Neuroprotective effects of MK 801 and hypothermia used alone and in combination in hypoxic-ischemic brain injury in neonatal rats

Archives of Physiology and Biochemistry

Volumn 109, Issue 2, 2001, Pages 135-144

  Alkan, T ^a   Kahveci, N ^a   Buyukuysal, L ^a   Korfali, E ^a   Ozluk, K ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

DOPAC; Dopamine; Hypothermia; Hypoxia; Ischemia; MK 801; N methyl D aspartate; Newborn

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; DIZOCILPINE MALEATE; DOPAMINE; NEUROPROTECTIVE AGENT;

ANIMAL; ARTICLE; BRAIN; BRAIN ISCHEMIA; BRAIN LEVEL; DRUG EFFECT; FEMALE; HYPOTHERMIA; MALE; METABOLISM; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; SURVIVAL RATE;

3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; ANIMALS, NEWBORN; BRAIN; BRAIN CHEMISTRY; DIZOCILPINE MALEATE; DOPAMINE; FEMALE; HYPOTHERMIA; HYPOXIA-ISCHEMIA, BRAIN; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SURVIVAL RATE;

EID: 0035322982     PISSN: 13813455     EISSN: None     Source Type: Journal    
DOI: 10.1076/apab.109.2.135.4271     Document Type: Article

References (65)

