Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis by gene targeting in mice

Frontiers in Neuroendocrinology

Volumn 36, Issue , 2015, Pages 150-164

  Laryea, Gloria ^a,b   Muglia, Lisa ^b   Arnett, Melinda ^b   Muglia, Louis J ^b,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Adrenocorticotropic hormone; Circadian regulation; Corticosterone; Corticotropin releasing hormone; Glucocorticoid receptor; Hypothalamic pituitary adrenal axis; Metabolism; Paraventricular nucleus of the hypothalamus; Pituitary; Stress

Indexed keywords

GLUCOCORTICOID RECEPTOR;

ADRENERGIC SYSTEM; BINDING SITE; BRAIN REGION; CIRCADIAN RHYTHM; DOPAMINERGIC NERVE CELL; DORSAL RAPHE NUCLEUS; FOREBRAIN; GENE TARGETING; HORMONAL REGULATION; HORMONE METABOLISM; HYPOPHYSIS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MENTAL DISEASE; METABOLIC DISORDER; MOUSE; NEGATIVE FEEDBACK; NEUROENDOCRINE SYSTEM; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; REVIEW; ANIMAL; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

ANIMALS; GENE TARGETING; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; MICE; PITUITARY-ADRENAL SYSTEM; RECEPTORS, GLUCOCORTICOID; STRESS, PHYSIOLOGICAL;

EID: 84923922377     PISSN: 00913022     EISSN: 10956808     Source Type: Journal    
DOI: 10.1016/j.yfrne.2014.09.002     Document Type: Review

References (213)

1. Ambroggi F., Turiault M., Milet A., Deroche-Gamonet V., Parnaudeau S., Balado E., Barik J., van der Veen R., Maroteaux G., Lemberger T., Schütz G., Lazar M., Marinelli M., Piazza P.V., Tronche F. Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. Nat. Neurosci. 2009, 12:247-249. 10.1038/nn.2282.
2. Arnett M.G., Kolber B.J., Boyle M.P., Muglia L.J. Behavioral insights from mouse models of forebrain - and amygdala-specific glucocorticoid receptor genetic disruption. Mol. Cell. Endocrinol. 2011, 336:2-5. 10.1016/j.mce.2010.11.011.
3. Atalar F., Gormez S., Caynak B., Akan G., Tanriverdi G., Bilgic-Gazioglu S., Gunay D., Duran C., Akpinar B., Ozbek U., Buyukdevrim A.S., Yazici Z. The role of mediastinal adipose tissue 11β-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease. Cardiovasc. Diabetol. 2012, 11:115. 10.1186/1475-2840-11-115.
4. Balsalobre A., Brown S.A., Marcacci L., Tronche F., Kellendonk C., Reichardt H.M., Schütz G., Schibler U. Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science 2000, 289:2344-2347.
5. Balthasar N., Dalgaard L.T., Lee C.E., Yu J., Funahashi H., Williams T., Ferreira M., Tang V., McGovern R.A., Kenny C.D., Christiansen L.M., Edelstein E., Choi B., Boss O., Aschkenasi C., Zhang C., Mountjoy K., Kishi T., Elmquist J.K., Lowell B.B. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 2005, 123:493-505. 10.1016/j.cell.2005.08.035.
6. Barat P., Duclos M., Gatta B., Roger P., Mormede P., Moisan M.P. Corticosteroid binding globulin gene polymorphism influences cortisol driven fat distribution in obese women. Obes. Res. 2005, 13:1485-1490.
7. Barik J., Marti F., Morel C., Fernandez S.P., Lanteri C., Godeheu G., Tassin J.-P., Mombereau C., Faure P., Tronche F. Chronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons. Science 2013, 339:332-335. 10.1126/science.1226767.
8. Bartholome B., Spies C.M., Gaber T., Schuchmann S., Berki T., Kunkel D., Bienert M., Radbruch A., Burmester G.-R., Lauster R., Scheffold A., Buttgereit F. Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis. FASEB J. 2004, 18:70-80. 10.1096/fj.03-0328com.
9. Beck-Friis J., Ljunggren J.G., Thorén M., von Rosen D., Kjellman B.F., Wetterberg L. Melatonin, cortisol and ACTH in patients with major depressive disorder and healthy humans with special reference to the outcome of the dexamethasone suppression test. Psychoneuroendocrinology 1985, 10:173-186.
10. Bentley L., Esapa C.T., Nesbit M.A., Head R.A., Evans H., Lath D., Scudamore C.L., Hough T.A., Podrini C., Hannan F.M., Fraser W.D., Croucher P.I., Brown M.A., Brown S.D.M., Cox R.D., Thakker R.V. An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess. Endocrinology 2014, 155:908-922. 10.1210/en.2013-1247.
11. Bernier J., Jobin N., Emptoz-Bonneton A., Pugeat M.M., Garrel D.R. Decreased corticosteroid-binding globulin in burn patients: relationship with interleukin-6 and fat in nutritional support. Crit. Care Med. 1998, 26:452-460.
12. Biddie S.C., Conway-Campbell B.L., Lightman S.L. Dynamic regulation of glucocorticoid signalling in health and disease. Rheumatology (Oxford) 2012, 51:403-412. 10.1093/rheumatology/ker215.
13. Binder E.B. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 2009, 34(Suppl. 1):S186-S195. 10.1016/j.psyneuen.2009.05.021.
14. Binder E.B., Salyakina D., Lichtner P., Wochnik G.M., Ising M., Pütz B., Papiol S., Seaman S., Lucae S., Kohli M.A., Nickel T., Künzel H.E., Fuchs B., Majer M., Pfennig A., Kern N., Brunner J., Modell S., Baghai T., Deiml T., Zill P., Bondy B., Rupprecht R., Messer T., Köhnlein O., Dabitz H., Brückl T., Müller N., Pfister H., Lieb R., Mueller J.C., Lõhmussaar E., Strom T.M., Bettecken T., Meitinger T., Uhr M., Rein T., Holsboer F., Muller-Myhsok B. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat. Genet. 2004, 36:1319-1325. 10.1038/ng1479.
15. Binder E.B., Bradley R.G., Liu W., Epstein M.P., Deveau T.C., Mercer K.B., Tang Y., Gillespie C.F., Heim C.M., Nemeroff C.B., Schwartz A.C., Cubells J.F., Ressler K.J. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 2008, 299:1291-1305. 10.1001/jama.299.11.1291.
