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Volumn 12, Issue 5, 2014, Pages 399-412

Combination of therapeutic hypothermia and other neuroprotective strategies after an ischemic cerebral insult

Author keywords

Acute ischemic stroke; Clinical; Combination therapy; Experimental; Human; Hypothermia; Neuroprotection; Rodent

Indexed keywords

ALBUMIN; ALCOHOL; ALTEPLASE; ANTICOAGULANT AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ARGATROBAN; ATORVASTATIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CAFFEINE; CITICOLINE; DEXTROMETHORPHAN; DIZOCILPINE; KETOPROFEN; MAGNESIUM; MAGNESIUM SULFATE; MANNITOL; METHOHEXITAL; MINOCYCLINE; N ACETYLASPARTYLGLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; NORPHENAZONE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STATIN (PROTEIN); TACROLIMUS; TIRILAZAD; XENON;

EID: 84924122415     PISSN: 1570159X     EISSN: 18756190     Source Type: Journal    
DOI: 10.2174/1570159X12666140424233036     Document Type: Article
Times cited : (20)

References (192)
  • 1
    • 34748912364 scopus 로고    scopus 로고
    • Acute ischemic stroke treatment in 2007
    • Goldstein, L. B. Acute ischemic stroke treatment in 2007. Circulation, 2007, 116(13), 1504-1514. DOI: http://dx.doi.org/10. 1161/CIRCULATIONAHA.106.670885
    • (2007) Circulation , vol.116 , Issue.13 , pp. 1504-1514
    • Goldstein, L.B.1
  • 4
    • 0029050323 scopus 로고
    • Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)
    • Hacke, W.; Kaste, M.; Fieschi, C.; Toni, D.; Lesaffre, E.; von Kummer, R.; Boysen, G.; Bluhmki, E.; Hoxter, G.; Mahagne, M. H.; Hennerici, M. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA, 1995, 274(13), 1017-1025. DOI: http://dx.doi.org/10.1001/jama.274.13.1017
    • (1995) JAMA , vol.274 , Issue.13 , pp. 1017-1025
    • Hacke, W.1    Kaste, M.2    Fieschi, C.3    Toni, D.4    Lesaffre, E.5    von Kummer, R.6    Boysen, G.7    Bluhmki, E.8    Hoxter, G.9    Mahagne, M.H.10    Hennerici, M.11
  • 5
    • 48849089052 scopus 로고    scopus 로고
    • Neuroprotection for ischemic stroke: Past, present and future
    • Ginsberg, M. D. Neuroprotection for ischemic stroke: past, present and future. Neuropharmacology, 2008, 55(3), 363-389. DOI: http://dx.doi.org/10.1016/j.neuropharm.2007.12.007
    • (2008) Neuropharmacology , vol.55 , Issue.3 , pp. 363-389
    • Ginsberg, M.D.1
  • 6
    • 66049147738 scopus 로고    scopus 로고
    • The complexity of neurobiological processes in acute ischemic stroke
    • Brouns, R.; De Deyn, P. P. The complexity of neurobiological processes in acute ischemic stroke. Clin. Neurol. Neurosurg., 2009, 111(6), 483-495. DOI: http://dx.doi.org/10.1016/j.clineuro.2009.04.001
    • (2009) Clin. Neurol. Neurosurg , vol.111 , Issue.6 , pp. 483-495
    • Brouns, R.1    De Deyn, P.P.2
  • 7
    • 46349090692 scopus 로고    scopus 로고
    • Mechanisms of ischemic brain damage
    • Doyle, K. P.; Simon, R. P.; Stenzel-Poore, M. P. Mechanisms of ischemic brain damage. Neuropharmacology, 2008, 55(3), 310-318. DOI: http://dx.doi.org/10.1016/j.neuropharm.2008.01.005
    • (2008) Neuropharmacology , vol.55 , Issue.3 , pp. 310-318
    • Doyle, K.P.1    Simon, R.P.2    Stenzel-Poore, M.P.3
  • 8
    • 34249852075 scopus 로고    scopus 로고
    • Acute ischemic stroke: Overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia
    • Durukan, A.; Tatlisumak, T. Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacol. Biochem. Behav., 2007, 87(1), 179-197. DOI: http://dx.doi.org/10.1016/j.pbb.2007.04.015
    • (2007) Pharmacol. Biochem. Behav , vol.87 , Issue.1 , pp. 179-197
    • Durukan, A.1    Tatlisumak, T.2
  • 9
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • Dirnagl, U.; Iadecola, C.; Moskowitz, M. A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci., 1999, 22(9), 391-397. DOI: http://dx.doi.org/10.1016/S0166-2236(99)01401-0
    • (1999) Trends Neurosci , vol.22 , Issue.9 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 10
    • 33845547792 scopus 로고    scopus 로고
    • Pathophysiology and therapy of experimental stroke
    • Hossmann, K. A. Pathophysiology and therapy of experimental stroke. Cell. Mol. Neurobiol., 2006, 26(7-8), 1057-1083. DOI: http://dx.doi.org/10.1016/j.nbd.2010.03.001
    • (2006) Cell. Mol. Neurobiol , vol.26 , Issue.7-8 , pp. 1057-1083
    • Hossmann, K.A.1
  • 11
    • 33646703742 scopus 로고    scopus 로고
    • Therapeutic hypothermia for acute stroke
    • Lyden, P. D.; Krieger, D.; Yenari, M.; Dietrich, W. D. Therapeutic hypothermia for acute stroke. Int. J. Stroke, 2006, 1(1), 9-19. DOI: http://dx.doi.org/10.1111/j.1747-4949.2005.00011.x
    • (2006) Int. J. Stroke , vol.1 , Issue.1 , pp. 9-19
    • Lyden, P.D.1    Krieger, D.2    Yenari, M.3    Dietrich, W.D.4
  • 12
    • 78650250223 scopus 로고    scopus 로고
    • Therapeutic hypothermia
    • So, H. Y. Therapeutic hypothermia. Korean J. Anesthesiol., 2010, 59(5), 299-304. DOI: http://dx.doi.org/10.4097/kjae.2010.59.5.299
    • (2010) Korean J. Anesthesiol , vol.59 , Issue.5 , pp. 299-304
    • So, H.Y.1
  • 13
    • 15944366585 scopus 로고    scopus 로고
    • Therapeutic hypothermia for stroke: Do new outfits change an old friend?
    • Gupta, R.; Jovin, T. G.; Krieger, D. W. Therapeutic hypothermia for stroke: do new outfits change an old friend? Expert Rev. Neurother., 2005, 5(2), 235-246. DOI: http://dx.doi.org/10.1586/14737175.5.2.235
    • (2005) Expert Rev. Neurother , vol.5 , Issue.2 , pp. 235-246
    • Gupta, R.1    Jovin, T.G.2    Krieger, D.W.3
  • 14
    • 0029072113 scopus 로고
    • Cerebral Metabolic-Rate and Hypothermia - Their Relationship with Ischemic Neurologic Injury
    • Lanier, W. L. Cerebral Metabolic-Rate and Hypothermia - Their Relationship with Ischemic Neurologic Injury. J. Neurosurg. Anesthesiol., 1995, 7(3), 216-221. DOI: http://dx.doi.org/10.1097/ 00008506-199507000-00021
    • (1995) J. Neurosurg. Anesthesiol , vol.7 , Issue.3 , pp. 216-221
    • Lanier, W.L.1
  • 15
    • 0013694986 scopus 로고
    • Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain
    • Busto, R.; Globus, M. Y.; Dietrich, W. D.; Martinez, E.; Valdes, I.; Ginsberg, M. D. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke, 1989, 20(7), 904-910. DOI: http://dx.doi.org/10.1161/01.STR.20. 7.904
    • (1989) Stroke , vol.20 , Issue.7 , pp. 904-910
    • Busto, R.1    Globus, M.Y.2    Dietrich, W.D.3    Martinez, E.4    Valdes, I.5    Ginsberg, M.D.6
  • 16
    • 0013694986 scopus 로고
    • Effect of Mild Hypothermia on Ischemia-Induced Release of Neurotransmitters and Free Fatty-Acids in Rat-Brain
    • Busto, R.; Globus, M. Y.; Dietrich, W. D.; Martinez, E.; Valdes, I.; Ginsberg, M. D. Effect of Mild Hypothermia on Ischemia-Induced Release of Neurotransmitters and Free Fatty-Acids in Rat-Brain. Stroke, 1989, 20(7), 904-910. DOI: http://dx.doi.org/10.1161/ 01.STR.20.7.904
    • (1989) Stroke , vol.20 , Issue.7 , pp. 904-910
    • Busto, R.1    Globus, M.Y.2    Dietrich, W.D.3    Martinez, E.4    Valdes, I.5    Ginsberg, M.D.6
  • 17
    • 0029130550 scopus 로고
    • Glutamate release and free radical production following brain injury: Effects of posttraumatic hypothermia
    • Globus, M. Y.; Alonso, O.; Dietrich, W. D.; Busto, R.; Ginsberg, M. D. Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia. J. Neurochem., 1995, 65(4), 1704-1711. DOI: http://dx.doi.org/10.1046/j.1471-4159. 1995.65041704.x
    • (1995) J. Neurochem , vol.65 , Issue.4 , pp. 1704-1711
    • Globus, M.Y.1    Alonso, O.2    Dietrich, W.D.3    Busto, R.4    Ginsberg, M.D.5
  • 18
    • 0141530958 scopus 로고    scopus 로고
    • Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation
    • Deng, H.; Han, H. S.; Cheng, D.; Sun, G. H.; Yenari, M. A. Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation. Stroke, 2003, 34(10), 2495-2501. DOI: http:// dx.doi.org/10.1161/01.STR.0000091269.67384.E7
    • (2003) Stroke , vol.34 , Issue.10 , pp. 2495-2501
    • Deng, H.1    Han, H.S.2    Cheng, D.3    Sun, G.H.4    Yenari, M.A.5
  • 19
    • 0030027456 scopus 로고    scopus 로고
    • Mild pre- and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat
    • Smith, S. L.; Hall, E. D. Mild pre- and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat. J. Neurotrauma, 1996, 13(1), 1-9. DOI: http://dx.doi.org/10.1089/neu.1996.13.1
    • (1996) J. Neurotrauma , vol.13 , Issue.1 , pp. 1-9
    • Smith, S.L.1    Hall, E.D.2
  • 20
    • 67149143154 scopus 로고    scopus 로고
    • Clinical application of therapeutic hypothermia in stroke
    • Liu, L. P.; Yenari, M. A. Clinical application of therapeutic hypothermia in stroke. Neurol. Res., 2009, 31(4), 331-335. DOI: http://dx.doi.org/10.1179/174313209X444099
    • (2009) Neurol. Res , vol.31 , Issue.4 , pp. 331-335
    • Liu, L.P.1    Yenari, M.A.2
  • 21
    • 2542566701 scopus 로고    scopus 로고
    • Therapeutic hypothermia for acute ischemic stroke - What do laboratory studies teach us?
    • Krieger, D. W.; Yenari, M. A. Therapeutic hypothermia for acute ischemic stroke - What do laboratory studies teach us? Stroke, 2004, 35(6), 1482-1489. DOI: http://dx.doi.org/10.1161/01.STR. 0000126118.44249.5c
    • (2004) Stroke , vol.35 , Issue.6 , pp. 1482-1489
    • Krieger, D.W.1    Yenari, M.A.2
  • 22
    • 36249003722 scopus 로고    scopus 로고
    • General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage
    • Zhao, H.; Steinberg, G. K.; Sapolsky, R. M. General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage. J. Cereb. Blood Flow Metab., 2007, 27(12), 1879-1894. DOI: http://dx.doi.org/10.1038/sj.jcbfm.9600540
    • (2007) J. Cereb. Blood Flow Metab , vol.27 , Issue.12 , pp. 1879-1894
    • Zhao, H.1    Steinberg, G.K.2    Sapolsky, R.M.3
  • 23
    • 80052751229 scopus 로고    scopus 로고
    • Experimental and clinical use of therapeutic hypothermia for ischemic stroke: Opportunities and limitations
    • Zgavc, T.; Ceulemans, A. G.; Sarre, S.; Michotte, Y.; Hachimi- Idrissi, S. Experimental and clinical use of therapeutic hypothermia for ischemic stroke: opportunities and limitations. Stroke Res. Treat., 2011, 2011, 689290.
    • (2011) Stroke Res. Treat , vol.2011
    • Zgavc, T.1    Ceulemans, A.G.2    Sarre, S.3    Michotte, Y.4    Hachimi-Idrissi, S.5
  • 24
    • 62649146471 scopus 로고    scopus 로고
    • Combination therapy with hypothermia for treatment of cerebral ischemia
    • Tang, X. N.; Liu, L.; Yenari, M. A. Combination therapy with hypothermia for treatment of cerebral ischemia. J. Neurotrauma, 2009, 26(3), 325-331. DOI: http://dx.doi.org/10.4061/2011/689290
    • (2009) J. Neurotrauma , vol.26 , Issue.3 , pp. 325-331
    • Tang, X.N.1    Liu, L.2    Yenari, M.A.3
  • 25
    • 62949249270 scopus 로고    scopus 로고
    • Multimodal neuroprotective therapy with induced hypothermia after ischemic stroke
    • Hemmen, T. M.; Lyden, P. D. Multimodal neuroprotective therapy with induced hypothermia after ischemic stroke. Stroke, 2009, 40(3 Suppl), S126-128. DOI: http://dx.doi.org/10.1161/STROKEAHA. 108.533083
    • (2009) Stroke , vol.40 , Issue.3 , pp. S126-S128
    • Hemmen, T.M.1    Lyden, P.D.2
  • 26
    • 19244380799 scopus 로고    scopus 로고
    • Mild resuscitative hypothermia to improve neurological outcome after cardiac arrest. A clinical feasibility trial. Hypothermia After Cardiac Arrest (HACA) Study Group
    • Zeiner, A.; Holzer, M.; Sterz, F.; Behringer, W.; Schorkhuber, W.; Mullner, M.; Frass, M.; Siostrzonek, P.; Ratheiser, K.; Kaff, A.; Laggner, A. N. Mild resuscitative hypothermia to improve neurological outcome after cardiac arrest. A clinical feasibility trial. Hypothermia After Cardiac Arrest (HACA) Study Group. Stroke, 2000, 31(1), 86-94.
