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Volumn 87, Issue 1, 2007, Pages 179-197

Acute ischemic stroke: Overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia

Author keywords

Experimental stroke model; Focal cerebral ischemia; Magnetic resonance imaging; Middle cerebral artery; Mouse; Pathophysiology; Rat; Therapy

Indexed keywords

3 (5 CHLORO 2 METHOXYPHENYL) 3 FLUORO 2,3 DIHYDRO 6 TRIFLUOROMETHYL 1H INDOL 2 ONE; 4 PHOSPHONOMETHYLPIPECOLIC ACID; 6,7 DICHLORO 5 NITRO 2,3 QUINOXALINEDIONE; [1,2,3,4 TETRAHYDRO 7 (1H IMIDAZOL 1 YL) 6 NITRO 2,3 DIOXO 1 QUINOXALINYL]ACETIC ACID; [[3,4 DIHYDRO 7 MORPHOLINO 2,3 DIOXO 6 (TRIFLUOROMETHYL) 1(2H) QUINOXALINYL]METHYL]PHOSPHONIC ACID; ALTEPLASE; APTIGANEL; CALCIUM ANTAGONIST; CITICOLINE; CLOMETHIAZOLE; DEXTRORPHAN; DIAZEPAM; DISUFENTON SODIUM; EBSELEN; ELIPRODIL; FIBRINOLYTIC AGENT; FLUNARIZINE; FOSPHENYTOIN SODIUM; GAVESTINEL; GLUTAMATE RECEPTOR ANTAGONIST; NALMEFENE; NEUROPROTECTIVE AGENT; NIMODIPINE; NORPHENAZONE; PICLOZOTAN; PROUROKINASE; REPINOTAN; SIPATRIGINE; TISSUE PLASMINOGEN ACTIVATOR; UNINDEXED DRUG;

EID: 34249852075     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2007.04.015     Document Type: Article
Times cited : (619)

References (235)
  • 1
    • 0036135339 scopus 로고    scopus 로고
    • Filament size influences temperature changes and brain damage following middle cerebral artery occlusion in rats
    • Abraham H., Somogyvari-Vigh A., Maderdrut J.L., Vigh S., and Arimura A. Filament size influences temperature changes and brain damage following middle cerebral artery occlusion in rats. Exp Brain Res 142 (2002) 131-138
    • (2002) Exp Brain Res , vol.142 , pp. 131-138
    • Abraham, H.1    Somogyvari-Vigh, A.2    Maderdrut, J.L.3    Vigh, S.4    Arimura, A.5
  • 2
    • 0025274838 scopus 로고
    • Efficacy of tissue plasminogen activator in the lysis of thrombosis of the cerebral venous sinus
    • Alexander L.F., Yamamoto Y., Ayoubi S., al-Mefty O., and Smith R.R. Efficacy of tissue plasminogen activator in the lysis of thrombosis of the cerebral venous sinus. Neurosurgery 26 (1990) 559-564
    • (1990) Neurosurgery , vol.26 , pp. 559-564
    • Alexander, L.F.1    Yamamoto, Y.2    Ayoubi, S.3    al-Mefty, O.4    Smith, R.R.5
  • 4
    • 0029123305 scopus 로고
    • Neurochemical changes following occlusion of the middle cerebral artery in rats
    • Allen G.V., Cheung R.T., and Cechetto D.F. Neurochemical changes following occlusion of the middle cerebral artery in rats. Neuroscience 68 (1995) 1037-1050
    • (1995) Neuroscience , vol.68 , pp. 1037-1050
    • Allen, G.V.1    Cheung, R.T.2    Cechetto, D.F.3
  • 5
  • 6
    • 0030856804 scopus 로고    scopus 로고
    • Reperfusion injury: demonstration of brain damage produced by reperfusion after transient focal ischemia in rats
    • Aronowski J., Strong R., and Grotta J.C. Reperfusion injury: demonstration of brain damage produced by reperfusion after transient focal ischemia in rats. J Cereb Blood Flow Metab 17 (1997) 1048-1056
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 1048-1056
    • Aronowski, J.1    Strong, R.2    Grotta, J.C.3
  • 7
    • 3042834682 scopus 로고    scopus 로고
    • MR molecular imaging of early endothelial activation in focal ischemia
    • Barber P.A., Foniok T., Kirk D., Buchan A.M., Laurent S., Boutry S., et al. MR molecular imaging of early endothelial activation in focal ischemia. Ann Neurol 56 (2004) 116-120
    • (2004) Ann Neurol , vol.56 , pp. 116-120
    • Barber, P.A.1    Foniok, T.2    Kirk, D.3    Buchan, A.M.4    Laurent, S.5    Boutry, S.6
  • 8
    • 24644456417 scopus 로고    scopus 로고
    • Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging
    • Bardutzky J., Shen Q., Henninger N., Bouley J., Duong T.Q., and Fisher M. Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging. Stroke 36 (2005) 2000-2005
    • (2005) Stroke , vol.36 , pp. 2000-2005
    • Bardutzky, J.1    Shen, Q.2    Henninger, N.3    Bouley, J.4    Duong, T.Q.5    Fisher, M.6
  • 9
    • 0022483434 scopus 로고
    • Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination
    • Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., and Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17 (1986) 472-476
    • (1986) Stroke , vol.17 , pp. 472-476
    • Bederson, J.B.1    Pitts, L.H.2    Tsuji, M.3    Nishimura, M.C.4    Davis, R.L.5    Bartkowski, H.6
  • 10
    • 0029839695 scopus 로고    scopus 로고
    • Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model
    • Belayev L., Alonso O.F., Busto R., Zhao W., and Ginsberg M.D. Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke 27 (1996) 1616-1622
    • (1996) Stroke , vol.27 , pp. 1616-1622
    • Belayev, L.1    Alonso, O.F.2    Busto, R.3    Zhao, W.4    Ginsberg, M.D.5
  • 11
    • 0030580410 scopus 로고    scopus 로고
    • Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats
    • Belayev L., Busto R., Zhao W., and Ginsberg M.D. Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res 739 (1996) 88-96
    • (1996) Brain Res , vol.739 , pp. 88-96
    • Belayev, L.1    Busto, R.2    Zhao, W.3    Ginsberg, M.D.4
  • 12
    • 0033519889 scopus 로고    scopus 로고
    • Middle cerebral artery occlusion in the mouse by intraluminal suture coated with poly-l-lysine: neurological and histological validation
    • Belayev L., Busto R., Zhao W., Fernandez G., and Ginsberg M.D. Middle cerebral artery occlusion in the mouse by intraluminal suture coated with poly-l-lysine: neurological and histological validation. Brain Res 833 (1999) 181-190
    • (1999) Brain Res , vol.833 , pp. 181-190
    • Belayev, L.1    Busto, R.2    Zhao, W.3    Fernandez, G.4    Ginsberg, M.D.5
  • 13
    • 0032738822 scopus 로고    scopus 로고
    • Thrombolysis of cerebral clot embolism in rat: effect of treatment delay
    • Brinker G., Franke C., Hoehn M., Uhlenkuken U., and Hossmann K.A. Thrombolysis of cerebral clot embolism in rat: effect of treatment delay. Neuroreport 10 (1999) 3269-3272
    • (1999) Neuroreport , vol.10 , pp. 3269-3272
    • Brinker, G.1    Franke, C.2    Hoehn, M.3    Uhlenkuken, U.4    Hossmann, K.A.5
  • 14
    • 0023786051 scopus 로고
    • Focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries
    • Brint S., Jacewicz M., Kiessling M., Tanabe J., and Pulsinelli W. Focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries. J Cereb Blood Flow Metab 8 (1988) 474-485
    • (1988) J Cereb Blood Flow Metab , vol.8 , pp. 474-485
    • Brint, S.1    Jacewicz, M.2    Kiessling, M.3    Tanabe, J.4    Pulsinelli, W.5
  • 15
    • 0026508278 scopus 로고
    • A new model of temporary focal neocortical ischemia in the rat
    • Buchan A.M., Xue D., and Slivka A. A new model of temporary focal neocortical ischemia in the rat. Stroke 23 (1992) 273-279
    • (1992) Stroke , vol.23 , pp. 273-279
    • Buchan, A.M.1    Xue, D.2    Slivka, A.3
  • 16
    • 0031555405 scopus 로고    scopus 로고
    • Improved model of thromboembolic stroke and rt-PA induced reperfusion in the rat
    • Busch E., Kruger K., and Hossmann K.A. Improved model of thromboembolic stroke and rt-PA induced reperfusion in the rat. Brain Res 778 (1997) 16-24
    • (1997) Brain Res , vol.778 , pp. 16-24
    • Busch, E.1    Kruger, K.2    Hossmann, K.A.3
  • 17
    • 0033659571 scopus 로고    scopus 로고
    • Multispectral analysis of the temporal evolution of cerebral ischemia in the rat brain
    • Carano R.A., Li F., Irie K., Helmer K.G., Silva M.D., Fisher M., et al. Multispectral analysis of the temporal evolution of cerebral ischemia in the rat brain. J Magn Reson Imaging 12 (2000) 842-858
    • (2000) J Magn Reson Imaging , vol.12 , pp. 842-858
    • Carano, R.A.1    Li, F.2    Irie, K.3    Helmer, K.G.4    Silva, M.D.5    Fisher, M.6
  • 18
    • 26844435654 scopus 로고    scopus 로고
    • Rodent models of focal stroke: size, mechanism, and purpose
    • Carmichael S.T. Rodent models of focal stroke: size, mechanism, and purpose. NeuroRx 2 (2005) 396-409
    • (2005) NeuroRx , vol.2 , pp. 396-409
    • Carmichael, S.T.1
  • 19
    • 0022545394 scopus 로고
    • A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction
    • Chen S.T., Hsu C.Y., Hogan E.L., Maricq H., and Balentine J.D. A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke 17 (1986) 738-743
    • (1986) Stroke , vol.17 , pp. 738-743
    • Chen, S.T.1    Hsu, C.Y.2    Hogan, E.L.3    Maricq, H.4    Balentine, J.D.5
  • 20
    • 14644444482 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice
    • Chen J., Zacharek A., Zhang C., Jiang H., Li Y., Roberts C., et al. Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. J Neurosci 25 (2005) 2366-2375
    • (2005) J Neurosci , vol.25 , pp. 2366-2375
    • Chen, J.1    Zacharek, A.2    Zhang, C.3    Jiang, H.4    Li, Y.5    Roberts, C.6
  • 21
    • 34249849555 scopus 로고    scopus 로고
    • Upregulation of dihydropyrimidinase-related protein 2, spectrin alpha II chain, heat shock cognate protein 70 pseudogene 1 and tropomodulin 2 after focal cerebral ischemia in rats-A proteomics approach
    • [Electronic publication ahead of print]
    • Chen A., Liao W.P., Lu Q., Wong W.S., and Wong P.T. Upregulation of dihydropyrimidinase-related protein 2, spectrin alpha II chain, heat shock cognate protein 70 pseudogene 1 and tropomodulin 2 after focal cerebral ischemia in rats-A proteomics approach. Neurochem Int (2006) [Electronic publication ahead of print]
    • (2006) Neurochem Int
    • Chen, A.1    Liao, W.P.2    Lu, Q.3    Wong, W.S.4    Wong, P.T.5
  • 22
    • 33845799304 scopus 로고    scopus 로고
    • A simple method to induce focal brain hypothermia in rats
    • Clark D.L., and Colbourne F. A simple method to induce focal brain hypothermia in rats. J Cereb Blood Flow Metab 27 (2007) 115-122
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 115-122
    • Clark, D.L.1    Colbourne, F.2
  • 23
    • 10644221090 scopus 로고
    • Some experiments and observations on tying the carotid and vertebral arteries, and the pneumo-gastric, phrenic and sympathetic nerves
    • Cooper A. Some experiments and observations on tying the carotid and vertebral arteries, and the pneumo-gastric, phrenic and sympathetic nerves. Guys Hosp Rep 1 (1836) 457-475
    • (1836) Guys Hosp Rep , vol.1 , pp. 457-475
    • Cooper, A.1
  • 24
    • 0022523131 scopus 로고
    • Different susceptibilities to cerebral infarction in spontaneously hypertensive (SHR) and normotensive Sprague-Dawley rats
    • Coyle P. Different susceptibilities to cerebral infarction in spontaneously hypertensive (SHR) and normotensive Sprague-Dawley rats. Stroke 17 (1986) 520-525
    • (1986) Stroke , vol.17 , pp. 520-525
    • Coyle, P.1
  • 25
    • 0034888287 scopus 로고    scopus 로고
    • Applications of the Morris water maze in the study of learning and memory
    • D'Hooge R., and De Deyn P.P. Applications of the Morris water maze in the study of learning and memory. Brain Res Brain Res Rev 36 (2001) 60-90
    • (2001) Brain Res Brain Res Rev , vol.36 , pp. 60-90
    • D'Hooge, R.1    De Deyn, P.P.2
  • 26
    • 22044441701 scopus 로고    scopus 로고
    • Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: results of a phase II clinical trial
    • Daffertshofer M., Gass A., Ringleb P., Sitzer M., Sliwka U., Els T., et al. Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: results of a phase II clinical trial. Stroke 36 (2005) 1441-1446
    • (2005) Stroke , vol.36 , pp. 1441-1446
    • Daffertshofer, M.1    Gass, A.2    Ringleb, P.3    Sitzer, M.4    Sliwka, U.5    Els, T.6
  • 27
    • 0037312886 scopus 로고    scopus 로고
    • Inflammatory mechanisms after ischemia and stroke
    • Danton G.H., and Dietrich W.D. Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol 62 (2003) 127-136
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 127-136
    • Danton, G.H.1    Dietrich, W.D.2
  • 28
    • 0029025265 scopus 로고
    • Experimental stroke and neuroprotection in the aging rat brain
    • Davis M., Mendelow A.D., Perry R.H., Chambers I.R., and James O.F. Experimental stroke and neuroprotection in the aging rat brain. Stroke 26 (1995) 1072-1078
    • (1995) Stroke , vol.26 , pp. 1072-1078
    • Davis, M.1    Mendelow, A.D.2    Perry, R.H.3    Chambers, I.R.4    James, O.F.5
  • 29
    • 3242787149 scopus 로고    scopus 로고
    • Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling
    • De Georgia M.A., Krieger D.W., Abou-Chebl A., Devlin T.G., Jauss M., Davis S.M., et al. Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling. Neurology 63 (2004) 312-317
    • (2004) Neurology , vol.63 , pp. 312-317
    • De Georgia, M.A.1    Krieger, D.W.2    Abou-Chebl, A.3    Devlin, T.G.4    Jauss, M.5    Davis, S.M.6
  • 30
    • 0033485704 scopus 로고    scopus 로고
    • Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing?