1. -2 independent releases of neurotransmitters. J Neurochem 58: 395-405.
2. Akiyama Y, Koshimura K, Ojue T, Lee K, Miwa S, Yamagata S, Kikuchi H (1991): Effects of hypoxia on the activity of the dopaminergic neuron system in the rat striatum as studied by in vivo brain microdialysis. J Neurochem 57: 997-1002.
3. Andiné P, Jacobson I, Hagberg H (1988): Calcium uptake evoked by electrical stimulation is enhanced postischemically and precedes delayed neuronal death of CA1 of rat hippocampus: Involvement of N-methyl-D-aspartate receptors. J Cereb Blood Flow Metab 8: 799-807.
4. Astrup J, Sorensen PM, Sorensen HR (1981): Inhibition of cerebral oxygen and glucose consumption in the dog by hypothermia, pentobarbital and lidocaine. Anesthesiology 55: 263-268.
5. Baiping L, Xiujuan T, Hongwei C, Qiming X, Quling G (1994): Effect of moderate hypothermia on lipid peroxidation in canine brain tissue after cardiac arrest and resuscitation. Stroke 25: 147-152.
6. Baker CJ, Fiore AJ, Frazzim VI, Choudhri TF, Zubay GP, Solomon RA (1995): Intraischemic hypothermia decreases the release of glutamate in the cores of permanent focal cerebral infarcts. Neurosurgery 36: 994-1001.
7. Baker CJ, Onesti ST, Solomon RA (1992): Reduction by delayed hypothermia of cerebral infarction following middle cerebral artery occlusion in the rat: a time-course study. J Neurosurg 77: 438-444.
8. Ben-Ari Y, Cherubini E, Krnjevic K (1988): Changes in voltage dependence of NMDA currents during development. Neurosci Lett 94: 88-92.
9. Bickler PE, Buck LT, Hansen BM (1994): Effects of isoflurane and hypothermia on glutamate receptor-mediated calcium influx in brain slices. Anesthesiology 81: 1461-1469.
10. Busto R, Dietrich WD, Globus MY, Ginsberg MD (1989): Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury. Neurosci Lett 101: 299-304.
11. Busto R, Globus MY, Dietrich WD, Martinez E, Valdes I, Ginsberg MD (1989): Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 20: 904-910.
12. Buyukuysal RL, Mete B (1999): Anoxia-induced dopamine release from rat striatal slices: Involvement of reverse transport mechanism. J Neurochem 72: 1507-1515.
13. Carroll M, Beek O (1992): Protection against hippocampal CA1 cell loss by post-ischemic hypothermia is dependent on delay of initiation and duration. Metab Brain Dis 7: 45-50.
14. Chen H, Chopp M, Zhang ZG, Garcia JH (1992): The effect of hypothermia on transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 12: 621-628.
15. Choi DW, Rothman SM (1990): The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Ann Rev Neurosci 13: 171-182.
16. Frazzini VI, Winfree CJ, Choudhri HE, Prestigiacomo CJ, Solomon RA (1994): Mild hypothermia and MK-801 have similar but not additive degrees of cerebroprotection in the rat permanent focal ischemia model, Neurosurgery 34: 1040-1045.
17. Gilland E, Hagberg H (1996): NMDA Receptor-dependent increase of cerebral glucose utilization after hypoxiaischemia in the immature rat. J Cereb Blood Flow Metab 16: 1005-1013.
18. Gilland E, Hagberg H (1997): Is MK 801 neuroprotection mediated by systemic hypothermia in the immature rat? Neuroreport 6: 1603-1605.
19. Globus MY, Busto R, Dietrich WD, Martinez E, Valdes I, Ginsberg MD (1988a): Effect of ischemia on the invivo release of striatal dopamine, glutamate, and γ-aminobutyric acid studied by intracerebral microdialysis. J Neurochem 51: 1455-1464.
20. Globus MY, Busto R, Diterich WD, Martinez E, Valdes I, Ginsberg MD (1988b): Intra-ischemic extracellular releases of dopamine and glutamate is associated with striatal vulnerability to ischemia. Neurosci Lett 91: 36-40.
21. Greenamyre T, Penney JB, Young AB, Hudson C, Silverstein FS, Johnston MV (1987): Evidence for transient perinatal glutamatergic innervation of globus pallidus. J Neurosci 7: 1022-1030.
22. Greene JG, Greenamyre JT (1995): Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate. J Neurochem 64: 2332-2338.
23. Hagberg H, Andine P, Lehmann A (1990): Excitatory aminoacids and hypoxic-ischemic damage in the immature brain. In: Schurr A, Riogor BM, ed., Cerebral ischemia and ressuscitation. pp. 115-120. CRC Press, Boca Raton, Florida.
24. Hattori H, Morin AM, Schwartz PH, Fujikawa DG, Wasterlain CG (1989): Posthypoxic treatment with MK 801 reduces hypoxic-ischemic damage in the neonatal rat. Neurology 39: 713-718.
25. Hattori H, Westerlain CG (1990): Excitatory aminoacids in the developing brain: ontogeny, plasticity, and excitotoxicity. Pediatr Neurol 6: 219-228.
26. Ikonomidou C, Mosinger JL, Olney JW (1989): Hypothermia enhances the protective effect of MK-801 against hypoxic; ischemic brain damage in infant rats. Brain Res 487: 184-187.
27. Illievich UM, Zornow MH, Choi KT, Scheller MS, Strnat MA (1994): Effects of hypothermic metabolic suppression on hippocampal glutamate concentrations after transient global cerebral ischemia. Anesth Analg 78: 905-911.
28. Jiang JY, Lyeth BG, Kapasi MZ, Jenkins LW, Povlishock JT (1992): Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat. Acta Neuropathol (Berl) 84: 495-500.
29. Kader A, Frazzini VI, Baker CJ, Solomon RA, Trifiletti RR (1994): Effect of mild hypothermia on nitric oxide synthesis during focal cerebral ischemia. Neurosurgery 35: 272-277 discussion 277.
30. Keller RW, Oke A, Mefford IN, Adams RN (1976): Liquid Chromatographic analysis of catecholamine: routine assay for regional brain mapping. Life Sci 19: 995-1004.
31. Kliegman RM: Hypoxia-Ischemia (Asphyxia). In: Berhman RE, Kliegman RM, Arvin AM, eds., Nelson textbook of pediatrics. W.B. Saunders Company, New York, Tokyo. London, 1996, pp. 469-471.
32. Levi G, Raiteri M (1993): Carrier mediated release of neurotransmitters. Trends Neurosci 16: 415 -419.