    • (2000) Stroke , vol.31 , Issue.1 , pp. 86-94
    • Zeiner, A.1    Holzer, M.2    Sterz, F.3    Behringer, W.4    Schorkhuber, W.5    Mullner, M.6    Frass, M.7    Siostrzonek, P.8    Ratheiser, K.9    Kaff, A.10    Laggner, A.N.11
  • 27
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi, D. W. Glutamate neurotoxicity and diseases of the nervous system. Neuron, 1988, 1(8), 623-634. DOI: http://dx.doi.org/10. 1016/0896-6273(88)90162-6
    • (1988) Neuron , vol.1 , Issue.8 , pp. 623-634
    • Choi, D.W.1
  • 28
    • 0025390880 scopus 로고
    • Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission
    • PMID: 2169834
    • Meldrum, B. Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission. Cerebrovasc. Brain Metab. Rev., 1990, 2(1), 27-57. PMID: 2169834
    • (1990) Cerebrovasc. Brain Metab. Rev , vol.2 , Issue.1 , pp. 27-57
    • Meldrum, B.1
  • 29
    • 0025876609 scopus 로고
    • Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: Brain microdialysis study
    • Mitani, A.; Kataoka, K. Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: brain microdialysis study. Neuroscience, 1991, 42(3), 661-670. DOI: http://dx.doi.org/10.1016/0306-4522(91)90035-M
    • (1991) Neuroscience , vol.42 , Issue.3 , pp. 661-670
    • Mitani, A.1    Kataoka, K.2
  • 31
    • 0028275984 scopus 로고
    • Mild Hypothermia and Mk-801 Have Similar but Not Additive Degrees of Cerebroprotection in the Rat Permanent Focal Ischemia Model
    • Frazzini, V. I.; Winfree, C. J.; Choudhri, H. F.; Prestigiacomo, C. J.; Solomon, R. A. Mild Hypothermia and Mk-801 Have Similar but Not Additive Degrees of Cerebroprotection in the Rat Permanent Focal Ischemia Model. Neurosurgery, 1994, 34(6), 1040-1045. DOI:10.1227/00006123-199406000-00013
    • (1994) Neurosurgery , vol.34 , Issue.6 , pp. 1040-1045
    • Frazzini, V.I.1    Winfree, C.J.2    Choudhri, H.F.3    Prestigiacomo, C.J.4    Solomon, R.A.5
  • 32
    • 33747190566 scopus 로고    scopus 로고
    • Is magnesium neuroprotective following global and focal cerebral ischaemia? A review of published studies
    • PMID: 16955724
    • Meloni, B. P.; Zhu, H.; Knuckey, N. W. Is magnesium neuroprotective following global and focal cerebral ischaemia? A review of published studies. Magnes. Res., 2006, 19(2), 123-137. PMID: 16955724
    • (2006) Magnes. Res , vol.19 , Issue.2 , pp. 123-137
    • Meloni, B.P.1    Zhu, H.2    Knuckey, N.W.3
  • 33
    • 0021260967 scopus 로고
    • Magnesium gates glutamate-activated channels in mouse central neurones
    • Nowak, L.; Bregestovski, P.; Ascher, P.; Herbet, A.; Prochiantz, A. Magnesium gates glutamate-activated channels in mouse central neurones. Nature, 1984, 307(5950), 462-465. DOI: http://dx.doi. org/10.1038/307462a0
    • (1984) Nature , vol.307 , Issue.5950 , pp. 462-465
    • Nowak, L.1    Bregestovski, P.2    Ascher, P.3    Herbet, A.4    Prochiantz, A.5
  • 34
    • 54049085315 scopus 로고    scopus 로고
    • Combined magnesium and mild hypothermia (35 degrees C) treatment reduces infarct volumes after permanent middle cerebral artery occlusion in the rat at 2 and 4, but not 6 h
    • Campbell, K.; Meloni, B. P.; Knuckey, N. W. Combined magnesium and mild hypothermia (35 degrees C) treatment reduces infarct volumes after permanent middle cerebral artery occlusion in the rat at 2 and 4, but not 6 h. Brain Res., 2008, 1230, 258-264. DOI: http://dx.doi.org/10.1016/j.brainres.2008.06.110
    • (2008) Brain Res , vol.1230 , pp. 258-264
    • Campbell, K.1    Meloni, B.P.2    Knuckey, N.W.3
  • 35
    • 84879686888 scopus 로고    scopus 로고
    • Intra-carotid cold magnesium sulfate infusion induces selective cerebral hypothermia and neuroprotection in rats with transient middle cerebral artery occlusion
    • Song, W.; Wu, Y. M.; Ji, Z.; Ji, Y. B.; Wang, S. N.; Pan, S. Y. Intra-carotid cold magnesium sulfate infusion induces selective cerebral hypothermia and neuroprotection in rats with transient middle cerebral artery occlusion. Neurol. Sci., 2013, 34(4), 479-486. DOI: http://dx.doi.org/10.1007/s10072-012-1064-3
    • (2013) Neurol. Sci , vol.34 , Issue.4 , pp. 479-486
    • Song, W.1    Wu, Y.M.2    Ji, Z.3    Ji, Y.B.4    Wang, S.N.5    Pan, S.Y.6
  • 36
    • 84880364627 scopus 로고    scopus 로고
    • FAST-Mag protocol with or without mild hypothermia (35 degrees C) does not improve outcome after permanent MCAO in rats
    • Meloni, B. P.; Cross, J. L.; Brookes, L. M.; Clark, V. W.; Campbell, K.; Knuckey, N. W. FAST-Mag protocol with or without mild hypothermia (35 degrees C) does not improve outcome after permanent MCAO in rats. Magnes. Res., 2013, 26(2), 67-73. DOI: http://dx.doi.org/10.1097/SHK.0b013e3181e86f49
    • (2013) Magnes. Res , vol.26 , Issue.2 , pp. 67-73
    • Meloni, B.P.1    Cross, J.L.2    Brookes, L.M.3    Clark, V.W.4    Campbell, K.5    Knuckey, N.W.6
  • 37
    • 0030690403 scopus 로고    scopus 로고
    • The nagging question of the function of Nacetylaspartylglutamate
    • Coyle, J. T. The nagging question of the function of Nacetylaspartylglutamate. Neurobiol. Dis., 1997, 4(3-4), 231-238. DOI: http://dx.doi.org/10.1006/nbdi.1997.0153
    • (1997) Neurobiol. Dis , vol.4 , Issue.3-4 , pp. 231-238
    • Coyle, J.T.1
  • 38
    • 0033943840 scopus 로고    scopus 로고
    • N-acetylaspartylglutamate: The most abundant peptide neurotransmitter in the mammalian central nervous system
    • Neale, J. H.; Bzdega, T.; Wroblewska, B. N-acetylaspartylglutamate: The most abundant peptide neurotransmitter in the mammalian central nervous system. J. Neurochem., 2000, 75(2), 443-452. DOI: http://dx.doi.org/10.1046/j.1471-4159.2000.0750443.x
    • (2000) J. Neurochem , vol.75 , Issue.2 , pp. 443-452
    • Neale, J.H.1    Bzdega, T.2    Wroblewska, B.3
  • 39
    • 0037154561 scopus 로고    scopus 로고
    • Neuroprotective effects of Nacetylaspartylglutamate in a neonatal rat model of hypoxiaischemia
    • Cai, Z. W.; Lin, S. Y.; Rhodes, P. G. Neuroprotective effects of Nacetylaspartylglutamate in a neonatal rat model of hypoxiaischemia. Eur. J. Pharmacol., 2002, 437(3), 139-145. DOI: http:// dx.doi.org/10.1016/S0014-2999(02)01289-X
    • (2002) Eur. J. Pharmacol , vol.437 , Issue.3 , pp. 139-145
    • Cai, Z.W.1    Lin, S.Y.2    Rhodes, P.G.3
  • 40
    • 0028912822 scopus 로고
    • The Metabotropic Glutamate Receptors - Structure and Functions
    • PMID: 7623957
    • Pin, J. P.; Duvoisin, R. The Metabotropic Glutamate Receptors - Structure and Functions. Neuropharmacology, 1995, 34(1), 1-26. PMID: 7623957
    • (1995) Neuropharmacology , vol.34 , Issue.1 , pp. 1-26
    • Pin, J.P.1    Duvoisin, R.2
  • 41
    • 28844467291 scopus 로고    scopus 로고
    • Neuroprotective effect of N-acetyl-aspartyl-glutamate in combination with mild hypothermia in the endothelin-1 rat model of focal cerebral ischaemia
    • Van Hemelrijck, A.; Hachimi-Idrissi, S.; Sarre, S.; Ebinger, G.; Michotte, Y. Neuroprotective effect of N-acetyl-aspartyl-glutamate in combination with mild hypothermia in the endothelin-1 rat model of focal cerebral ischaemia. J. Neurochem., 2005, 95(5), 1287- 1297. DOI: http://dx.doi.org/10.1111/j.1471-4159.2005.03450.x
    • (2005) J. Neurochem , vol.95 , Issue.5 , pp. 1287-1297
    • Van Hemelrijck, A.1    Hachimi-Idrissi, S.2    Sarre, S.3    Ebinger, G.4    Michotte, Y.5
  • 43
    • 0035996047 scopus 로고    scopus 로고
    • Ontogeny of the N-methyl-Daspartate (NMDA) receptor system and susceptibility to neurotoxicity
    • Haberny, K. A.; Paule, M. G.; Scallet, A. C.; Sistare, F. D.; Lester, D. S.; Hanig, J. P.; Slikker, W., Jr. Ontogeny of the N-methyl-Daspartate (NMDA) receptor system and susceptibility to neurotoxicity. Toxicol. Sci., 2002, 68(1), 9-17. DOI: http://dx.doi. org/10.1093/toxsci/68.1.9
    • (2002) Toxicol. Sci , vol.68 , Issue.1 , pp. 9-17
    • Haberny, K.A.1    Paule, M.G.2    Scallet, A.C.3    Sistare, F.D.4    Lester, D.S.5    Hanig, J.P.6    Slikker, W.7
  • 44
    • 0037301661 scopus 로고    scopus 로고
    • The Yin and Yang of NMDA receptor signalling
    • Hardingham, G. E.; Bading, H. The Yin and Yang of NMDA receptor signalling. Trends Neurosci., 2003, 26(2), 81-89. DOI: http://dx.doi.org/10.1016/S0166-2236(02)00040-1
    • (2003) Trends Neurosci , vol.26 , Issue.2 , pp. 81-89
    • Hardingham, G.E.1    Bading, H.2
  • 46
    • 0036330007 scopus 로고    scopus 로고
    • Heart Stroke Foundation of Ontario Centre of Excellence in Stroke, R. Toward wisdom from failure: Lessons from neuroprotective stroke trials and new therapeutic directions
    • Gladstone, D. J.; Black, S. E.; Hakim, A. M. Heart Stroke Foundation of Ontario Centre of Excellence in Stroke, R. Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke, 2002, 33(8), 2123-2136. DOI: http://dx.doi.org/10.1161/01.STR.0000025518.34157.51
    • (2002) Stroke , vol.33 , Issue.8 , pp. 2123-2136
    • Gladstone, D.J.1    Black, S.E.2    Hakim, A.M.3
  • 47
    • 0141676771 scopus 로고    scopus 로고
    • Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
    • Ikonomidou, C.T. L. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol., 2002, 1(6), 383-386. DOI: http://dx.doi.org/10.1016/S1474-4422 (02)00164-3
    • (2002) Lancet Neurol , vol.1 , Issue.6 , pp. 383-386
    • Ikonomidou, C.T.L.1
  • 48
    • 0029888311 scopus 로고    scopus 로고
    • Role of oxidants in ischemic brain damage
    • Chan, P. H. Role of oxidants in ischemic brain damage. Stroke, 1996, 27(6), 1124-1129. DOI: http://dx.doi.org/10.1161/01.STR. 27.6.1124
    • (1996) Stroke , vol.27 , Issue.6 , pp. 1124-1129
    • Chan, P.H.1
  • 49
    • 34249797890 scopus 로고    scopus 로고
    • Mild hypothermia diminishes oxidative DNA damage and prodeath signaling events after cerebral ischemia: A mechanism for neuroprotection
    • Ji, X.; Luo, Y.; Ling, F.; Stetler, R. A.; Lan, J.; Cao, G.; Chen, J. Mild hypothermia diminishes oxidative DNA damage and prodeath signaling events after cerebral ischemia: a mechanism for neuroprotection. Front Biosci., 2007, 12, 1737-1747. DOI: http://dx.doi.org/10.2741/2185
    • (2007) Front Biosci , vol.12 , pp. 1737-1747
    • Ji, X.1    Luo, Y.2    Ling, F.3    Stetler, R.A.4    Lan, J.5    Cao, G.6    Chen, J.7
  • 50
    • 1442352732 scopus 로고    scopus 로고
    • The neuroprotective effect of a free radical scavenger and mild hypothermia following transient focal ischemia in rats
    • Nito, C.; Kamiya, T.; Amemiya, S.; Katoh, K.; Katayama, Y. The neuroprotective effect of a free radical scavenger and mild hypothermia following transient focal ischemia in rats. Acta Neurochir. Suppl., 2003, 86, 199-203. DOI: http://dx.doi.org/10. 1007/978-3-7091-0651-8_43
    • (2003) Acta Neurochir. Suppl , vol.86 , pp. 199-203
    • Nito, C.1    Kamiya, T.2    Amemiya, S.3    Katoh, K.4    Katayama, Y.5
  • 51