16. Bittman E.L., Doherty L., Huang L., Paroskie A. Period gene expression in mouse endocrine tissues. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003, 285:R561-R569. 10.1152/ajpregu.00783.2002.
17. Boyle M.P., Brewer J.a., Funatsu M., Wozniak D.F., Tsien J.Z., Izumi Y., Muglia L.J. Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proc. Natl. Acad. Sci. USA 2005, 102:473-478. 10.1073/pnas.0406458102.
18. Boyle M.P., Kolber B.J., Vogt S.K., Wozniak D.F., Muglia L.J. Forebrain glucocorticoid receptors modulate anxiety-associated locomotor activation and adrenal responsiveness. J. Neurosci. 2006, 26:1971-1978. 10.1523/JNEUROSCI.2173-05.2006.
19. Buijs R.M., Wortel J., Van Heerikhuize J.J., Feenstra M.G., Ter Horst G.J., Romijn H.J., Kalsbeek A. Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway. Eur. J. Neurosci. 1999, 11:1535-1544.
20. Buwalda B., Stubbendorff C., Zickert N., Koolhaas J.M. Adolescent social stress does not necessarily lead to a compromised adaptive capacity during adulthood: a study on the consequences of social stress in rats. Neuroscience 2013, 249:258-270. 10.1016/j.neuroscience.2012.12.050.
21. Carroll B.J., Feinberg M., Greden J.F., Haskett R.F., James N.M., Steiner M., Tarika J. Diagnosis of endogenous depression. Comparison of clinical, research and neuroendocrine criteria. J. Affect. Disord. 1980, 2:177-194.
22. Cascio C.S., Shinsako J., Dallman M.F. The suprachiasmatic nuclei stimulate evening ACTH secretion in the rat. Brain Res. 1987, 423:173-178.
23. Cato A.C.B., Nestl A., Mink S. Rapid actions of steroid receptors in cellular signaling pathways. Sci. STKE 2002, re9. 10.1126/stke.2002.138.re9.
24. Champagne D.L., Bagot R.C., van Hasselt F., Ramakers G., Meaney M.J., de Kloet E.R., Joëls M., Krugers H. Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. J. Neurosci. 2008, 28:6037-6045. 10.1523/JNEUROSCI.0526-08.2008.
25. Champagne D.L., de Kloet E.R., Joëls M. Fundamental aspects of the impact of glucocorticoids on the (immature) brain. Semin. Fetal Neonatal Med. 2009, 14:136-142. 10.1016/j.siny.2008.11.006.
26. Chimin P., Farias T.da S.M., Torres-Leal F.L., Bolsoni-Lopes A., Campaña A.B., Andreotti S., Lima F.B. Chronic glucocorticoid treatment enhances lipogenic activity in visceral adipocytes of male Wistar rats. Acta Physiol. (Oxf) 2014, 10.1111/apha.12226.
27. Clow A., Hucklebridge F., Stalder T., Evans P., Thorn L. The cortisol awakening response: more than a measure of HPA axis function. Neurosci. Biobehav. Rev. 2010, 35:97-103. 10.1016/j.neubiorev.2009.12.011.
28. Cone R.D., Cowley M.A., Butler A.A., Fan W., Marks D.L., Low M.J. The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int. J. Obes. Relat. Metab. Disord. 2001, 25(Suppl. 5):S63-S67. 10.1038/sj.ijo.0801913.
29. Crawford P.A., Sadovsky Y., Woodson K., Lee S.L., Milbrandt J. Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice. Mol. Cell. Biol. 1995, 15. pp. 4331-4316.
30. Dallman M.F. Fast glucocorticoid actions on brain: back to the future. Front. Neuroendocrinol. 2005, 26:103-108. 10.1016/j.yfrne.2005.08.001.
31. Daskalakis N.P., Oitzl M.S., Schächinger H., Champagne D.L., de Kloet E.R. Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity. Physiol. Behav. 2012, 106:707-721. 10.1016/j.physbeh.2012.01.015.
32. Daskalakis N.P., Bagot R.C., Parker K.J., Vinkers C.H., de Kloet E.R. The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology 2013, 38:1858-1873. 10.1016/j.psyneuen.2013.06.008.
33. Dayanithi G., Antoni F.A. Rapid as well as delayed inhibitory effects of glucocorticoid hormones on pituitary adrenocorticotropic hormone release are mediated by type II glucocorticoid receptors and require newly synthesized messenger ribonucleic acid as well as protein. Endocrinology 1989, 125:308-313. 10.1210/endo-125-1-308.
34. De Kloet E.R., Reul J.M. Feedback action and tonic influence of corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems. Psychoneuroendocrinology 1987, 12:83-105.
35. De Kloet E.R., Vreugdenhil E., Oitzl M.S., Joëls M. Brain corticosteroid receptor balance in health and disease. Endocr. Rev. 1998, 19:269-301.
36. De Kloet E.R., Joëls M., Holsboer F. Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 2005, 6:463-475. 10.1038/nrn1683.
37. De Kloet E.R., Karst H., Joëls M. Corticosteroid hormones in the central stress response: quick-and-slow. Front. Neuroendocrinol. 2008, 29:268-272. 10.1016/j.yfrne.2007.10.002.
38. DeFremery P., Laqueur E., Reichstein T. Corticosteron, a crystallized compound with the biological activity of the adrenalcortical hormone. Nature 1937, 139:26.
39. DeRijk R., de Kloet E.R. Corticosteroid receptor genetic polymorphisms and stress responsivity. Endocrine 2005, 28:263-270. 10.1385/ENDO:28:3:263.
40. Di S., Malcher-Lopes R., Halmos K.C., Tasker J.G. Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. J. Neurosci. 2003, 23:4850-4857.
41. Diorio D., Viau V., Meaney M.J. The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress. J. Neurosci. 1993, 13:3839-3847.
42. Drake A.J., Raubenheimer P.J., Kerrigan D., McInnes K.J., Seckl J.R., Walker B.R. Prenatal dexamethasone programs expression of genes in liver and adipose tissue and increased hepatic lipid accumulation but not obesity on a high-fat diet. Endocrinology 2010, 151:1581-1587. 10.1210/en.2009-1088.
43. Drouin J., Sun Y.L., Chamberland M., Gauthier Y., De Léan A., Nemer M., Schmidt T.J. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J. 1993, 12:145-156.