    • De Keyser J., Sulter G., and Luiten P.G. Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing?. Trends Neurosci 22 (1999) 535-540
    • (1999) Trends Neurosci , vol.22 , pp. 535-540
    • De Keyser, J.1    Sulter, G.2    Luiten, P.G.3
  • 31
    • 0028923459 scopus 로고
    • Why do all drugs work in animals but none in stroke patients? 1. Drugs promoting cerebral blood flow
    • Del Zoppo G.J. Why do all drugs work in animals but none in stroke patients? 1. Drugs promoting cerebral blood flow. J Intern Med 237 (1995) 79-88
    • (1995) J Intern Med , vol.237 , pp. 79-88
    • Del Zoppo, G.J.1
  • 32
    • 0348048839 scopus 로고    scopus 로고
    • Thrombolysis: from the experimental findings to the clinical practice
    • Del Zoppo G.J. Thrombolysis: from the experimental findings to the clinical practice. Cerebrovasc Dis 17 Suppl 1 (2004) 144-152
    • (2004) Cerebrovasc Dis , vol.17 , Issue.SUPPL. 1 , pp. 144-152
    • Del Zoppo, G.J.1
  • 34
    • 20344364186 scopus 로고    scopus 로고
    • Astrocytic contributions to bioenergetics of cerebral ischemia
    • Dienel G.A., and Hertz L. Astrocytic contributions to bioenergetics of cerebral ischemia. Glia 50 (2005) 362-388
    • (2005) Glia , vol.50 , pp. 362-388
    • Dienel, G.A.1    Hertz, L.2
  • 37
    • 0346250982 scopus 로고    scopus 로고
    • Magnetic resonance imaging in experimental models of brain disorders
    • Dijkhuizen R.M., and Nicolay K. Magnetic resonance imaging in experimental models of brain disorders. J Cereb Blood Flow Metab 23 (2003) 1383-1402
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 1383-1402
    • Dijkhuizen, R.M.1    Nicolay, K.2
  • 39
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: an integrated view
    • Dirnagl U., Iadecola C., and Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22 (1999) 391-397
    • (1999) Trends Neurosci , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 40
    • 33747188955 scopus 로고    scopus 로고
    • Fischer-344 rats are unsuitable for the MCAO filament model due to their cerebrovascular anatomy
    • Dittmar M.S., Vatankhah B., Fehm N.P., Schuierer G., Bogdahn U., Horn M., et al. Fischer-344 rats are unsuitable for the MCAO filament model due to their cerebrovascular anatomy. J Neurosci Methods 156 (2006) 50-54
    • (2006) J Neurosci Methods , vol.156 , pp. 50-54
    • Dittmar, M.S.1    Vatankhah, B.2    Fehm, N.P.3    Schuierer, G.4    Bogdahn, U.5    Horn, M.6
  • 41
    • 0042919455 scopus 로고    scopus 로고
    • Prediction of malignant course in MCA infarction by PET and microdialysis
    • Dohmen C., Bosche B., Graf R., Staub F., Kracht L., Sobesky J., et al. Prediction of malignant course in MCA infarction by PET and microdialysis. Stroke 34 (2003) 2152-2158
    • (2003) Stroke , vol.34 , pp. 2152-2158
    • Dohmen, C.1    Bosche, B.2    Graf, R.3    Staub, F.4    Kracht, L.5    Sobesky, J.6
  • 42
    • 0029842750 scopus 로고    scopus 로고
    • Streptokinase for acute ischemic stroke with relationship to time of administration: Australian Streptokinase (ASK) trial study group
    • Donnan G.A., Davis S.M., Chambers B.R., Gates P.C., Hankey G.J., McNeil J.J., et al. Streptokinase for acute ischemic stroke with relationship to time of administration: Australian Streptokinase (ASK) trial study group. JAMA 276 (1996) 961-966
    • (1996) JAMA , vol.276 , pp. 961-966
    • Donnan, G.A.1    Davis, S.M.2    Chambers, B.R.3    Gates, P.C.4    Hankey, G.J.5    McNeil, J.J.6
  • 43
    • 33845334199 scopus 로고    scopus 로고
    • Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations
    • Dreier J.P., Woitzik J., Fabricius M., Bhatia R., Major S., Drenckhahn C., et al. Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations. Brain 129 (2006) 3224-3237
    • (2006) Brain , vol.129 , pp. 3224-3237
    • Dreier, J.P.1    Woitzik, J.2    Fabricius, M.3    Bhatia, R.4    Major, S.5    Drenckhahn, C.6
  • 44
    • 0023801585 scopus 로고
    • The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration, and age
    • Duverger D., and MacKenzie E.T. The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration, and age. J Cereb Blood Flow Metab 8 (1988) 449-461
    • (1988) J Cereb Blood Flow Metab , vol.8 , pp. 449-461
    • Duverger, D.1    MacKenzie, E.T.2
  • 46
    • 5444234867 scopus 로고    scopus 로고
    • Erythropoietin: novel approaches to neuroprotection in human brain disease
    • Ehrenreich H., Aust C., Krampe H., Jahn H., Jacob S., Herrmann M., et al. Erythropoietin: novel approaches to neuroprotection in human brain disease. Metab Brain Dis 19 (2004) 195-206
    • (2004) Metab Brain Dis , vol.19 , pp. 195-206
    • Ehrenreich, H.1    Aust, C.2    Krampe, H.3    Jahn, H.4    Jacob, S.5    Herrmann, M.6
  • 47
    • 0036146687 scopus 로고    scopus 로고
    • The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct?
    • Emerich D.F., Dean III R.L., and Bartus R.T. The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct?. Exp Neurol 173 (2002) 168-181
    • (2002) Exp Neurol , vol.173 , pp. 168-181
    • Emerich, D.F.1    Dean III, R.L.2    Bartus, R.T.3
  • 48
    • 0034722808 scopus 로고    scopus 로고
    • An overview of acute stroke therapy: past, present, and future
    • Fisher M., and Schaebitz W. An overview of acute stroke therapy: past, present, and future. Arch Intern Med 160 (2000) 3196-3206
    • (2000) Arch Intern Med , vol.160 , pp. 3196-3206
    • Fisher, M.1    Schaebitz, W.2
  • 49
    • 26444574779 scopus 로고    scopus 로고
    • Use of animal models has not contributed to development of acute stroke therapies: con
    • Fisher M., and Tatlisumak T. Use of animal models has not contributed to development of acute stroke therapies: con. Stroke 36 (2005) 2324-2325
    • (2005) Stroke , vol.36 , pp. 2324-2325
    • Fisher, M.1    Tatlisumak, T.2
  • 51
    • 0028047476 scopus 로고
    • Cerebral sinus and venous thrombosis in rats induces long-term deficits in brain function and morphology-evidence for a cytotoxic genesis
    • Frerichs K.U., Deckert M., Kempski O., Schurer L., Einhaupl K., and Baethmann A. Cerebral sinus and venous thrombosis in rats induces long-term deficits in brain function and morphology-evidence for a cytotoxic genesis. J Cereb Blood Flow Metab 14 (1994) 289-300
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 289-300
    • Frerichs, K.U.1    Deckert, M.2    Kempski, O.3    Schurer, L.4    Einhaupl, K.5    Baethmann, A.6
  • 52
    • 0026736493 scopus 로고
    • Occlusion of the pig superior sagittal sinus, bridging and cortical veins: multistep evolution of sinus-vein thrombosis
    • Fries G., Wallenfang T., Hennen J., Velthaus M., Heimann A., Schild H., et al. Occlusion of the pig superior sagittal sinus, bridging and cortical veins: multistep evolution of sinus-vein thrombosis. J Neurosurg 77 (1992) 127-133
    • (1992) J Neurosurg , vol.77 , pp. 127-133
    • Fries, G.1    Wallenfang, T.2    Hennen, J.3    Velthaus, M.4    Heimann, A.5    Schild, H.6
  • 53
    • 0033135367 scopus 로고    scopus 로고
    • Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
    • Fujimura M., Morita-Fujimura Y., Kawase M., Copin J.C., Calagui B., Epstein C.J., et al. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J Neurosci 19 (1999) 3414-3422
    • (1999) J Neurosci , vol.19 , pp. 3414-3422
    • Fujimura, M.1    Morita-Fujimura, Y.2    Kawase, M.3    Copin, J.C.4    Calagui, B.5    Epstein, C.J.6
  • 54
    • 0032751052 scopus 로고    scopus 로고
    • Correlation of sequential MR images of microsphere-induced cerebral ischemia with histologic changes in rats
    • Fukuchi K., Kusuoka H., Watanabe Y., and Nishimura T. Correlation of sequential MR images of microsphere-induced cerebral ischemia with histologic changes in rats. Invest Radiol 34 (1999) 698-703
    • (1999) Invest Radiol , vol.34 , pp. 698-703
    • Fukuchi, K.1    Kusuoka, H.2    Watanabe, Y.3    Nishimura, T.4
  • 55
    • 0033486107 scopus 로고    scopus 로고
    • Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism
    • Furlan A., Higashida R., Wechsler L., Gent M., Rowley H., Kase C., et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 282 (1999) 2003-2011
    • (1999) JAMA , vol.282 , pp. 2003-2011
    • Furlan, A.1    Higashida, R.2    Wechsler, L.3    Gent, M.4    Rowley, H.5    Kase, C.6
  • 56
    • 33646705400 scopus 로고    scopus 로고
    • Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset
    • Furlan A.J., Eyding D., Albers G.W., Al-Rawi Y., Lees K.R., Rowley H.A., et al. Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset. Stroke 37 (2006) 1227-1231
    • (2006) Stroke , vol.37 , pp. 1227-1231
    • Furlan, A.J.1    Eyding, D.2    Albers, G.W.3    Al-Rawi, Y.4    Lees, K.R.5    Rowley, H.A.6
  • 57
    • 0030807617 scopus 로고    scopus 로고
    • Endothelin-1 induced lesions of the frontoparietal cortex of the rat. A possible model of focal cortical ischemia
    • Fuxe K., Bjelke B., Andbjer B., Grahn H., Rimondini R., and Agnati L.F. Endothelin-1 induced lesions of the frontoparietal cortex of the rat. A possible model of focal cortical ischemia. Neuroreport 8 (1997) 2623-2629
    • (1997) Neuroreport , vol.8 , pp. 2623-2629
    • Fuxe, K.1    Bjelke, B.2    Andbjer, B.3    Grahn, H.4    Rimondini, R.5    Agnati, L.F.6
  • 58
    • 0028947743 scopus 로고
    • Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudoputamen and the cortex
    • Garcia J.H., Liu K.F., and Ho K.L. Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudoputamen and the cortex. Stroke 26 (1995) 636-642
    • (1995) Stroke , vol.26 , pp. 636-642
    • Garcia, J.H.1    Liu, K.F.2    Ho, K.L.3
  • 59
    • 0031257676 scopus 로고    scopus 로고
    • Influence of ischemia and reperfusion on the course of brain tissue swelling and blood-brain barrier permeability in a rodent model of transient focal cerebral ischemia