    • 0027220391 scopus 로고
    • Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis
    • Eddleston, M.; de la Torre, J. C.; Oldstone, M. B.; Loskutoff, D. J.; Edgington, T. S.; Mackman, N. Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis. J. Clin. Invest., 1993, 92(1), 349- 358. DOI: http://dx.doi.org/10.1172/JCI116573
    • (1993) J. Clin. Invest , vol.92 , Issue.1 , pp. 349-358
    • Eddleston, M.1    de la Torre, J.C.2    Oldstone, M.B.3    Loskutoff, D.J.4    Edgington, T.S.5    Mackman, N.6
  • 52
    • 35348998944 scopus 로고    scopus 로고
    • Intravenous rt-PA: A tenth anniversary reflection
    • Grotta, J.; Marler, J. Intravenous rt-PA: a tenth anniversary reflection. Surgical Neurol., 2007, 68 (1), 12-16. DOI: http://dx. doi.org/10.1016/j.surneu.2007.07.079
    • (2007) Surgical Neurol , vol.68 , Issue.1 , pp. 12-16
    • Grotta, J.1    Marler, J.2
  • 53
    • 62649139699 scopus 로고    scopus 로고
    • Mild hypothermia reduces hemorrhage and blood brain barrier (BBB) disruption following tissue plasminogen activator treatment in experimental stroke
    • ISSN: 0028-3878, IDS Number: 022PM, Accession Number: WOS:000236068103009
    • Liu, L. P.; Tang, X. N.; Yenari, M. A. Mild hypothermia reduces hemorrhage and blood brain barrier (BBB) disruption following tissue plasminogen activator treatment in experimental stroke. Neurology, 2006, 66(5), A242-A243. ISSN: 0028-3878, IDS Number: 022PM, Accession Number: WOS:000236068103009
    • (2006) Neurology , vol.66 , Issue.5 , pp. A242-A243
    • Liu, L.P.1    Tang, X.N.2    Yenari, M.A.3
  • 54
    • 84859344037 scopus 로고    scopus 로고
    • Mild hypothermia of 34 degrees C reduces side effects of rt-PA treatment after thromboembolic stroke in rats
    • Kallmunzer, B.; Schwab, S.; Kollmar, R. Mild hypothermia of 34 degrees C reduces side effects of rt-PA treatment after thromboembolic stroke in rats. Exp. Transl. Stroke Med., 2012, 4(1), 3. DOI: http://dx.doi.org/10.1186/2040-7378-4-3
    • (2012) Exp. Transl. Stroke Med , vol.4 , Issue.1 , pp. 3
    • Kallmunzer, B.1    Schwab, S.2    Kollmar, R.3
  • 55
    • 0028142010 scopus 로고
    • Effect of hypothermia and delayed thrombolysis in a rat embolic stroke model
    • Meden, P.; Overgaard, K.; Pedersen, H.; Boysen, G. Effect of hypothermia and delayed thrombolysis in a rat embolic stroke model. Acta Neurol. Scand., 1994, 90(2), 91-98. DOI: http://dx.doi.org/10.1111/j.1600-0404.1994.tb02686.x
    • (1994) Acta Neurol. Scand , vol.90 , Issue.2 , pp. 91-98
    • Meden, P.1    Overgaard, K.2    Pedersen, H.3    Boysen, G.4
  • 56
    • 5044232108 scopus 로고    scopus 로고
    • Combination therapy of moderate hypothermia and thrombolysis in experimental thromboembolic stroke--an MRI study
    • Kollmar, R.; Henninger, N.; Bardutzky, J.; Schellinger, P. D.; Schabitz, W. R.; Schwab, S. Combination therapy of moderate hypothermia and thrombolysis in experimental thromboembolic stroke--an MRI study. Exp. Neurol., 2004, 190(1), 204-212. DOI: http://dx.doi.org/10.1111/j.1600-0404.1994.tb02686.x
    • (2004) Exp. Neurol , vol.190 , Issue.1 , pp. 204-212
    • Kollmar, R.1    Henninger, N.2    Bardutzky, J.3    Schellinger, P.D.4    Schabitz, W.R.5    Schwab, S.6
  • 57
    • 80053602560 scopus 로고    scopus 로고
    • Local mild hypothermia with thrombolysis for acute ischemic stroke within a 6-h window
    • Bi, M.; Ma, Q.; Zhang, S.; Li, J.; Zhang, Y.; Lin, L.; Tong, S.; Wang, D. Local mild hypothermia with thrombolysis for acute ischemic stroke within a 6-h window. Clin. Neurol. Neurosurg., 2011, 113(9), 768-773. DOI: http://dx.doi.org/10.1016/j.clineuro. 2011.08.010
    • (2011) Clin. Neurol. Neurosurg , vol.113 , Issue.9 , pp. 768-773
    • Bi, M.1    Ma, Q.2    Zhang, S.3    Li, J.4    Zhang, Y.5    Lin, L.6    Tong, S.7    Wang, D.8
  • 58
    • 77957994535 scopus 로고    scopus 로고
    • Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L): Final results
    • Hemmen, T. M.; Raman, R.; Guluma, K. Z.; Meyer, B. C.; Gomes, J. A.; Cruz-Flores, S.; Wijman, C. A.; Rapp, K. S.; Grotta, J. C.; Lyden, P. D.; Investigators, I. C.-L. Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L): final results. Stroke, 2010, 41(10), 2265-2270. DOI: http://dx.doi. org/10.1161/STROKEAHA.110.592295
    • (2010) Stroke , vol.41 , Issue.10 , pp. 2265-2270
    • Hemmen, T.M.1    Raman, R.2    Guluma, K.Z.3    Meyer, B.C.4    Gomes, J.A.5    Cruz-Flores, S.6    Wijman, C.A.7    Rapp, K.S.8    Grotta, J.C.9    Lyden, P.D.10
  • 59
    • 0027435760 scopus 로고
    • Synthetic selective inhibitors of thrombin
    • Okamoto, S.; Hijikata-Okunomiya, A. Synthetic selective inhibitors of thrombin. Methods Enzymol., 1993, 222, 328-340. DOI: http://dx.doi.org/10.1016/0076-6879(93)22022-8
    • (1993) Methods Enzymol , vol.222 , pp. 328-340
    • Okamoto, S.1    Hijikata-Okunomiya, A.2
  • 60
    • 0034049121 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of argatroban: Effects of age, gender, and hepatic or renal dysfunction
    • Swan, S. K.; Hursting, M. J. The pharmacokinetics and pharmacodynamics of argatroban: effects of age, gender, and hepatic or renal dysfunction. Pharmacotherapy, 2000, 20(3), 318-329. DOI: http://dx.doi.org/10.1592/phco.20.4.318.34881
    • (2000) Pharmacotherapy , vol.20 , Issue.3 , pp. 318-329
    • Swan, S.K.1    Hursting, M.J.2
  • 61
    • 0028004409 scopus 로고
    • Antithrombotic actions of argatroban in rat models of venous, 'mixed' and arterial thrombosis, and its effects on the tail transection bleeding time
    • Berry, C. N.; Girard, D.; Lochot, S.; Lecoffre, C. Antithrombotic actions of argatroban in rat models of venous, 'mixed' and arterial thrombosis, and its effects on the tail transection bleeding time. Br. J. Pharmacol., 1994, 113(4), 1209-1214. DOI: http://dx.doi.org/ 10.1111/j.1476-5381.1994.tb17126.x
    • (1994) Br. J. Pharmacol , vol.113 , Issue.4 , pp. 1209-1214
    • Berry, C.N.1    Girard, D.2    Lochot, S.3    Lecoffre, C.4
  • 63
    • 0030436893 scopus 로고    scopus 로고
    • Effects of a thrombin inhibitor, argatroban, on ischemic brain damage in the rat distal middle cerebral artery occlusion model
    • PMID: 8768731
    • Kawai, H.; Yuki, S.; Sugimoto, J.; Tamao, Y. Effects of a thrombin inhibitor, argatroban, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J. Pharmacol. Exp. Ther., 1996, 278(2), 780-785. PMID: 8768731
    • (1996) J. Pharmacol. Exp. Ther , vol.278 , Issue.2 , pp. 780-785
    • Kawai, H.1    Yuki, S.2    Sugimoto, J.3    Tamao, Y.4
  • 64
    • 0035168889 scopus 로고    scopus 로고
    • Extension of the therapeutic window for recombinant tissue plasminogen activator with argatroban in a rat model of embolic stroke
    • Morris, D. C.; Zhang, L.; Zhang, Z. G.; Lu, M.; Berens, K. L.; Brown, P. M.; Chopp, M. Extension of the therapeutic window for recombinant tissue plasminogen activator with argatroban in a rat model of embolic stroke. Stroke, 2001, 32(11), 2635-2640. DOI: http://dx.doi.org/10.1161/hs1101.097390
    • (2001) Stroke , vol.32 , Issue.11 , pp. 2635-2640
    • Morris, D.C.1    Zhang, L.2    Zhang, Z.G.3    Lu, M.4    Berens, K.L.5    Brown, P.M.6    Chopp, M.7
  • 65
    • 1442352731 scopus 로고    scopus 로고
    • Mild hypothermia enhances the neuroprotective effects of a selective thrombin inhibitor following transient focal ischemia in rats
    • Kamiya, T.; Nito, C.; Ueda, M.; Kato, K.; Amemiya, S.; Terashi, A.; Katayama, Y. Mild hypothermia enhances the neuroprotective effects of a selective thrombin inhibitor following transient focal ischemia in rats. Acta Neurochir. Suppl., 2003, 86, 195-198. DOI: http://dx.doi.org/10.1007/978-3-7091-0651-8_42
    • (2003) Acta Neurochir. Suppl , vol.86 , pp. 195-198
    • Kamiya, T.1    Nito, C.2    Ueda, M.3    Kato, K.4    Amemiya, S.5    Terashi, A.6    Katayama, Y.7
  • 66
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs, U.; La Fata, V.; Plutzky, J.; Liao, J. K. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation, 1998, 97(12), 1129-1135. DOI: http://dx. doi.org/10.1161/01.CIR.97.12.1129
    • (1998) Circulation , vol.97 , Issue.12 , pp. 1129-1135
    • Laufs, U.1    La Fata, V.2    Plutzky, J.3    Liao, J.K.4
  • 67
    • 0033800718 scopus 로고    scopus 로고
    • Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice
    • Laufs, U.; Gertz, K.; Huang, P.; Nickenig, G.; Bohm, M.; Dirnagl, U.; Endres, M. Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice. Stroke, 2000, 31(10), 2442-2449. DOI: http://dx.doi.org/10.1161/ 01.STR.31.10.2442
    • (2000) Stroke , vol.31 , Issue.10 , pp. 2442-2449
    • Laufs, U.1    Gertz, K.2    Huang, P.3    Nickenig, G.4    Bohm, M.5    Dirnagl, U.6    Endres, M.7
  • 68
    • 0032555154 scopus 로고    scopus 로고
    • Stroke protection by 3-hydroxy-3- methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
    • PMID: 9671773
    • Endres, M.; Laufs, U.; Huang, Z.; Nakamura, T.; Huang, P.; Moskowitz, M. A.; Liao, J. K. Stroke protection by 3-hydroxy-3- methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. U. S. A., 1998, 95(15), 8880-8885. PMID: 9671773
    • (1998) Proc. Natl. Acad. Sci. U. S. A , vol.95 , Issue.15 , pp. 8880-8885
    • Endres, M.1    Laufs, U.2    Huang, Z.3    Nakamura, T.4    Huang, P.5    Moskowitz, M.A.6    Liao, J.K.7
  • 69
    • 55649123457 scopus 로고    scopus 로고
    • Atorvastatin enhances hypothermia-induced neuroprotection after stroke
    • Lee, S. H.; Kim, Y. H.; Kim, Y. J.; Yoon, B. W. Atorvastatin enhances hypothermia-induced neuroprotection after stroke. J. Neurol. Sci., 2008, 275(1-2), 64-68. DOI: http://dx.doi.org/10. 1016/j.jns.2008.07.029
    • (2008) J. Neurol. Sci , vol.275 , Issue.1-2 , pp. 64-68
    • Lee, S.H.1    Kim, Y.H.2    Kim, Y.J.3    Yoon, B.W.4
  • 70
    • 0027343618 scopus 로고
    • Reactive Glia as Rivals in Regulating Neuronal Survival
    • Giulian, D. Reactive Glia as Rivals in Regulating Neuronal Survival. Glia, 1993, 7(1), 102-110. DOI: http://dx.doi.org/10. 1002/glia.440070116
    • (1993) Glia , vol.7 , Issue.1 , pp. 102-110
    • Giulian, D.1
  • 71
    • 0023614999 scopus 로고
    • Ameboid Microglia as Effectors of Inflammation in the Central-Nervous-System
    • Giulian, D. Ameboid Microglia as Effectors of Inflammation in the Central-Nervous-System. J. Neurosci. Res., 1987, 18(1), 155-171. DOI: http://dx.doi.org/10.1002/jnr.490180123
    • (1987) J. Neurosci. Res , vol.18 , Issue.1 , pp. 155-171
    • Giulian, D.1
  • 72
    • 0028675999 scopus 로고
    • Cytokines, inflammation, and brain injury: Role of tumor necrosis factor-alpha
    • PMID: 7880718
    • Feuerstein, G. Z.; Liu, T.; Barone, F. C. Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha. Cerebrovasc. Brain Metab. Rev., 1994, 6(4), 341-360. PMID: 7880718