44. Duma D., Collins J.B., Chou J.W., Cidlowski J.A. Sexually dimorphic actions of glucocorticoids provide a link to inflammatory diseases with gender differences in prevalence. Sci. Signal. 2010, 3:ra74. 10.1126/scisignal.2001077.
45. Elliott E., Ezra-Nevo G., Regev L., Neufeld-Cohen A., Chen A. Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice. Nat. Neurosci. 2010, 13:1351-1353. 10.1038/nn.2642.
46. Erdmann G., Schütz G., Berger S. Loss of glucocorticoid receptor function in the pituitary results in early postnatal lethality. Endocrinology 2008, 149:3446-3451. 10.1210/en.2007-1786.
47. Evans A.N., Liu Y., Macgregor R., Huang V., Aguilera G. Regulation of hypothalamic corticotropin-releasing hormone transcription by elevated glucocorticoids. Mol. Endocrinol. 2013, 27:1796-1807. 10.1210/me.2013-1095.
48. Evanson N.K., Tasker J.G., Hill M.N., Hillard C.J., Herman J.P. Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling. Endocrinology 2010, 151:4811-4819. 10.1210/en.2010-0285.
49. Fardet L., Nazareth I., Whitaker H.J., Petersen I. Severe neuropsychiatric outcomes following discontinuation of long-term glucocorticoid therapy: a cohort study. J. Clin. Psychiatry 2013, 74:e281-e286. 10.4088/JCP.12m08034.
50. Feldman S., Conforti N. Modifications of adrenocortical responses following frontal cortex simulation in rats with hypothalamic deafferentations and medial forebrain bundle lesions. Neuroscience 1985, 15:1045-1047.
51. Fernandez P.M., Brunel F., Jimenez M.A., Saez J.M., Cereghini S., Zakin M.M. Nuclear receptors Nor1 and NGFI-B/Nur77 play similar, albeit distinct, roles in the hypothalamo-pituitary-adrenal axis. Endocrinology 2000, 141:2392-2400. 10.1210/endo.141.7.7562.
52. Fernandez-Real J.-M., Pugeat M., López-Bermejo A., Bornet H., Ricart W. Corticosteroid-binding globulin affects the relationship between circulating adiponectin and cortisol in men and women. Metabolism 2005, 54:584-589. 10.1016/j.metabol.2004.11.015.
53. Finotto S., Krieglstein K., Schober A., Deimling F., Lindner K., Brühl B., Beier K., Metz J., Garcia-Arraras J.E., Roig-Lopez J.L., Monaghan P., Schmid W., Cole T.J., Kellendonk C., Tronche F., Schütz G., Unsicker K. Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. Development 1999, 126:2935-2944.
54. Francis D.D., Champagne F.A., Liu D., Meaney M.J. Maternal care, gene expression, and the development of individual differences in stress reactivity. Ann. N. Y. Acad. Sci. 1999, 896:66-84.
55. Franco-Colín M., Villanueva I., Piñón M., Racotta R. The effects of sympathectomy and dexamethasone in rats ingesting sucrose. Int. J. Biol. Sci. 2006, 2:17-22.
56. Frodl T., Carballedo a., Hughes M.M., Saleh K., Fagan a., Skokauskas N., McLoughlin D.M., Meaney J., O'Keane V., Connor T.J. Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder. Transl. Psychiatry 2012, 2:e88. 10.1038/tp.2012.14.
57. Furay A.R., Bruestle A.E., Herman J.P. The role of the forebrain glucocorticoid receptor in acute and chronic stress. Endocrinology 2008, 149:5482-5490. 10.1210/en.2008-0642.
58. Gametchu B., Watson C.S., Pasko D. Size and steroid-binding characterization of membrane-associated glucocorticoid receptor in S-49 lymphoma cells. Steroids 1991, 56:402-410. 10.1016/0039-128X(91)90028-T.
59. Gibbons J.L. Cortisol secretion rate in depressive illness. Arch. Gen. Psychiatry 1964, 10:572-575.
60. Goldstein M.F. Chronic glucocorticoid therapy-induced osteoporosis in patients with obstructive lung disease*. Chest 1999, 116:1733-1749. 10.1378/chest.116.6.1733.
61. Gormley G.J., Lowy M.T., Reder A.T., Hospelhorn V.D., Antel J.P., Meltzer H.Y. Glucocorticoid receptors in depression: relationship to the dexamethasone suppression test. Am. J. Psychiatry 1985, 142:1278-1284.
62. Goto M., Piper Hanley K., Marcos J., Wood P.J., Wright S., Postle A.D., Cameron I.T., Mason J.I., Wilson D.I., Hanley N.A. In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development. J. Clin. Invest. 2006, 116:953-960. 10.1172/JCI25091.
63. Grasa M.M., Cabot C., Balada F., Virgili J., Sanchis D., Monserrat C., Fernández-López J.A., Remesar X., Alemany M. Corticosterone binding to tissues of adrenalectomized lean and obese Zucker rats. Horm. Metab. Res. 1998, 30:699-704. 10.1055/s-2007-978962.
64. Groeneweg F.L., Karst H., de Kloet E.R., Joëls M. Rapid non-genomic effects of corticosteroids and their role in the central stress response. J. Endocrinol. 2011, 209:153-167. 10.1530/JOE-10-0472.
65. Groeneweg F.L., Karst H., de Kloet E.R., Joëls M. Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling. Mol. Cell. Endocrinol. 2011, 10.1016/j.mce.2011.06.020.
66. Hartman F.A., Brownell K.A. The hormone of the adrenal cortex. Science 1930, 72:76. 10.1126/science.72.1855.76.
67. Heck S., Kullmann M., Gast A., Ponta H., Rahmsdorf H.J., Herrlich P., Cato A.C. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 1994, 13:4087-4095.
68. Hench P.S., Kendall E.C. The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc. Staff Meet. Mayo Clin. 1949, 24:181-197.
69. Herman J.P., Cullinan W.E. Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci. 1997, 20:78-84.
70. Herman J.P., Cullinan W.E., Young E.a., Akil H., Watson S.J. Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression. Brain Res. 1992, 592:228-238.
71. Herman J.P., Dolgas C.M., Carlson S.L. Ventral subiculum regulates hypothalamo-pituitary-adrenocortical and behavioural responses to cognitive stressors. Neuroscience 1998, 86:449-459.
72. Hermes M.L., Coderre E.M., Buijs R.M., Renaud L.P. GABA and glutamate mediate rapid neurotransmission from suprachiasmatic nucleus to hypothalamic paraventricular nucleus in rat. J. Physiol. 1996, 496(Pt 3):749-757.