    • Gartshore G., Patterson J., and Macrae I.M. Influence of ischemia and reperfusion on the course of brain tissue swelling and blood-brain barrier permeability in a rodent model of transient focal cerebral ischemia. Exp Neurol 147 (1997) 353-360
    • (1997) Exp Neurol , vol.147 , pp. 353-360
    • Gartshore, G.1    Patterson, J.2    Macrae, I.M.3
  • 60
    • 0042418531 scopus 로고    scopus 로고
    • Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance
    • Gerriets T., Stolz E., Walberer M., Kaps M., Bachmann G., and Fisher M. Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance. Stroke 34 (2003) 2234-2239
    • (2003) Stroke , vol.34 , pp. 2234-2239
    • Gerriets, T.1    Stolz, E.2    Walberer, M.3    Kaps, M.4    Bachmann, G.5    Fisher, M.6
  • 61
    • 0842267565 scopus 로고    scopus 로고
    • Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging
    • Gerriets T., Stolz E., Walberer M., Muller C., Kluge A., Bachmann A., et al. Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging. Stroke 35 (2004) 566-571
    • (2004) Stroke , vol.35 , pp. 566-571
    • Gerriets, T.1    Stolz, E.2    Walberer, M.3    Muller, C.4    Kluge, A.5    Bachmann, A.6
  • 62
    • 4744352158 scopus 로고    scopus 로고
    • Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography
    • Gerriets T., Stolz E., Walberer M., Muller C., Rottger C., Kluge A., et al. Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography. Stroke 35 (2004) 2372-2377
    • (2004) Stroke , vol.35 , pp. 2372-2377
    • Gerriets, T.1    Stolz, E.2    Walberer, M.3    Muller, C.4    Rottger, C.5    Kluge, A.6
  • 63
    • 33751019983 scopus 로고    scopus 로고
    • Parallel stages of learning and recovery of skilled reaching after motor cortex stroke: "oppositions" organize normal and compensatory movements
    • Gharbawie O.A., and Whishaw I.Q. Parallel stages of learning and recovery of skilled reaching after motor cortex stroke: "oppositions" organize normal and compensatory movements. Behav Brain Res 175 (2006) 249-262
    • (2006) Behav Brain Res , vol.175 , pp. 249-262
    • Gharbawie, O.A.1    Whishaw, I.Q.2
  • 64
    • 0029819292 scopus 로고    scopus 로고
    • The validity of rodent brain-ischemia models is self-evident
    • Ginsberg M.D. The validity of rodent brain-ischemia models is self-evident. Arch Neurol 53 (1996) 1065-1067
    • (1996) Arch Neurol , vol.53 , pp. 1065-1067
    • Ginsberg, M.D.1
  • 65
    • 0024805137 scopus 로고
    • Rodent models of cerebral ischemia
    • Ginsberg M.D., and Busto R. Rodent models of cerebral ischemia. Stroke 20 (1989) 1627-1642
    • (1989) Stroke , vol.20 , pp. 1627-1642
    • Ginsberg, M.D.1    Busto, R.2
  • 66
    • 0023235238 scopus 로고
    • Hyperglycemia reduces the extent of cerebral infarction in rats
    • Ginsberg M.D., Prado R., Dietrich W.D., Busto R., and Watson B.D. Hyperglycemia reduces the extent of cerebral infarction in rats. Stroke 18 (1987) 570-574
    • (1987) Stroke , vol.18 , pp. 570-574
    • Ginsberg, M.D.1    Prado, R.2    Dietrich, W.D.3    Busto, R.4    Watson, B.D.5
  • 67
    • 0036402443 scopus 로고    scopus 로고
    • Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective
    • Green A.R. Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective. Clin Exp Pharmacol Physiol 29 (2002) 1030-1034
    • (2002) Clin Exp Pharmacol Physiol , vol.29 , pp. 1030-1034
    • Green, A.R.1
  • 68
    • 0041659304 scopus 로고    scopus 로고
    • Animal models of stroke: do they have value for discovering neuroprotective agents?
    • Green R.A., Odergren T., and Ashwood T. Animal models of stroke: do they have value for discovering neuroprotective agents?. Trends Pharmacol Sci 24 (2003) 402-408
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 402-408
    • Green, R.A.1    Odergren, T.2    Ashwood, T.3
  • 69
    • 0028925907 scopus 로고
    • Why do all drugs work in animals but none in stroke patients? 2. Neuroprotective therapy
    • Grotta J. Why do all drugs work in animals but none in stroke patients? 2. Neuroprotective therapy. J Intern Med 237 (1995) 89-94
    • (1995) J Intern Med , vol.237 , pp. 89-94
    • Grotta, J.1
  • 70
    • 34249853069 scopus 로고    scopus 로고
    • Stroke treatment in the human versus animal models
    • Ginsberg M.D., and Bogousslavsky J. (Eds), Blackwell Scientific Publications
    • Grotta J. Stroke treatment in the human versus animal models. In: Ginsberg M.D., and Bogousslavsky J. (Eds). Cerebrovascular disease: pathophysiology, diagnosis, and management (1998), Blackwell Scientific Publications 1901-1906
    • (1998) Cerebrovascular disease: pathophysiology, diagnosis, and management , pp. 1901-1906
    • Grotta, J.1
  • 71
    • 0031806464 scopus 로고    scopus 로고
    • The temporal profile and morphologic features of neuronal death in human stroke resemble those observed in experimental forebrain ischemia: the potential role of apoptosis
    • Guglielmo M.A., Chan P.T., Cortez S., Stopa E.G., McMillan P., Johanson C.E., et al. The temporal profile and morphologic features of neuronal death in human stroke resemble those observed in experimental forebrain ischemia: the potential role of apoptosis. Neurol Res 20 (1998) 283-296
    • (1998) Neurol Res , vol.20 , pp. 283-296
    • Guglielmo, M.A.1    Chan, P.T.2    Cortez, S.3    Stopa, E.G.4    McMillan, P.5    Johanson, C.E.6
  • 72
    • 21444446874 scopus 로고    scopus 로고
    • Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia
    • Gunther A., Kuppers-Tiedt L., Schneider P.M., Kunert I., Berrouschot J., Schneider D., et al. Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia. Eur J Neurosci 21 (2005) 3189-3194
    • (2005) Eur J Neurosci , vol.21 , pp. 3189-3194
    • Gunther, A.1    Kuppers-Tiedt, L.2    Schneider, P.M.3    Kunert, I.4    Berrouschot, J.5    Schneider, D.6
  • 73
    • 0028922942 scopus 로고
    • A canine model of acute hindbrain ischemia and reperfusion
    • Guo J., Liao J.J., Preston J.K., and Batjer H.H. A canine model of acute hindbrain ischemia and reperfusion. Neurosurgery 36 (1995) 986-992
    • (1995) Neurosurgery , vol.36 , pp. 986-992
    • Guo, J.1    Liao, J.J.2    Preston, J.K.3    Batjer, H.H.4
  • 74
    • 2542551340 scopus 로고    scopus 로고
    • Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia
    • Gursoy-Ozdemir Y., Can A., and Dalkara T. Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia. Stroke 35 (2004) 1449-1453
    • (2004) Stroke , vol.35 , pp. 1449-1453
    • Gursoy-Ozdemir, Y.1    Can, A.2    Dalkara, T.3
  • 75
    • 19944426190 scopus 로고    scopus 로고
    • The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase
    • Hacke W., Albers G., Al-Rawi Y., Bogousslavsky J., Davalos A., Eliasziw M., et al. The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 36 (2005) 66-73
    • (2005) Stroke , vol.36 , pp. 66-73
    • Hacke, W.1    Albers, G.2    Al-Rawi, Y.3    Bogousslavsky, J.4    Davalos, A.5    Eliasziw, M.6
  • 76
    • 14844300868 scopus 로고    scopus 로고
    • A pilot dose-escalation safety study of tenecteplase in acute ischemic stroke
    • Haley Jr. E.C., Lyden P.D., Johnston K.C., and Hemmen T.M. A pilot dose-escalation safety study of tenecteplase in acute ischemic stroke. Stroke 36 (2005) 607-612
    • (2005) Stroke , vol.36 , pp. 607-612
    • Haley Jr., E.C.1    Lyden, P.D.2    Johnston, K.C.3    Hemmen, T.M.4
  • 77
    • 0345802826 scopus 로고    scopus 로고
    • Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection
    • Hartings J.A., Rolli M.L., Lu X.C., and Tortella F.C. Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection. J Neurosci 23 (2003) 11602-11610
    • (2003) J Neurosci , vol.23 , pp. 11602-11610
    • Hartings, J.A.1    Rolli, M.L.2    Lu, X.C.3    Tortella, F.C.4
  • 78
    • 0037332270 scopus 로고    scopus 로고
    • Occurrence of nonconvulsive seizures, periodic epileptiform discharges, and intermittent rhythmic delta activity in rat focal ischemia
    • Hartings J.A., Williams A.J., and Tortella F.C. Occurrence of nonconvulsive seizures, periodic epileptiform discharges, and intermittent rhythmic delta activity in rat focal ischemia. Exp Neurol 179 (2003) 139-149
    • (2003) Exp Neurol , vol.179 , pp. 139-149
    • Hartings, J.A.1    Williams, A.J.2    Tortella, F.C.3
  • 79
    • 0000220399 scopus 로고    scopus 로고
    • A reproducible model of middle cerebral artery occlusion in mice: hemodynamic, biochemical, and magnetic resonance imaging
    • Hata R., Mies G., Wiessner C., Fritze K., Hesselbarth D., Brinker G., et al. A reproducible model of middle cerebral artery occlusion in mice: hemodynamic, biochemical, and magnetic resonance imaging. J Cereb Blood Flow Metab 18 (1998) 367-375
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 367-375
    • Hata, R.1    Mies, G.2    Wiessner, C.3    Fritze, K.4    Hesselbarth, D.5    Brinker, G.6
  • 80
    • 0032757130 scopus 로고    scopus 로고
    • Experimental model of small deep infarcts involving the hypothalamus in rats: changes in body temperature and postural reflex
    • He Z., Yamawaki T., Yang S., Day A.L., Simpkins J.W., and Naritomi H. Experimental model of small deep infarcts involving the hypothalamus in rats: changes in body temperature and postural reflex. Stroke 30 (1999) 2743-2751
    • (1999) Stroke , vol.30 , pp. 2743-2751
    • He, Z.1    Yamawaki, T.2    Yang, S.3    Day, A.L.4    Simpkins, J.W.5    Naritomi, H.6
  • 81
    • 33751266740 scopus 로고    scopus 로고
    • Intravenous ancrod for acute ischaemic stroke in the European Stroke Treatment with Ancrod Trial: a randomised controlled trial
    • Hennerici M.G., Kay R., Bogousslavsky J., Lenzi G.L., Verstraete M., and Orgogozo J.M. Intravenous ancrod for acute ischaemic stroke in the European Stroke Treatment with Ancrod Trial: a randomised controlled trial. Lancet 368 (2006) 1871-1878