    • (1994) Cerebrovasc. Brain Metab. Rev , vol.6 , Issue.4 , pp. 341-360
    • Feuerstein, G.Z.1    Liu, T.2    Barone, F.C.3
  • 73
    • 0031982968 scopus 로고    scopus 로고
    • Inflammation and acute stroke
    • Becker, K. J. Inflammation and acute stroke. Curr. Opin. Neurol., 1998, 11(1), 45-49. DOI: http://dx.doi.org/10.1097/00019052- 199802000-00008
    • (1998) Curr. Opin. Neurol , vol.11 , Issue.1 , pp. 45-49
    • Becker, K.J.1
  • 74
    • 0037424434 scopus 로고    scopus 로고
    • Neuroprotective action of tacrolimus (FK506) in focal and global cerebral ischemia in rodents: Dose dependency, therapeutic time window and long-term efficacy
    • Furuichi, Y.; Katsuta, K.; Maeda, M.; Ueyama, N.; Moriguchi, A.; Matsuoka, N.; Goto, T.; Yanagihara, T. Neuroprotective action of tacrolimus (FK506) in focal and global cerebral ischemia in rodents: dose dependency, therapeutic time window and long-term efficacy. Brain Res., 2003, 965(1-2), 137-145. DOI: http://dx.doi.org/10.1016/S0006-8993(02)04151-3
    • (2003) Brain Res , vol.965 , Issue.1-2 , pp. 137-145
    • Furuichi, Y.1    Katsuta, K.2    Maeda, M.3    Ueyama, N.4    Moriguchi, A.5    Matsuoka, N.6    Goto, T.7    Yanagihara, T.8
  • 75
    • 0030019624 scopus 로고    scopus 로고
    • An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the mongolian gerbil
    • Ide, T.; Morikawa, E.; Kirino, T. An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the mongolian gerbil. Neurosci. Lett., 1996, 204(3), 157-160. DOI: http://dx.doi.org/10.1016/0304-3940(96)12352-1
    • (1996) Neurosci. Lett , vol.204 , Issue.3 , pp. 157-160
    • Ide, T.1    Morikawa, E.2    Kirino, T.3
  • 76
    • 0032482134 scopus 로고    scopus 로고
    • Dosedependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia
    • Wakita, H.; Tomimoto, H.; Akiguchi, I.; Kimura, J. Dosedependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia. Brain Res., 1998, 792(1), 105-113. DOI: http://dx.doi.org/10.1016/S0006-8993(98) 00126-7
    • (1998) Brain Res , vol.792 , Issue.1 , pp. 105-113
    • Wakita, H.1    Tomimoto, H.2    Akiguchi, I.3    Kimura, J.4
  • 77
    • 2442431643 scopus 로고    scopus 로고
    • Mild hypothermia enhances the neuroprotective effects of FK506 and expands its therapeutic window following transient focal ischemia in rats
    • Nito, C.; Kamiya, T.; Ueda, M.; Arii, T.; Katayama, Y. Mild hypothermia enhances the neuroprotective effects of FK506 and expands its therapeutic window following transient focal ischemia in rats. Brain Res., 2004, 1008(2), 179-185. DOI: http://dx.doi.org/ 10.1016/j.brainres.2004.02.031
    • (2004) Brain Res , vol.1008 , Issue.2 , pp. 179-185
    • Nito, C.1    Kamiya, T.2    Ueda, M.3    Arii, T.4    Katayama, Y.5
  • 78
    • 77957306859 scopus 로고    scopus 로고
    • Expression of HSP70 in cerebral ischemia and neuroprotetive action of hypothermia and ketoprofen
    • Tirapelli, D. P. D.; Carlotti, C. G.; Leite, J. P.; Tirapelli, L. F.; Colli, B. O. Expression of HSP70 in cerebral ischemia and neuroprotetive action of hypothermia and ketoprofen. Arq. Neuropsiquiatr., 2010, 68(4), 592-596. DOI: http://dx.doi.org/10.1590/S0004-282 X2010000400021
    • (2010) Arq. Neuropsiquiatr , vol.68 , Issue.4 , pp. 592-596
    • Tirapelli, D.P.D.1    Carlotti, C.G.2    Leite, J.P.3    Tirapelli, L.F.4    Colli, B.O.5
  • 79
    • 0011824269 scopus 로고
    • The synthesis of cytidine diphosphate choline, cytidine diphosphate ethanolamine, and related compounds
    • PMID: 13366992
    • Kennedy, E. P. The synthesis of cytidine diphosphate choline, cytidine diphosphate ethanolamine, and related compounds. J. Biol. Chem., 1956, 222(1), 185-191. PMID: 13366992
    • (1956) J. Biol. Chem , vol.222 , Issue.1 , pp. 185-191
    • Kennedy, E.P.1
  • 80
    • 0037107919 scopus 로고    scopus 로고
    • Citicoline mechanisms and clinical efficacy in cerebral ischemia
    • Adibhatla, R. M.; Hatcher, J. F. Citicoline mechanisms and clinical efficacy in cerebral ischemia. J. Neurosci. Res., 2002, 70(2), 133-139. DOI: http://dx.doi.org/10.1002/jnr.10403
    • (2002) J. Neurosci. Res , vol.70 , Issue.2 , pp. 133-139
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 81
    • 0019856239 scopus 로고
    • Effect of Cytidine Diphosphate Choline (Cdp-Choline) on Ischemia-Induced Alterations of Brain Lipid in the Gerbil
    • Trovarelli, G.; Demedio, G. E.; Dorman, R. V.; Piccinin, G. L.; Horrocks, L. A.; Porcellati, G. Effect of Cytidine Diphosphate Choline (Cdp-Choline) on Ischemia-Induced Alterations of Brain Lipid in the Gerbil. Neurochem. Res., 1981, 6(8), 821-833. DOI: http://dx.doi.org/10.1007/BF00965041
    • (1981) Neurochem. Res , vol.6 , Issue.8 , pp. 821-833
    • Trovarelli, G.1    Demedio, G.E.2    Dorman, R.V.3    Piccinin, G.L.4    Horrocks, L.A.5    Porcellati, G.6
  • 82
    • 0033777506 scopus 로고    scopus 로고
    • Lipid alterations in transient forebrain ischemia: Possible new mechanisms of CDPcholine neuroprotection
    • Rao, A. M.; Hatcher, J. F.; Dempsey, R. J. Lipid alterations in transient forebrain ischemia: possible new mechanisms of CDPcholine neuroprotection. J. Neurochem., 2000, 75(6), 2528-2535. DOI: http://dx.doi.org/10.1046/j.1471-4159.2000.0752528.x
    • (2000) J. Neurochem , vol.75 , Issue.6 , pp. 2528-2535
    • Rao, A.M.1    Hatcher, J.F.2    Dempsey, R.J.3
  • 83
    • 0345561549 scopus 로고    scopus 로고
    • Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia
    • discussion 431-422
    • Schabitz, W. R.; Li, F.; Irie, K.; Sandage, B. W., Jr.; Locke, K. W.; Fisher, M. Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia. Stroke, 1999, 30(2), 427-431; discussion 431-422. DOI: http://dx.doi.org/10.1161/01.STR.30.2.427
    • (1999) Stroke , vol.30 , Issue.2 , pp. 427-431
    • Schabitz, W.R.1    Li, F.2    Irie, K.3    Sandage, B.W.4    Locke, K.W.5    Fisher, M.6
  • 84
    • 0028896412 scopus 로고
    • Metabolism and Actions of Cdp-Choline as an Endogenous Compound and Administered Exogenously as Citicoline
    • Weiss, G. B. Metabolism and Actions of Cdp-Choline as an Endogenous Compound and Administered Exogenously as Citicoline. Life Sci., 1995, 56(9), 637-660. DOI: http://dx.doi.org/ 10.1016/0024-3205(94)00427-T
    • (1995) Life Sci , vol.56 , Issue.9 , pp. 637-660
    • Weiss, G.B.1
  • 85
    • 0036098560 scopus 로고    scopus 로고
    • CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat
    • Krupinski, J.; Ferrer, I.; Barrachina, M.; Secades, J. J.; Mercadal, J.; Lozano, R. CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat. Neuropharmacology, 2002, 42(6), 846-854. DOI: http://dx.doi.org/10.1016/S0028-3908(02) 00032-1
    • (2002) Neuropharmacology , vol.42 , Issue.6 , pp. 846-854
    • Krupinski, J.1    Ferrer, I.2    Barrachina, M.3    Secades, J.J.4    Mercadal, J.5    Lozano, R.6
  • 86
    • 73449126488 scopus 로고    scopus 로고
    • Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats
    • Sahin, S.; Alkan, T.; Temel, S. G.; Tureyen, K.; Tolunay, S.; Korfali, E. Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats. J. Clin. Neurosci., 2010, 17(2), 227-231. DOI: http://dx.doi.org/10.1016/j.jocn.2009.05.016
    • (2010) J. Clin. Neurosci , vol.17 , Issue.2 , pp. 227-231
    • Sahin, S.1    Alkan, T.2    Temel, S.G.3    Tureyen, K.4    Tolunay, S.5    Korfali, E.6
  • 88
    • 0035871840 scopus 로고    scopus 로고
    • Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    • PMID: 11306611
    • Tikka, T.; Fiebich, B. L.; Goldsteins, G.; Keinanen, R.; Koistinaho, J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J. Neurosci., 2001, 21(8), 2580-2588. PMID: 11306611
    • (2001) J. Neurosci , vol.21 , Issue.8 , pp. 2580-2588
    • Tikka, T.1    Fiebich, B.L.2    Goldsteins, G.3    Keinanen, R.4    Koistinaho, J.5
  • 89
    • 0032442475 scopus 로고    scopus 로고
    • Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
    • Yrjanheikki, J.; Keinanen, R.; Pellikka, M.; Hokfelt, T.; Koistinaho, J. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc. Natl. Acad. Sci. U. S. A., 1998, 95(26), 15769-15774. DOI: http://dx.doi.org/10.1073/ pnas.95.26.15769
    • (1998) Proc. Natl. Acad. Sci. U. S. A , vol.95 , Issue.26 , pp. 15769-15774
    • Yrjanheikki, J.1    Keinanen, R.2    Pellikka, M.3    Hokfelt, T.4    Koistinaho, J.5
  • 90
    • 10744226569 scopus 로고    scopus 로고
    • Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO
    • Scarabelli, T. M.; Stephanou, A.; Pasini, E.; Gitti, G.; Townsend, P.; Lawrence, K.; Chen-Scarabelli, C.; Saravolatz, L.; Latchman, D.; Knight, R.; Gardin, J. Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO. J. Am. Coll. Cardiol., 2004, 43(5), 865-874. f DOI: http://dx.doi.org/10.1016/j.jacc.2003.09.050
    • (2004) J. Am. Coll. Cardiol , vol.43 , Issue.5 , pp. 865-874
    • Scarabelli, T.M.1    Stephanou, A.2    Pasini, E.3    Gitti, G.4    Townsend, P.5    Lawrence, K.6    Chen-Scarabelli, C.7    Saravolatz, L.8    Latchman, D.9    Knight, R.10    Gardin, J.11
  • 91
    • 18144393838 scopus 로고    scopus 로고
    • Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage
    • Morimoto, N.; Shimazawa, M.; Yamashima, T.; Nagai, H.; Hara, H. Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage. Brain Res., 2005, 1044(1), 8-15. DOI: http://dx.doi.org/10.1016/j.brainres.2005.02.062
    • (2005) Brain Res , vol.1044 , Issue.1 , pp. 8-15
    • Morimoto, N.1    Shimazawa, M.2    Yamashima, T.3    Nagai, H.4    Hara, H.5
  • 92
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • Yrjanheikki, J.; Tikka, T.; Keinanen, R.; Goldsteins, G.; Chan, P. H.; Koistinaho, J. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc. Natl. Acad. Sci. U S A, 1999, 96(23), 13496-13500. DOI: http://dx.doi.org/10.1073/pnas.96. 23.13496
    • (1999) Proc. Natl. Acad. Sci. U S A , vol.96 , Issue.23 , pp. 13496-13500
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 93
    • 8844254741 scopus 로고    scopus 로고
    • The promise of minocycline in neurology
    • Yong, V. W.; Wells, J.; Giuliani, F.; Casha, S.; Power, C.; Metz, L. M. The promise of minocycline in neurology. Lancet Neurol., 2004, 3(12), 744-751. DOI: http://dx.doi.org/10.1016/S1474- 4422(04)00937-8
    • (2004) Lancet Neurol , vol.3 , Issue.12 , pp. 744-751
    • Yong, V.W.1    Wells, J.2    Giuliani, F.3    Casha, S.4    Power, C.5    Metz, L.M.6
  • 94
    • 0013071212 scopus 로고    scopus 로고
    • Delayed minocycline but not delayed mild hypothermia protects against embolic stroke
    • Wang, C. X.; Yang, T.; Noor, R.; Shuaib, A. Delayed minocycline but not delayed mild hypothermia protects against embolic stroke. BMC Neurol., 2002, 2, 2. doi:10.1186/1471-2377-2-2
    • (2002) BMC Neurol , vol.2 , pp. 2
    • Wang, C.X.1    Yang, T.2    Noor, R.3    Shuaib, A.4
  • 95
