Abnormal glucocorticoid receptor mRNA and protein isoform expression in the prefrontal cortex in psychiatric illness

Neuropsychopharmacology

Volumn 36, Issue 13, 2011, Pages 2698-2709

  Sinclair, Duncan ^a,b   Tsai, Shan Yuan ^a,b   Woon, Heng Giap ^a,b   Weickert, Cynthia Shannon ^a,b  

^a SCHIZOPHRENIA RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

bipolar; glucocorticoid; schizophrenia; stress; suicide

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ALPHA; ISOPROTEIN; MESSENGER RNA; MINERALOCORTICOID RECEPTOR;

ADULT; AGED; ARTICLE; BIPOLAR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MENTAL DISEASE; PREDICTIVE VALUE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ADOLESCENT; ADULT; AGED; BIPOLAR DISORDER; COHORT STUDIES; DOWN-REGULATION; FEMALE; HUMANS; MALE; MIDDLE AGED; PREFRONTAL CORTEX; PROTEIN ISOFORMS; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; RNA, MESSENGER; SCHIZOPHRENIA; YOUNG ADULT;

EID: 80855123705     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.160     Document Type: Article

References (54)

1. Agid O, Shapira B, Zislin J, Ritsner M, Hanin B, Murad H et al (1999). Environment and vulnerability to major psychiatric illness: A case control study of early parental loss in major depression, bipolar disorder and schizophrenia. Mol Psychiatry 4: 163-172. (Pubitemid 29163979)
2. Arabadzisz D, Diaz-Heijtz R, Knuesel I, Weber E, Pilloud S, Dettling AC et al (2010). Primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression. Biol Psychiatry 67: 1106-1109.
3. Arseneault L, Cannon M, Fisher HL, Polanczyk G, Moffitt TE, Caspi A (2011). Childhood trauma and children's emerging psychotic symptoms: A genetically sensitive longitudinal cohort study. Am J Psychiatry 168: 65-72.
4. Bamberger CM, Bamberger AM, de Castro M, Chrousos GP (1995). Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 95: 2435-2441.
5. Bradley AJ, Dinan TG (2010). A systematic review of hypotha-lamic- pituitary-adrenal axis function in schizophrenia: implications for mortality. J Psychopharmacol 24: 91-118.
6. Brown AS, Begg MD, Gravenstein S, Schaefer CA, Wyatt RJ, Bresnahan M et al (2004). Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry 61: 774-780. (Pubitemid 39031117)
7. Brown AS, Schaefer CA, Quesenberry Jr CP., Liu L, Babulas VP, Susser ES (2005). Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry 162: 767-773. (Pubitemid 40489141)
8. Cannon M, Jones PB, Murray RM (2002). Obstetric complications and schizophrenia: Historical and meta-analytic review. Am J Psychiatry 159: 1080-1092. (Pubitemid 34743246)
9. Corcoran C, Walker E, Huot R, Mittal V, Tessner K, Kestler L et al (2003). The stress cascade and schizophrenia: etiology and onset. Schizophr Bull 29: 671-692. (Pubitemid 38181949)
10. Day R, Nielsen JA, Korten A, Ernberg G, Dube KC, Gebhart J et al (1987). Stressful life events preceding the acute onset of schizophrenia: a cross-national study from the World Health Organization. Cult Med Psychiatry 11: 123-205.
11. DeRijk RH, Schaaf M, Stam FJ, De Jong IEM, Swaab DF, Ravid R et al (2003). Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry. Mol Brain Res 116: 17-26. (Pubitemid 36993693)
12. Diorio D, Viau V, Meaney MJ (1993). The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress. J Neurosci 13: 3839-3847. (Pubitemid 23264368)
13. Fisher HL, Jones PB, Fearon P, Craig TK, Dazzan P, Morgan K et al (2010). The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder. Psychol Med 40: 1967-1978.
14. Fowles DC (1992). Schizophrenia: diathesis-stress revisited. Annu Rev Psychol 43: 303-336.
15. Gallagher P, Watson S, Smith MS, Young AH, Ferrier IN (2007). Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder. Schizophr Res 90: 258-265. (Pubitemid 46177576)