73. Heydendael W., Jacobson L. Differential effects of imipramine and phenelzine on corticosteroid receptor gene expression in mouse brain: potential relevance to antidepressant response. Brain Res. 2008, 1238:93-107. 10.1016/j.brainres.2008.08.018.
74. Hinz B., Hirschelmann R. Rapid non-genomic feedback effects of glucocorticoids on CRF-induced ACTH secretion in rats. Pharm. Res. 2000, 17:1273-1277.
75. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 2000, 23:477-501. 10.1016/S0893-133X(00)00159-7.
76. Ishida A., Mutoh T., Ueyama T., Bando H., Masubuchi S., Nakahara D., Tsujimoto G., Okamura H. Light activates the adrenal gland: timing of gene expression and glucocorticoid release. Cell Metab. 2005, 2:297-307. 10.1016/j.cmet.2005.09.009.
77. Jacobson L., Sapolsky R. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr. Rev. 1991, 12:118-134. 10.1210/edrv-12-2-118.
78. Jeanneteau F.D., Lambert W.M., Ismaili N., Bath K.G., Lee F.S., Garabedian M.J., Chao M.V. BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc. Natl. Acad. Sci. USA 2012, 109:1305-1310. 10.1073/pnas.1114122109.
79. Joëls M., Sarabdjitsingh R.A., Karst H. Unraveling the time domains of corticosteroid hormone influences on brain activity: rapid, slow, and chronic modes. Pharmacol. Rev. 2012, 64:901-938. 10.1124/pr.112.005892.
80. John C.D., Christian H.C., Morris J.F., Flower R.J., Solito E., Buckingham J.C. Annexin 1 and the regulation of endocrine function. Trends Endocrinol. Metab. 2004, 15:103-109. 10.1016/j.tem.2004.02.001.
81. Jonat C., Rahmsdorf H.J., Park K.K., Cato A.C., Gebel S., Ponta H., Herrlich P. Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 1990, 62:1189-1204.
82. Kalsbeek a., van Heerikhuize J.J., Wortel J., Buijs R.M. A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1 antagonist. J. Neurosci. 1996, 16:5555-5565.
83. Kannisto K., Pietiläinen K.H., Ehrenborg E., Rissanen A., Kaprio J., Hamsten A., Yki-Järvinen H. Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. J. Clin. Endocrinol. Metab. 2004, 89:4414-4421. 10.1210/jc.2004-0153.
84. Kellendonk C., Eiden S., Kretz O., Schütz G., Schmidt I., Tronche F., Simon E. Inactivation of the GR in the nervous system affects energy accumulation. Endocrinology 2002, 143:2333-2340.
85. Kellendonk C., Gass P., Kretz O., Schütz G., Tronche F. Corticosteroid receptors in the brain: gene targeting studies. Brain Res. Bull. 2002, 57:73-83.
86. Keller-Wood M.E., Dallman M.F. Corticosteroid inhibition of ACTH secretion. Endocr. Rev. 1984, 5:1-24. 10.1210/edrv-5-1-1.
87. Kendall E.C. The development of cortisone as a therapeutic agent. Indian Med. J. 1951, 45:239-241.
88. Khandaker G.M., Dibben C.R.M., Jones P.B. Does maternal body mass index during pregnancy influence risk of schizophrenia in the adult offspring?. Obes. Rev. 2012, 13:518-527. 10.1111/j.1467-789X.2011.00971.x.
89. Kino T., Chrousos G. Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes. J. Endocrinol. 2001, 437-445.
90. Klengel T., Mehta D., Anacker C., Rex-Haffner M., Pruessner J.C., Pariante C.M., Pace T.W.W., Mercer K.B., Mayberg H.S., Bradley B., Nemeroff C.B., Holsboer F., Heim C.M., Ressler K.J., Rein T., Binder E.B. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat. Neurosci. 2013, 16:33-41. 10.1038/nn.3275.
91. Knable M.B., Torrey E.F., Webster M.J., Bartko J.J. Multivariate analysis of prefrontal cortical data from the Stanley Foundation Neuropathology Consortium. Brain Res. Bull. 2001, 55:651-659.
92. Koenig J.I., Kirkpatrick B., Lee P. Glucocorticoid hormones and early brain development in schizophrenia. Neuropsychopharmacology 2002, 27:309-318. 10.1016/S0893-133X(01)00396-7.
93. Kolber B.J., Muglia L.J. Defining brain region-specific glucocorticoid action during stress by conditional gene disruption in mice. Brain Res. 2009, 1293:85-90. 10.1016/j.brainres.2009.03.061.
94. Kolber B.J., Wieczorek L., Muglia L.J. Hypothalamic-pituitary-adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function. Stress 2008, 11:321-338. 10.1080/10253890701821081.
95. Kolber B.J., Boyle M.P., Wieczorek L., Kelley C.L., Onwuzurike C.C., Nettles S.a., Vogt S.K., Muglia L.J. Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice. J. Neurosci. 2010, 30:2571-2581. 10.1523/JNEUROSCI.4470-09.2010.
96. Korebrits C., Yu D.H., Ramirez M.M., Marinoni E., Bocking A.D., Challis J.R. Antenatal glucocorticoid administration increases corticotrophin-releasing hormone in maternal plasma. Br. J. Obstet. Gynaecol. 1998, 105:556-561.
97. Krieger D.T., Hauser H., Krey L.C. Suprachiasmatic nuclear lesions do not abolish food-shifted circadian adrenal and temperature rhythmicity. Science 1977, 197:398-399.
98. Kumar R., Thompson E.B. Gene regulation by the glucocorticoid receptor: structure: function relationship. J. Steroid Biochem. Mol. Biol. 2005, 94:383-394. 10.1016/j.jsbmb.2004.12.046.
99. Labonte B., Yerko V., Gross J., Mechawar N., Meaney M.J., Szyf M., Turecki G. Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biol. Psychiatry 2012, 72:41-48. 10.1016/j.biopsych.2012.01.034.
100. Laryea G., Schütz G., Muglia L.J. Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity. Mol. Endocrinol. 2013, 27:1655-1665. 10.1210/me.2013-1187.
101. Lesage J., Blondeau B., Grino M., Bréant B., Dupouy J.P. Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat. Endocrinology 2001, 142:1692-1702. 10.1210/endo.142.5.8139.