    • 0037435882 scopus 로고    scopus 로고
    • Effects of minocycline alone and in combination with mild hypothermia in embolic stroke
    • Wang, C. X.; Yang, T.; Shuaib, A. Effects of minocycline alone and in combination with mild hypothermia in embolic stroke. Brain Res., 2003, 963(1-2), 327-329. DOI: http://dx.doi.org/10.1016/ S0006-8993(02)04045-3
    • (2003) Brain Res , vol.963 , Issue.1-2 , pp. 327-329
    • Wang, C.X.1    Yang, T.2    Shuaib, A.3
  • 96
    • 37349030729 scopus 로고    scopus 로고
    • Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat: Effects on BBB breakdown and MMP expression in the acute and subacute phase
    • Nagel, S.; Su, Y.; Horstmann, S.; Heiland, S.; Gardner, H.; Koziol, J.; Martinez-Torres, F. J.; Wagner, S. Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat: effects on BBB breakdown and MMP expression in the acute and subacute phase. Brain Res., 2008, 1188, 198-206. DOI: http://dx.doi.org/10.1016/j.brainres.2007.10.052
    • (2008) Brain Res , vol.1188 , pp. 198-206
    • Nagel, S.1    Su, Y.2    Horstmann, S.3    Heiland, S.4    Gardner, H.5    Koziol, J.6    Martinez-Torres, F.J.7    Wagner, S.8
  • 97
    • 0024365888 scopus 로고
    • Ischaemic damage in gerbil hippocampus is reduced following upregulation of adenosine (A1) receptors by caffeine treatment
    • Rudolphi, K. A.; Keil, M.; Fastbom, J.; Fredholm, B. B. Ischaemic damage in gerbil hippocampus is reduced following upregulation of adenosine (A1) receptors by caffeine treatment. Neurosci. Lett., 1989, 103(3), 275-280. DOI: http://dx.doi.org/10.1016/0304- 3940(89)90112-2
    • (1989) Neurosci. Lett , vol.103 , Issue.3 , pp. 275-280
    • Rudolphi, K.A.1    Keil, M.2    Fastbom, J.3    Fredholm, B.B.4
  • 98
    • 0026777267 scopus 로고
    • Therapeutic potential for adenosine receptor activation in ischemic brain injury
    • PMID: 1613814
    • Miller, L. P.; Hsu, C. Therapeutic potential for adenosine receptor activation in ischemic brain injury. J. Neurotrauma, 1992, 9 Suppl 2, S563-577. PMID: 1613814
    • (1992) J. Neurotrauma , vol.9 , pp. S563-S577
    • Miller, L.P.1    Hsu, C.2
  • 99
    • 0024535962 scopus 로고
    • Ethanol inhibits NMDAactivated ion current in hippocampal neurons
    • Lovinger, D. M.; White, G.; Weight, F. F. Ethanol inhibits NMDAactivated ion current in hippocampal neurons. Science, 1989, 243(4899), 1721-1724. DOI: http://dx.doi.org/10.1126/science. 2467382
    • (1989) Science , vol.243 , Issue.4899 , pp. 1721-1724
    • Lovinger, D.M.1    White, G.2    Weight, F.F.3
  • 100
    • 0032513070 scopus 로고    scopus 로고
    • Protective effects of the free radical scavengers, dimethyl sulfoxide and ethanol, in cerebral ischemia in gerbils
    • Phillis, J. W.; Estevez, A. Y.; O'Regan, M. H. Protective effects of the free radical scavengers, dimethyl sulfoxide and ethanol, in cerebral ischemia in gerbils. Neurosci. Lett., 1998, 244(2), 109- 111. DOI: http://dx.doi.org/10.1016/S0304-3940(98)00139-6
    • (1998) Neurosci. Lett , vol.244 , Issue.2 , pp. 109-111
    • Phillis, J.W.1    Estevez, A.Y.2    O'Regan, M.H.3
  • 101
    • 0038222577 scopus 로고    scopus 로고
    • Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: Preclinical experience
    • Aronowski, J.; Strong, R.; Shirzadi, A.; Grotta, J. C. Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: preclinical experience. Stroke, 2003, 34(5), 1246-1251. DOI: http://dx.doi. org/10.1161/01.STR.0000068170.80517.B3
    • (2003) Stroke , vol.34 , Issue.5 , pp. 1246-1251
    • Aronowski, J.1    Strong, R.2    Shirzadi, A.3    Grotta, J.C.4
  • 102
    • 0030611345 scopus 로고    scopus 로고
    • A(1) and A(2A) adenosine receptors and A(1) mRNA in mouse brain: Effect of long-term caffeine treatment
    • Johansson, B.; Georgiev, V.; Lindstrom, K.; Fredholm, B. B. A(1) and A(2A) adenosine receptors and A(1) mRNA in mouse brain: effect of long-term caffeine treatment. Brain Res., 1997, 762(1-2), 153-164. DOI: http://dx.doi.org/10.1016/S0006-8993(97)00378-8
    • (1997) Brain Res , vol.762 , Issue.1-2 , pp. 153-164
    • Johansson, B.1    Georgiev, V.2    Lindstrom, K.3    Fredholm, B.B.4
  • 103
    • 0027405992 scopus 로고
    • Radioligand binding to the N-methyl-D-aspartate receptor/ionophore complex: Alterations by ethanol in vitro and by chronic in vivo ethanol ingestion
    • Snell, L. D.; Tabakoff, B.; Hoffman, P. L. Radioligand binding to the N-methyl-D-aspartate receptor/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion. Brain Res., 1993, 602(1), 91-98. DOI: http://dx.doi.org/10.1016/0006- 8993(93)90246-J
    • (1993) Brain Res , vol.602 , Issue.1 , pp. 91-98
    • Snell, L.D.1    Tabakoff, B.2    Hoffman, P.L.3
  • 104
    • 0027419443 scopus 로고
    • Ethanol inhibits NMDA receptor-mediated excitotoxicity in rat primary neuronal cultures
    • Chandler, L. J.; Sumners, C.; Crews, F. T. Ethanol inhibits NMDA receptor-mediated excitotoxicity in rat primary neuronal cultures. Alcohol Clin. Exp. Res., 1993, 17(1), 54-60. DOI: http://dx.doi.org/ 10.1111/j.1530-0277.1993.tb00726.x
    • (1993) Alcohol Clin. Exp. Res , vol.17 , Issue.1 , pp. 54-60
    • Chandler, L.J.1    Sumners, C.2    Crews, F.T.3
  • 105
    • 0033978741 scopus 로고    scopus 로고
    • Combination of low dose ethanol and caffeine protects brain from damage produced by focal ischemia in rats
    • Strong, R.; Grotta, J. C.; Aronowski, J. Combination of low dose ethanol and caffeine protects brain from damage produced by focal ischemia in rats. Neuropharmacology, 2000, 39(3), 515-522. DOI: http://dx.doi.org/10.1016/S0028-3908(99)00156-2
    • (2000) Neuropharmacology , vol.39 , Issue.3 , pp. 515-522
    • Strong, R.1    Grotta, J.C.2    Aronowski, J.3
  • 106
    • 60949087646 scopus 로고    scopus 로고
    • Combined neuroprotective modalities coupled with thrombolysis in acute ischemic stroke: A pilot study of caffeinol and mild hypothermia
    • Martin-Schild, S.; Hallevi, H.; Shaltoni, H.; Barreto, A. D.; Gonzales, N. R.; Aronowski, J.; Savitz, S. I.; Grotta, J. C. Combined neuroprotective modalities coupled with thrombolysis in acute ischemic stroke: a pilot study of caffeinol and mild hypothermia. J. Stroke Cerebrovasc. Dis., 2009, 18(2), 86-96. DOI: http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2008.09.015
    • (2009) J. Stroke Cerebrovasc. Dis , vol.18 , Issue.2 , pp. 86-96
    • Martin-Schild, S.1    Hallevi, H.2    Shaltoni, H.3    Barreto, A.D.4    Gonzales, N.R.5    Aronowski, J.6    Savitz, S.I.7    Grotta, J.C.8
  • 107
    • 33644848728 scopus 로고    scopus 로고
    • Xenon provides short-term neuroprotection in neonatal rats when administered after hypoxia-ischemia
    • Dingley, J.; Tooley, J.; Porter, H.; Thoresen, M. Xenon provides short-term neuroprotection in neonatal rats when administered after hypoxia-ischemia. Stroke, 2006, 37(2), 501-506. DOI: http://dx.doi.org/10.1161/01.STR.0000198867.31134.ac
    • (2006) Stroke , vol.37 , Issue.2 , pp. 501-506
    • Dingley, J.1    Tooley, J.2    Porter, H.3    Thoresen, M.4
  • 108
    • 56149093066 scopus 로고    scopus 로고
    • Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model
    • Luo, Y.; Ma, D.; Ieong, E.; Sanders, R. D.; Yu, B.; Hossain, M.; Maze, M. Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model. Anesthesiology, 2008, 109(5), 782-789. DOI: http://dx.doi.org/10.1097/ALN.0b013e3181895f88
    • (2008) Anesthesiology , vol.109 , Issue.5 , pp. 782-789
    • Luo, Y.1    Ma, D.2    Ieong, E.3    Sanders, R.D.4    Yu, B.5    Hossain, M.6    Maze, M.7
  • 109
    • 0141655167 scopus 로고    scopus 로고
    • The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice
    • Homi, H. M.; Yokoo, N.; Ma, D.; Warner, D. S.; Franks, N. P.; Maze, M.; Grocott, H. P. The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Anesthesiology, 2003, 99(4), 876-881. DOI: http://dx.doi.org/10.1097/00000542-200310000-00020
    • (2003) Anesthesiology , vol.99 , Issue.4 , pp. 876-881
    • Homi, H.M.1    Yokoo, N.2    Ma, D.3    Warner, D.S.4    Franks, N.P.5    Maze, M.6    Grocott, H.P.7
  • 111
    • 72749088179 scopus 로고    scopus 로고
    • Xenon preconditioning confers neuroprotection regardless of gender in a mouse model of transient middle cerebral artery occlusion
    • Limatola, V.; Ward, P.; Cattano, D.; Gu, J.; Giunta, F.; Maze, M.; Ma, D. Xenon preconditioning confers neuroprotection regardless of gender in a mouse model of transient middle cerebral artery occlusion. Neuroscience, 2010, 165(3), 874-881. DOI: http://dx. doi.org/10.1016/j.neuroscience.2009.10.063
    • (2010) Neuroscience , vol.165 , Issue.3 , pp. 874-881
    • Limatola, V.1    Ward, P.2    Cattano, D.3    Gu, J.4    Giunta, F.5    Maze, M.6    Ma, D.7
  • 112
    • 0037372183 scopus 로고    scopus 로고
    • Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat
    • Ma, D.; Yang, H.; Lynch, J.; Franks, N. P.; Maze, M.; Grocott, H. P. Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Anesthesiology, 2003, 98(3), 690-698. DOI: http://dx.doi.org/10.1097/00000542-200303000- 00017
    • (2003) Anesthesiology , vol.98 , Issue.3 , pp. 690-698
    • Ma, D.1    Yang, H.2    Lynch, J.3    Franks, N.P.4    Maze, M.5    Grocott, H.P.6
  • 113
    • 17844397464 scopus 로고    scopus 로고
    • Xenon attenuates cerebral damage after ischemia in pigs
    • Schmidt, M.; Marx, T.; Gloggl, E.; Reinelt, H.; Schirmer, U. Xenon attenuates cerebral damage after ischemia in pigs. Anesthesiology, 2005, 102(5), 929-936. DOI: http://dx.doi.org/10.1097/00000542- 200505000-00011
    • (2005) Anesthesiology , vol.102 , Issue.5 , pp. 929-936
    • Schmidt, M.1    Marx, T.2    Gloggl, E.3    Reinelt, H.4    Schirmer, U.5
  • 114
    • 0035947177 scopus 로고    scopus 로고
    • Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure
    • Yamada, K.; Ji, J. J.; Yuan, H.; Miki, T.; Sato, S.; Horimoto, N.; Shimizu, T.; Seino, S.; Inagaki, N. Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science, 2001, 292(5521), 1543-1546. DOI: http://dx.doi.org/10. 1126/science.1059829
    • (2001) Science , vol.292 , Issue.5521 , pp. 1543-1546
    • Yamada, K.1    Ji, J.J.2    Yuan, H.3    Miki, T.4    Sato, S.5    Horimoto, N.6    Shimizu, T.7    Seino, S.8    Inagaki, N.9
  • 115
    • 77649143663 scopus 로고    scopus 로고
    • Noble gas xenon is a novel adenosine triphosphate-sensitive potassium channel opener
    • Bantel, C.; Maze, M.; Trapp, S. Noble gas xenon is a novel adenosine triphosphate-sensitive potassium channel opener. Anesthesiology, 2010, 112(3), 623-630. DOI: http://dx.doi.org/ 10.1097/ALN.0b013e3181cf894a
    • (2010) Anesthesiology , vol.112 , Issue.3 , pp. 623-630
    • Bantel, C.1    Maze, M.2    Trapp, S.3
  • 116
    • 18844481528 scopus 로고    scopus 로고
    • How does xenon produce anaesthesia?
