Combination therapy with hypothermia for treatment of cerebral ischemia

Journal of Neurotrauma

Volumn 26, Issue 3, 2009, Pages 325-331

  Tang, Xian N ^a,b   Liu, Liping ^c   Yenari, Midori A ^a,d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Hypothermia; Neuroprotection; Stroke; Tissue plasminogen activator

Indexed keywords

ALCOHOL; ALTEPLASE; BARBITURIC ACID DERIVATIVE; BRAIN DERIVED NEUROTROPHIC FACTOR; CAFFEINE; DEXAMETHASONE; DIPYRONE; DIZOCILPINE; FIBRINOLYTIC AGENT; INTERLEUKIN 10; MAGNESIUM CHLORIDE; MANNITOL; MINOCYCLINE; N ACETYLASPARTYLGLUTAMIC ACID; N TERT BUTYL ALPHA PHEYLNITRONE; NITRONE DERIVATIVE; TACROLIMUS; TIRILAZAD; UNCLASSIFIED DRUG;

BLEEDING; BRAIN EMBOLISM; BRAIN PERFUSION; BRAIN PROTECTION; BRAIN TEMPERATURE; CEREBROVASCULAR ACCIDENT; FIBRINOLYTIC THERAPY; HEMODILUTION; HUMAN; INDUCED HYPOTHERMIA; MECHANICAL THROMBECTOMY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PROFOUND INDUCED HYPOTHERMIA; RECANALIZATION; REVIEW; RISK FACTOR; STROKE; TEMPERATURE DEPENDENCE; TREATMENT DURATION;

ANIMALS; BODY TEMPERATURE; BRAIN; BRAIN ISCHEMIA; CLINICAL PROTOCOLS; FIBRINOLYTIC AGENTS; HUMANS; HYPOTHERMIA, INDUCED; RISK ASSESSMENT; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 62649146471     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2008.0594     Document Type: Review

References (61)