    • (2006) Lancet , vol.368 , pp. 1871-1878
    • Hennerici, M.G.1    Kay, R.2    Bogousslavsky, J.3    Lenzi, G.L.4    Verstraete, M.5    Orgogozo, J.M.6
  • 83
    • 3042813312 scopus 로고    scopus 로고
    • Characterization of a novel chronic photothrombotic ring stroke model in rats by magnetic resonance imaging, biochemical imaging, and histology
    • Hilger T., Blunk J.A., Hoehn M., Mies G., and Wester P. Characterization of a novel chronic photothrombotic ring stroke model in rats by magnetic resonance imaging, biochemical imaging, and histology. J Cereb Blood Flow Metab 24 (2004) 789-797
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 789-797
    • Hilger, T.1    Blunk, J.A.2    Hoehn, M.3    Mies, G.4    Wester, P.5
  • 84
    • 0027211912 scopus 로고
    • Criteria for valid preclinical trials using animal stroke models
    • Hsu C.Y. Criteria for valid preclinical trials using animal stroke models. Stroke 24 (1993) 633-636
    • (1993) Stroke , vol.24 , pp. 633-636
    • Hsu, C.Y.1
  • 85
    • 0035080062 scopus 로고    scopus 로고
    • Progressive and reproducible focal cortical ischemia with or without late spontaneous reperfusion generated by a ring-shaped, laser-driven photothrombotic lesion in rats
    • Hu X., Wester P., Brannstrom T., Watson B.D., and Gu W. Progressive and reproducible focal cortical ischemia with or without late spontaneous reperfusion generated by a ring-shaped, laser-driven photothrombotic lesion in rats. Brain Res Brain Res Protoc 7 (2001) 76-85
    • (2001) Brain Res Brain Res Protoc , vol.7 , pp. 76-85
    • Hu, X.1    Wester, P.2    Brannstrom, T.3    Watson, B.D.4    Gu, W.5
  • 86
    • 4544356494 scopus 로고    scopus 로고
    • Ischemic stroke: "acidotoxicity" is a perpetrator
    • Huang Y., and McNamara J.O. Ischemic stroke: "acidotoxicity" is a perpetrator. Cell 118 (2004) 665-666
    • (2004) Cell , vol.118 , pp. 665-666
    • Huang, Y.1    McNamara, J.O.2
  • 87
    • 0027945658 scopus 로고
    • Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
    • Huang Z., Huang P.L., Panahian N., Dalkara T., Fishman M.C., and Moskowitz M.A. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265 (1994) 1883-1885
    • (1994) Science , vol.265 , pp. 1883-1885
    • Huang, Z.1    Huang, P.L.2    Panahian, N.3    Dalkara, T.4    Fishman, M.C.5    Moskowitz, M.A.6
  • 88
    • 0029877221 scopus 로고    scopus 로고
    • A comparison of the early development of ischemic brain damage in normoglycemic and hyperglycemic rats using magnetic resonance imaging
    • Huang N.C., Wei J., and Quast M.J. A comparison of the early development of ischemic brain damage in normoglycemic and hyperglycemic rats using magnetic resonance imaging. Exp Brain Res 109 (1996) 33-42
    • (1996) Exp Brain Res , vol.109 , pp. 33-42
    • Huang, N.C.1    Wei, J.2    Quast, M.J.3
  • 89
    • 0032692563 scopus 로고    scopus 로고
    • Biphasic opening of the blood-brain barrier following transient focal ischemia: effects of hypothermia
    • Huang Z.G., Xue D., Preston E., Karbalai H., and Buchan A.M. Biphasic opening of the blood-brain barrier following transient focal ischemia: effects of hypothermia. Can J Neurol Sci 26 (1999) 298-304
    • (1999) Can J Neurol Sci , vol.26 , pp. 298-304
    • Huang, Z.G.1    Xue, D.2    Preston, E.3    Karbalai, H.4    Buchan, A.M.5
  • 90
    • 0014745653 scopus 로고
    • Transorbital approach to the middle cerebral artery of the squirrel monkey: a technique for experimental cerebral infarction applicable to ultrastructural studies
    • Hudgins W.R., and Garcia J.H. Transorbital approach to the middle cerebral artery of the squirrel monkey: a technique for experimental cerebral infarction applicable to ultrastructural studies. Stroke 1 (1970) 107-111
    • (1970) Stroke , vol.1 , pp. 107-111
    • Hudgins, W.R.1    Garcia, J.H.2
  • 93
    • 0029880261 scopus 로고    scopus 로고
    • Brainstem ischemic damage following occlusion of the blood vessels in the rat's posterior cerebral circulation
    • Inui H., Murai T., Yane K., and Matsunaga T. Brainstem ischemic damage following occlusion of the blood vessels in the rat's posterior cerebral circulation. Eur Arch Otorhinolaryngol 253 (1996) 176-181
    • (1996) Eur Arch Otorhinolaryngol , vol.253 , pp. 176-181
    • Inui, H.1    Murai, T.2    Yane, K.3    Matsunaga, T.4
  • 94
    • 0021882156 scopus 로고
    • A new model of bilateral hemispheric ischemia in the rat-three vessel occlusion model
    • Kameyama M., Suzuki J., Shirane R., and Ogawa A. A new model of bilateral hemispheric ischemia in the rat-three vessel occlusion model. Stroke 16 (1985) 489-493
    • (1985) Stroke , vol.16 , pp. 489-493
    • Kameyama, M.1    Suzuki, J.2    Shirane, R.3    Ogawa, A.4
  • 95
    • 0021927919 scopus 로고
    • Cerebral infarction in rats using homologous blood emboli: development of a new experimental model
    • Kaneko D., Nakamura N., and Ogawa T. Cerebral infarction in rats using homologous blood emboli: development of a new experimental model. Stroke 16 (1985) 76-84
    • (1985) Stroke , vol.16 , pp. 76-84
    • Kaneko, D.1    Nakamura, N.2    Ogawa, T.3
  • 96
    • 26444483296 scopus 로고    scopus 로고
    • Use of animal models has not contributed to development of acute stroke therapies: pro
    • Kaste M. Use of animal models has not contributed to development of acute stroke therapies: pro. Stroke 36 (2005) 2323-2324
    • (2005) Stroke , vol.36 , pp. 2323-2324
    • Kaste, M.1
  • 97
    • 0029991601 scopus 로고    scopus 로고
    • Intracisternal basic fibroblast growth factor (bFGF) enhances behavioral recovery following focal cerebral infarction in the rat
    • Kawamata T., Alexis N.E., Dietrich W.D., and Finklestein S.P. Intracisternal basic fibroblast growth factor (bFGF) enhances behavioral recovery following focal cerebral infarction in the rat. J Cereb Blood Flow Metab 16 (1996) 542-547
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 542-547
    • Kawamata, T.1    Alexis, N.E.2    Dietrich, W.D.3    Finklestein, S.P.4
  • 98
    • 2642533479 scopus 로고    scopus 로고
    • Delayed genomic responses to transient middle cerebral artery occlusion in the rat
    • Kim J.B., Piao C.S., Lee K.W., Han P.L., Ahn J.I., Lee Y.S., et al. Delayed genomic responses to transient middle cerebral artery occlusion in the rat. J Neurochem 89 (2004) 1271-1282
    • (2004) J Neurochem , vol.89 , pp. 1271-1282
    • Kim, J.B.1    Piao, C.S.2    Lee, K.W.3    Han, P.L.4    Ahn, J.I.5    Lee, Y.S.6
  • 99
    • 20444416673 scopus 로고    scopus 로고
    • Vascular endothelial growth factor antagonist reduces brain edema formation and venous infarction
    • Kimura R., Nakase H., Tamaki R., and Sakaki T. Vascular endothelial growth factor antagonist reduces brain edema formation and venous infarction. Stroke 36 (2005) 1259-1263
    • (2005) Stroke , vol.36 , pp. 1259-1263
    • Kimura, R.1    Nakase, H.2    Tamaki, R.3    Sakaki, T.4
  • 100
    • 0029844999 scopus 로고    scopus 로고
    • Anesthetics and cerebroprotection: experimental aspects
    • Kirsch J.R., Traystman R.J., and Hurn P.D. Anesthetics and cerebroprotection: experimental aspects. Int Anesthesiol Clin 34 (1996) 73-93
    • (1996) Int Anesthesiol Clin , vol.34 , pp. 73-93
    • Kirsch, J.R.1    Traystman, R.J.2    Hurn, P.D.3
  • 101
    • 0002254106 scopus 로고
    • Experimental studies of ischemic brain edema: 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area
    • Koizumi J., Yoshida Y., Nakazawa T., and Ooneda G. Experimental studies of ischemic brain edema: 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn Stroke J 8 (1986) 1-8
    • (1986) Jpn Stroke J , vol.8 , pp. 1-8
    • Koizumi, J.1    Yoshida, Y.2    Nakazawa, T.3    Ooneda, G.4
  • 102
    • 3242661769 scopus 로고    scopus 로고
    • Improvements in the intraluminal thread technique to induce focal cerebral ischaemia in rabbits
    • Kong L.Q., Xie J.X., Han H.B., and Liu H.D. Improvements in the intraluminal thread technique to induce focal cerebral ischaemia in rabbits. J Neurosci Methods 137 (2004) 315-319
    • (2004) J Neurosci Methods , vol.137 , pp. 315-319
    • Kong, L.Q.1    Xie, J.X.2    Han, H.B.3    Liu, H.D.4
  • 103
    • 2542566701 scopus 로고    scopus 로고
    • Therapeutic hypothermia for acute ischemic stroke: what do laboratory studies teach us?
    • Krieger D.W., and Yenari M.A. Therapeutic hypothermia for acute ischemic stroke: what do laboratory studies teach us?. Stroke 35 (2004) 1482-1489
    • (2004) Stroke , vol.35 , pp. 1482-1489
    • Krieger, D.W.1    Yenari, M.A.2
  • 104
    • 0034889655 scopus 로고    scopus 로고
    • Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke
    • Krieger D.W., De Georgia M.A., Abou-Chebl A., Andrefsky J.C., Sila C.A., Katzan I.L., et al. Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke. Stroke 32 (2001) 1847-1854
    • (2001) Stroke , vol.32 , pp. 1847-1854
    • Krieger, D.W.1    De Georgia, M.A.2    Abou-Chebl, A.3    Andrefsky, J.C.4    Sila, C.A.5    Katzan, I.L.6
  • 105
    • 0022410974 scopus 로고
    • The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion
    • Kuroiwa T., Ting P., Martinez H., and Klatzo I. The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion. Acta Neuropathol (Berl) 68 (1985) 122-129
    • (1985) Acta Neuropathol (Berl) , vol.68 , pp. 122-129
    • Kuroiwa, T.1    Ting, P.2    Martinez, H.3    Klatzo, I.4
  • 106
    • 0023914223 scopus 로고
    • A new model of brainstem ischemia in dogs
    • Kuwabara S., Uno J., and Ishikawa S. A new model of brainstem ischemia in dogs. Stroke 19 (1988) 365-371
    • (1988) Stroke , vol.19 , pp. 365-371
    • Kuwabara, S.1    Uno, J.2    Ishikawa, S.3
  • 107
    • 0027452885 scopus 로고
    • Middle cerebral artery occlusion without craniectomy in rats. Which method works best?