    • Franks, N. P.; Dickinson, R.; de Sousa, S. L.; Hall, A. C.; Lieb, W. R. How does xenon produce anaesthesia? Nature, 1998, 396(6709), 324. DOI: http://dx.doi.org/10.1016/0140-6736(90)91872-8
    • (1998) Nature , vol.396 , Issue.6709 , pp. 324
    • Franks, N.P.1    Dickinson, R.2    de Sousa, S.L.3    Hall, A.C.4    Lieb, W.R.5
  • 117
    • 33749559195 scopus 로고    scopus 로고
    • Morphological evidence that xenon neuroprotects against N-methyl-DL-aspartic acid-induced damage in the rat arcuate nucleus: A time-dependent study
    • Natale, G.; Cattano, D.; Abramo, A.; Forfori, F.; Fulceri, F.; Fornai, F.; Paparelli, A.; Giunta, F. Morphological evidence that xenon neuroprotects against N-methyl-DL-aspartic acid-induced damage in the rat arcuate nucleus: a time-dependent study. Ann. N Acad. Sci., 2006, 1074, 650-658. DOI: http://dx.doi.org/10.1196/ annals.1369.063
    • (2006) Ann. N Acad. Sci , vol.1074 , pp. 650-658
    • Natale, G.1    Cattano, D.2    Abramo, A.3    Forfori, F.4    Fulceri, F.5    Fornai, F.6    Paparelli, A.7    Giunta, F.8
  • 118
    • 38449123896 scopus 로고    scopus 로고
    • Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: Evidence from molecular modeling and electrophysiology
    • Dickinson, R.; Peterson, B. K.; Banks, P.; Simillis, C.; Martin, J. C.; Valenzuela, C. A.; Maze, M.; Franks, N. P. Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. Anesthesiology, 2007, 107(5), 756-767. DOI: http://dx.doi.org/10.1097/01.anes.0000287061.77674.71
    • (2007) Anesthesiology , vol.107 , Issue.5 , pp. 756-767
    • Dickinson, R.1    Peterson, B.K.2    Banks, P.3    Simillis, C.4    Martin, J.C.5    Valenzuela, C.A.6    Maze, M.7    Franks, N.P.8
  • 119
    • 0034992405 scopus 로고    scopus 로고
    • Participation of the Ca(2+)-calmodulin-activated Kinase II in the control of metaphase-anaphase transition in human cells
    • PMID: 11401327
    • Petzelt, C. P.; Kodirov, S.; Taschenberger, G.; Kox, W. J. Participation of the Ca(2+)-calmodulin-activated Kinase II in the control of metaphase-anaphase transition in human cells. Cell. Biol. Int., 2001, 25(5), 403-409. PMID: 11401327
    • (2001) Cell. Biol. Int , vol.25 , Issue.5 , pp. 403-409
    • Petzelt, C.P.1    Kodirov, S.2    Taschenberger, G.3    Kox, W.J.4
  • 120
    • 17044433904 scopus 로고    scopus 로고
    • Xenon reduces glutamate-, AMPA-, and kainateinduced membrane currents in cortical neurones
    • Dinse, A.; Fohr, K. J.; Georgieff, M.; Beyer, C.; Bulling, A.; Weigt, H. U. Xenon reduces glutamate-, AMPA-, and kainateinduced membrane currents in cortical neurones. Br. J. Anaesth., 2005, 94(4), 479-485. DOI: http://dx.doi.org/10.1093/bja/aei080
    • (2005) Br. J. Anaesth , vol.94 , Issue.4 , pp. 479-485
    • Dinse, A.1    Fohr, K.J.2    Georgieff, M.3    Beyer, C.4    Bulling, A.5    Weigt, H.U.6
  • 121
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green, D. R.; Reed, J. C. Mitochondria and apoptosis. Science, 1998, 281(5381), 1309-1312. DOI: http://dx.doi.org/10.1126/ science.281.5381.1309
    • (1998) Science , vol.281 , Issue.5381 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 122
    • 0030898680 scopus 로고    scopus 로고
    • Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice
    • PMID: 9096145
    • Shindler, K. S.; Latham, C. B.; Roth, K. A. Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J. Neurosci., 1997, 17(9), 3112-3119. PMID: 9096145
    • (1997) J. Neurosci , vol.17 , Issue.9 , pp. 3112-3119
    • Shindler, K.S.1    Latham, C.B.2    Roth, K.A.3
  • 123
    • 33847736191 scopus 로고    scopus 로고
    • Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat
    • Martin, J. L.; Ma, D.; Hossain, M.; Xu, J.; Sanders, R. D.; Franks, N. P.; Maze, M. Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat. Br. J. Anaesth., 2007, 98(2), 236-240. DOI: http://dx.doi.org/ 10.1093/bja/ael340
    • (2007) Br. J. Anaesth , vol.98 , Issue.2 , pp. 236-240
    • Martin, J.L.1    Ma, D.2    Hossain, M.3    Xu, J.4    Sanders, R.D.5    Franks, N.P.6    Maze, M.7
  • 124
    • 1642457188 scopus 로고    scopus 로고
    • Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane
    • Gruss, M.; Bushell, T. J.; Bright, D. P.; Lieb, W. R.; Mathie, A.; Franks, N. P. Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane. Mol. Pharmacol., 2004, 65(2), 443-452. DOI: http://dx.doi.org/10.1124/ mol.65.2.443
    • (2004) Mol. Pharmacol , vol.65 , Issue.2 , pp. 443-452
    • Gruss, M.1    Bushell, T.J.2    Bright, D.P.3    Lieb, W.R.4    Mathie, A.5    Franks, N.P.6
  • 125
    • 13244255268 scopus 로고    scopus 로고
    • The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK
    • Weber, N. C.; Toma, O.; Wolter, J. I.; Obal, D.; Mullenheim, J.; Preckel, B.; Schlack, W. The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK. Br. J. Pharmacol., 2005, 144(1), 123-132. DOI: http://dx.doi.org/10.1038/sj.bjp. 0706063
    • (2005) Br. J. Pharmacol , vol.144 , Issue.1 , pp. 123-132
    • Weber, N.C.1    Toma, O.2    Wolter, J.I.3    Obal, D.4    Mullenheim, J.5    Preckel, B.6    Schlack, W.7
  • 126
    • 0029810469 scopus 로고    scopus 로고
    • Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis
    • PMCID: PMC231554
    • Wilson, B. E.; Mochon, E.; Boxer, L. M. Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. Mol. Cell. Biol., 1996, 16(10), 5546-5556. PMCID: PMC231554
    • (1996) Mol. Cell. Biol , vol.16 , Issue.10 , pp. 5546-5556
    • Wilson, B.E.1    Mochon, E.2    Boxer, L.M.3
  • 127
    • 0036263574 scopus 로고    scopus 로고
    • Effects of xenon on in vitro and in vivo models of neuronal injury
    • Wilhelm, S.; Ma, D.; Maze, M.; Franks, N. P. Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology, 2002, 96(6), 1485-1491. DOI: http://dx.doi.org/10.1097/00000542- 200206000-00031
    • (2002) Anesthesiology , vol.96 , Issue.6 , pp. 1485-1491
    • Wilhelm, S.1    Ma, D.2    Maze, M.3    Franks, N.P.4
  • 128
    • 0031852221 scopus 로고    scopus 로고
    • Characterization of neuroprotection from excitotoxicity by moderate and profound hypothermia in cultured cortical neurons unmasks a temperature-insensitive component of glutamate neurotoxicity
    • Tymianski, M.; Sattler, R.; Zabramski, J. M.; Spetzler, R. F. Characterization of neuroprotection from excitotoxicity by moderate and profound hypothermia in cultured cortical neurons unmasks a temperature-insensitive component of glutamate neurotoxicity. J. Cereb. Blood Flow Metab., 1998, 18(8), 848-867. DOI: http://dx.doi.org/10.1097/00004647-199808000-00005
    • (1998) J. Cereb. Blood Flow Metab , vol.18 , Issue.8 , pp. 848-867
    • Tymianski, M.1    Sattler, R.2    Zabramski, J.M.3    Spetzler, R.F.4
  • 129
    • 0033998845 scopus 로고    scopus 로고
    • Effects of hypothermia on hypoxia-induced apoptosis in cultured neurons from developing rat forebrain: Comparison with preconditioning
    • Bossenmeyer-Pourie, C.; Koziel, V.; Daval, J. L. Effects of hypothermia on hypoxia-induced apoptosis in cultured neurons from developing rat forebrain: comparison with preconditioning. Pediatr. Res., 2000, 47(3), 385-391. DOI: http://dx.doi.org/10. 1203/00006450-200003000-00017
    • (2000) Pediatr. Res , vol.47 , Issue.3 , pp. 385-391
    • Bossenmeyer-Pourie, C.1    Koziel, V.2    Daval, J.L.3
  • 130
    • 0036139651 scopus 로고    scopus 로고
    • Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade
    • Xu, L.; Yenari, M. A.; Steinberg, G. K.; Giffard, R. G. Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. J. Cereb. Blood Flow Metab., 2002, 22(1), 21-28. DOI: http://dx.doi.org/10.1097/00004647-200201000-00003
    • (2002) J. Cereb. Blood Flow Metab , vol.22 , Issue.1 , pp. 21-28
    • Xu, L.1    Yenari, M.A.2    Steinberg, G.K.3    Giffard, R.G.4
  • 133
    • 77950520058 scopus 로고    scopus 로고
    • Xenon is an inhibitor of tissue-plasminogen activator: Adverse and beneficial effects in a rat model of thromboembolic stroke
    • David, H. N.; Haelewyn, B.; Risso, J. J.; Colloc'h, N.; Abraini, J. H. Xenon is an inhibitor of tissue-plasminogen activator: adverse and beneficial effects in a rat model of thromboembolic stroke. J. Cereb. Blood Flow Metab., 2010, 30(4), 718-728. DOI: http://dx.doi.org/10.1038/jcbfm.2009.275
    • (2010) J. Cereb. Blood Flow Metab , vol.30 , Issue.4 , pp. 718-728
    • David, H.N.1    Haelewyn, B.2    Risso, J.J.3    Colloc'h, N.4    Abraini, J.H.5
  • 134
    • 0021635585 scopus 로고
    • Magnesium: Nature's physiologic calcium blocker
    • Iseri, L. T.; French, J. H. Magnesium: nature's physiologic calcium blocker. Am. Heart J., 1984, 108(1), 188-193. DOI: http://dx.doi. org/10.1016/0002-8703(84)90572-6
    • (1984) Am. Heart J , vol.108 , Issue.1 , pp. 188-193
    • Iseri, L.T.1    French, J.H.2
  • 135
    • 0021697621 scopus 로고
    • Interactions of Mg and K on cerebral vessels--aspects in view of stroke. Review of present status and new findings
    • PMID: 6399342
    • Altura, B. T.; Altura, B. M. Interactions of Mg and K on cerebral vessels--aspects in view of stroke. Review of present status and new findings. Magnesium, 1984, 3(4-6), 195-211. PMID: 6399342
    • (1984) Magnesium , vol.3 , Issue.4-6 , pp. 195-211
    • Altura, B.T.1    Altura, B.M.2
  • 136
    • 0025195220 scopus 로고
    • Mg2+ protects against PCP-induced cerebrovasospasms and vascular damage in rat brain
    • PMID: 2158788
    • Huang, Q. F.; Gebrewold, A.; Altura, B. T.; Altura, B. M. Mg2+ protects against PCP-induced cerebrovasospasms and vascular damage in rat brain. Magnes. Trace Elem., 1990, 9(1), 44-46. PMID: 2158788
    • (1990) Magnes. Trace Elem , vol.9 , Issue.1 , pp. 44-46
    • Huang, Q.F.1    Gebrewold, A.2    Altura, B.T.3    Altura, B.M.4
  • 137
    • 0028938443 scopus 로고
    • Blockers of NMDA-operated channels decrease glutamate and aspartate extracellular accumulation in striatum during forebrain ischaemia in rats
    • Ghribi, O.; Callebert, J.; Verrecchia, C.; Plotkine, M.; Boulu, R. G. Blockers of NMDA-operated channels decrease glutamate and aspartate extracellular accumulation in striatum during forebrain ischaemia in rats. Fundam. Clin. Pharmacol., 1995, 9(2), 141-146. DOI: http://dx.doi.org/10.1111/j.1472-8206.1995.tb00273.x
    • (1995) Fundam. Clin. Pharmacol , vol.9 , Issue.2 , pp. 141-146
    • Ghribi, O.1    Callebert, J.2    Verrecchia, C.3    Plotkine, M.4    Boulu, R.G.5
  • 138
    • 0028187682 scopus 로고
    • Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage
    • Hall, E. D.; McCall, J. M.; Means, E. D. Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage. Adv. Pharmacol., 1994, 28, 221-268. DOI: http://dx.doi.org/10.1016/S1054-3589(08) 60497-4
    • (1994) Adv. Pharmacol , vol.28 , pp. 221-268
    • Hall, E.D.1    McCall, J.M.2    Means, E.D.3
  • 139
    • 0025923678 scopus 로고
    • Mg2+ administered up to twenty-four hours following reperfusion prevents ischemic damage of the Ca1 neurons in the rat hippocampus
    • Tsuda, T.; Kogure, K.; Nishioka, K.; Watanabe, T. Mg2+ administered up to twenty-four hours following reperfusion prevents ischemic damage of the Ca1 neurons in the rat hippocampus. Neuroscience, 1991, 44(2), 335-341. DOI: http://dx.doi.org/10. 1016/0306-4522(91)90058-V
    • (1991) Neuroscience , vol.44 , Issue.2 , pp. 335-341
    • Tsuda, T.1    Kogure, K.2    Nishioka, K.3    Watanabe, T.4
  • 140
    • 33846625176 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke
    • Sena, E.; Wheble, P.; Sandercock, P.; Macleod, M. Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke. Stroke, 2007, 38(2), 388-394. DOI: http://dx.doi.org/10. 1161/01.STR.0000254462.75851.22
    • (2007) Stroke , vol.38 , Issue.2 , pp. 388-394
    • Sena, E.1    Wheble, P.2    Sandercock, P.3    Macleod, M.4
  • 141
    • 0024503446 scopus 로고
    • Magnesium protects against neurological deficit after brain injury
    • McIntosh, T. K.; Vink, R.; Yamakami, I.; Faden, A. I. Magnesium protects against neurological deficit after brain injury. Brain Res., 1989, 482(2), 252-260. DOI: http://dx.doi.org/10.1016/0006-8993 (89)91188-8
    • (1989) Brain Res , vol.482 , Issue.2 , pp. 252-260
    • McIntosh, T.K.1    Vink, R.2    Yamakami, I.3    Faden, A.I.4
  • 142
    • 0025737646 scopus 로고
    • Magnesium sulfate reverses experimental delayed cerebral vasospasm after subarachnoid hemorrhage in rats