102. Lesch K.P., Laux G., Schulte H.M., Pfüller H., Beckmann H. Corticotropin and cortisol response to human CRH as a probe for HPA system integrity in major depressive disorder. Psychiatry Res. 1988, 24:25-34.
103. Li A.-J., Wiater M.F., Oostrom M.T., Smith B.R., Wang Q., Dinh T.T., Roberts B.L., Jansen H.T., Ritter S. Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2012, 302:R1313-R1326. 10.1152/ajpregu.00086.2012.
104. Lightman S.L. The neuroendocrinology of stress: a never ending story. J. Neuroendocrinol. 2008, 20:880-884. 10.1111/j.1365-2826.2008.01711.x.
105. Linkowski P., Kerkhofs M., Van Onderbergen A., Hubain P., Copinschi G., L'Hermite-Balériaux M., Leclercq R., Brasseur M., Mendlewicz J., Van Cauter E. The 24-hour profiles of cortisol, prolactin, and growth hormone secretion in mania. Arch. Gen. Psychiatry 1994, 51:616-624.
106. Liu D., Diorio J., Tannenbaum B., Caldji C., Francis D., Freedman A., Sharma S., Pearson D., Plotsky P.M., Meaney M.J. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 1997, 277:1659-1662.
107. Liu W., Wang J., Sauter N.K., Pearce D. Steroid receptor heterodimerization demonstrated in vitro and in vivo. Proc. Natl. Acad. Sci. USA 1995, 92:12480-12484.
108. Liu Y., Smith L.I., Huang V., Poon V., Coello A., Olah M., Spiga F., Lightman S.L., Aguilera G. Transcriptional regulation of episodic glucocorticoid secretion. Mol. Cell. Endocrinol. 2013, 371:62-70. 10.1016/j.mce.2012.10.011.
109. López J.F., Chalmers D.T., Little K.Y., Watson S.J. A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biol. Psychiatry 1998, 43:547-573.
110. Lowy M.T., Reder A.T., Gormley G.J., Meltzer H.Y. Comparison of in vivo and in vitro glucocorticoid sensitivity in depression: relationship to the dexamethasone suppression test. Biol. Psychiatry 1988, 24:619-630.
111. Makino S., Gold P.W., Schulkin J. Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus. Brain Res. 1994, 640:105-112.
112. Makino S., Gold P.W., Schulkin J. Effects of corticosterone on CRH mRNA and content in the bed nucleus of the stria terminalis; comparison with the effects in the central nucleus of the amygdala and the paraventricular nucleus of the hypothalamus. Brain Res. 1994, 657:141-149.
113. Malcher-Lopes R., Di S., Marcheselli V.S., Weng F.-J., Stuart C.T., Bazan N.G., Tasker J.G. Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J. Neurosci. 2006, 26:6643-6650. 10.1523/JNEUROSCI.5126-05.2006.
114. Malkoski S.P., Handanos C.M., Dorin R.I. Localization of a negative glucocorticoid response element of the human corticotropin releasing hormone gene. Mol. Cell. Endocrinol. 1997, 127:189-199. 10.1016/S0303-7207(96)04004-X.
115. Marinoni E., Korebrits C., Di Iorio R., Cosmi E.V., Challis J.R. Effect of betamethasone in vivo on placental corticotropin-releasing hormone in human pregnancy. Am. J. Obstet. Gynecol. 1998, 178:770-778.
116. Marques A.H., Silverman M.N., Sternberg E.M. Glucocorticoid dysregulations and their clinical correlates. From receptors to therapeutics. Ann. N. Y. Acad. Sci. 2009, 1179:1-18. 10.1111/j.1749-6632.2009.04987.x.
117. McEwen B.S. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol. Rev. 2007, 87:873-904. 10.1152/physrev.00041.2006.
118. McGowan P.O., Sasaki A., D'Alessio A.C., Dymov S., Labonté B., Szyf M., Turecki G., Meaney M.J. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 2009, 12:342-348. 10.1038/nn.2270.
119. McKlveen J.M., Myers B., Flak J.N., Bundzikova J., Solomon M.B., Seroogy K.B., Herman J.P. Role of prefrontal cortex glucocorticoid receptors in stress and emotion. Biol. Psychiatry 2013, 74:672-679. 10.1016/j.biopsych.2013.03.024.
120. Michelsohn a.M., Anderson D.J. Changes in competence determine the timing of two sequential glucocorticoid effects on sympathoadrenal progenitors. Neuron 1992, 8:589-604.
121. Miller W.L. StAR search - what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import. Mol. Endocrinol. 2007, 21:589-601. 10.1210/me.2006-0303.
122. Minet-Quinard, R., Moinard, C., Walrand, S., Villié, F., Normand, B., Vasson, M.P., Chopineau, J., Cynober, L., n.d. Induction of a catabolic state in rats by dexamethasone: dose or time dependency? JPEN. J. Parenter. Enteral Nutr. 24, 30-36.
123. Moore R.Y., Eichler V.B. Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Res. 1972, 42:201-206.
124. Mück-Seler D., Pivac N., Jakovljević M., Brzović Z. Platelet serotonin, plasma cortisol, and dexamethasone suppression test in schizophrenic patients. Biol. Psychiatry 1999, 45:1433-1439.
125. Munck A., Guyre P.M., Holbrook N.J. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr. Rev. 1984, 5:25-44. 10.1210/edrv-5-1-25.
126. Myers B., McKlveen J.M., Herman J.P. Neural regulation of the stress response: the many faces of feedback. Cell. Mol. Neurobiol. 2012, 10.1007/s10571-012-9801-y.
127. Nederhof E., Schmidt M.V. Mismatch or cumulative stress: toward an integrated hypothesis of programming effects. Physiol. Behav. 2012, 106:691-700. 10.1016/j.physbeh.2011.12.008.
128. Nishi M. Dynamics of corticosteroid receptors: lessons from live cell imaging. Acta Histochem. Cytochem. 2011, 44:1-7. 10.1267/ahc.10028.
129. Nishi M., Tanaka M., Matsuda K., Sunaguchi M., Kawata M. Visualization of glucocorticoid receptor and mineralocorticoid receptor interactions in living cells with GFP-based fluorescence resonance energy transfer. J. Neurosci. 2004, 24:4918-4927. 10.1523/JNEUROSCI.5495-03.2004.