16. Jansen LMC, Gispen-de Wied CC, Kahn RS (2000). Selective impairments in the stress response in schizophrenic patients. Psychopharmacology 149: 319-325. (Pubitemid 30262347)
17. Khashan AS, Abel KM, McNamee R, Pedersen MG, Webb RT, Baker PN et al (2008). Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. Arch Gen Psychiatry 65: 146-152. (Pubitemid 351214313)
18. Knable MB, Barci BM, Webster MJ, Meador-Woodruff J, Torrey EF (2004). Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Mol Psychiatry 9: 609-620 , 544. (Pubitemid 38850430)
19. Knable MB, Torrey EF, Webster MJ, Bartko JJ (2001). Multivariate analysis of prefrontal cortical data from the Stanley Foundation Neuropathology Consortium. Brain Res Bull 55: 651-659. (Pubitemid 32888384)
20. Lammers CH, Garcia-Borreguero D, Schmider J, Gotthardt U, Dettling M, Holsboer F et al (1995). Combined dexamethasone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II. Biol Psychiatry 38: 803-807. (Pubitemid 3020007)
21. Lewis DA, Gonzalez-Burgos G (2008). Neuroplasticity of neo-cortical circuits in schizophrenia. Neuropsychopharmacology 33: 141-165.
22. Lu NZ, Cidlowski JA (2005). Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell 18: 331-342. (Pubitemid 41350538)
23. Maniam J, Morris MJ (2010). Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment. Psychoneuroendocrinology 35: 717-728.
24. Marcelis M, Cavalier E, Gielen J, Delespaul P, van Os J (2004). Abnormal response to metabolic stress in schizophrenia: Marker of vulnerability or acquired sensitization? Psychol Med 34: 1103-1111. (Pubitemid 39199979)
25. Meaney MJ, Diorio J, Francis D, Widdowson J, LaPlante P, Caldji C et al (1996). Early environmental regulation of forebrain glucocorticoid receptor gene expression: Implications for adrenocortical responses to stress. Dev Neurosci 18: 49-72. (Pubitemid 26257908)
26. Meltzer HY, Lee MA, Jayathilake K (2001). The blunted plasma cortisol response to apomorphine and its relationship to treatment response in patients with schizophrenia. Neuro-psychopharmacology 24: 278-290. (Pubitemid 32144813)
27. Mizoguchi K, Ishige A, Aburada M, Tabira T (2003). Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus. Neuroscience 119: 887-897. (Pubitemid 36694813)
28. Moalli PA, Pillay S, Krett NL, Rosen ST (1993). Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorti-coid-resistant human multiple myeloma cells. Cancer Res 53: 3877-3879. (Pubitemid 23267681)
29. Mortensen PB, Pedersen CB, Melbye M, Mors O, Ewald H (2003). Individual and familial risk factors for bipolar affective disorders in Denmark. Arch Gen Psychiatry 60: 1209-1215. (Pubitemid 37494074)
30. Muck-Seler D, Pivac N, Jakovljevic M, Brzovic Z (1999). Platelet serotonin, plasma cortisol, and dexamethasone suppression test in schizophrenic patients. Biol Psychiatry 45: 1433-1439. (Pubitemid 29457555)
31. Patel PD, Katz M, Karssen AM, Lyons DM (2008). Stress-induced changes in corticosteroid receptor expression in primate hippocampus and prefrontal cortex. Psychoneuroendocrinology 33: 360-367.
32. Perlman WR, Webster MJ, Kleinman JE, Weickert CS (2004). Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness. Biol Psychiatry 56: 844-852. (Pubitemid 39575458)
33. Plocka-Lewandowska M, Araszkiewicz A, Rybakowski JK (2001). Dexamethasone suppression test and suicide attempts in schizophrenic patients. Eur Psychiatry 16: 428-431. (Pubitemid 33101279)
34. Poulton R, Caspi A, Moffitt TE, Cannon M, Murray R, Harrington H (2000). Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch Gen Psychiatry 57: 1053-1058.