    • Ram, Z.; Sadeh, M.; Shacked, I.; Sahar, A.; Hadani, M. Magnesium sulfate reverses experimental delayed cerebral vasospasm after subarachnoid hemorrhage in rats. Stroke, 1991, 22(7), 922-927. DOI: http://dx.doi.org/10.1161/01.STR.22.7.922
    • (1991) Stroke , vol.22 , Issue.7 , pp. 922-927
    • Ram, Z.1    Sadeh, M.2    Shacked, I.3    Sahar, A.4    Hadani, M.5
  • 143
    • 0022510777 scopus 로고
    • Protection against experimental ischemic spinal cord injury
    • Robertson, C. S.; Foltz, R.; Grossman, R. G.; Goodman, J. C. Protection against experimental ischemic spinal cord injury. J. Neurosurg., 1986, 64(4), 633-642. DOI: http://dx.doi.org/10.3171/ jns.1986.64.4.0633
    • (1986) J. Neurosurg , vol.64 , Issue.4 , pp. 633-642
    • Robertson, C.S.1    Foltz, R.2    Grossman, R.G.3    Goodman, J.C.4
  • 144
    • 0032904206 scopus 로고    scopus 로고
    • Neuroprotective effects of combination therapy with tirilazad and magnesium in rats subjected to reversible focal cerebral ischemia
    • discussion 171-162
    • Schmid-Elsaesser, R.; Zausinger, S.; Hungerhuber, E.; Baethmann, A.; Reulen, H. J. Neuroprotective effects of combination therapy with tirilazad and magnesium in rats subjected to reversible focal cerebral ischemia. Neurosurgery, 1999, 44(1), 163-171; discussion 171-162. DOI: http://dx.doi.org/10.1097/00006123-199901000- 00101
    • (1999) Neurosurgery , vol.44 , Issue.1 , pp. 163-171
    • Schmid-Elsaesser, R.1    Zausinger, S.2    Hungerhuber, E.3    Baethmann, A.4    Reulen, H.J.5
  • 145
    • 0032876536 scopus 로고    scopus 로고
    • Combination drug therapy and mild hypothermia: A promising treatment strategy for reversible, focal cerebral ischemia
    • Schmid-Elsaesser, R.; Hungerhuber, E.; Zausinger, S.; Baethmann, A.; Reulen, H. J. Combination drug therapy and mild hypothermia: a promising treatment strategy for reversible, focal cerebral ischemia. Stroke, 1999, 30(9), 1891-1899. DOI: http://dx.doi.org/ 10.1161/01.STR.30.9.1891
    • (1999) Stroke , vol.30 , Issue.9 , pp. 1891-1899
    • Schmid-Elsaesser, R.1    Hungerhuber, E.2    Zausinger, S.3    Baethmann, A.4    Reulen, H.J.5
  • 146
    • 4544256004 scopus 로고    scopus 로고
    • Neuroprotection in ischemic stroke--combination drug therapy and mild hypothermia in a rat model of permanent focal cerebral ischemia
    • Scholler, K.; Zausinger, S.; Baethmann, A.; Schmid-Elsaesser, R. Neuroprotection in ischemic stroke--combination drug therapy and mild hypothermia in a rat model of permanent focal cerebral ischemia. Brain Res., 2004, 1023(2), 272-278. DOI: http://dx.doi. org/10.1016/j.brainres.2004.01.094
    • (2004) Brain Res , vol.1023 , Issue.2 , pp. 272-278
    • Scholler, K.1    Zausinger, S.2    Baethmann, A.3    Schmid-Elsaesser, R.4
  • 147
    • 0042418486 scopus 로고    scopus 로고
    • Combination drug therapy and mild hypothermia after transient focal cerebral ischemia in rats
    • Zausinger, S.; Scholler, K.; Plesnila, N.; Schmid-Elsaesser, R. Combination drug therapy and mild hypothermia after transient focal cerebral ischemia in rats. Stroke, 2003, 34(9), 2246-2251. DOI: http://dx.doi.org/10.1161/01.STR.0000083622.65684.21
    • (2003) Stroke , vol.34 , Issue.9 , pp. 2246-2251
    • Zausinger, S.1    Scholler, K.2    Plesnila, N.3    Schmid-Elsaesser, R.4
  • 148
    • 0019132603 scopus 로고
    • Recirculation in the acute period of cerebral infarction: Brain swelling and its suppression using mannitol
    • PMID: 6784261
    • Suzuki, J.; Tanaka, S.; Yoshimoto, T. Recirculation in the acute period of cerebral infarction: brain swelling and its suppression using mannitol. Surg. Neurol., 1980, 14(6), 467-472. PMID: 6784261
    • (1980) Surg. Neurol , vol.14 , Issue.6 , pp. 467-472
    • Suzuki, J.1    Tanaka, S.2    Yoshimoto, T.3
  • 149
    • 0018090504 scopus 로고
    • Modification of acute focal ischemia by treatment with mannitol
    • Little, J. R. Modification of acute focal ischemia by treatment with mannitol. Stroke, 1978, 9(1), 4-9. DOI: http://dx.doi.org/10.1161/ 01.STR.9.1.4
    • (1978) Stroke , vol.9 , Issue.1 , pp. 4-9
    • Little, J.R.1
  • 150
    • 0018582486 scopus 로고
    • Treatment of acute focal cerebral ischemia with intermittent, low dose mannitol
    • Little, J. R. Treatment of acute focal cerebral ischemia with intermittent, low dose mannitol. Neurosurgery, 1979, 5(6), 687- 691. DOI: http://dx.doi.org/10.1227/00006123-197912000-00007
    • (1979) Neurosurgery , vol.5 , Issue.6 , pp. 687-691
    • Little, J.R.1
  • 151
    • 0020053826 scopus 로고
    • The protective effect of mannitol and perfluorochemicals on hemorrhagic infarction: An experimental study
    • Kagawa, S.; Koshu, K.; Yoshimoto, T.; Suzuki, J. The protective effect of mannitol and perfluorochemicals on hemorrhagic infarction: an experimental study. Surg. Neurol., 1982, 17(1), 66-70. DOI: http://dx.doi.org/10.1016/0090-3019(82)90048-9
    • (1982) Surg. Neurol , vol.17 , Issue.1 , pp. 66-70
    • Kagawa, S.1    Koshu, K.2    Yoshimoto, T.3    Suzuki, J.4
  • 152
    • 0019805115 scopus 로고
    • The effects of mannitol on blood viscosity
    • Burke, A. M.; Quest, D. O.; Chien, S.; Cerri, C. The effects of mannitol on blood viscosity. J. Neurosurg., 1981, 55(4), 550-553. DOI: http://dx.doi.org/10.3171/jns.1981.55.4.0550
    • (1981) J. Neurosurg , vol.55 , Issue.4 , pp. 550-553
    • Burke, A.M.1    Quest, D.O.2    Chien, S.3    Cerri, C.4
  • 153
    • 0027461875 scopus 로고
    • Effects of mannitol on cerebral blood flow, blood pressure, blood viscosity, hematocrit, sodium, and potassium
    • Andrews, R. J.; Bringas, J. R.; Muto, R. P. Effects of mannitol on cerebral blood flow, blood pressure, blood viscosity, hematocrit, sodium, and potassium. Surg. Neurol., 1993, 39(3), 218-222. DOI: http://dx.doi.org/10.1016/0090-3019(93)90186-5
    • (1993) Surg. Neurol , vol.39 , Issue.3 , pp. 218-222
    • Andrews, R.J.1    Bringas, J.R.2    Muto, R.P.3
  • 154
    • 0023193323 scopus 로고
    • Treatment of experimental focal cerebral ischemia with mannitol. Assessment by intracellular brain pH, cortical blood flow, and electroencephalography
    • Meyer, F. B.; Anderson, R. E.; Sundt, T. M., Jr.; Yaksh, T. L. Treatment of experimental focal cerebral ischemia with mannitol. Assessment by intracellular brain pH, cortical blood flow, and electroencephalography. J. Neurosurg., 1987, 66(1), 109-115. DOI: http://dx.doi.org/10.3171/jns.1987.66.1.0109
    • (1987) J. Neurosurg , vol.66 , Issue.1 , pp. 109-115
    • Meyer, F.B.1    Anderson, R.E.2    Sundt, T.M.3    Yaksh, T.L.4
  • 155
    • 0023146437 scopus 로고
    • Brain water measured by magnetic resonance imaging. Correlation with direct estimation and changes after mannitol and dexamethasone
    • Bell, B. A.; Smith, M. A.; Kean, D. M.; McGhee, C. N.; MacDonald, H. L.; Miller, J. D.; Barnett, G. H.; Tocher, J. L.; Douglas, R. H.; Best, J. J. Brain water measured by magnetic resonance imaging. Correlation with direct estimation and changes after mannitol and dexamethasone. Lancet, 1987, 1(8524), 66-69. DOI: http://dx.doi.org/10.1016/S0140-6736(87)91908-8
    • (1987) Lancet , vol.1 , Issue.8524 , pp. 66-69
    • Bell, B.A.1    Smith, M.A.2    Kean, D.M.3    McGhee, C.N.4    MacDonald, H.L.5    Miller, J.D.6    Barnett, G.H.7    Tocher, J.L.8    Douglas, R.H.9    Best, J.J.10
  • 156
    • 0005414143 scopus 로고
    • The effect of mannitol in prolongation of permissible occlusion time of cerebral arteries: Clinical data of aneurysm surgery
    • Suzuki J, Y. T. The effect of mannitol in prolongation of permissible occlusion time of cerebral arteries: Clinical data of aneurysm surgery. Neurosurg. Rev., 1979, 1, 13-19. DOI: http://dx.doi.org/10.1007/BF01644042
    • (1979) Neurosurg. Rev , vol.1 , pp. 13-19
    • Suzuki, J.Y.T.1
  • 157
    • 0029061949 scopus 로고
    • Use of mild intraischemic hypothermia versus mannitol to reduce infarct size after temporary middle cerebral artery occlusion in rats
    • Karibe, H.; Zarow, G. J.; Weinstein, P. R. Use of mild intraischemic hypothermia versus mannitol to reduce infarct size after temporary middle cerebral artery occlusion in rats. J. Neurosurg., 1995, 83(1), 93-98. DOI: http://dx.doi.org/10.3171/jns. 1995.83.1.0093
    • (1995) J. Neurosurg , vol.83 , Issue.1 , pp. 93-98
    • Karibe, H.1    Zarow, G.J.2    Weinstein, P.R.3
  • 158
    • 0029946656 scopus 로고    scopus 로고
    • Mild hypothermia, hypertension, and mannitol are protective against infarction during experimental intracranial temporary vessel occlusion
    • discussion 1209-1210
    • Ogilvy, C. S.; Chu, D.; Kaplan, S. Mild hypothermia, hypertension, and mannitol are protective against infarction during experimental intracranial temporary vessel occlusion. Neurosurgery, 1996, 38(6), 1202-1209; discussion 1209-1210. DOI: http://dx.doi.org/10.1097/ 00006123-199606000-00030
    • (1996) Neurosurgery , vol.38 , Issue.6 , pp. 1202-1209
    • Ogilvy, C.S.1    Chu, D.2    Kaplan, S.3
  • 159
    • 0020634826 scopus 로고
    • Mannitol causes compensatory cerebral vasoconstriction and vasodilation in response to blood viscosity changes
    • Muizelaar, J. P.; Wei, E. P.; Kontos, H. A.; Becker, D. P. Mannitol causes compensatory cerebral vasoconstriction and vasodilation in response to blood viscosity changes. J. Neurosurg., 1983, 59(5), 822-828. DOI: http://dx.doi.org/10.3171/jns.1983.59.5.0822
    • (1983) J. Neurosurg , vol.59 , Issue.5 , pp. 822-828
    • Muizelaar, J.P.1    Wei, E.P.2    Kontos, H.A.3    Becker, D.P.4
  • 160
    • 0026403955 scopus 로고
    • Effect of mannitol on intracranial pressure in focal cerebral ischemia. An experimental study in a rat
    • PMID: 1842234
    • Kotwica, Z.; Persson, L. Effect of mannitol on intracranial pressure in focal cerebral ischemia. An experimental study in a rat. Mater. Med. Pol., 1991, 23(4), 280-284. PMID: 1842234
    • (1991) Mater. Med. Pol , vol.23 , Issue.4 , pp. 280-284
    • Kotwica, Z.1    Persson, L.2
  • 161
    • 0019270141 scopus 로고
    • Barbiturates as protective agents in brain ischemia and as free radical scavengers in vitro
    • PMID: 6939303
    • Smith, D. S.; Rehncrona, S.; Siesjo, B. K. Barbiturates as protective agents in brain ischemia and as free radical scavengers in vitro. Acta Physiol. Scand. Suppl., 1980, 492, 129-134. PMID: 6939303
    • (1980) Acta Physiol. Scand. Suppl , vol.492 , pp. 129-134
    • Smith, D.S.1    Rehncrona, S.2    Siesjo, B.K.3
  • 162
    • 0034433444 scopus 로고    scopus 로고
    • No additional neuroprotection provided by barbiturate-induced burst suppression under mild hypothermic conditions in rats subjected to reversible focal ischemia
    • Westermaier, T.; Zausinger, S.; Baethmann, A.; Steiger, H. J.; Schmid-Elsaesser, R. No additional neuroprotection provided by barbiturate-induced burst suppression under mild hypothermic conditions in rats subjected to reversible focal ischemia. J. Neurosurg., 2000, 93(5), 835-844. DOI: http://dx.doi.org/10.3171/ jns.2000.93.5.0835
    • (2000) J. Neurosurg , vol.93 , Issue.5 , pp. 835-844
    • Westermaier, T.1    Zausinger, S.2    Baethmann, A.3    Steiger, H.J.4    Schmid-Elsaesser, R.5
  • 163
    • 84875020639 scopus 로고    scopus 로고
    • From molecular to nanotechnology strategies for delivery of neurotrophins: Emphasis on brain-derived neurotrophic factor (BDNF)
    • Geral, C.; Angelova, A.; Lesieur, S. From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF). Pharmaceutics, 2013, 5(1), 127-167. doi: 10.3390/pharmaceutics5010127
    • (2013) Pharmaceutics , vol.5 , Issue.1 , pp. 127-167
    • Geral, C.1    Angelova, A.2    Lesieur, S.3
  • 164
    • 0030951213 scopus 로고    scopus 로고
    • Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats
    • PMID: 9183287
    • Schabitz, W. R.; Schwab, S.; Spranger, M.; Hacke, W. Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J Cereb Blood Flow Metab, 1997, 17(5), 500-506. PMID: 9183287
    • (1997) J Cereb Blood Flow Metab , vol.17 , Issue.5 , pp. 500-506
    • Schabitz, W.R.1    Schwab, S.2    Spranger, M.3    Hacke, W.4
  • 165
    • 0033811469 scopus 로고    scopus 로고
    • Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia
    • PMID: 10978054
    • Schabitz, W. R.; Sommer, C.; Zoder, W.; Kiessling, M.; Schwaninger, M.; Schwab, S. Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia. Stroke, 2000, 31(9), 2212-2217. PMID: 10978054