130. Nissen R.M., Yamamoto K.R. The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev. 2000, 14:2314-2329.
131. Niwa M., Jaaro-Peled H., Tankou S., Seshadri S., Hikida T., Matsumoto Y., Cascella N.G., Kano S., Ozaki N., Nabeshima T., Sawa A. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science 2013, 339:335-339. 10.1126/science.1226931.
132. Oakley R.H., Cidlowski J.a. The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease. J. Allergy Clin. Immunol. 2013, 132:1033-1044. 10.1016/j.jaci.2013.09.007.
133. Oakley R.H., Webster J.C., Sar M., Parker C.R., Cidlowski J.A. Expression and subcellular distribution of the beta-isoform of the human glucocorticoid receptor. Endocrinology 1997, 138:5028-5038. 10.1210/endo.138.11.5501.
134. Oitzl M.S., Reichardt H.M., Joëls M., de Kloet E.R. Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory. Proc. Natl. Acad. Sci. USA 2001, 98:12790-12795. 10.1073/pnas.231313998.
135. Oster H., Damerow S., Kiessling S., Jakubcakova V., Abraham D., Tian J., Hoffmann M.W., Eichele G. The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock. Cell Metab. 2006, 4:163-173. 10.1016/j.cmet.2006.07.002.
136. Owens M.J., Nemeroff C.B. The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: laboratory and clinical studies. Ciba Found. Symp. 1993, 172:296-308. discussion 308-16.
137. Papadimitriou A., Priftis K.N. Regulation of the hypothalamic-pituitary-adrenal axis. NeuroImmunoModulation 2009, 16:265-271. 10.1159/000216184.
138. Pariante C.M., Lightman S.L. The HPA axis in major depression: classical theories and new developments. Trends Neurosci. 2008, 31:464-468. 10.1016/j.tins.2008.06.006.
139. Pariante C.M., Miller A.H. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 2001, 49:391-404.
140. Payne A.H., Hales D.B. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr. Rev. 2004, 25:947-970.
141. Perlman W.R., Webster M.J., Kleinman J.E., Weickert C.S. Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness. Biol. Psychiatry 2004, 56:844-852. 10.1016/j.biopsych.2004.09.006.
142. Polman, J.A.E., Kloet, E.R. de, Datson, N.A., 2013. Two Populations of Glucocorticoid Receptor-Binding Sites in the Male Rat Hippocampal Genome.
143. Pruessner J.C., Wolf O.T., Hellhammer D.H., Buske-Kirschbaum A., von Auer K., Jobst S., Kaspers F., Kirschbaum C. Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity. Life Sci. 1997, 61:2539-2549. 10.1016/S0024-3205(97)01008-4.
144. Radley J.J., Kabbaj M., Jacobson L., Heydendael W., Yehuda R., Herman J.P. Stress risk factors and stress-related pathology: neuroplasticity, epigenetics and endophenotypes. Stress 2011, 14:481-497. 10.3109/10253890.2011.604751.
145. Raisman G., Brown-Grant K. The "suprachiasmatic syndrome": endocrine and behavioural abnormalities following lesions of the suprachiasmatic nuclei in the female rat. Proc. Roy. Soc. Lond. B. Biol. Sci. 1977, 198:297-314.
146. Raju T.N. The Nobel chronicles. Lancet 1999, 353:1370. 10.1016/S0140-6736(05)74374-9.
147. Rask E., Walker B.R., Söderberg S., Livingstone D.E.W., Eliasson M., Johnson O., Andrew R., Olsson T. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. J. Clin. Endocrinol. Metab. 2002, 87:3330-3336. 10.1210/jcem.87.7.8661.
148. Reichardt H.M., Schütz G. Feedback control of glucocorticoid production is established during fetal development. Mol. Med. 1996, 2:735-744.
149. Reichardt H.M., Kaestner K.H., Tuckermann J., Kretz O., Wessely O., Bock R., Gass P., Schmid W., Herrlich P., Angel P., Schütz G. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 1998, 93:531-541.
150. Reichstein T., Verzar F., Laszt L. Activity of corticosteron in the glucose test in rats. Nature 1937, 139:331.
151. Reul J.M., de Kloet E.R. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 1985, 117:2505-2511. 10.1210/endo-117-6-2505.
152. Reul J.M., Stec I., Söder M., Holsboer F. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology 1993, 133:312-320. 10.1210/endo.133.1.8391426.
153. Reul J.M., Labeur M.S., Grigoriadis D.E., De Souza E.B., Holsboer F. Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide. Neuroendocrinology 1994, 60:509-519.
154. Reynolds R.M., Labad J., Buss C., Ghaemmaghami P., Räikkönen K. Transmitting biological effects of stress in utero: implications for mother and offspring. Psychoneuroendocrinology 2013, 38:1843-1849. 10.1016/j.psyneuen.2013.05.018.
155. Ridder S., Chourbaji S., Hellweg R., Urani A., Zacher C., Schmid W., Zink M., Hörtnagl H., Flor H., Henn F.a., Schütz G., Gass P. Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J. Neurosci. 2005, 25:6243-6250. 10.1523/JNEUROSCI.0736-05.2005.
156. Robinson B.G., Emanuel R.L., Frim D.M., Majzoub J.A. Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Proc. Natl. Acad. Sci. USA 1988, 85:5244-5248.
157. Rubin R.T., Phillips J.J., McCracken J.T., Sadow T.F. Adrenal gland volume in major depression: relationship to basal and stimulated pituitary-adrenal cortical axis function. Biol. Psychiatry 1996, 40:89-97. 10.1016/0006-3223(95)00358-4.
158. Sallee F.R., Nesbitt L., Dougherty D., Hilal R., Nandagopal V.S., Sethuraman G. Lymphocyte glucocorticoid receptor: predictor of sertraline response in adolescent major depressive disorder (MDD). Psychopharmacol. Bull. 1995, 31:339-345.
159. Santarelli S., Lesuis S.L., Wang X.-D., Wagner K.V., Hartmann J., Labermaier C., Scharf S.H., Müller M.B., Holsboer F., Schmidt M.V. Evidence supporting the match/mismatch hypothesis of psychiatric disorders. Eur. Neuropsychopharmacol. 2014, 24:907-918. 10.1016/j.euroneuro.2014.02.002.
160. Sapolsky R.M., Romero L.M., Munck A.U. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 2000, 21:55-89. 10.1210/edrv.21.1.0389.
