Combination drug therapy and mild hypothermia after transient focal cerebral ischemia in rats

Stroke

Volumn 34, Issue 9, 2003, Pages 2246-2251

  Zausinger, Stefan ^a   Schöller, Karsten ^a   Plesnila, Nikolaus ^a   Schmid Elsaesser, Robert ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Cerebral ischemia, focal; Drug therapy, combination; Hypothermia; Neuroprotection; Rats; Therapeutics

Indexed keywords

MAGNESIUM CHLORIDE; TIRILAZAD;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFICACY; FUNCTIONAL ASSESSMENT; HYPOTHERMIA; LASER DOPPLER FLOWMETRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; RISK FACTOR; STROKE; TREATMENT PLANNING;

ANIMALS; ANTIOXIDANTS; BLOOD FLOW VELOCITY; BLOOD GLUCOSE; BLOOD PRESSURE; CEREBRAL INFARCTION; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; HYPOTHERMIA, INDUCED; ISCHEMIC ATTACK, TRANSIENT; LASER-DOPPLER FLOWMETRY; MAGNESIUM CHLORIDE; MALE; NEUROPROTECTIVE AGENTS; PREGNATRIENES; RATS; RATS, SPRAGUE-DAWLEY; SURVIVAL RATE; TIME FACTORS; TREATMENT OUTCOME;

EID: 0042418486     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000083622.65684.21     Document Type: Article

References (42)