    • Laing R.J., Jakubowski J., and Laing R.W. Middle cerebral artery occlusion without craniectomy in rats. Which method works best?. Stroke 24 (1993) 294-297
    • (1993) Stroke , vol.24 , pp. 294-297
    • Laing, R.J.1    Jakubowski, J.2    Laing, R.W.3
  • 108
    • 0036179665 scopus 로고    scopus 로고
    • Focal cerebral ischemia in rats produced by intracarotid embolization with viscous silicone
    • Lauer K.K., Shen H., Stein E.A., Ho K.C., Kampine J.P., and Hudetz A.G. Focal cerebral ischemia in rats produced by intracarotid embolization with viscous silicone. Neurol Res 24 (2002) 181-190
    • (2002) Neurol Res , vol.24 , pp. 181-190
    • Lauer, K.K.1    Shen, H.2    Stein, E.A.3    Ho, K.C.4    Kampine, J.P.5    Hudetz, A.G.6
  • 109
    • 0036054502 scopus 로고    scopus 로고
    • Local intraarterial urokinase thrombolysis of acute ischemic stroke with or without intravenous abciximab: a pilot study
    • Lee D.H., Jo K.D., Kim H.G., Choi S.J., Jung S.M., Ryu D.S., et al. Local intraarterial urokinase thrombolysis of acute ischemic stroke with or without intravenous abciximab: a pilot study. J Vasc Interv Radiol 13 (2002) 769-774
    • (2002) J Vasc Interv Radiol , vol.13 , pp. 769-774
    • Lee, D.H.1    Jo, K.D.2    Kim, H.G.3    Choi, S.J.4    Jung, S.M.5    Ryu, D.S.6
  • 111
    • 34249852976 scopus 로고    scopus 로고
    • Animal modeling for developing stroke therapy
    • Fisher M. (Ed), Butterworth-Heinemann, Woburn, MA
    • Li F., and Fisher M. Animal modeling for developing stroke therapy. In: Fisher M. (Ed). Stroke therapy (2001), Butterworth-Heinemann, Woburn, MA 83-96
    • (2001) Stroke therapy , pp. 83-96
    • Li, F.1    Fisher, M.2
  • 112
    • 0031881004 scopus 로고    scopus 로고
    • A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging
    • Li F., Han S., Tatlisumak T., Carano R.A., Irie K., Sotak C.H., et al. A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging. Stroke 29 (1998) 1715-1719
    • (1998) Stroke , vol.29 , pp. 1715-1719
    • Li, F.1    Han, S.2    Tatlisumak, T.3    Carano, R.A.4    Irie, K.5    Sotak, C.H.6
  • 113
    • 0032857920 scopus 로고    scopus 로고
    • Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats
    • Li F., Han S.S., Tatlisumak T., Liu K.F., Garcia J.H., Sotak C.H., et al. Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats. Ann Neurol 46 (1999) 333-342
    • (1999) Ann Neurol , vol.46 , pp. 333-342
    • Li, F.1    Han, S.S.2    Tatlisumak, T.3    Liu, K.F.4    Garcia, J.H.5    Sotak, C.H.6
  • 114
    • 0032745304 scopus 로고    scopus 로고
    • Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats
    • Li F., Omae T., and Fisher M. Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats. Stroke 30 (1999) 2464-2470
    • (1999) Stroke , vol.30 , pp. 2464-2470
    • Li, F.1    Omae, T.2    Fisher, M.3
  • 115
    • 7744225558 scopus 로고    scopus 로고
    • The pre-ischaemic neuroprotective effect of a novel polyamine antagonist, N1-dansyl-spermine in a permanent focal cerebral ischaemia model in mice
    • Li J., Henman M.C., Doyle K.M., Strbian D., Kirby B.P., Tatlisumak T., et al. The pre-ischaemic neuroprotective effect of a novel polyamine antagonist, N1-dansyl-spermine in a permanent focal cerebral ischaemia model in mice. Brain Res 1029 (2004) 84-92
    • (2004) Brain Res , vol.1029 , pp. 84-92
    • Li, J.1    Henman, M.C.2    Doyle, K.M.3    Strbian, D.4    Kirby, B.P.5    Tatlisumak, T.6
  • 116
    • 33644850091 scopus 로고    scopus 로고
    • The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice
    • Li J., Henman M.C., Atkinson J., Fixon-Owoo S., Tatlisumak T., Shaw G.G., et al. The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice. Brain Res 1076 (2006) 209-215
    • (2006) Brain Res , vol.1076 , pp. 209-215
    • Li, J.1    Henman, M.C.2    Atkinson, J.3    Fixon-Owoo, S.4    Tatlisumak, T.5    Shaw, G.G.6
  • 117
    • 1342345209 scopus 로고    scopus 로고
    • Increased calpain expression following experimental cerebral venous thrombosis in rats
    • Liebetrau M., Gabriejcic-Geiger D., Meyer P., Roether J., and Hamann G.F. Increased calpain expression following experimental cerebral venous thrombosis in rats. Thromb Res 112 (2003) 239-243
    • (2003) Thromb Res , vol.112 , pp. 239-243
    • Liebetrau, M.1    Gabriejcic-Geiger, D.2    Meyer, P.3    Roether, J.4    Hamann, G.F.5
  • 118
    • 84984763363 scopus 로고    scopus 로고
    • Mechanisms, challenges and opportunities in stroke
    • Lo E.H., Dalkara T., and Moskowitz M.A. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 4 (2003) 399-415
    • (2003) Nat Rev Neurosci , vol.4 , pp. 399-415
    • Lo, E.H.1    Dalkara, T.2    Moskowitz, M.A.3
  • 119
    • 12844251253 scopus 로고    scopus 로고
    • Exciting, radical, suicidal: how brain cells die after stroke
    • Lo E.H., Moskowitz M.A., and Jacobs T.P. Exciting, radical, suicidal: how brain cells die after stroke. Stroke 36 (2005) 189-192
    • (2005) Stroke , vol.36 , pp. 189-192
    • Lo, E.H.1    Moskowitz, M.A.2    Jacobs, T.P.3
  • 120
    • 0024494427 scopus 로고
    • Reversible middle cerebral artery occlusion without craniectomy in rats
    • Longa E.Z., Weinstein P.R., Carlson S., and Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1989) 84-91
    • (1989) Stroke , vol.20 , pp. 84-91
    • Longa, E.Z.1    Weinstein, P.R.2    Carlson, S.3    Cummins, R.4
  • 123
    • 4444304728 scopus 로고    scopus 로고
    • Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion
    • Lu X.C., Williams A.J., Yao C., Berti R., Hartings J.A., Whipple R., et al. Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion. J Neurosci Res 77 (2004) 843-857
    • (2004) J Neurosci Res , vol.77 , pp. 843-857
    • Lu, X.C.1    Williams, A.J.2    Yao, C.3    Berti, R.4    Hartings, J.A.5    Whipple, R.6
  • 124
    • 33747188112 scopus 로고    scopus 로고
    • Selective, reversible occlusion of the middle cerebral artery in rats by an intraluminal approach. Optimized filament design and methodology
    • Ma J., Zhao L., and Nowak Jr. T.S. Selective, reversible occlusion of the middle cerebral artery in rats by an intraluminal approach. Optimized filament design and methodology. J Neurosci Methods 156 (2006) 76-83
    • (2006) J Neurosci Methods , vol.156 , pp. 76-83
    • Ma, J.1    Zhao, L.2    Nowak Jr., T.S.3
  • 125
    • 0015370793 scopus 로고
    • Histochemical studies in the zone of ischemia following middle cerebral artery occlusion in cats
    • MacDonald V.D., Sundt Jr. T.M., and Winkelmann R.K. Histochemical studies in the zone of ischemia following middle cerebral artery occlusion in cats. J Neurosurg 37 (1972) 45-54
    • (1972) J Neurosurg , vol.37 , pp. 45-54
    • MacDonald, V.D.1    Sundt Jr., T.M.2    Winkelmann, R.K.3
  • 126
    • 10744229657 scopus 로고    scopus 로고
    • Serial magnetic resonance imaging in experimental primate stroke: validation of MRI for pre-clinical cerebroprotective trials
    • Mack W.J., Komotar R.J., Mocco J., Coon A.L., Hoh D.J., King R.G., et al. Serial magnetic resonance imaging in experimental primate stroke: validation of MRI for pre-clinical cerebroprotective trials. Neurol Res 25 (2003) 846-852
    • (2003) Neurol Res , vol.25 , pp. 846-852
    • Mack, W.J.1    Komotar, R.J.2    Mocco, J.3    Coon, A.L.4    Hoh, D.J.5    King, R.G.6
  • 127
    • 29144449182 scopus 로고    scopus 로고
    • The discovery of slowness-recent progress in DC-MEG research
    • Mackert B.M. The discovery of slowness-recent progress in DC-MEG research. Neurol Clin Neurophysiol 2004 (2004) 41
    • (2004) Neurol Clin Neurophysiol , vol.2004 , pp. 41
    • Mackert, B.M.1
  • 128
    • 0033782416 scopus 로고    scopus 로고
    • Apoptosis after experimental stroke: fact or fashion?
    • MacManus J.P., and Buchan A.M. Apoptosis after experimental stroke: fact or fashion?. J Neurotrauma 17 (2000) 899-914
    • (2000) J Neurotrauma , vol.17 , pp. 899-914
    • MacManus, J.P.1    Buchan, A.M.2
  • 129
    • 84982003493 scopus 로고
    • New models of focal cerebral ischaemia
    • Macrae I. New models of focal cerebral ischaemia. Br J Clin Pharmacol 34 (1992) 302-308
    • (1992) Br J Clin Pharmacol , vol.34 , pp. 302-308
    • Macrae, I.1
  • 130
    • 0027399173 scopus 로고
    • Endothelin-1-induced reductions in cerebral blood flow: dose dependency, time course, and neuropathological consequences
    • Macrae I.M., Robinson M.J., Graham D.I., Reid J.L., and McCulloch J. Endothelin-1-induced reductions in cerebral blood flow: dose dependency, time course, and neuropathological consequences. J Cereb Blood Flow Metab 13 (1993) 276-284
    • (1993) J Cereb Blood Flow Metab , vol.13 , pp. 276-284
    • Macrae, I.M.1    Robinson, M.J.2    Graham, D.I.3    Reid, J.L.4    McCulloch, J.5
  • 132
    • 0028847213 scopus 로고
    • Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke. Multicentre Acute Stroke Trial-Italy (MAST-I) Group
    • MAST-1. Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke. Multicentre Acute Stroke Trial-Italy (MAST-I) Group. Lancet 346 (1995) 1509-1514
    • (1995) Lancet , vol.346 , pp. 1509-1514
    • MAST-11
  • 133
    • 0027322855 scopus 로고
    • Elevation of neuroactive substances in the cortex of cats during prolonged focal ischemia
    • Matsumoto K., Graf R., Rosner G., Taguchi J., and Heiss W.D. Elevation of neuroactive substances in the cortex of cats during prolonged focal ischemia. J Cereb Blood Flow Metab 13 (1993) 586-594
    • (1993) J Cereb Blood Flow Metab , vol.13 , pp. 586-594
    • Matsumoto, K.1    Graf, R.2    Rosner, G.3    Taguchi, J.4    Heiss, W.D.5
  • 134
    • 33644794676 scopus 로고    scopus 로고
    • Selecting patients for early stroke treatment with penumbra images
    • Maulaz A., Piechowski-Jozwiak B., Michel P., and Bogousslavsky J. Selecting patients for early stroke treatment with penumbra images. Cerebrovasc Dis 20 Suppl 2 (2005) 19-24
    • (2005) Cerebrovasc Dis , vol.20 , Issue.SUPPL. 2 , pp. 19-24
    • Maulaz, A.1    Piechowski-Jozwiak, B.2    Michel, P.3    Bogousslavsky, J.4
  • 136
  • 137
    • 33644878328 scopus 로고    scopus 로고
    • The effect of hypothermia and hyperthermia on acute brain injury
    • McIlvoy L.H. The effect of hypothermia and hyperthermia on acute brain injury. AACN Clin Issues 16 (2005) 488-500
    • (2005) AACN Clin Issues , vol.16 , pp. 488-500
    • McIlvoy, L.H.1
  • 138
    • 0026532184 scopus 로고
    • Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat
    • Memezawa H., Minamisawa H., Smith M.L., and Siesjo B.K. Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp Brain Res 89 (1992) 67-78
    • (1992) Exp Brain Res , vol.89 , pp. 67-78
    • Memezawa, H.1    Minamisawa, H.2    Smith, M.L.3    Siesjo, B.K.4
  • 139
    • 0026795049 scopus 로고
    • Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model
    • Menzies S.A., Hoff J.T., and Betz A.L. Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery 31 (1992) 100-106
    • (1992) Neurosurgery , vol.31 , pp. 100-106
    • Menzies, S.A.1    Hoff, J.T.2    Betz, A.L.3
  • 140
    • 1342330571 scopus 로고    scopus 로고
    • Neuroprotection by estrogen in animal models of global and focal ischemia
    • Merchenthaler I., Dellovade T.L., and Shughrue P.J. Neuroprotection by estrogen in animal models of global and focal ischemia. Ann N Y Acad Sci 1007 (2003) 89-100
    • (2003) Ann N Y Acad Sci , vol.1007 , pp. 89-100
    • Merchenthaler, I.1    Dellovade, T.L.2    Shughrue, P.J.3
  • 141
    • 5444233626 scopus 로고    scopus 로고
    • Pathophysiology of stroke: lessons from animal models
    • Mergenthaler P., Dirnagl U., and Meisel A. Pathophysiology of stroke: lessons from animal models. Metab Brain Dis 19 (2004) 151-167
    • (2004) Metab Brain Dis , vol.19 , pp. 151-167
    • Mergenthaler, P.1    Dirnagl, U.2    Meisel, A.3
  • 142
    • 0022593262 scopus 로고
    • Intracellular brain pH, indicator tissue perfusion, electroencephalography, and histology in severe and moderate focal cortical ischemia in the rabbit
    • Meyer F.B., Anderson R.E., Sundt Jr. T.M., and Yaksh T.L. Intracellular brain pH, indicator tissue perfusion, electroencephalography, and histology in severe and moderate focal cortical ischemia in the rabbit. J Cereb Blood Flow Metab 6 (1986) 71-78
    • (1986) J Cereb Blood Flow Metab , vol.6 , pp. 71-78
    • Meyer, F.B.1    Anderson, R.E.2    Sundt Jr., T.M.3    Yaksh, T.L.4
  • 143
    • 33646552070 scopus 로고    scopus 로고
    • The need for new therapies for acute ischaemic stroke
    • Millan M., and Davalos A. The need for new therapies for acute ischaemic stroke. Cerebrovasc Dis 22 Suppl 1 (2006) 3-9
    • (2006) Cerebrovasc Dis , vol.22 , Issue.SUPPL. 1 , pp. 3-9
    • Millan, M.1    Davalos, A.2
  • 144
    • 0023758694 scopus 로고
    • A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy
    • Molnar L., Hegedus K., and Fekete I. A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. Stroke 19 (1988) 1262-1266
    • (1988) Stroke , vol.19 , pp. 1262-1266
    • Molnar, L.1    Hegedus, K.2    Fekete, I.3
  • 145
    • 0030983708 scopus 로고    scopus 로고
    • Mortality by cause for eight regions of the world: global burden of disease study
    • Murray C.J., and Lopez A.D. Mortality by cause for eight regions of the world: global burden of disease study. Lancet 349 (1997) 1269-1276
    • (1997) Lancet , vol.349 , pp. 1269-1276
    • Murray, C.J.1    Lopez, A.D.2
  • 146
    • 4043069121 scopus 로고    scopus 로고
    • The stroke-prone spontaneously hypertensive rat: how good is it as a model for cerebrovascular diseases?
