, Ui M (1991) Mouse DNA primase plays the principal role in determination of permissiveness for polyomavirus DNA replication. J Virol 65(9): 4874-4881.
12. Foiani M, Santocanale C, Plevani P, Lucchini G (1989) A single essential gene, PRI2, encodes the large subunit of DNA primase in Saccharomyces cerevisiae. Mol Cell Biol 9(7): 3081-3087.
13. Frick DN, Richardson CC (2001) DNA primases. Annu Rev Biochem 70: 39-80.
14. Hubscher U (1983) The mammalian primase is part of a high molecular weight DNA polymerase α polypeptide. EMBO J 2(1): 133-136.
15. Ito N, Nureki O, Shirouzu M, Yokoyama S, Hanaoka F (2003) Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis. Genes Cells 8(12): 913-923.
16. Iyer LM, Koonin EV, Leipe DD, Aravind L (2005) Origin and evolution of the archaeo-eukaryotic primase superfamily and related palm-domain proteins: structural insights and new members. Nucleic Acids Res 33(12): 3875-3896.
17. Johansson E, MacNeill SA (2010) The eukaryotic replicative DNA polymerases take shape. Trends Biochem Sci 35: 339-347.
18. Jokela M, Eskelinen A, Pospiech H, Rouvinen J, Syväoja JE (2004) Characterization of the 3 ʹ exonuclease subunit DP1 of Methanococcus jannaschii replicative DNA polymerase D. Nucleic Acids Res 32(8): 2430-2440.
19. Kaufmann G, Falk HH (1982) An oligoribonucleotide polymerase from SV40-infected cells with properties of a primase. Nucleic Acids Res 10(7): 2309-2321.
20. Klinge S, Hirst J, Maman JD, Krude T, Pellegrini L (2007) An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis. Nat Struct Mol Biol 14(9): 875-877.
21. Klinge S, Nunez-Ramirez R, Llorca O, Pellegrini L (2009) 3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerases. EMBO J 28(13): 1978-1987.
22. Kuchta RD, Stengel G (2010) Mechanism and evolution of DNA primases. Biochim Biophys Acta 1804(5): 1180-1189.
23. Kuchta RD, Reid B, Chang LM (1990) DNA primase. Processivity and the primase to polymerase α activity switch. J Biol Chem 265(27): 16158-16165.
24. Lao-Sirieix SH, Nookala RK, Roversi P, Bell SD, Pellegrini L (2005) Structure of the heterodimeric core primase. Nat Struct Mol Biol 12(12): 1137-1144.
25. Lipps G, Rother S, Hart C, Krauss G (2003) A novel type of replicative enzyme harbouring ATPase, primase and DNA polymerase activity. EMBO J 22(10): 2516-2525.
26. Makiniemi M, Pospiech H, Kilpelainen S, Jokela M, Vihinen M, Syvaoja JE (1999) A novel family of DNA-polymerase-associated B subunits. Trends Biochem Sci 24(1): 14-16.
27. McGeoch AT, Bell SD (2005) Eukaryotic/archaeal primase and MCM proteins encoded in a bacteriophage genome. Cell 120(2): 167-168.
28. Mizuno T, Yamagishi K, Miyazawa H, Hanaoka F (1999) Molecular architecture of the mouse DNA polymerase α-primase complex. Mol Cell Biol 19(11): 7886-7896.
29. Muzi-Falconi M, Giannattasio M, Foiani M, Plevani P (2003) The DNA polymerase α-primase complex: multiple functions and interactions. ScientificWorldJournal 3: 21-33.
30. Nunez-Ramirez R, Klinge S, Sauguet L, Melero R, Recuero-Checa MA, Kilkenny M, Perera RL, Garcia-Alvarez B, Hall RJ, Nogales E, Pellegrini L, Llorca O (2011) Flexible tethering of primase and DNA Pol α in the eukaryotic primosome. Nucleic Acids Res 39(18): 8187-8199.
31. Plevani P, Badaracco G, Augl C, Chang LM (1984) DNA polymerase I and DNA primase complex in yeast. J Biol Chem 259(12): 7532-7539.
32. Pokorny R, Klar T, Hennecke U, Carell T, Batschauer A, Essen LO (2008) Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome. Proc Natl Acad Sci USA 105(52): 21023-21027.
33. Sanchez Garcia J, Ciufo LF, Yang X, Kearsey SE, MacNeill SA (2004) The C-terminal zincfinger of the catalytic subunit of DNA polymerase δ is responsible for direct interaction with the B-subunit. Nucleic Acids Res 32(10): 3005-3016.
34. Sauguet L, Klinge S, Perera RL, Maman JD, Pellegrini L (2010) Shared active site architecture between the large subunit of eukaryotic primase and DNA photolyase. PLoS One 5(4): e10083.
35. Sheaff RJ, Kuchta RD, Ilsley D (1994) Calf thymus DNA polymerase α-primase: "communication" and primer-template movement between the two active sites. Biochemistry 33(8): 2247-2254.
36. Shen Y, Tang XÄ, Yokoyama H, Matsui E, Matsui I (2004) A 21-amino acid peptide from the cysteine cluster II of the family D DNA polymerase from Pyrococcus horikoshii stimulates its nuclease activity which is Mre11-ike and prefers manganese ion as the cofactor. Nucleic Acids Res 32(1): 158-168.
37. Stillman B (2008) DNA polymerases at the replication fork in eukaryotes. Mol Cell 30(3): 259-260.
38. Vaithiyalingam S, Warren EM, Eichman BF, Chazin WJ (2010) Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase. Proc Natl Acad Sci 107(31): 13684-13689.
39. Weiner BE, Huang H, Dattilo BM, Nilges MJ, Fanning E, Chazin WJ (2007) An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase. J Biol Chem 282(46): 33444-33451.
40. Yagura T, Kozu T, Seno T (1982) Mouse DNA replicase. DNA polymerase associated with a novel RNA polymerase activity to synthesize initiator RNA of strict size. J Biol Chem 257(18): 11121-11127.
41. 2+ -ion catalysis and substrate specificity. Mol Cell 22(1): 5.
42. Zerbe LK, Kuchta RD (2002) The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting. Biochemistry 41(15): 4891-4900.