161. Sasaki A., de Vega W.C., St-Cyr S., Pan P., McGowan P.O. Perinatal high fat diet alters glucocorticoid signaling and anxiety behavior in adulthood. Neuroscience 2013, 240:1-12. 10.1016/j.neuroscience.2013.02.044.
162. Savary I., Debras E., Dardevet D., Sornet C., Capitan P., Prugnaud J., Mirand P.P., Grizard J. Effect of glucocorticoid excess on skeletal muscle and heart protein synthesis in adult and old rats. Br. J. Nutr. 1998, 79:297-304.
163. Scheinman R.I., Gualberto A., Jewell C.M., Cidlowski J.A., Baldwin A.S. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol. Cell. Biol. 1995, 15:943-953.
164. Schmidt M.V. Animal models for depression and the mismatch hypothesis of disease. Psychoneuroendocrinology 2011, 36:330-338. 10.1016/j.psyneuen.2010.07.001.
165. Schmidt M.V., Enthoven L., van der Mark M., Levine S., de Kloet E.R., Oitzl M.S. The postnatal development of the hypothalamic-pituitary-adrenal axis in the mouse. Int. J. Dev. Neurosci. 2003, 21:125-132. 10.1016/S0736-5748(03)00030-3.
166. Schmidt M.V., Schmidt M., Levine S., Oitzl M.S., van der Mark M., Müller M.B., Holsboer F., de Kloet E.R. Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse. Endocrinology 2005, 146:1458-1464. 10.1210/en.2004-1042.
167. Schmidt M.V., Sterlemann V., Wagner K., Niederleitner B., Ganea K., Liebl C., Deussing J.M., Berger S., Schütz G., Holsboer F., Müller M.B. Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences. Endocrinology 2009, 150:2709-2716. 10.1210/en.2008-1211.
168. Schulz P., Kirschbaum C., Prüßner J., Hellhammer D. Increased free cortisol secretion after awakening in chronically stressed individuals due to work overload. Stress Med. 1998, 14:91-97. 10.1002/(SICI)1099-1700(199804)14:2<91::AID-SMI7653.0.CO;2-S.
169. Schwartz M.W., Woods S.C., Porte D., Seeley R.J., Baskin D.G. Central nervous system control of food intake. Nature 2000, 404:661-671. 10.1038/35007534.
170. Seckl J.R., Fink G. Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo. Neuroendocrinology 1992, 55:621-626.
171. Sharma D., Bhave S., Gregg E., Uht R. Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter. Mol. Endocrinol. 2013, 27:1142-1152. 10.1210/me.2013-1079.
172. Sinclair D., Tsai S.Y., Woon H.G., Weickert C.S. Abnormal glucocorticoid receptor mRNA and protein isoform expression in the prefrontal cortex in psychiatric illness. Neuropsychopharmacology 2011, 36:2698-2709. 10.1038/npp.2011.160.
173. Solomon M.B., Furay a.R., Jones K., Packard a.E.B., Packard B.a., Wulsin a.C., Herman J.P. Deletion of forebrain glucocorticoid receptors impairs neuroendocrine stress responses and induces depression-like behavior in males but not females. Neuroscience 2012, 203:135-143. 10.1016/j.neuroscience.2011.12.014.
174. Spies C.M., Strehl C., van der Goes M.C., Bijlsma J.W.J., Buttgereit F. Glucocorticoids. Best Pract. Res. Clin. Rheumatol. 2011, 25:891-900. 10.1016/j.berh.2011.11.002.
175. Stengel A., Taché Y. CRF and urocortin peptides as modulators of energy balance and feeding behavior during stress. Front. Neurosci. 2014, 8:52. 10.3389/fnins.2014.00052.
176. Stengel A., Goebel M., Million M., Stenzel-Poore M.P., Kobelt P., Mönnikes H., Taché Y., Wang L. Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting. Endocrinology 2009, 150:153-160. 10.1210/en.2008-0723.
177. Stenzel-Poore M.P., Cameron V.A., Vaughan J., Sawchenko P.E., Vale W. Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice. Endocrinology 1992, 130:3378-3386. 10.1210/en.130.6.3378.
178. Stevens A., White A. ACTH: cellular peptide hormone synthesis and secretory pathways. Results Probl. Cell Differ. 2010, 50:63-84. 10.1007/400_2009_30.
179. Stimson R.H., Andersson J., Andrew R., Redhead D.N., Karpe F., Hayes P.C., Olsson T., Walker B.R. Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans. Diabetes 2009, 58:46-53. 10.2337/db08-0969.
180. Szafarczyk a., Ixart G., Alonso G., Malaval F., Nouguier-Soulé J., Assenmacher I. CNS control of the circadian adrenocortical rhythm. J. Steroid Biochem. 1983, 19:1009-1015.
181. Tasker J.G. Rapid glucocorticoid actions in the hypothalamus as a mechanism of homeostatic integration. Obesity (Silver Spring) 2006, 14(Suppl 5):259S-265S. 10.1038/oby.2006.320.
182. Tatro E.T., Everall I.P., Masliah E., Hult B.J., Lucero G., Chana G., Soontornniyomkij V., Achim C.L. Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder. J. Neuroimmune Pharmacol. 2009, 4:218-226. 10.1007/s11481-009-9146-6.
183. Tinnikov A.A., Legan M.V., Sheveluk N.A., Cvetovskaya G.A., Naumenko S.E., Sidelnikov S.G. Corticosteroid and immune responses to cardiac surgery. Steroids 1996, 61:411-415.
184. Tonsfeldt K.J., Chappell P.E. Clocks on top: the role of the circadian clock in the hypothalamic and pituitary regulation of endocrine physiology. Mol. Cell. Endocrinol. 2012, 349:3-12. 10.1016/j.mce.2011.07.003.
185. Trapp T., Holsboer F. Heterodimerization between mineralocorticoid and glucocorticoid receptors increases the functional diversity of corticosteroid action. Trends Pharmacol. Sci. 1996, 17:145-149. 10.1016/0165-6147(96)81590-2.
186. Trapp T., Rupprecht R., Castrén M., Reul J.M., Holsboer F. Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS. Neuron 1994, 13:1457-1462.
187. Trapp T., Rupprecht R., Castrén M., Reul J.M.H.M., Holsboer F. Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS. Neuron 1994, 13:1457-1462. 10.1016/0896-6273(94)90431-6.
