Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting

Endocrinology

Volumn 150, Issue 1, 2009, Pages 153-160

  Stengel, Andreas ^a   Goebel, Miriam ^a   Million, Mulugeta ^a   Stenzel Poore, Mary P ^b   Kobelt, Peter ^c   Mönnikes, Hubert ^d   Taché, Yvette ^a   Wang, Lixin ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d Martin Luther Hospital   (Germany)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; CORTICOTROPIN RELEASING FACTOR; GHRELIN; PROTEIN FOS;

ADAPTIVE BEHAVIOR; ANIMAL EXPERIMENT; ARCUATE NUCLEUS; ARTICLE; CELL ACTIVATION; CELL COUNT; CONTROLLED STUDY; DIET RESTRICTION; FEEDING BEHAVIOR; FOOD DEPRIVATION; FOOD INTAKE; HORMONE BLOOD LEVEL; HORMONE SYNTHESIS; HYPERPHAGIA; IMMUNOCOMPETENT CELL; LOW CALORY DIET; MALE; MOTONEURON NUCLEUS; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH EMPTYING; THALAMUS NUCLEUS; VAGUS NERVE; WILD TYPE;

ANIMALS; ARCUATE NUCLEUS; CHOLECYSTOKININ; CORTICOTROPIN-RELEASING HORMONE; EATING; ENERGY INTAKE; FASTING; GASTRIC EMPTYING; GENE EXPRESSION REGULATION; GENES, FOS; GHRELIN; HYPERPHAGIA; HYPOTHALAMUS, MIDDLE; MICE; NEURONS; NOOTROPIC AGENTS; SINCALIDE;

EID: 58149475674     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0723     Document Type: Article

References (61)

