An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the Mongolian gerbil

Neuroscience Letters

Volumn 204, Issue 3, 1996, Pages 157-160

  Ide, Takafumi ^a   Morikawa, Eiharu ^a   Kirino, Takaaki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Delayed neuronal death; FK506; Forebrain ischemia; Gerbil; Hippocampus; Immunosuppressant

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; NEUROPROTECTIVE AGENT; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; GERBIL; HIPPOCAMPUS; HISTOLOGY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030019624     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12352-1     Document Type: Article

References (20)

1. Busto, R., Dietrich, W.D., Globus, M.Y.-T., Valdes, I., Scheinberg, P. and Ginsberg, M.D., Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury, J. Cereb. Blood Flow Metab., 7 (1987) 729-738.
2. Busto, R., Dietrich, W.D., Globus, M.Y.-T. and Ginsberg, M.D., Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury, Neurosci. Lett., 101 (1989) 299-304.
3. Coimbra, C. and Wieloch, T., Hypothermia ameliorates neuronal survival when induced two hours after ischaemia in the rat, Acta Physiol. Scand., 146 (1992) 543-544.
4. Dawson, D.A., Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome, Cerebrovasc. Brain Metab. Rev., 6 (1994) 299-324.
5. Dawson, T.M., Steiner, J.P., Dawson, V.L., Dinerman, J.L., Uhl, G.R. and Snyder, S.H., Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity, Proc. Natl. Acad. Sci. USA, 90 (1993) 9808-9812.
6. Dietrich, W.D., Busto, R., Alonso, O., Globus, M.Y.-T. and Ginsberg, M.D., Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats, J. Cereb. Blood Flow Metab., 13 (1993) 541-549.
7. Fruman, D.A., Mather, P.E., Burakoff, S.J. and Bierer, B.E., Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas, Eur. J. Immunol., 22 (1992) 2513-2517.
8. Galat, A., Lane, W.S., Standaert, R.F. and Schreiber, S.L., A rapamycin-selective 25-kDa immunophilin, Biochemistry, 31 (1992) 2427-2434.
9. Jin, Y.J., Albers, M.W., Lane, W.S., Bierer, B.E., Schreiber, S.L. and Burakoff, S.J., Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13, Proc. Natl. Acad. Sci. USA, 88 (1991) 6677-6681.
10. Kirino, T., Delayed neuronal death in the gerbil hippocampus following ischemia, Brain Res., 239 (1982) 57-69.
11. Liu, J., Albers, M.W., Wandless, T.J., Luan, S., Alberg, D.G., Belshaw, P.J., Cohen, P., MacKintosh, C., Klee, C.B. and Schreiber, S.L., Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity, Biochemistry, 31 (1992) 3896-3901.
12. Nagafuji, T., Sugiyama, M., Matsui, T. and Koide, T., A narrow therapeutical window of a nitric oxide synthase inhibitor against transient ischemic brain injury, Eur. J. Pharmacol., 248 (1993) 325-328.
13. Ning, Y.M. and Sanchez, E.R., Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin, J. Biol. Chem., 268 (1993) 6073-6076.
14. Nishinaka, Y., Sugiyama, S., Yokota, M., Saito, H. and Ozawa, T., Protective effect of FK506 on ischemia/reperfusion-induced myocardial damage in canine heart, J. Cardiovasc. Pharmacol., 21 (1993) 448-454.
15. Pulsinelli, W.A., Brierley, J.B., Plum, F., Temporal profile of neuronal damage in a model of transient forebrain ischemia, Ann. Neurol., 11 (1982) 491-498.
16. Sakr, M.F., Zetti, G., Hassanein, T., Nalesnik, M., Gavaler, J., Starzl T. and Thiel, D., FK506 ameliorates the hepatic injury associated with ischemia and reperfusion in rats, Hepatology, 13 (1991) 947.
17. Sakr, M., Zetti, G., McClain, C., Gavaler, J., Nalesnik, M., Todo, S., Starzl, T. and Thiel, D.V., The protective effect of FK506 pretreatment against renal ischemia/reperfusion injury in rats, Transplantation, 53 (1992) 987-991.
18. Sharkey, J. and Butcher, S.P., Immunophilins mediate the neuro-protective effects of FK506 in focal cerebral ischemia, Nature, 371 (1994) 336-339.
19. Steiner, J.P., Dawson, T.M., Fotuhi, M., Glatt, C.E., Snowman, A.M., Cohen, N. and Snyder, S.H., High brain densities of the immunophilin FKBP colocalized with calcineurin, Nature (London), 358 (1992) 584-587.
20. Tai, P.K., Chang, H., Albers, M.W., Schreiber, S.L., Toft, D.O. and Faber, L.E, P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors, Biochemistry, 32 (1993) 8842-8847.