    • Nabika T., Cui Z., and Masuda J. The stroke-prone spontaneously hypertensive rat: how good is it as a model for cerebrovascular diseases?. Cell Mol Neurobiol 24 (2004) 639-646
    • (2004) Cell Mol Neurobiol , vol.24 , pp. 639-646
    • Nabika, T.1    Cui, Z.2    Masuda, J.3
  • 147
    • 23244433435 scopus 로고    scopus 로고
    • MitoKATP-channel opener protects against neuronal death in rat venous ischemia
    • Nakagawa I., Alessandri B., Heimann A., and Kempski O. MitoKATP-channel opener protects against neuronal death in rat venous ischemia. Neurosurgery 57 (2005) 334-340
    • (2005) Neurosurgery , vol.57 , pp. 334-340
    • Nakagawa, I.1    Alessandri, B.2    Heimann, A.3    Kempski, O.4
  • 148
    • 0029129532 scopus 로고
    • Use of local cerebral blood flow monitoring to predict brain damage after disturbance to the venous circulation: cortical vein occlusion model by photochemical dye
    • Nakase H., Kakizaki T., Miyamoto K., Hiramatsu K., and Sakaki T. Use of local cerebral blood flow monitoring to predict brain damage after disturbance to the venous circulation: cortical vein occlusion model by photochemical dye. Neurosurgery 37 (1995) 280-285
    • (1995) Neurosurgery , vol.37 , pp. 280-285
    • Nakase, H.1    Kakizaki, T.2    Miyamoto, K.3    Hiramatsu, K.4    Sakaki, T.5
  • 149
    • 0023204401 scopus 로고
    • Transient focal ischemia in hyperglycemic rats is associated with increased cerebral infarction
    • Nedergaard M. Transient focal ischemia in hyperglycemic rats is associated with increased cerebral infarction. Brain Res 408 (1987) 79-85
    • (1987) Brain Res , vol.408 , pp. 79-85
    • Nedergaard, M.1
  • 150
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA stroke study group
    • NINDS. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA stroke study group. N Engl J Med 333 (1995) 1581-1587
    • (1995) N Engl J Med , vol.333 , pp. 1581-1587
    • NINDS1
  • 151
    • 33645055135 scopus 로고    scopus 로고
    • In vivo isotropic 3D diffusion tensor mapping of the rat brain using diffusion-weighted 3D MP-RAGE MRI
    • Numano T., Homma K., Iwasaki N., Hyodo K., Nitta N., and Hirose T. In vivo isotropic 3D diffusion tensor mapping of the rat brain using diffusion-weighted 3D MP-RAGE MRI. Magn Reson Imaging 24 (2006) 287-293
    • (2006) Magn Reson Imaging , vol.24 , pp. 287-293
    • Numano, T.1    Homma, K.2    Iwasaki, N.3    Hyodo, K.4    Nitta, N.5    Hirose, T.6
  • 152
    • 0015790186 scopus 로고
    • Transorbital approach for occluding the middle cerebral artery without craniectomy
    • O'Brien M.D., and Waltz A.G. Transorbital approach for occluding the middle cerebral artery without craniectomy. Stroke 4 (1973) 201-206
    • (1973) Stroke , vol.4 , pp. 201-206
    • O'Brien, M.D.1    Waltz, A.G.2
  • 153
    • 0030603145 scopus 로고    scopus 로고
    • The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor
    • Oliff H.S., Marek P., Miyazaki B., and Weber E. The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor. Brain Res 731 (1996) 208-212
    • (1996) Brain Res , vol.731 , pp. 208-212
    • Oliff, H.S.1    Marek, P.2    Miyazaki, B.3    Weber, E.4
  • 154
    • 0030900123 scopus 로고    scopus 로고
    • Rat strain and vendor differences in collateral anastomoses
    • Oliff H.S., Coyle P., and Weber E. Rat strain and vendor differences in collateral anastomoses. J Cereb Blood Flow Metab 17 (1997) 571-576
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 571-576
    • Oliff, H.S.1    Coyle, P.2    Weber, E.3
  • 155
    • 0028511585 scopus 로고
    • Thrombolytic therapy in experimental embolic stroke
    • Overgaard K. Thrombolytic therapy in experimental embolic stroke. Cerebrovasc Brain Metab Rev 6 (1994) 257-286
    • (1994) Cerebrovasc Brain Metab Rev , vol.6 , pp. 257-286
    • Overgaard, K.1
  • 157
    • 0023270228 scopus 로고
    • Clot embolic stroke in the vertebrobasilar system of rabbits: a transfemoral angiographic technique
    • Pan G., and Wright K.C. Clot embolic stroke in the vertebrobasilar system of rabbits: a transfemoral angiographic technique. Cardiovasc Intervent Radiol 10 (1987) 285-290
    • (1987) Cardiovasc Intervent Radiol , vol.10 , pp. 285-290
    • Pan, G.1    Wright, K.C.2
  • 158
    • 0023198005 scopus 로고
    • Recombinant human tissue-type plasminogen activator therapy in acute thromboembolic stroke
    • Papadopoulos S.M., Chandler W.F., Salamat M.S., Topol E.J., and Sackellares J.C. Recombinant human tissue-type plasminogen activator therapy in acute thromboembolic stroke. J Neurosurg 67 (1987) 394-398
    • (1987) J Neurosurg , vol.67 , pp. 394-398
    • Papadopoulos, S.M.1    Chandler, W.F.2    Salamat, M.S.3    Topol, E.J.4    Sackellares, J.C.5
  • 161
    • 0033936423 scopus 로고    scopus 로고
    • Transfemoral digital subtraction angiography for assessment of vertebral artery occlusion in rats
    • Plaschke K., Martin E., Bardenheuer H.J., Knauth M., and Sartor K. Transfemoral digital subtraction angiography for assessment of vertebral artery occlusion in rats. Stroke 31 (2000) 1789-1790
    • (2000) Stroke , vol.31 , pp. 1789-1790
    • Plaschke, K.1    Martin, E.2    Bardenheuer, H.J.3    Knauth, M.4    Sartor, K.5
  • 162
    • 0023840629 scopus 로고
    • Hyperglycemia increases infarct size in collaterally perfused but not end-arterial vascular territories
    • Prado R., Ginsberg M.D., Dietrich W.D., Watson B.D., and Busto R. Hyperglycemia increases infarct size in collaterally perfused but not end-arterial vascular territories. J Cereb Blood Flow Metab 8 (1988) 186-192
    • (1988) J Cereb Blood Flow Metab , vol.8 , pp. 186-192
    • Prado, R.1    Ginsberg, M.D.2    Dietrich, W.D.3    Watson, B.D.4    Busto, R.5
  • 163
    • 0002330511 scopus 로고
    • Animal models of brain ischemia
    • Barnett H.J., Mohr J.P., Stein B.M., and Yatsu F.M. (Eds), Churchill Livingstone, New York, NY, USA
    • Pulsinelli W., and Jacewicz M. Animal models of brain ischemia. In: Barnett H.J., Mohr J.P., Stein B.M., and Yatsu F.M. (Eds). Stroke: pathophysiology, diagnosis, and management (1992), Churchill Livingstone, New York, NY, USA 49-67
    • (1992) Stroke: pathophysiology, diagnosis, and management , pp. 49-67
    • Pulsinelli, W.1    Jacewicz, M.2
  • 165
    • 19944390591 scopus 로고    scopus 로고
    • A novel behavioural registration system LABORAS and the social interaction paradigm detect long-term functional deficits following middle cerebral artery occlusion in the rat
    • Quinn L.P., Grundy R.I., Campbell C.A., Collier S., Lawman A., Stean T.O., et al. A novel behavioural registration system LABORAS and the social interaction paradigm detect long-term functional deficits following middle cerebral artery occlusion in the rat. Brain Res 1031 (2005) 118-124
    • (2005) Brain Res , vol.1031 , pp. 118-124
    • Quinn, L.P.1    Grundy, R.I.2    Campbell, C.A.3    Collier, S.4    Lawman, A.5    Stean, T.O.6
  • 166
    • 0042623453 scopus 로고    scopus 로고
    • Cerebral ischemia and infarction from atheroemboli < 100 micron in size
    • Rapp J.H., Pan X.M., Yu B., Swanson R.A., Higashida R.T., Simpson P., et al. Cerebral ischemia and infarction from atheroemboli < 100 micron in size. Stroke 34 (2003) 1976-1980
    • (2003) Stroke , vol.34 , pp. 1976-1980
    • Rapp, J.H.1    Pan, X.M.2    Yu, B.3    Swanson, R.A.4    Higashida, R.T.5    Simpson, P.6
  • 167
    • 0036660726 scopus 로고    scopus 로고
    • Impaired functionality of reperfused brain tissue following short transient focal ischemia in rats
    • Reese T., Bochelen D., Baumann D., Rausch M., Sauter A., and Rudin M. Impaired functionality of reperfused brain tissue following short transient focal ischemia in rats. Magn Reson Imaging 20 (2002) 447-454
    • (2002) Magn Reson Imaging , vol.20 , pp. 447-454
    • Reese, T.1    Bochelen, D.2    Baumann, D.3    Rausch, M.4    Sauter, A.5    Rudin, M.6
  • 168
    • 18644367954 scopus 로고    scopus 로고
    • What has diffusion imaging in animals told us about diffusion imaging in patients with ischaemic stroke?
    • Rivers C.S., and Wardlaw J.M. What has diffusion imaging in animals told us about diffusion imaging in patients with ischaemic stroke?. Cerebrovasc Dis 19 (2005) 328-336
    • (2005) Cerebrovasc Dis , vol.19 , pp. 328-336
    • Rivers, C.S.1    Wardlaw, J.M.2
  • 169
    • 0025027060 scopus 로고
    • Reduction of local cerebral blood flow to pathological levels by endothelin-1 applied to the middle cerebral artery in the rat
    • Robinson M.J., Macrae I.M., Todd M., Reid J.L., and McCulloch J. Reduction of local cerebral blood flow to pathological levels by endothelin-1 applied to the middle cerebral artery in the rat. Neurosci Lett 118 (1990) 269-272
    • (1990) Neurosci Lett , vol.118 , pp. 269-272
    • Robinson, M.J.1    Macrae, I.M.2    Todd, M.3    Reid, J.L.4    McCulloch, J.5
  • 170
    • 0016680525 scopus 로고
    • Effect of experimental cerebral infarction in rat brain on
    • Robinson R.G., Shoemaker W.J., Schlumpf M., Valk T., and Bloom F.E. Effect of experimental cerebral infarction in rat brain on catecholamines and behaviour. Nature 255 (1975) 332-334
    • (1975) Nature , vol.255 , pp. 332-334
    • Robinson, R.G.1    Shoemaker, W.J.2    Schlumpf, M.3    Valk, T.4    Bloom, F.E.5
  • 171
    • 0035168782 scopus 로고    scopus 로고
    • A comparison of long-term functional outcome after 2 middle cerebral artery occlusion models in rats
    • Roof R.L., Schielke G.P., Ren X., and Hall E.D. A comparison of long-term functional outcome after 2 middle cerebral artery occlusion models in rats. Stroke 32 (2001) 2648-2657
    • (2001) Stroke , vol.32 , pp. 2648-2657
    • Roof, R.L.1    Schielke, G.P.2    Ren, X.3    Hall, E.D.4
  • 174
    • 33846369402 scopus 로고    scopus 로고
    • Experimental treatments for acute ischaemic stroke
    • Sacco R.L., Chong J.Y., Prabhakaran S., and Elkind M.S. Experimental treatments for acute ischaemic stroke. Lancet 369 (2007) 331-341
    • (2007) Lancet , vol.369 , pp. 331-341
    • Sacco, R.L.1    Chong, J.Y.2    Prabhakaran, S.3    Elkind, M.S.4
  • 175
    • 0032501397 scopus 로고    scopus 로고
    • Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery
    • Sadamoto Y., Igase K., Sakanaka M., Sato K., Otsuka H., Sakaki S., et al. Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery. Biochem Biophys Res Commun 253 (1998) 26-32
    • (1998) Biochem Biophys Res Commun , vol.253 , pp. 26-32
    • Sadamoto, Y.1    Igase, K.2    Sakanaka, M.3    Sato, K.4    Otsuka, H.5    Sakaki, S.6
  • 176
    • 30344438523 scopus 로고    scopus 로고
    • Apoptosis dominant in the periinfarct area of human ischaemic stroke-a possible target of antiapoptotic treatments
    • Sairanen T., Karjalainen-Lindsberg M.L., Paetau A., Ijas P., and Lindsberg P.J. Apoptosis dominant in the periinfarct area of human ischaemic stroke-a possible target of antiapoptotic treatments. Brain 129 (2006) 189-199
    • (2006) Brain , vol.129 , pp. 189-199
    • Sairanen, T.1    Karjalainen-Lindsberg, M.L.2    Paetau, A.3    Ijas, P.4    Lindsberg, P.J.5
  • 177
    • 0021916097 scopus 로고
    • Experimental production of superior sagittal sinus thrombosis in the dog
    • Sarwar M., Virapongse C., and Carbo P. Experimental production of superior sagittal sinus thrombosis in the dog. AJNR Am J Neuroradiol 6 (1985) 19-22
    • (1985) AJNR Am J Neuroradiol , vol.6 , pp. 19-22
    • Sarwar, M.1    Virapongse, C.2    Carbo, P.3
  • 178
    • 1842586172 scopus 로고    scopus 로고
    • Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy
    • Schaller B., and Graf R. Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy. J Cereb Blood Flow Metab 24 (2004) 351-371
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 351-371
    • Schaller, B.1    Graf, R.2
  • 179
    • 0141625117 scopus 로고    scopus 로고
    • A new animal model of cerebral venous infarction: ligation of the posterior part of the superior sagittal sinus in the cat
    • Schaller B., Graf R., Wienhard K., and Heiss W.D. A new animal model of cerebral venous infarction: ligation of the posterior part of the superior sagittal sinus in the cat. Swiss Med Wkly 133 (2003) 412-418
    • (2003) Swiss Med Wkly , vol.133 , pp. 412-418
    • Schaller, B.1    Graf, R.2    Wienhard, K.3    Heiss, W.D.4
  • 180
    • 1542328963 scopus 로고    scopus 로고
    • An update on thrombolytic therapy for acute stroke
    • Schellinger P.D., Kaste M., and Hacke W. An update on thrombolytic therapy for acute stroke. Curr Opin Neurol 17 (2004) 69-77
    • (2004) Curr Opin Neurol , vol.17 , pp. 69-77
    • Schellinger, P.D.1    Kaste, M.2    Hacke, W.3
  • 181
    • 0042190147 scopus 로고    scopus 로고
    • Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice
    • Schilling M., Besselmann M., Leonhard C., Mueller M., Ringelstein E.B., and Kiefer R. Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice. Exp Neurol 183 (2003) 25-33
    • (2003) Exp Neurol , vol.183 , pp. 25-33
    • Schilling, M.1    Besselmann, M.2    Leonhard, C.3    Mueller, M.4    Ringelstein, E.B.5    Kiefer, R.6
  • 182
    • 0031665617 scopus 로고    scopus 로고
    • A critical reevaluation of the intraluminal thread model of focal cerebral ischemia: evidence of inadvertent premature reperfusion and subarachnoid hemorrhage in rats by laser-Doppler flowmetry
    • Schmid-Elsaesser R., Zausinger S., Hungerhuber E., Baethmann A., and Reulen H.J. A critical reevaluation of the intraluminal thread model of focal cerebral ischemia: evidence of inadvertent premature reperfusion and subarachnoid hemorrhage in rats by laser-Doppler flowmetry. Stroke 29 (1998) 2162-2170
    • (1998) Stroke , vol.29 , pp. 2162-2170
    • Schmid-Elsaesser, R.1    Zausinger, S.2    Hungerhuber, E.3    Baethmann, A.4    Reulen, H.J.5
  • 183
    • 0037121819 scopus 로고    scopus 로고
    • DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in rat
    • Schmidt-Kastner R., Zhang B., Belayev L., Khoutorova L., Amin R., Busto R., et al. DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in rat. Brain Res Mol Brain Res 108 (2002) 81-93
    • (2002) Brain Res Mol Brain Res , vol.108 , pp. 81-93
    • Schmidt-Kastner, R.1    Zhang, B.2    Belayev, L.3    Khoutorova, L.4    Amin, R.5    Busto, R.6
  • 185
    • 0021363309 scopus 로고
    • Microangiographic study of the normal anatomy of the cerebral venous system in rats
    • Schumacher M. Microangiographic study of the normal anatomy of the cerebral venous system in rats. Neuroradiology 26 (1984) 137-140
    • (1984) Neuroradiology , vol.26 , pp. 137-140
    • Schumacher, M.1
  • 187
  • 188
    • 0037169236 scopus 로고    scopus 로고
    • Aging has a complex effect on a rat model of ischemic stroke
    • Shapira S., Sapir M., Wengier A., Grauer E., and Kadar T. Aging has a complex effect on a rat model of ischemic stroke. Brain Res 925 (2002) 148-158
    • (2002) Brain Res , vol.925 , pp. 148-158
    • Shapira, S.1    Sapir, M.2    Wengier, A.3    Grauer, E.4    Kadar, T.5
  • 189
    • 0027164675 scopus 로고
    • Perivascular microapplication of endothelin-1: a new model of focal cerebral ischaemia in the rat
    • Sharkey J., Ritchie I.M., and Kelly P.A. Perivascular microapplication of endothelin-1: a new model of focal cerebral ischaemia in the rat. J Cereb Blood Flow Metab 13 (1993) 865-871
    • (1993) J Cereb Blood Flow Metab , vol.13 , pp. 865-871
    • Sharkey, J.1    Ritchie, I.M.2    Kelly, P.A.3
  • 190
    • 0034630876 scopus 로고    scopus 로고
    • Intravenous ancrod for treatment of acute ischemic stroke: the STAT study: a randomized controlled trial. Stroke treatment with Ancrod trial
    • Sherman D.G., Atkinson R.P., Chippendale T., Levin K.A., Ng K., Futrell N., et al. Intravenous ancrod for treatment of acute ischemic stroke: the STAT study: a randomized controlled trial. Stroke treatment with Ancrod trial. JAMA 283 (2000) 2395-2403
    • (2000) JAMA , vol.283 , pp. 2395-2403
    • Sherman, D.G.1    Atkinson, R.P.2    Chippendale, T.3    Levin, K.A.4    Ng, K.5    Futrell, N.6
  • 191
    • 0021932513 scopus 로고
    • Recirculation model following MCA occlusion in rats. Cerebral blood flow, cerebrovascular permeability, and brain edema
    • Shigeno T., Teasdale G.M., McCulloch J., and Graham D.I. Recirculation model following MCA occlusion in rats. Cerebral blood flow, cerebrovascular permeability, and brain edema. J Neurosurg 63 (1985) 272-277
    • (1985) J Neurosurg , vol.63 , pp. 272-277
    • Shigeno, T.1    Teasdale, G.M.2    McCulloch, J.3    Graham, D.I.4
  • 192
    • 33747180872 scopus 로고    scopus 로고
    • Comparison of silicon-coated nylon suture to plain nylon suture in the rat middle cerebral artery occlusion model
    • Shimamura N., Matchett G., Tsubokawa T., Ohkuma H., and Zhang J. Comparison of silicon-coated nylon suture to plain nylon suture in the rat middle cerebral artery occlusion model. J Neurosci Methods 156 (2006) 161-165
    • (2006) J Neurosci Methods , vol.156 , pp. 161-165
    • Shimamura, N.1    Matchett, G.2    Tsubokawa, T.3    Ohkuma, H.4    Zhang, J.5
  • 193
    • 33646572857 scopus 로고    scopus 로고
    • Neuroprotection - STAIR-way to the future?
    • Shuaib A. Neuroprotection - STAIR-way to the future?. Cerebrovasc Dis 22 Suppl 1 (2006) 10-17
    • (2006) Cerebrovasc Dis , vol.22 , Issue.SUPPL. 1 , pp. 10-17
    • Shuaib, A.1
  • 195
    • 1642498231 scopus 로고    scopus 로고
    • Pathophysiology of focal cerebral ischemia: a therapeutic perspective
    • Smith W.S. Pathophysiology of focal cerebral ischemia: a therapeutic perspective. J Vasc Interv Radiol 15 (2004) S3-S12
    • (2004) J Vasc Interv Radiol , vol.15
    • Smith, W.S.1
  • 196
    • 22044433673 scopus 로고    scopus 로고
    • Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial
    • Smith W.S., Sung G., Starkman S., Saver J.L., Kidwell C.S., Gobin Y.P., et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 36 (2005) 1432-1438
    • (2005) Stroke , vol.36 , pp. 1432-1438
    • Smith, W.S.1    Sung, G.2    Starkman, S.3    Saver, J.L.4    Kidwell, C.S.5    Gobin, Y.P.6
  • 197
    • 0344065373 scopus 로고    scopus 로고
    • Recommendations for standards regarding preclinical neuroprotective and restorative drug development
    • STAIR. Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 30 (1999) 2752-2758
    • (1999) Stroke , vol.30 , pp. 2752-2758
    • STAIR1
  • 199
    • 3543054632 scopus 로고    scopus 로고
    • Krypton laser-induced photothrombotic distal middle cerebral artery occlusion without craniectomy in mice
    • Sugimori H., Yao H., Ooboshi H., Ibayashi S., and Iida M. Krypton laser-induced photothrombotic distal middle cerebral artery occlusion without craniectomy in mice. Brain Res Brain Res Protoc 13 (2004) 189-196
    • (2004) Brain Res Brain Res Protoc , vol.13 , pp. 189-196
    • Sugimori, H.1    Yao, H.2    Ooboshi, H.3    Ibayashi, S.4    Iida, M.5
  • 200
    • 0018974695 scopus 로고
    • Production of various models of cerebral infarction in the dog by means of occlusion of intracranial trunk arteries
    • Suzuki J., Yoshimoto T., Tnanka S., and Sakamoto T. Production of various models of cerebral infarction in the dog by means of occlusion of intracranial trunk arteries. Stroke 11 (1980) 337-341
    • (1980) Stroke , vol.11 , pp. 337-341
    • Suzuki, J.1    Yoshimoto, T.2    Tnanka, S.3    Sakamoto, T.4
  • 201
    • 0029874934 scopus 로고    scopus 로고
    • The role of spreading depression in focal ischemia evaluated by diffusion mapping
    • Takano K., Latour L.L., Formato J.E., Carano R.A., Helmer K.G., Hasegawa Y., et al. The role of spreading depression in focal ischemia evaluated by diffusion mapping. Ann Neurol 39 (1996) 308-318
    • (1996) Ann Neurol , vol.39 , pp. 308-318
    • Takano, K.1    Latour, L.L.2    Formato, J.E.3    Carano, R.A.4    Helmer, K.G.5    Hasegawa, Y.6
  • 202
    • 0031925103 scopus 로고    scopus 로고
    • Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging
    • Takano K., Carano R.A., Tatlisumak T., Meiler M., Sotak C.H., Kleinert H.D., et al. Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging. Neurology 50 (1998) 870-875
    • (1998) Neurology , vol.50 , pp. 870-875
    • Takano, K.1    Carano, R.A.2    Tatlisumak, T.3    Meiler, M.4    Sotak, C.H.5    Kleinert, H.D.6
  • 203
    • 0031444569 scopus 로고    scopus 로고
    • Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats
    • Takano K., Tatlisumak T., Bergmann A.G., Gibson III D.G., and Fisher M. Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats. J Neurol Sci 153 (1997) 8-11
    • (1997) J Neurol Sci , vol.153 , pp. 8-11
    • Takano, K.1    Tatlisumak, T.2    Bergmann, A.G.3    Gibson III, D.G.4    Fisher, M.5
  • 204
    • 0030949144 scopus 로고    scopus 로고
    • Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies
    • Takano K., Tatlisumak T., Formato J.E., Carano R.A., Bergmann A.G., Pullan L.M., et al. Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies. Stroke 28 (1997) 1255-1262
    • (1997) Stroke , vol.28 , pp. 1255-1262
    • Takano, K.1    Tatlisumak, T.2    Formato, J.E.3    Carano, R.A.4    Bergmann, A.G.5    Pullan, L.M.6
  • 205
    • 0025992317 scopus 로고
    • The effects of a competitive NMDA receptor antagonist (CGS-19755) on cerebral blood flow and pH in focal ischemia
    • Takizawa S., Hogan M., and Hakim A.M. The effects of a competitive NMDA receptor antagonist (CGS-19755) on cerebral blood flow and pH in focal ischemia. J Cereb Blood Flow Metab 11 (1991) 786-793
    • (1991) J Cereb Blood Flow Metab , vol.11 , pp. 786-793
    • Takizawa, S.1    Hogan, M.2    Hakim, A.M.3
  • 206
    • 0019868418 scopus 로고
    • Focal cerebral ischaemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion
    • Tamura A., Graham D.I., McCulloch J., and Teasdale G.M. Focal cerebral ischaemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1 (1981) 53-60
    • (1981) J Cereb Blood Flow Metab , vol.1 , pp. 53-60
    • Tamura, A.1    Graham, D.I.2    McCulloch, J.3    Teasdale, G.M.4
  • 207
    • 24144459553 scopus 로고    scopus 로고
    • Neuroprotective efficacy of selective brain hypothermia induced by a novel external cooling device on permanent cerebral ischemia in rats
    • Taniguchi T., Morikawa E., Mori T., and Matsui T. Neuroprotective efficacy of selective brain hypothermia induced by a novel external cooling device on permanent cerebral ischemia in rats. Neurol Res 27 (2005) 613-619
    • (2005) Neurol Res , vol.27 , pp. 613-619
    • Taniguchi, T.1    Morikawa, E.2    Mori, T.3    Matsui, T.4
  • 208
    • 0037844641 scopus 로고    scopus 로고
    • Use of diffusion- and perfusion-weighted magnetic resonance imaging in drug development for ischemic stroke
    • Tatlisumak T., and Li F. Use of diffusion- and perfusion-weighted magnetic resonance imaging in drug development for ischemic stroke. Curr Drug Targets CNS Neurol Disord 2 (2003) 131-141
    • (2003) Curr Drug Targets CNS Neurol Disord , vol.2 , pp. 131-141
    • Tatlisumak, T.1    Li, F.2
  • 209
    • 0031945018 scopus 로고    scopus 로고