1. Aronowski, J., Strong, R., Shirzadi, A., and Grotta, J.C. (2003). Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: preclinical experience. Stroke. 34, 1246-1251.
2. Baker, C.J., Onesti, S.T., Barth, K.N., Prestigiacomo, C.J., and Solomon, R.A. (1991). Hypothermic protection following middle cerebral artery occlusion in the rat. Surg. Neurol. 36, 175-180.
3. Baker, C.J., Onesti, S.T., and Solomon, R.A. (1992). Reduction by delayed hypothermia of cerebral infarction following middle cerebral artery occlusion in the rat: a time-course study. J. Neurosurg. 77, 438-444.
4. Berger, C., Schabitz, W.R., Wolf, M., Mueller, H., Sommer, C., and Schwab, S. (2004). Hypothermia and brain-derived neurotrophic factor reduce glutamate synergistically in acute stroke. Exp. Neurol. 185, 305-312.
5. Bernard, S.A., Gray, T.W., Buist, M.D., Jones, B.M., Silvester, W., Gutteridge, G., and Smith, K. (2002). Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N. Engl. J. Med. 346, 557-563.
6. Busto, R., Dietrich, W.D., Globus, M.Y., andGinsberg, M.D. (1989). Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury. Neurosci. Lett. 101, 299-304.
7. Carroll, M., and Beek, O. (1992). Protection against hippocampal CA1 cell loss by post-ischemic hypothermia is dependent on delay of initiation and duration. Metab. Brain Dis. 7, 45-50.
8. Coimbra, C., Drake, M., Boris-Moller, F., and Wieloch, T. (1996). Long-lasting neuroprotective effect of postischemic hypothermia and treatment with an anti-inflammatory/antipyretic drug. Evidence for chronic encephalopathic processes following ischemia. Stroke 27, 1578-1585.
9. Colbourne, F., and Corbett, D. (1995). Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection. J. Neurosci. 15, 7250-7260.
10. Colbourne, F., Corbett, D., Zhao, Z., Yang, J., and Buchan, A.M. (2000). Prolonged but delayed postischemic hypothermia: a long-term outcome study in the rat middle cerebral artery occlusion model. J. Cereb. Blood Flow Metab. 20, 1702-1708.
11. Colbourne, F., Li, H., and Buchan, A.M. (1999). Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 19, 742-749.
12. Corbett, D., Hamilton, M., and Colbourne, F. (2000). Persistent neuroprotection with prolonged postischemic hypothermia in adult rats subjected to transient middle cerebral artery occlusion. Exp. Neurol. 163, 200-206.
13. Dietrich, W.D., Busto, R., Alonso, O., Globus, M.Y., and Ginsberg, M.D. (1993). Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 13, 541-549.
14. Dietrich, W.D., Busto, R., and Bethea, J.R. (1999). Postischemic hypothermia and IL-10 treatment provide long-lasting neuroprotection of CA1 hippocampus following transient global ischemia in rats. Exp. Neurol. 158, 444-450.
15. Dietrich, W.D., Lin, B., Globus, M.Y., Green, E.J., Ginsberg, M.D., and Busto, R. (1995). Effect of delayed MK-801 (dizocilpine) treatment with or without immediate postischemic hypothermia on chronic neuronal survival after global forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 15, 960-968.
16. Ginsberg, M.D. (2008). Neuroprotection for ischemic stroke: Past, present and future. Neuropharmacology 55, 363-389.
17. Gisvold, S.E., Safar, P., Rao, G., Moossy, J., Kelsey, S., and Alexander, H. (1984). Multifaceted therapy after global brain ischemia in monkeys. Stroke 15, 803-812.
18. Green, E.J., Pazos, A.J., Dietrich, W.D., McCabe, P.M., Schneiderman, N., Lin, B., Busto, R., Globus, M.Y., and Ginsberg, M.D. (1995). Combined postischemic hypothermia and delayed MK-801 treatment attenuates neurobehavioral deficits associated with transient global ischemia in rats. Brain Res. 702, 145-152.
19. Guluma, K.Z., Hemmen, T.M., Olsen, S.E., Rapp, K.S., and Lyden, P.D. (2006). A trial of therapeutic hypothermia via endovascular approach in awake patients with acute ischemic stroke: methodology. Acad. Emerg. Med. 13, 820-827.
20. Gupta, R., Jovin, T.G., and Krieger, D.W. (2005). Therapeutic hypothermia for stroke: do new outfits change an old friend? Expert. Rev. Neurother. 5, 235-246.
21. Hemmen, T.M., and Lyden, P.D. (2007). Induced hypothermia for acute stroke. Stroke 38, 794-799.