33. Lo EH, Steinberg GK (1992): Effects of hypothermia on evoked potentials, magnetic resonance imaging, and blood flow in focal ischemia in rabbits. Stroke 23: 889-893.
34. - independent dopamine release from striatal slices. A possible role of reverse dopamine transport. J Pharmacol Exp Ther 256: 1132-1138.
35. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951): Protein measurement with the foline phenol reagent. J Biol Chem 193: 265-275.
36. McDonald JW, Silverstein FS, Johnston MV (1988): Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system. Brain Res 459: 200-203.
37. Mefford IN, Gilberg NJ, Barchas JD (1980): Simultaneous determination of catecholamines and unconjugated 3,4-dihydroxyphenylacetic acid (DOPAC) by ion-pairing reverse phase high performance liquid chromatography with electrochemical detection. Anal Biochem 104: 469-472.
38. Mitani A, Kataoka K (1991): Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: brain microdialysis study. Neuroscience 42: 661-670.
39. Nakashima K, Todd MM (1996): Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization. Stroke 27: 913-918.
40. Nieoullon A, Cheramy A, Glowinski J (1977): Interdependence of the nigrostriatal dopaminergic systems on the two sides of the brain in the cat. Science 198: 416-418.
41. Novelh A, Reilly JA, Lysko PG, Henneberry RC (1988): Glutamate becomes neurotoxic via the NMDA receptor when intracellular energy levels are reduced. Brain Res 451: 205-212.
42. Olney JW, Ikconomidou C, Mosinger JL, Frierdich G (1989): MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain- J Neurosci 9(5): 1701-1704.
43. Ozyurt E, Graham DI, Woodruff GN, McCulloch J (1988): Protective effect of the glutamate antagonist MK-801 in focal cerebral ischemia in the cat. J Cereb Blood Flow Metab 8: 138-143.
44. Palmer C, Brucklacher RM, Christensen MA, Vannucci RC (1990): Carbohydrate and energy metabolism during the evolution of hypoxic-ischemic brain damage in the immature rat. J Cereb Blood Flow Metab 10: 227-235.
45. Park CK, Mendelow AD, Graham DI, McCulloch J, Teasdale GM (1988): Correlation of triphenyltetrazolium chloride perfusion staining with conventional neurohistology in the detection of early brain ischemia. Neuropath and Applied Neurobiology, 14: 289-298.
46. Park CK, Nehls DG, Graham DI, Teasdale GM, McCulloch J (1988): The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat. Ann Neurol 24: 543-551.
47. Patel PM, Drummond JC, Cole DJ, Yaksh TL (1994): Differential temperature sensitivity of ischemia-induced glutamate release and eicosanoid production in rats. Brain Res 650: 205-211.
48. Perez-Pinzon MA, Nilsson GE, Lutz PL (1992): Relationship between ion gradients and neurotransmitter release in the newborn rat striatum during anoxia. Brain Res 602: 228-233.
49. Puka-Sundvall M, Sandberg M, Bona E, Gilland E, Hagberg E (1995): Excitatory amino acids and cysteine in relation to brain damage in a neonatal rat model of hypoxic-ischemia. J Cereb Blood Flow Metab 15 Suppl. 1, 282.
50. Rice J, Vanucci RC, Brierley J (1981): The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 9: 131-141.
51. Richards D, Obrenovitch TP, Symon L, Curzon G (1993): Extracellular dopamine and serotonin in the rat striatum during transient ischemia of different severities: a microdiaiysis study. J Neurochem 60: 128-136.
52. Santos MS, Moreno AJ, Carvalho AP (1996): Relationships between ATP depletion, membrane potential, and release of neurotransmitters in rat nerve terminals. Stroke 27: 941-950.
53. Sherwood MN, Timiras PS: 10 day old Rats. In: Sherwood MM, Timiras PS, eds., A stereotaxic atlas of the developing rat brain. University of California press, Berkley Los Angeles, London, 1970, pp. 78-139.
54. Siesjö BK (1992): Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. J Neurosurg 77: 169-184.
55. Silverstetn F, Johnston MV (1984): Effects of hypoxia-ischemia on monoamine metabolism in the immature rat. Ann Neurol 15: 342-347.
56. Toner CC, Stanford JA (1997a): Sodium channel blockade unmasks two temporally distinct mechanisms of striatal dopamine release during transient ischemia of different severities: a microdialysis study. Neuroscience 81: 999-1007.
57. Toner CC, Stanford JA (1997b): Involvement of N- and P/Q but not L- or T type voltage gated calcium channels in ischemia-induced striatal dopamine release in vitro. Brain Res 748: 85-92.
58. Toner CC, Stanford JA (1997c): Characteristics of the NMDA receptor modulating hypoxia/hypoglycemia-induced dopamine release in vitro. Euro J Pharmacol 340: 133-143.
59. Towfight J, Yager JY, Housman C, Vannucci RC (1991): Neuropathology of remote hypoxic-ischemic damage in the immature rat. Acta Neuropathol 81: 578-587.
60. Toyoda T, Suzuki S, Kassell NF, Lee KS (1996): Intraischemic hypothermia attenuates neutrophil infiltration in the rat neocortex after focal ischemia-reperfusion injury. Neurosurgery 39: 1200-1205.
61. Vanucci RC, Yager JY, Vanucci SJ (1994): Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat. J Cereb Blood Flow Metab 14: 279-288.
62. Venditti P, Masullo P, Di Meo S, Agnisola C (1999): Protection against ischemia-reperfusion induced oxidative stress by vitamin E treatment. Arch Physiol Biochem 107: 27-34.
63. Vezzani A, Serafini R, Stasi MA, Caccia S, Conti I, Tridico V Samanin R (1989): Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats. J Pharmacol Exp Ther 249: 278-283.
64. Wallace MC, Teasdale GM, McCulloch J (1992): Autoradiographic analysis of 3H-MK-801 (dizocilpine) in vivo uptake and in vitro binding after focal cerebral ischemia in the rat, J Neurosurg 76: 127-133.
65. Yager JY, Brucklacher RM, Vanucci RC (1991): Cerebral oxidative metabolism and redox state during hypoxia-ischemia and early recovery in immature rats. Am J Physiol 261: H1102-1108.