Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats

Journal of Clinical Neuroscience

Volumn 17, Issue 2, 2010, Pages 227-231

  Sahin, S ^a   Alkan, T ^a   Temel, S G ^a   Tureyen, K ^b   Tolunay, S ^a   Korfali, E ^a  

^a ULUDAG UNIVERSITY   (Turkey)

^b SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Apoptosis; Cerebral ischemia; Citicoline; Hypothermia; Rat

Indexed keywords

CASPASE 3; CASPASE 9; CITICOLINE; PROTEIN BAX; PROTEIN BCL 2; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DAMAGE; BRAIN PROTECTION; CONTROLLED STUDY; DISEASE MARKER; DRUG EFFECT; HEART PERFUSION; IMMUNOHISTOCHEMISTRY; INDUCED HYPOTHERMIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHAM PROCEDURE; SUTURING METHOD; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BIOLOGICAL MARKERS; BRAIN; BRAIN INFARCTION; BRAIN ISCHEMIA; COMBINED MODALITY THERAPY; CYTIDINE DIPHOSPHATE CHOLINE; DISEASE MODELS, ANIMAL; HYPOTHERMIA, INDUCED; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; NOOTROPIC AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 73449126488     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2009.05.016     Document Type: Article

References (33)

1. Benchoua A., Guégan C., Couriaud C., et al. Specific caspase pathways are activated in two stages of cerebral infarction. J Neurosci 21 (2001) 7127-7134
2. Li Y., Sharov V.G., Jiang N., et al. Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat. Am J Pathol 146 (1995) 1045-1051
3. Chen J., Graham S.H., Chan P.H., et al. Bcl-2 is expressed in neurons that survive focal ischemia in the rat. Neuroreport 6 (1995) 394-398
4. Alkan T., Kahveci N., Buyukuysal L., et al. Neuroprotective effects of MK 801 and hypothermia used alone and in combination in hypoxic-ischemic brain injury in neonatal rats. Arch Physiol Biochem 109 (2001) 135-144
5. Miyazawa T., Tamura A., Fukui S., et al. Effect of mild hypothermia on focal cerebral ischemia. Review of experimental studies. Neurol Res 25 (2003) 457-464
6. Yanamoto H., Nagata I., Niitsu Y., et al. Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia. Stroke 32 (2001) 232-239
7. The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurological outcome after cardiac arrest. N Engl J Med 346 (2002) 549-556
8. Alkan T., Kahveci N., Goren B., et al. Ischemic brain injury caused by interrupted versus uninterrupted occlusion in hypotensive rats with subarachnoid hemorrhage: neuroprotective effects of citicoline. Arch Physiol Biochem 109 (2001) 161-167
9. Rao A.M., Hatcher J.F., and Dempsey R.J. Lipid alterations in transient forebrain ischemia: possible new mechanisms of CDP-choline neuroprotection. J Neurochem 75 (2000) 2528-2535
10. Schäbitz W.R., Li F., Irie K., et al. Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia. Stroke 30 (1999) 427-431
11. Krupinski J., Ferrer I., Barrachina M., et al. CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat. Neuropharmacology 42 (2002) 846-854
12. Kawamura S., Yasui N., Shirasawa M., et al. Rat middle cerebral artery occlusion using an intraluminal thread technique. Acta Neurochir (Wien) 109 (1991) 126-132
13. Bederson J.B., Pitts L.H., Tsuji M., et al. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17 (1986) 472-476
14. Thoresen M., Haaland K., Loberg E.M., et al. A piglet survival model of posthypoxic encephalopathy. Pediatr Res 40 (1996) 738-748
15. Thoresen M., Satas S., Loberg E.M., et al. Twenty-four hours of mild hypothermia in unsedated newborn pigs starting after a severe global hypoxic-ischemic insult is not neuroprotective. Pediatr Res 50 (2001) 405-411
16. Tooley J.R., Satas S., Porter H., et al. Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotective. Ann Neurol 53 (2003) 65-72
17. Gressens P., Dingley J., Plaisant F., et al. Analysis of neuronal, glial, endothelial, axonal and apoptotic markers following moderate therapeutic hypothermia and anesthesia in the developing piglet brain. Brain Pathol 18 (2008) 10-20
18. Love S. Apoptosis and brain ischemia. Prog Neuropsychopharmacol Biol Psychiatry 27 (2003) 267-282
19. Quyang Y.B., and Giffard R.G. Cellular neuroprotective mechanisms in cerebral ischemia: Bcl-2 family proteins and protection of mitochondrial function. Cell Calcium 36 (2004) 303-311
20. Hermann D.M., Kilic E., Hata R., et al. Relationship between metabolic dysfunctions, gene responses and delayed cell death after mild focal cerebral ischemia in mice. Neuroscience 104 (2001) 947-955
21. Niwa M., Hara A., Iwai T., et al. Caspase activation as an apoptotic evidence in the gerbil hippocampal CA1 pyramidal cells following transient forebrain ischemia. Neurosci Lett 300 (2001) 103-106
22. Cao G., Minami M., Pei W., et al. Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death. J Cereb Blood Flow Metab 21 (2001) 321-333
23. Luo Y., Cao G., Pei W., et al. Induction of caspase-activated deoxyribonuclease activity after focal cerebral ischemia and reperfusion. J Cereb Blood Flow Metab 22 (2002) 15-20
24. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 15 (2001) 2922-2933
25. Marion D.W., Obrist W.D., Carlier P.M., et al. The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report. J Neurosurg 79 (1993) 354-362
26. Markarian G.Z., Lee J.H., Stein D.J., et al. Mild hypothermia: therapeutic time window after experimental cerebral ischemia. Neurosurgery 38 (1996) 542-551
27. Eberspächer E., Werner C., Engelhard K., et al. Long-term effects of hypothermia on neuronal cell death and the concentration of apoptotic proteins after incomplete cerebral ischemia and reperfusion in rats. Acta Anaesthesiol Scand 49 (2005) 477-487
28. Dorman R.V., Dabrowiecki Z., and Horrocks L.A. Effects of CDPcholine and CDPethanolamine on the alterations in rat brain lipid metabolism induced by global ischemia. J Neurochem 40 (1983) 276-279
29. Trovarelli G., de Medio G.E., Dorman R.V., et al. Effect of cytidine diphosphate choline (CDP-choline) on ischemia-induced alterations of brain lipid in the gerbil. Neurochem Res 6 (1981) 821-833
30. Schäbitz W.R., Weber J., Takano K., et al. The effects of prolonged treatment with citicoline in temporary experimental focal ischemia. J Neurol Sci 138 (1996) 21-25
31. Kennedy E.P., and Weiss S.B. The function of cytidine coenzymes in the biosynthesis of phospholipids. J Biol Chem 222 (1956) 193-214
32. Weiss G.B. Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline. Life Sci 56 (1995) 637-660
33. Goracci G., Francescangeli E., Horrocks L.A., et al. The reverse reactions of cholinephosphotransferase in rat brain microsomes: a new pathway for degradation of phosphatidylcholine. Biochim Biophys Acta 664 (1981) 373-379