22. Huh, P.W., Belayev, L., Zhao, W., Koch, S., Busto, R., and Ginsberg, M.D. (2000). Comparative neuroprotective efficacy of prolonged moderate intraischemic and postischemic hypothermia in focal cerebral ischemia. J. Neurosurg. 92, 91-99.
23. Hypothermia after Cardiac Arrest Study Group. (2002). Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N. Engl. J. Med. 346, 549-556.
24. Kader, A., Brisman, M.H., Maraire, N., Huh, J.T., and Solomon, R.A. (1992). The effect of mild hypothermia on permanent focal ischemia in the rat. Neurosurgery 31, 1051-1060.
25. Karibe, H., Chen, J., Zarow, G.J., Graham, S.H., and Weinstein, P.R. (1994). Delayed induction of mild hypothermia to reduce infarct volume after temporary middle cerebral artery occlusion in rats. J. Neurosurg. 80, 112-119.
26. Kollmar, R., Henninger, N., Bardutzky, J., Schellinger, P.D., Schabitz, W.R., and Schwab, S. (2004). Combination therapy of moderate hypothermia and thrombolysis in experimental thromboembolic stroke-an MRI study. Exp. Neurol. 190, 204-212.
27. Krieger, D.W., and Yenari, M.A. (2004). Therapeutic hypothermia for acute ischemic stroke: what do laboratory studies teach us? Stroke 35, 1482-1489.
28. Lawrence, M.S., McLaughlin, J.R., Sun, G.H., Ho, D.Y., McIntosh, L., Kunis, D.M., Sapolsky, R.M., and Steinberg, G.K. (1997). Herpes simplex viral vectors expressing Bcl-2 are neuroprotective when delivered after a stroke. J. Cereb. Blood Flow Metab. 17, 740-744.
29. Liu, L., Tang, X., Koike, M., and Yenari, M. (2006). Mild Hypothermia reduces hemorrhage and blood-brain barrier (BBB) disruption following tissue plasminogen activator treatment in experimental stroke. Neurology 66, A242-A243.
30. Lyden, P., Krieger, D.W., Yenari, M.A., and Dietrich, W.D. (2006). Therapeutic hypothermia for acute stroke. Int. J. Stroke 1, 9-19.
31. Lyden, P.D., Allgren, R.L., Ng, K., Akins, P., Meyer, B., Al-Sanani, F., Lutsep, H., Dobak, J., Matsubara, B.S., and Zivin, J. (2005). Intravascular cooling in the treatment of stroke (ICTuS): early clinical experience. J. Stroke Cerebrovasc. Dis. 14, 107-114.
32. Maier, C.M., Ahern, K., Cheng, M.L., Lee, J.E., Yenari, M.A., and Steinberg, G.K. (1998). Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: effects on neurologic outcome, infarct size, apoptosis, and inflammation. Stroke 29, 2171-2180.
33. Maier, C.M., Sun, G.H., Kunis, D., Yenari, M.A., and Steinberg, G.K. (2001). Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size. J. Neurosurg. 94, 90-96.
34. Markarian, G.Z., Lee, J.H., Stein, D.J., and Hong, S.C. (1996). Mild hypothermia: therapeutic window after experimental cerebral ischemia. Neurosurgery 38, 542-551.
35. Martin-Schild, S., Barreto, A.D., Hallevi, H., Khaja, A.M., Shaltoni, H., Gonzales, N.R., Illoh, I., Noser, E.A., Aronowski, J., and Savitz, S.I. (2008). Feasibility of caffeinol and hypothermia for acute ischemic stroke. Stroke 39, 532.
36. Meden, P., Overgaard, K., Pedersen, H., and Boysen, G. (1994). Effect of hypothermia and delayed thrombolysis in a rat embolic stroke model. Acta Neurol. Scand. 90, 91-98.
37. Morikawa, E., Ginsberg, M.D., Dietrich, W.D., Duncan, R.C., Kraydieh, S., Globus, M.Y., and Busto, R. (1992). The significance of brain temperature in focal cerebral ischemia: histopathological consequences of middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 12, 380-389.
38. Nagel, S., Su, Y., Horstmann, S., Heiland, S., Gardner, H., Koziol, J., Martinez-Torres, F.J., and Wagner, S. (2008). Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat: effects on BBB breakdown and MMP expression in the acute and subacute phase. Brain Res. 1188, 198-206.
39. Nito, C., Kamiya, T., Ueda, M., Arii, T., and Katayama, Y. (2004). Mild hypothermia enhances the neuroprotective effects of FK506 and expands its therapeutic window following transient focal ischemia in rats. Brain Res. 1008, 179-185.
40. Ogilvy, C.S., Chu, D., and Kaplan, S. (1996). Mild hypothermia, hypertension, and mannitol are protective against infarction during experimental intracranial temporary vessel occlusion. Neurosurgery 38, 1202-1209.
41. Olsen, T.S., Weber, U.J., and Kammersgaard, L.P. (2003). Therapeutic hypothermia for acute stroke. Lancet Neurol. 2, 410-416.