    • A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study
    • Tatlisumak T., Carano R.A., Takano K., Opgenorth T.J., Sotak C.H., and Fisher M. A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study. Stroke 29 (1998) 850-857
    • (1998) Stroke , vol.29 , pp. 850-857
    • Tatlisumak, T.1    Carano, R.A.2    Takano, K.3    Opgenorth, T.J.4    Sotak, C.H.5    Fisher, M.6
  • 210
    • 0031692409 scopus 로고    scopus 로고
    • Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion
    • Tatlisumak T., Takano K., Carano R.A., Miller L.P., Foster A.C., and Fisher M. Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion. Stroke 29 (1998) 1952-1958
    • (1998) Stroke , vol.29 , pp. 1952-1958
    • Tatlisumak, T.1    Takano, K.2    Carano, R.A.3    Miller, L.P.4    Foster, A.C.5    Fisher, M.6
  • 211
    • 0031974355 scopus 로고    scopus 로고
    • A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion
    • Tatlisumak T., Takano K., Meiler M.R., and Fisher M. A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Stroke 29 (1998) 190-195
    • (1998) Stroke , vol.29 , pp. 190-195
    • Tatlisumak, T.1    Takano, K.2    Meiler, M.R.3    Fisher, M.4
  • 212
    • 4444315721 scopus 로고    scopus 로고
    • The role of diffusion- and perfusion-weighted magnetic resonance imaging in drug development for ischemic stroke: from laboratory to clinics
    • Tatlisumak T., Strbian D., Abo Ramadan U., and Li F. The role of diffusion- and perfusion-weighted magnetic resonance imaging in drug development for ischemic stroke: from laboratory to clinics. Curr Vasc Pharmacol 2 (2004) 343-355
    • (2004) Curr Vasc Pharmacol , vol.2 , pp. 343-355
    • Tatlisumak, T.1    Strbian, D.2    Abo Ramadan, U.3    Li, F.4
  • 213
    • 0035321964 scopus 로고    scopus 로고
    • New directions in thrombolytic therapy
    • Toombs C.F. New directions in thrombolytic therapy. Curr Opin Pharmacol 1 (2001) 164-168
    • (2001) Curr Opin Pharmacol , vol.1 , pp. 164-168
    • Toombs, C.F.1
  • 214
    • 20344394152 scopus 로고    scopus 로고
    • Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning
    • Trendelenburg G., and Dirnagl U. Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning. Glia 50 (2005) 307-320
    • (2005) Glia , vol.50 , pp. 307-320
    • Trendelenburg, G.1    Dirnagl, U.2
  • 215
    • 13444256139 scopus 로고    scopus 로고
    • Ideal suture diameter is critical for consistent middle cerebral artery occlusion in mice
    • Tureyen K., Vemuganti R., Sailor K.A., and Dempsey R.J. Ideal suture diameter is critical for consistent middle cerebral artery occlusion in mice. Neurosurgery 56 (2005) 196-200
    • (2005) Neurosurgery , vol.56 , pp. 196-200
    • Tureyen, K.1    Vemuganti, R.2    Sailor, K.A.3    Dempsey, R.J.4
  • 216
    • 4344629590 scopus 로고    scopus 로고
    • Apoptotic and necrotic death mechanisms are concomitantly activated in the same cell after cerebral ischemia
    • Unal-Cevik I., Kilinc M., Can A., Gursoy-Ozdemir Y., and Dalkara T. Apoptotic and necrotic death mechanisms are concomitantly activated in the same cell after cerebral ischemia. Stroke 35 (2004) 2189-2194
    • (2004) Stroke , vol.35 , pp. 2189-2194
    • Unal-Cevik, I.1    Kilinc, M.2    Can, A.3    Gursoy-Ozdemir, Y.4    Dalkara, T.5
  • 218
    • 0037210863 scopus 로고    scopus 로고
    • Effect of age in rats following middle cerebral artery occlusion
    • Wang R.Y., Wang P.S., and Yang Y.R. Effect of age in rats following middle cerebral artery occlusion. Gerontology 49 (2003) 27-32
    • (2003) Gerontology , vol.49 , pp. 27-32
    • Wang, R.Y.1    Wang, P.S.2    Yang, Y.R.3
  • 219
    • 0032564144 scopus 로고    scopus 로고
    • Epidemiology of stroke
    • Warlow C.P. Epidemiology of stroke. Lancet 352 Suppl 3 (1998) SIII1-SIII4
    • (1998) Lancet , vol.352 , Issue.SUPPL. 3
    • Warlow, C.P.1
  • 220
    • 0017623721 scopus 로고
    • Experimental regional cerebral ischemia in the middle cerebral artery territory in primates. Part 1: angio-anatomy and description of an experimental model with selective embolization of the internal carotid artery bifurcation
    • Watanabe O., Bremer A.M., and West C.R. Experimental regional cerebral ischemia in the middle cerebral artery territory in primates. Part 1: angio-anatomy and description of an experimental model with selective embolization of the internal carotid artery bifurcation. Stroke 8 (1977) 61-70
    • (1977) Stroke , vol.8 , pp. 61-70
    • Watanabe, O.1    Bremer, A.M.2    West, C.R.3
  • 221
    • 0021826450 scopus 로고
    • Induction of reproducible brain infarction by photochemically initiated thrombosis
    • Watson B.D., Dietrich W.D., Busto R., Wachtel M.S., and Ginsberg M.D. Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann Neurol 17 (1985) 497-504
    • (1985) Ann Neurol , vol.17 , pp. 497-504
    • Watson, B.D.1    Dietrich, W.D.2    Busto, R.3    Wachtel, M.S.4    Ginsberg, M.D.5
  • 222
    • 0028918312 scopus 로고
    • A photothrombotic 'ring' model of rat stroke-in-evolution displaying putative penumbral inversion
    • Wester P., Watson B.D., Prado R., and Dietrich W.D. A photothrombotic 'ring' model of rat stroke-in-evolution displaying putative penumbral inversion. Stroke 26 (1995) 444-450
    • (1995) Stroke , vol.26 , pp. 444-450
    • Wester, P.1    Watson, B.D.2    Prado, R.3    Dietrich, W.D.4
  • 223
    • 0025141697 scopus 로고
    • Animal models of stroke: are they relevant to human disease?
    • Wiebers D.O., Adams Jr. H.P., and Whisnant J.P. Animal models of stroke: are they relevant to human disease?. Stroke 21 (1990) 1-3
    • (1990) Stroke , vol.21 , pp. 1-3
    • Wiebers, D.O.1    Adams Jr., H.P.2    Whisnant, J.P.3
  • 224
    • 0037207289 scopus 로고    scopus 로고
    • Control of completeness and immediate detection of bleeding by a single laser-Doppler flow probe during intravascular middle cerebral artery occlusion in rats
    • Woitzik J., and Schilling L. Control of completeness and immediate detection of bleeding by a single laser-Doppler flow probe during intravascular middle cerebral artery occlusion in rats. J Neurosci Methods 122 (2002) 75-78
    • (2002) J Neurosci Methods , vol.122 , pp. 75-78
    • Woitzik, J.1    Schilling, L.2
  • 225
    • 33644554212 scopus 로고    scopus 로고
    • Comparison of different intravascular thread occlusion models for experimental stroke in rats
    • Woitzik J., Schneider U.C., Thome C., Schroeck H., and Schilling L. Comparison of different intravascular thread occlusion models for experimental stroke in rats. J Neurosci Methods 151 (2006) 224-231
    • (2006) J Neurosci Methods , vol.151 , pp. 224-231
    • Woitzik, J.1    Schneider, U.C.2    Thome, C.3    Schroeck, H.4    Schilling, L.5
  • 226
    • 0026064408 scopus 로고
    • Basilar artery occlusion in rats
    • Wojak J.C., DeCrescito V., and Young W. Basilar artery occlusion in rats. Stroke 22 (1991) 247-252
    • (1991) Stroke , vol.22 , pp. 247-252
    • Wojak, J.C.1    DeCrescito, V.2    Young, W.3
  • 227
    • 0028887364 scopus 로고
    • YM796, a novel muscarinic agonist, improves the impairment of learning behavior in a rat model of chronic focal cerebral ischemia
    • Yamaguchi T., Suzuki M., and Yamamoto M. YM796, a novel muscarinic agonist, improves the impairment of learning behavior in a rat model of chronic focal cerebral ischemia. Brain Res 669 (1995) 107-114
    • (1995) Brain Res , vol.669 , pp. 107-114
    • Yamaguchi, T.1    Suzuki, M.2    Yamamoto, M.3
  • 228
    • 0032964243 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha expression produces increased blood-brain barrier permeability following temporary focal cerebral ischemia in mice
    • Yang G.Y., Gong C., Qin Z., Liu X.H., and Lorris Betz A. Tumor necrosis factor alpha expression produces increased blood-brain barrier permeability following temporary focal cerebral ischemia in mice. Brain Res Mol Brain Res 69 (1999) 135-143
    • (1999) Brain Res Mol Brain Res , vol.69 , pp. 135-143
    • Yang, G.Y.1    Gong, C.2    Qin, Z.3    Liu, X.H.4    Lorris Betz, A.5
  • 229
    • 0037200716 scopus 로고    scopus 로고
    • A new reproducible focal cerebral ischemia model by introduction of polyvinylsiloxane into the middle cerebral artery: a comparison study
    • Yang Y., Yang T., Li Q., Wang C.X., and Shuaib A. A new reproducible focal cerebral ischemia model by introduction of polyvinylsiloxane into the middle cerebral artery: a comparison study. J Neurosci Methods 118 (2002) 199-206
    • (2002) J Neurosci Methods , vol.118 , pp. 199-206
    • Yang, Y.1    Yang, T.2    Li, Q.3    Wang, C.X.4    Shuaib, A.5
  • 230
    • 0030737572 scopus 로고    scopus 로고
    • Endovascular suture occlusion of the middle cerebral artery in rats: effect of suture insertion distance on cerebral blood flow, infarct distribution and infarct volume
    • Zarow G.J., Karibe H., States B.A., Graham S.H., and Weinstein P.R. Endovascular suture occlusion of the middle cerebral artery in rats: effect of suture insertion distance on cerebral blood flow, infarct distribution and infarct volume. Neurol Res 19 (1997) 409-416
    • (1997) Neurol Res , vol.19 , pp. 409-416
    • Zarow, G.J.1    Karibe, H.2    States, B.A.3    Graham, S.H.4    Weinstein, P.R.5
  • 231
    • 0036267791 scopus 로고    scopus 로고
    • Anesthetic methods in rats determine outcome after experimental focal cerebral ischemia: mechanical ventilation is required to obtain controlled experimental conditions
    • Zausinger S., Baethmann A., and Schmid-Elsaesser R. Anesthetic methods in rats determine outcome after experimental focal cerebral ischemia: mechanical ventilation is required to obtain controlled experimental conditions. Brain Res Brain Res Protoc 9 (2002) 112-121
    • (2002) Brain Res Brain Res Protoc , vol.9 , pp. 112-121
    • Zausinger, S.1    Baethmann, A.2    Schmid-Elsaesser, R.3
  • 232
    • 9444284316 scopus 로고    scopus 로고
    • Intravenous administration of a GPIIb/IIIa receptor antagonist extends the therapeutic window of intra-arterial tenecteplase-tissue plasminogen activator in a rat stroke model
    • Zhang L., Zhang Z.G., Zhang C., Zhang R.L., and Chopp M. Intravenous administration of a GPIIb/IIIa receptor antagonist extends the therapeutic window of intra-arterial tenecteplase-tissue plasminogen activator in a rat stroke model. Stroke 35 (2004) 2890-2895
    • (2004) Stroke , vol.35 , pp. 2890-2895
    • Zhang, L.1    Zhang, Z.G.2    Zhang, C.3    Zhang, R.L.4    Chopp, M.5
  • 233
    • 16844372455 scopus 로고    scopus 로고
    • Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor
    • Zhang L., Zhang R.L., Wang Y., Zhang C., Zhang Z.G., Meng H., et al. Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor. Stroke 36 (2005) 847-852
    • (2005) Stroke , vol.36 , pp. 847-852
    • Zhang, L.1    Zhang, R.L.2    Wang, Y.3    Zhang, C.4    Zhang, Z.G.5    Meng, H.6
  • 234
    • 0030670117 scopus 로고    scopus 로고
    • Transient middle cerebral artery occlusion by intraluminal suture: II. Neurological deficits, and pixel-based correlation of histopathology with local blood flow and glucose utilization
    • Zhao W., Belayev L., and Ginsberg M.D. Transient middle cerebral artery occlusion by intraluminal suture: II. Neurological deficits, and pixel-based correlation of histopathology with local blood flow and glucose utilization. J Cereb Blood Flow Metab 17 (1997) 1281-1290
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 1281-1290
    • Zhao, W.1    Belayev, L.2    Ginsberg, M.D.3


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