1. Reith J, Jorgensen HS, Pedersen PM, Nakayama H, Raaschou HO, Jeppesen LL, Olsen TS. Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet. 1996;347:422-425.
2. Schwab S, Schwarz S, Spranger M, Keller E, Bertram M, Hacke W. Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke. 1998;29:2461-2466.
3. Dietrich WD, Lin B, Globus MY, Green EJ, Ginsberg MD, Busto R. Effect of delayed MK-801 (dizocilpine) treatment with or without immediate postischemic hypothermia on chronic neuronal survival after global forebrain ischemia in rats. J Cereb Blood Flow Metab. 1995;15:960-968.
4. Maier CM, Sun GH, Kunis D, Yenari MA, Steinberg GK. Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size. J Neurosurg. 2001;94:90-96.
5. Meden P, Overgaard K, Pedersen H, Boysen G. The influence of body temperature on infarct volume and thrombolytic therapy in a rat embolic stroke model. Brain Res. 1994;647:131-138.
6. Schmid-Elsaesser R, Zausinger S, Hungerhuber E, Baethmann A, Reulen HJ. Neuroprotective effects of combination therapy with tirilazad and magnesium in rats subjected to reversible focal cerebral ischemia. Neurosurgery. 1999;44:163-172.
7. Schmid-Elsaesser R, Hungerhuber E, Zausinger S, Baethmann A, Reulen HJ. Combination drug therapy and mild hypothermia: a promising treatment strategy for reversible focal cerebral ischemia. Stroke. 1999;30:1891-1899.
8. Zausinger S, Westermaier T, Plesnila N, Steiger HJ, Schmid-Elsaesser R. Neuroprotection in transient focal cerebral ischemia by combination therapy and mild hypothermia: Comparison with customary therapeutic regimen. Stroke. 2003;1526-1532.
9. Zausinger S, Baethmann A, Schmid-Elsaesser R. Anesthetic methods in rats determine outcome after experimental focal cerebral ischemia: mechanical ventilation is required to obtain controlled experimental conditions. Brain Res Protocols. 2002;9:112-121.
10. Lomax P. Measurement of "core" temperature in the rat. Nature. 1966; 210:854-855.
11. Schmid-Elsaesser R, Zausinger S, Hungerhuber E, Baethmann A, Reulen HJ. A critical reevaluation of the intraluminal thread model of focal cerebral ischemia: evidence of inadvertent premature reperfusion and subarachnoid hemorrhage by laser Doppler flowmetry. Stroke. 1998;29:2162-2170.
12. Zausinger S, Hungerhuber E, Baethmann A, Reulen HJ, Schmid-Elsaesser R. Neurological impairment in rats after transient middle cerebral artery occlusion: a comparative study under various treatment paradigms. Brain Res. 2000;863:94-105.
13. Pellegrino LJ. A Stereotaxic Atlas of the Rat Brain. New York, NY: Plenum Press; 1979.
14. Lin TN, He YY, Wu G, Khan M, Hsu CY. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke. 1993;24:117-121.
15. Zhang RL, Chopp M, Chen H, Garcia JH, Zhang ZG. Postischemic (1 hour) hypothermia significantly reduces ischemic cell damage in rats subjected to 2 hours of middle cerebral artery occlusion. Stroke. 1993;24:1235-1240.
16. Schubert A. Side effects of mild hypothermia. J Neurosurg Anesthesiol. 1995;7:139-147.
17. Huh PW, Belayev L, Zhao W, Koch S, Busto R, Ginsberg MD. Comparative neuroprotective efficacy of prolonged moderate intraischemic and postischemic hypothermia in focal cerebral ischemia. J Neurosurg. 2000;92:91-99.
18. Karibe H, Chen J, Zarow GJ, Graham SH, Weinstein PR. Delayed induction of mild hypothermia to reduce infarct volume after temporary middle cerebral artery occlusion in rats. J Neurosurg. 1994;80:112-119.
19. Kawai N, Okauchi M, Morisaki K, Nagao S. Effects of delayed intraischemic and postischemic hypothermia on a focal model of transient cerebral ischemia in rats. Stroke. 2000;31:1982-1989.
20. Maier CM, Ahern K, Cheng ML, Lee JE, Yenari MA, Steinberg GK. Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: effects on neurologic outcome, infarct size, apoptosis, and inflammation. Stroke. 1998;29:2171-2180.
21. Yanamoto H, Nagata I, Nakahara I, Tohnai N, Zhang Z, Kikuchi H. Combination of intraischemic and postischemic hypothermia provides potent and persistent neuroprotection against temporary focal ischemia in rats. Stroke. 1999;30:2720-2726.
22. Kollmar R, Schabitz WR, Heiland S, Georgiadis D, Schellinger PD, Bardutzky J, Schwab S. Neuroprotective effect of delayed moderate hypothermia after focal cerebral ischemia: an MRI study. Stroke. 2002;33:1899-1904.
23. Kaplan B, Brint S, Tanabe J, Jacewicz M, Wang XJ, Pulsinelli W. Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia. Stroke. 1991;22:1032-1039.
24. Memezawa H, Smith ML, Siesjö BK. Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke. 1992;23:552-559.
25. Aronowski J, Cho KH, Strong R, Grotta JC. Neurofilament proteolysis after focal ischemia: when do cells die after experimental stroke? J Cereb Blood Flow Metab. 1999;19:652-660.
26. Colbourne F, Corbett D. Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection. J Neurosci. 1995;15:7250-7260.
27. Sarraf-Yazdi S, Sheng H, Brinkhous AD, Pearlstein RD, Warner DS. Effects of postischemic halothane administration on outcome from transient focal cerebral ischemia in the rat. J Neurosurg Anesthesiol. 1999;11:31-36.
28. Yang Y, Li Q, Ahmad F, Shuaib A. Survival and histological evaluation of therapeutic window of post-ischemia treatment with magnesium sulfate in embolic stroke model of rat. Neurosci Lett. 2000;285:119-122.
29. Muir KW, Lees KR. A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke. Stroke. 1995;26:1183-1188.
30. Muir KW. Magnesium for neuroprotection in ischaemic stroke: rationale for use and evidence of effectiveness. CNS Drugs. 2001;15:921-930.
31. RANTTAS Investigators. A randomized trial of tirilazad mesylate in patients with acute stoke (RANTTAS). Stroke. 1996;27:1453-1458.
32. Boisvert DP, Hall ED. Tirilazad prevention of reperfusion edema after focal ischemia in cynomolgus monkeys. Can J Neurol Sci. 1996;23:46-52.
33. Lanzino G, Kassell NF. Double-blind, randomized, vehicle-controlled study of high-dose tirilazad mesylate in women with aneurysmal subarachnoid hemorrhage, part II: a cooperative study in North America. J Neurosurg. 1999;90:1018-1024.
34. Tirilazad International Steering Committee. Tirilazad mesylate in acute ischemic stroke: a systematic review. Stroke. 2000;32:2257-2265.
35. Xue D, Slivka A, Buchan AM. Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats. Stroke. 1992;23:894-899.
36. Moore LE, Traystman RJ. Role of oxygen free radicals and lipid peroxidation in cerebral reperfusion injury. Adv Pharmacol. 1994;31:565-576.
37. Siesjö BK, Katsura K, Zhao Q, Folbergrova J, Pahlmark K, Siesjö P, Smith ML. Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis. J Neurotrauma. 1995;12:943-956.
38. Hacke W, Brott T, Caplan L, Meier D, Fieschi C, von Kummer R, Donnan G, Heiss WD, Wahlgren NG, Spranger M, et al. Thrombolysis in acute ischemic stroke: controlled trials and clinical experience. Neurology. 1999;53:S3-S14.
39. Christou I, Alexandrov AV, Burgin WS, Wojner AW, Felberg RA, Malkoff M, Grotta JC. Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke. Stroke. 2000;31:1812-1816.
40. Schwab S, Georgiadis D, Berrouschot J, Schellinger PD, Graffagnino C, Mayer SA. Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke. 2001;32:2033-2035.
41. Kammersgaard LP, Rasmussen BH, Jorgensen HS, Reith J, Weber U, Olsen TS. Feasibility and safety of inducing modest hypothermia in awake patients with acute stroke through surface cooling: a case-control study: the Copenhagen Stroke Study. Stroke. 2000;31:2251-2256.
42. Georgiadis D, Schwarz S, Kollmar R, Schwab S. Endovascular cooling for moderate hypothermia in patients with acute stroke: first results of a novel approach. Stroke. 2001;32:2550-2553.