188. Trivedi B.P. Neuroscience: dissecting appetite. Nature 2014, 508:S64-S65. 10.1038/508S64a.
189. Tronche F., Kellendonk C., Kretz O., Gass P., Anlag K., Orban P.C., Bock R., Klein R., Schütz G. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat. Genet. 1999, 23:99-103. 10.1038/12703.
190. Tsien J.Z., Chen D.F., Gerber D., Tom C., Mercer E.H., Anderson D.J., Mayford M., Kandel E.R., Tonegawa S. Subregion- and cell type-restricted gene knockout in mouse brain. Cell 1996, 87:1317-1326. 10.1016/S0092-8674(00)81826-7.
191. Van Haarst A.D., Oitzl M.S., de Kloet E.R. Facilitation of feedback inhibition through blockade of glucocorticoid receptors in the hippocampus. Neurochem. Res. 1997, 22:1323-1328.
192. Vincent M.Y., Jacobson L. Glucocorticoid receptor deletion from the dorsal raphé nucleus of mice reduces dysphoria-like behavior and impairs hypothalamic-pituitary-adrenocortical axis feedback inhibition. Eur. J. Neurosci. 2014, 10.1111/ejn.12538.
193. Wagner K.V., Wang X.-D., Liebl C., Scharf S.H., Müller M.B., Schmidt M.V. Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress. Psychoneuroendocrinology 2011, 36:579-587. 10.1016/j.psyneuen.2010.09.007.
194. Waite E.J., McKenna M., Kershaw Y., Walker J.J., Cho K., Piggins H.D., Lightman S.L. Ultradian corticosterone secretion is maintained in the absence of circadian cues. Eur. J. Neurosci. 2012, 36:3142-3150. 10.1111/j.1460-9568.2012.08213.x.
195. Walker J.J., Terry J.R., Lightman S.L. Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis. Proc. Biol. Sci. 2010, 277:1627-1633. 10.1098/rspb.2009.2148.
196. Wang, M., 2005. The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome. Nutr. Metab. (Lond). 2, 3. doi:10.1186/1743-7075-2-3.
197. Waselus M., Valentino R.J., Van Bockstaele E.J. Collateralized dorsal raphe nucleus projections: a mechanism for the integration of diverse functions during stress. J. Chem. Neuroanat. 2011, 41:266-280. 10.1016/j.jchemneu.2011.05.011.
198. Weaver I.C., D'Alessio A. The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes. J. Neurosci. 2007, 27:1756-1768. 10.1523/JNEUROSCI.4164-06.2007.The.
199. Weaver I.C., Cervoni N., Champagne F.A., D'Alessio A.C., Sharma S., Seckl J.R., Dymov S., Szyf M., Meaney M.J. Epigenetic programming by maternal behavior. Nat. Neurosci. 2004, 7:847-854. 10.1038/nn1276.
200. Webster J.C., Cidlowski J.A. Mechanisms of glucocorticoid-receptor-mediated repression of gene expression. Trends Endocrinol. Metab. 1999, 10:396-402. 10.1016/S1043-2760(99)00186-1.
201. Webster M.J., Knable M.B., O'Grady J., Orthmann J., Weickert C.S. Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Mol. Psychiatry 2002, 7. 985-94, 924. 10.1038/sj.mp.4001139.
202. Whalley L.J., Borthwick N., Copolov D., Dick H., Christie J.E., Fink G. Glucocorticoid receptors and depression. Br. Med. J. (Clin. Res. Ed.) 1986, 292:859-861.
203. Widmaier E.P., Dallman M.F. The effects of corticotropin-releasing factor on adrenocorticotropin secretion from perifused pituitaries in vitro: rapid inhibition by glucocorticoids. Endocrinology 1984, 115:2368-2374. 10.1210/endo-115-6-2368.
204. Wolkowitz O.M., Burke H., Epel E.S., Reus V.I. Glucocorticoids. Mood, memory, and mechanisms. Ann. N. Y. Acad. Sci. 2009, 1179:19-40. 10.1111/j.1749-6632.2009.04980.x.
205. Yamamori E., Iwasaki Y., Taguchi T., Nishiyama M., Yoshida M., Asai M., Oiso Y., Itoi K., Kambayashi M., Hashimoto K. Molecular mechanisms for corticotropin-releasing hormone gene repression by glucocorticoid in BE(2)C neuronal cell line. Mol. Cell. Endocrinol. 2007, 264:142-148. 10.1016/j.mce.2006.11.001.
206. Yehuda R., Boisoneau D., Mason J.W., Giller E.L. Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders. Biol. Psychiatry 1993, 34:18-25.
207. Young E.A., Abelson J., Lightman S.L. Cortisol pulsatility and its role in stress regulation and health. Front. Neuroendocrinol. 2004, 25:69-76. 10.1016/j.yfrne.2004.07.001.
208. Zanchi N.E., Filho M.A.D.S., Felitti V., Nicastro H., Lorenzeti F.M., Lancha A.H. Glucocorticoids: extensive physiological actions modulated through multiple mechanisms of gene regulation. J. Cell. Physiol. 2010, 224:311-315. 10.1002/jcp.22141.
209. Zhang T.Y., Chrétien P., Meaney M.J., Gratton A. Influence of naturally occurring variations in maternal care on prepulse inhibition of acoustic startle and the medial prefrontal cortical dopamine response to stress in adult rats. J. Neurosci. 2005, 25:1493-1502. 10.1523/JNEUROSCI.3293-04.2005.
210. Zhang A., Neumeyer J.L., Baldessarini R.J. Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders. Chem. Rev. 2007, 107:274-302. 10.1021/cr050263h.
211. Zhang Y., Sheng H., Qi J., Ma B., Sun J., Li S., Ni X. Glucocorticoid acts on a putative G protein-coupled receptor to rapidly regulate the activity of NMDA receptors in hippocampal neurons. Am. J. Physiol. Endocrinol. Metab. 2012, 302:E747-E758. 10.1152/ajpendo.00302.2011.
212. Zhang T.Y., Labonté B., Wen X.L., Turecki G., Meaney M.J. Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans. Neuropsychopharmacology 2013, 38:111-123. 10.1038/npp.2012.149.
213. Zobel A., Jessen F., von Widdern O., Schuhmacher A., Höfels S., Metten M., Rietschel M., Scheef L., Block W., Becker T., Schild H.H., Maier W., Schwab S.G. Unipolar depression and hippocampal volume: impact of DNA sequence variants of the glucocorticoid receptor gene. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2008, 147B:836-843. 10.1002/ajmg.b.30709.