35. Pujols L, Mullol J, Roca-Ferrer J, Torrego A, Xaubet A, Cidlowski JA et al (2002). Expression of glucocorticoid receptor alpha-and beta-isoforms in human cells and tissues. Am J Physiol Cell Physiol 283: C1324-C1331.
36. Read J, van Os J, Morrison AP, Ross CA (2005). Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand 112: 330-350. (Pubitemid 41564319)
37. Rivers C, Levy A, Hancock J, Lightman S, Norman M (1999). Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing. J Clin Endocrinol Metab 84: 4283-4286. (Pubitemid 30644231)
38. Sapolsky RM, Krey LC, McEwen BS (1984). Stress down-regulates corticosterone receptors in a site-specific manner in the brain. Endocrinology 114: 287-292. (Pubitemid 14221903)
39. Schreier A, Wolke D, Thomas K, Horwood J, Hollis C, Gunnell D et al (2009). Prospective study of peer victimization in childhood and psychotic symptoms in a nonclinical population at age 12 years. Arch Gen Psychiatry 66: 527-536.
40. Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM et al (2011). Identification of a biological signature for schizophrenia in serum. Mol Psychiatry; e-pub ahead of print 12 April 2011.
41. Sinclair D, Webster MJ, Wong J, Weickert CS (2011). Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development. Mol Psychiatry 16: 504-515.
42. St Clair D, Xu M, Wang P, Yu Y, Fang Y, Zhang F et al (2005). Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. J Am Med Assoc 294: 557-562. (Pubitemid 41126897)
43. Susser E, Neugebauer R, Hoek HW, Brown AS, Lin S, Labovitz D et al (1996). Schizophrenia after prenatal famine further evidence. Arch Gen Psychiatry 53: 25-31.
44. Susser ES, Lin SP (1992). Schizophrenia after prenatal exposure to the Dutch hunger winter of 1944-1945. Arch Gen Psychiatry 49: 983-988.
45. Van Os J, Selten JP (1998). Prenatal exposure to maternal stress and subsequent schizophrenia. The May 1940 invasion of The Netherlands. Br J Psychiatry 172: 324-326. (Pubitemid 28183858)
46. van Venrooij JA, Fluitman SB, Lijmer JG, Kavelaars A, Heijnen CJ, Westenberg HG et al (2010). Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis. Schizophr Bull; e-pub ahead of print 17 June 2010.
47. Venkatasubramanian G, Chittiprol S, Neelakantachar N, Shetty T, Gangadhar BN (2010). Effect of antipsychotic treatment on insulin-like growth factor-1 and cortisol in schizophrenia: a longitudinal study. Schizophr Res 119: 131-137.
48. Walker EF, Diforio D (1997). Schizophrenia: a neural diathesis-stress model. Psychol Rev 104: 667-685. (Pubitemid 127499376)
49. Watson S, Gallagher P, Ritchie JC, Ferrier IN, Young AH (2004). Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder. Br J Psychiatry 184: 496-502. (Pubitemid 38725709)
50. Webster MJ, Knable MB, O'Grady J, Orthmann J, Weickert CS (2002). Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Mol Psychiatry 7: 985-994. (Pubitemid 35333054)
51. Weickert CS, Sheedy D, Rothmond DA, Dedova I, Fung S, Garrick T et al (2010). Selection of reference gene expression in a schizophrenia brain cohort. Aust N Z J Psychiatry 44: 59-70.
52. Xing GQ, Russell S, Webster MJ, Post RM (2004). Decreased expression of mineralocorticoid receptor mRNA in the pre-frontal cortex in schizophrenia and bipolar disorder. Int J Neuropsychopharmacol 7: 143-153. (Pubitemid 38823281)
53. Yazici K, Yazici AE, Taneli B (2002). Different neuroendocrine profiles of remitted and nonremitted schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry 26: 579-584. (Pubitemid 34252954)
54. Yung AR, Yuen HP, McGorry PD, Phillips LJ, Kelly D, Dell'Olio M et al (2005). Mapping the onset of psychosis: the comprehensive assessment of at-risk mental states. Aust N Z J Psychiatry 39: 964-971. (Pubitemid 43904432)