    • (2000) Stroke , vol.31 , Issue.9 , pp. 2212-2217
    • Schabitz, W.R.1    Sommer, C.2    Zoder, W.3    Kiessling, M.4    Schwaninger, M.5    Schwab, S.6
  • 166
    • 0347003761 scopus 로고    scopus 로고
    • Hypothermia and brain-derived neurotrophic factor reduce glutamate synergistically in acute stroke
    • Berger, C.; Schabitz, W. R.; Wolf, M.; Mueller, H.; Sommer, C.; Schwab, S. Hypothermia and brain-derived neurotrophic factor reduce glutamate synergistically in acute stroke. Exp. Neurol., 2004, 185(2), 305-312. DOI: http://dx.doi.org/10.1016/j.expneurol. 2003.10.008
    • (2004) Exp. Neurol , vol.185 , Issue.2 , pp. 305-312
    • Berger, C.1    Schabitz, W.R.2    Wolf, M.3    Mueller, H.4    Sommer, C.5    Schwab, S.6
  • 167
    • 0028791689 scopus 로고
    • Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats
    • PMID: 7593356
    • Fisher, M.; Meadows, M. E.; Do, T.; Weise, J.; Trubetskoy, V.; Charette, M.; Finklestein, S. P. Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats. J Cereb Blood Flow Metab, 1995, 15(6), 953-959. PMID: 7593356
    • (1995) J Cereb Blood Flow Metab , vol.15 , Issue.6 , pp. 953-959
    • Fisher, M.1    Meadows, M.E.2    Do, T.3    Weise, J.4    Trubetskoy, V.5    Charette, M.6    Finklestein, S.P.7
  • 168
    • 0030759006 scopus 로고    scopus 로고
    • Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity
    • PMID: 9279893
    • Sakane, T.; Pardridge, W. M. Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity. Pharm Res, 1997, 14(8), 1085-1091. PMID: 9279893
    • (1997) Pharm Res , vol.14 , Issue.8 , pp. 1085-1091
    • Sakane, T.1    Pardridge, W.M.2
  • 169
    • 84864541816 scopus 로고    scopus 로고
    • Prolonged therapeutic hypothermia does not adversely impact neuroplasticity after global ischemia in rats
    • Silasi, G.; Klahr, A. C.; Hackett, M. J.; Auriat, A. M.; Nichol, H.; Colbourne, F. Prolonged therapeutic hypothermia does not adversely impact neuroplasticity after global ischemia in rats. J Cereb Blood Flow Metab, 2012, 32(8), 1525-1534. doi: 10.1038/ jcbfm.2012.38
    • (2012) J Cereb Blood Flow Metab , vol.32 , Issue.8 , pp. 1525-1534
    • Silasi, G.1    Klahr, A.C.2    Hackett, M.J.3    Auriat, A.M.4    Nichol, H.5    Colbourne, F.6
  • 171
    • 0035133027 scopus 로고    scopus 로고
    • Human albumin therapy of acute ischemic stroke: Marked neuroprotective efficacy at moderate doses and with a broad therapeutic window
    • Belayev, L.; Liu, Y.; Zhao, W.; Busto, R.; Ginsberg, M. D. Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke, 2001, 32(2), 553-560. DOI: http://dx.doi.org/10.1161/01. STR.32.2.553
    • (2001) Stroke , vol.32 , Issue.2 , pp. 553-560
    • Belayev, L.1    Liu, Y.2    Zhao, W.3    Busto, R.4    Ginsberg, M.D.5
  • 172
    • 33747195315 scopus 로고    scopus 로고
    • The ALIAS Pilot Trial: A dose-escalation and safety study of albumin therapy for acute ischemic stroke--I: Physiological responses and safety results
    • Ginsberg, M. D.; Hill, M. D.; Palesch, Y. Y.; Ryckborst, K. J.; Tamariz, D. The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--I: Physiological responses and safety results. Stroke, 2006, 37(8), 2100-2106. DOI: http://dx.doi.org/10.1161/01.STR.0000231388.72646.05
    • (2006) Stroke , vol.37 , Issue.8 , pp. 2100-2106
    • Ginsberg, M.D.1    Hill, M.D.2    Palesch, Y.Y.3    Ryckborst, K.J.4    Tamariz, D.5
  • 173
    • 84872058259 scopus 로고    scopus 로고
    • Enhanced neuroprotection by local intra-arterial infusion of human albumin solution and local hypothermia
    • Chen, J.; Fredrickson, V.; Ding, Y.; Cheng, H.; Wang, N.; Ling, F.; Ji, X. Enhanced neuroprotection by local intra-arterial infusion of human albumin solution and local hypothermia. Stroke, 2013, 44(1), 260-262. DOI: http://dx.doi.org/10.1161/STROKEAHA.112. 675462
    • (2013) Stroke , vol.44 , Issue.1 , pp. 260-262
    • Chen, J.1    Fredrickson, V.2    Ding, Y.3    Cheng, H.4    Wang, N.5    Ling, F.6    Ji, X.7
  • 174
    • 0016157521 scopus 로고
    • Surgical decompression for cerebral and cerebellar infarcts
    • Ivamoto, H. S.; Numoto, M.; Donaghy, R. M. Surgical decompression for cerebral and cerebellar infarcts. Stroke, 1974, 5(3), 365-370. DOI: http://dx.doi.org/10.1161/01.STR.5.3.365
    • (1974) Stroke , vol.5 , Issue.3 , pp. 365-370
    • Ivamoto, H.S.1    Numoto, M.2    Donaghy, R.M.3
  • 175
    • 0035164373 scopus 로고    scopus 로고
    • Combination of decompressive craniectomy and mild hypothermia ameliorates infarction volume after permanent focal ischemia in rats
    • CrossRef
    • Doerfler, A.; Schwab, S.; Hoffmann, T. T.; Engelhorn, T.; Forsting, M. Combination of decompressive craniectomy and mild hypothermia ameliorates infarction volume after permanent focal ischemia in rats. Stroke, 2001, 32(11), 2675-2681. CrossRef DOI: http://dx.doi.org/10.1161/hs1101.098369
    • (2001) Stroke , vol.32 , Issue.11 , pp. 2675-2681
    • Doerfler, A.1    Schwab, S.2    Hoffmann, T.T.3    Engelhorn, T.4    Forsting, M.5
  • 176
    • 33645230752 scopus 로고    scopus 로고
    • Decompressive craniectomy and mild hypothermia reduces infarction size and counterregulates Bax and Bcl-2 expression after permanent focal ischemia in rats
    • Jieyong, B.; Zhong, W.; Shiming, Z.; Dai, Z.; Kato, Y.; Kanno, T.; Sano, H. Decompressive craniectomy and mild hypothermia reduces infarction size and counterregulates Bax and Bcl-2 expression after permanent focal ischemia in rats. Neurosurg. Rev., 2006, 29(2), 168-172. DOI: http://dx.doi.org/10.1007/s10143-005- 0010-8
    • (2006) Neurosurg. Rev , vol.29 , Issue.2 , pp. 168-172
    • Jieyong, B.1    Zhong, W.2    Shiming, Z.3    Dai, Z.4    Kato, Y.5    Kanno, T.6    Sano, H.7
  • 177
    • 30944436640 scopus 로고    scopus 로고
    • Safety and therapeutical benefit of hemicraniectomy combined with mild hypothermia in comparison with hemicraniectomy alone in patients with malignant ischemic stroke
    • Els, T.; Oehm, E.; Voigt, S.; Klisch, J.; Hetzel, A.; Kassubek, J. Safety and therapeutical benefit of hemicraniectomy combined with mild hypothermia in comparison with hemicraniectomy alone in patients with malignant ischemic stroke. Cerebrovasc. Dis., 2006, 21(1-2), 79-85. DOI: http://dx.doi.org/10.1159/000090007
    • (2006) Cerebrovasc. Dis , vol.21 , Issue.1-2 , pp. 79-85
    • Els, T.1    Oehm, E.2    Voigt, S.3    Klisch, J.4    Hetzel, A.5    Kassubek, J.6
  • 179
    • 0842267570 scopus 로고    scopus 로고
    • Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release
    • Zhao, H.; Yenari, M. A.; Sapolsky, R. M.; Steinberg, G. K. Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release. Stroke, 2004, 35(2), 572-577. DOI: http://dx.doi.org/10.1161/01.STR.0000110787. 42083.58
    • (2004) Stroke , vol.35 , Issue.2 , pp. 572-577
    • Zhao, H.1    Yenari, M.A.2    Sapolsky, R.M.3    Steinberg, G.K.4
  • 180
    • 0036470422 scopus 로고    scopus 로고
    • Protein transduction technology
    • Wadia, J. S.; Dowdy, S. F. Protein transduction technology. Curr. Opin. Biotechnol., 2002, 13(1), 52-56. http://dx.doi.org/10.1016/ S0958-1669(02)00284-7
    • (2002) Curr. Opin. Biotechnol , vol.13 , Issue.1 , pp. 52-56
    • Wadia, J.S.1    Dowdy, S.F.2
  • 181
    • 3242811587 scopus 로고    scopus 로고
    • Protein transduction domains and their utility in gene therapy
    • Beerens, A. M.; Al Hadithy, A. F.; Rots, M. G.; Haisma, H. J. Protein transduction domains and their utility in gene therapy. Curr. Gene Ther., 2003, 3(5), 486-494. DOI: http://dx.doi.org/10. 2174/1566523034578258
    • (2003) Curr. Gene Ther , vol.3 , Issue.5 , pp. 486-494
    • Beerens, A.M.1    Al Hadithy, A.F.2    Rots, M.G.3    Haisma, H.J.4
  • 182
    • 0038325747 scopus 로고    scopus 로고
    • Protein transduction technology offers novel therapeutic approach for brain ischemia
    • Denicourt, C.; Dowdy, S. F. Protein transduction technology offers novel therapeutic approach for brain ischemia. Trends Pharmacol. Sci., 2003, 24(5), 216-218. DOI: http://dx.doi.org/10.1016/S0165- 6147(03)00074-9
    • (2003) Trends Pharmacol. Sci , vol.24 , Issue.5 , pp. 216-218
    • Denicourt, C.1    Dowdy, S.F.2
  • 184
    • 45249100240 scopus 로고    scopus 로고
    • Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat
    • Katsura, K.; Takahashi, K.; Asoh, S.; Watanabe, M.; Sakurazawa, M.; Ohsawa, I.; Mori, T.; Igarashi, H.; Ohkubo, S.; Katayama, Y.; Ohta, S. Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat. J. Neurochem., 2008, 106(1), 258-270. DOI: http://dx.doi.org/10.1111/j.1471-4159.2008.05360.x
    • (2008) J. Neurochem , vol.106 , Issue.1 , pp. 258-270
    • Katsura, K.1    Takahashi, K.2    Asoh, S.3    Watanabe, M.4    Sakurazawa, M.5    Ohsawa, I.6    Mori, T.7    Igarashi, H.8    Ohkubo, S.9    Katayama, Y.10    Ohta, S.11
  • 185
    • 83655184727 scopus 로고    scopus 로고
    • Mild hypothermia enhanced the protective effect of protein therapy with transductive anti-death FNK protein using a rat focal transient cerebral ischemia model
    • Sakurazawa, M.; Katsura, K.; Saito, M.; Asoh, S.; Ohta, S.; Katayama, Y. Mild hypothermia enhanced the protective effect of protein therapy with transductive anti-death FNK protein using a rat focal transient cerebral ischemia model. Brain. Res., 2012, 1430, 86-92. DOI: http://dx.doi.org/10.1016/j.brainres.2011.10.041
    • (2012) Brain. Res , vol.1430 , pp. 86-92
    • Sakurazawa, M.1    Katsura, K.2    Saito, M.3    Asoh, S.4    Ohta, S.5    Katayama, Y.6
  • 186
    • 0030707511 scopus 로고    scopus 로고
    • Interventions for perinatal HIischemic encephalopathy
    • Vannucci, R. C.; Perlman, J. M. Interventions for perinatal HIischemic encephalopathy. Pediatrics, 1997, 100(6), 1004-1014.
    • (1997) Pediatrics , vol.100 , Issue.6 , pp. 1004-1014
    • Vannucci, R.C.1    Perlman, J.M.2
  • 187
    • 0022644021 scopus 로고
    • Comparison of two methods of predicting outcome in perinatal asphyxia
    • PMID: 2867316
    • Levene, M. I.; Sands, C.; Grindulis, H.; Moore, J. R. Comparison of two methods of predicting outcome in perinatal asphyxia. Lancet, 1986, 1(8472), 67-69. PMID: 2867316
    • (1986) Lancet , vol.1 , Issue.8472 , pp. 67-69
    • Levene, M.I.1    Sands, C.2    Grindulis, H.3    Moore, J.R.4
  • 188
    • 41149176603 scopus 로고    scopus 로고
    • Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia
    • Hobbs, C.; Thoresen, M.; Tucker, A.; Aquilina, K.; Chakkarapani, E.; Dingley, J. Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia. Stroke, 2008, 39(4), 1307-1313. doi: 10.1161/STROKEAHA.107.499822.
    • (2008) Stroke , vol.39 , Issue.4 , pp. 1307-1313
    • Hobbs, C.1    Thoresen, M.2    Tucker, A.3    Aquilina, K.4    Chakkarapani, E.5    Dingley, J.6
  • 189
    • 0024354789 scopus 로고
    • Hypothermia enhances protective effect of MK-801 against hypoxic/ischemic brain damage in infant rats
    • PMID: 2546648
    • Ikonomidou, C.; Mosinger, J. L.; Olney, J. W. Hypothermia enhances protective effect of MK-801 against hypoxic/ischemic brain damage in infant rats. Brain Res, 1989, 487(1), 184-187. PMID: 2546648
    • (1989) Brain Res , vol.487 , Issue.1 , pp. 184-187
    • Ikonomidou, C.1    Mosinger, J.L.2    Olney, J.W.3
  • 190
    • 0035322982 scopus 로고    scopus 로고
    • Neuroprotective effects of MK 801 and hypothermia used alone and in combination in hypoxic-ischemic brain injury in neonatal rats
    • PMID: 11780774
    • Alkan, T.; Kahveci, N.; Buyukuysal, L.; Korfali, E.; Ozluk, K. Neuroprotective effects of MK 801 and hypothermia used alone and in combination in hypoxic-ischemic brain injury in neonatal rats. Arch Physiol Biochem, 2001, 109(2), 135-144. PMID: 11780774
    • (2001) Arch Physiol Biochem , vol.109 , Issue.2 , pp. 135-144
    • Alkan, T.1    Kahveci, N.2    Buyukuysal, L.3    Korfali, E.4    Ozluk, K.5
  • 191
    • 84884750931 scopus 로고    scopus 로고
    • The failure of animal models of neuroprotection in acute ischemic stroke to translate to clinical efficacy
    • PMID: 23353570
    • Xu, S. Y.; Pan, S. Y. The failure of animal models of neuroprotection in acute ischemic stroke to translate to clinical efficacy. Med. Sci. Monit. Basic Res., 2013, 19, 37-45. PMID: 23353570
    • (2013) Med. Sci. Monit. Basic Res , vol.19 , pp. 37-45
    • Xu, S.Y.1    Pan, S.Y.2


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