42. Pazos, A.J., Green, E.J., Busto, R., McCabe, P.M., Baena, R.C., Ginsberg, M.D., Globus, M.Y., Schneiderman, N., and Dietrich, W.D. (1999). Effects of combined postischemic hypothermia and delayed N-tert-butyl-alpha-pheylnitrone (PBN) administration on histopathologicaland behavioral deficits associated with transient global ischemia in rats. Brain Res. 846, 186-195.
43. Reed, S.D., Cramer, S.C., Blough, D.K., Meyer, K., and Jarvik, J.G. (2001). Treatment with tissue plasminogen activator and inpatient mortality rates for patients with ischemic stroke treated in community hospitals. Stroke 32, 1832-1840.
44. Reith, J., Jorgensen, H.S., Pedersen, P.M., Nakayama, H., Raaschou, H.O., Jeppesen, L.L., and Olsen, T.S. (1996). Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet 347, 422-425.
45. Ridenour, T.R., Warner, D.S., Todd, M.M., and McAllister, A.C. (1992). Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats. Stroke 23, 733-738.
46. Rogalewski, A., Schneider, A., Ringelstein, E.B., and Schabitz, W.R. (2006). Toward a multimodal neuroprotective treatment of stroke. Stroke 37, 1129-1136.
47. Schmid-Elsaesser, R., Hungerhuber, E., Zausinger, S., Baethmann, A., and Reulen, H.J. (1999). Combination drug therapy and mild hypothermia: a promising treatment strategy for reversible, focal cerebral ischemia. Stroke 30, 1891-1899.
48. Scholler, K., Zausinger, S., Baethmann, A., and Schmid-Elsaesser, R. (2004). Neuroprotection in ischemic stroke-combination drug therapy and mild hypothermia in a rat model of permanent focal cerebral ischemia. Brain Res. 1023, 272-278.
49. Schwab, S., Georgiadis, D., Berrouschot, J., Schellinger, P.D., Graffagnino, C., and Mayer, S.A. (2001). Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke 32, 2033-2035.
50. Shuaib, A., Waqar, T., Wishart, T., and Kanthan, R. (1995). Postischemic therapy with CGS-19755 (alone or in combination with hypothermia) in gerbils. Neurosci. Lett. 191, 87-90.
51. Smith, W.S., Sung, G., Saver, J., Budzik, R., Duckwiler, G., Liebeskind, D.S., Lutsep, H.L., Rymer, M.M., Higashida, R.T., Starkman, S., Gobin, Y.P., Frei, D., Grobelny, T., Hellinger, F., Huddle, D., Kidwell, C., Koroshetz, W., Marks, M., Nesbit, G., and Silverman, I.E. (2008). Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke 39, 1205-1212.
52. Van Hemelrijck, A., Hachimi-Idrissi, S., Sarre, S., Ebinger, G., and Michotte, Y. (2005). Neuroprotective effect of N-acetyl-aspartyl- glutamate in combination with mild hypothermia in the endothelin-1 rat model of focal cerebral ischaemia. J. Neurochem. 95, 1287-1297.
53. Wahlgren, N.G., and Lyden, P. (2000). Neuroprotectants in the treatment of stroke-an overview. J. Stroke Cerebrovasc. Dis. 9, 32-35.
54. Wang, C.X., Yang, T., Noor, R., and Shuaib, A. (2002). Delayed minocycline but not delayed mild hypothermia protects against embolic stroke. BMC Neurol. 2, 2.
55. Wang, C.X., Yang, T., and Shuaib, A. (2003). Effects of minocycline alone and in combination with mild hypothermia in embolic stroke. Brain Res. 963, 327-329.
56. Yanamoto, H., Nagata, I., Niitsu, Y., Zhang, Z., Xue, J.H., Sakai, N., and Kikuchi, H. (2001). Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia. Stroke 32, 232-239.
57. Yenari, M.A., Palmer, J.T., Bracci, P.M., and Steinberg, G.K. (1995). Thrombolysis with tissue plasminogen activator (tPA) is temperature dependent. Thromb. Res. 77, 475-481.
58. Zausinger, S., Scholler, K., Plesnila, N., and Schmid-Elsaesser, R. (2003). Combination drug therapy and mild hypothermia after transient focal cerebral ischemia in rats. Stroke 34, 2246-2251.
59. Zhang, Z.G., Chopp, M., and Chen, H. (1993). Duration dependent post-ischemic hypothermia alleviates cortical damage after transient middle cerebral artery occlusion in the rat. J. Neurol. Sci. 117, 240-244.
60. Zhao, H., Wang, J.Q., Shimohata, T., Sun, G., Yenari, M.A., Sapolsky, R.M., and Steinberg, G.K. (2007). Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusion. J. Neurosurg. 107, 636-641.
61. Zhao, H., Yenari, M.A., Sapolsky, R.M., and Steinberg, G.K. (2004). Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release. Stroke 35, 572-577.