1. Bale TL, Vale WW 2004 CRF and CRF receptors: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol 44:525-557
2. Tache Y, Bonaz B 2007 Corticotropin-releasing factor receptors and stressrelated alterations of gut motor function. J Clin Invest 117:33-40
3. Heinrichs SC, Koob GF 2004 Cor tic otropin- releasing factor in brain: a role in activation, arousal, and affect regulation. J Pharmacol Exp Ther 311:427-440
4. Zorrilla EP, Taché Y, Koob GF 2003 Nibbling at CRF receptor control of feeding and gastrocolonic motility. Trends Pharmacol Sci 24:421-427
5. Richard D, Lin Q, Timofeeva E 2002 The corticotropin-releasing factor family of peptides and CRF receptors: their roles in the regulation of energy balance. Eur J Pharmacol 440:189-197
6. Miragaya JR, Harris RB 2008 Antagonism of corticotrophin-releasing factor receptors in the fourth ventricle modifies responses to mild but not restraint stress. Am J Physiol Regul lntegr Comp Physiol 295:R404-R416
7. Mastorakos G, Zapanti E 2004 The hypothalamic-pituitary-adrenal axis in the neuroendocrine regulation of food intake and obesity: the role of corticotropin releasing hormone. Nutr Neurosci 7:271-280
8. Menzaghi F, Heinrichs SC, Pich EM, Tilders FJ, Koob GF 1993 Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y. Brain Res 618:76-82
9. Heinrichs SC, Menzaghi F, Pich EM, Hauger RL, Koob GF 1993 Corticotropin-releasing factor in the para ventricular nucleus modulates feeding induced by neuropeptide Y. Brain Res 611:18-24
10. Stenzel-Poore MP, Cameron VA, Vaughan J, Sawchenko PE, Vale W 1992 Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice. Endocrinology 130:3378-3386
11. Coste SC, Murray SE, Stenzel-Poore MP 2001 Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress. Peptides 22:733-741
12. Stenzel-Poore MP, Heinrichs SC, Rivest S, Koob GF, Vale WW 1994 Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. J Neurosci 14:2579-2584
13. van Gaalen MM, Stenzel-Poore MP, Holsboer F, Steckler T 2002 Effects of transgenic overproduction of CRH on anxiety-like behaviour. Eur J Neurosci 15:2007-2015
14. Million M, Wang L, Stenzel-Poore MP, Coste SC, Yuan PQ, Lamy C, Rivier J, Buffington T, Taché Y 2007 Enhanced pelvic responses to stressors in female CRF-overexpressing mice. Am J Physiol Regul lntegr Comp Physiol 292: R1429-R1438
15. Dirks A, Groenink L, Bouwknecht JA, Hijzen TH, Van Der GJ, Ronken E, Verbeek JS, Veening JG, Dederen PJ, Korosi A, Sclioolderman LF, Roubos EW, Olivier B 2002 Overexpression of corticotropin-releasing hormone in transgenic mice and chronic stress-like autonomic and physiological alterations. Eur J Neurosci 16:1751-1760
16. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG 2000 Central nervous system control of food intake. Nature 404:661-671
17. Schwartz MW, Dallman MF, Woods SC 1995 Hypothalamic response to starvation: implications for the study of wasting disorders. Am J Physiol 269: R949-R957
18. Swanson LW, Kuypers HG 1980 The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. J Comp Neurol 194:555-570
19. Wang L, Martinez V, Barrachina MD, Taché Y 1998 Fos expression in the brain induced by peripheral injection of CCK or leptin plus CCK in fasted lean mice. Brain Res 791:157-166
20. Mizuno TM, Makimura H, Silverstein J, Roberts JL, Lopingco T, Mobbs CV 1999 Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin. Endocrinology 140:4551-4557
21. Morikawa Y, Ueyama E, Senba E 2004 Fasting-induced activation of mitogenactivated protein kinases (ERK/p38) in the mouse hypothalamus. J Neuroendocrinol 16:105-112
22. Schwartz MW, Erickson JC, Baskin DG, Palmiter RD 1998 Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. Endocrinology 139:2629-2635
23. Wang L, Saint-Pierre DH, Taché Y 2002 Peripheral ghrelin selectively increases Fos expression in neuropeptide Y-synthesizing neurons in mouse hypothalamic arcuate nucleus. Neurosci Lett 325:47-51
24. Taché Y, Yang H, Miampamba M, Martinez V, Yuan PQ 2006 Role of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feeding. Auton Neurosci 125:42-52
25. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
26. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Sliimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K 2001 Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 86:4753-4758
27. Smith GP, Gibbs J 1994 Satiating effect of cholecystokinin. Ann NY Acad Sci 713:236-241
28. Cuomo R, Samelli G 2004 Food intake and gastrointestinal motility. A complex interplay. Nutr Metab Cardiovasc Dis 14:173-179
29. Dallman MF 1993 Stress update Adaptation of the hypothalamic-pituitaryadrenal axis to chronic stress. Trends Endocrinol Metab 4:62-69
30. Barrachina MD, Martinez V, Wang L, Wei JY, Taché Y 1997 Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 94:10455-10460
31. Luckey A, Wang L, Jamieson PM, Basa NR, Million M, Czimmer J, Vale W, Taché Y 2003 Corticotropin-releasing factor receptor 1-deficient mice do not develop postoperative gastric ileus. Gastrcenterology 125:654-659
32. Franklin KBJ, Paxinos G 1997The mouse brain in stereotaxic coordinates. San Diego: Academic Press, Inc.
33. Dallman MF, Strack AM, Akana SF, Bradbury MJ, Hanson ES, Scribner KA, Smith M 1993 Feast and famine: critical role of glueocorticoids with insulin in daily energy flow. Front Neuroendocrinol 14:303-347
34. Singru PS, Sanchez E, Fekete C, Lechan RM 2007 Importance of melanocortin signaling in refeed ing-induced neuronal activation and satiety. Endocrinology 148:638-646
35. Becskei C, Lutz TA, Riediger T 2008 Glucose reverses fasting-induced activation in the arcuate nucleus of mice. Neuroreport 19:105-109
36. Hewson AK, Tung LY, Connell DW, Tookman L, Dickson SL 2002 The rat arcuate nucleus integrates peripheral signals provided by leptin, insulin, and a ghrelin mimetic. Diabetes 51:3412-3419
37. Hewson AK, Dickson SL 2000 Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats. J Neuroendocrinol 12:1047-1049
38. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M 2001 Ghrelin is an appetitestimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120:337-345
39. Riediger T, Traebert M, Schmid HA, Scheel C, Lutz TA, Scharrer E 2003 Site-specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus. Neurosci Lett 341:151-155
40. Sun Y, Wang P, Zheng H, Smith RG 2004 Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci USA 101:4679-4684
41. Camina JP, Carreira MC, El Messari S, Llorens-Cortes C, Smith RG, Casanueva FF 2004Desensitizationand endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor la. Endocrinology 145:930-940
42. Becskei C, Bilik KU, Klussmann S, Jarosch F, Lutz TA, Riediger T 2008 The anti-ghrelin Spiegelmer NOX-B11-3 blocks ghrelin - but not fasting-induced neuronal activation in the hypothalamic arcuate nucleus. J Neuroendocrinol 20:85-92
43. Otto B, Tschop M, Heldwein W, Pfeiffer AF, Diederich S 2004 Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans. Eur J Endocrinol 151:113-117
44. Sun Y, Ahmed S, Smith RG 2003 Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 23:7973-7981
45. Dallman MF, Akana SF, Bhatnagar S, Bell ME, Choi S, Chu A, Horsley C, Levin N, Meijer O, Soriano LR, Strack AM, Viau V 1999 Starvation: early signals, sensors, and sequelae. Endocrinology 140:4015-4023
46. Kaneda T, Makino S, Nishiyama M, Asaba K, Hashimoto K 2001 Differential neuropeptide responses to starvation with ageing. J Neuroendocrinol 13:1066-1075
47. Heinrichs SC, Min H, Tamraz S, Carmouche M, Boehme SA, Vale WW 1997 Anti-sexual and anxiogenic behavioral consequences of corticotropin- releasing factor overexpression are centrally mediated. Psychoneuroendocrinology 22:215-224
48. Groenink L, Dirks A, Verdouw PM, Schipholt M, Veening JG, Van Der GJ, Olivier B 2002 HPA axis dysregulation in mice overexpressing corticotropin releasing hormone. Biol Psychiatry 51:875-881
49. Nieuwenhuizen AG, Rutters F 2008 The hypothalamic-pituitary- adrenal-axis in the regulation of energy balance. Physiol Behav 94:169-177
50. Warwick BP, Romsos DR 1988 Energy balance in adrenalectomized ob/ob mice: effects of dietary starch and glucose. Am J Physiol 255:R141-R148
51. Asensio C, Muzzin P, Rohner-Jeanrenaud F 2004 Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance, Int J Obes Relat Metab Disord 28(Suppl 4):S45-S52
52. Valassi E, Scacchi M, Cavagnini F 2008 Neuroendocrine control of food intake. Nutr Metab Cardiovasc Dis 18:158-168
53. Berthoud HR, Carlson NR, Powley TL 1991 Topography of efferent vagal innervation of the rat gastrointestinal tract. Am J Physiol 260:R200-R207
54. Cruz MT, Murphy EC, Sahibzada N, Verbalis JG, Gillis RA 2007 A reevaluation of the effects of stimulation of the dorsal motor nucleus of the vagus on gastric motility in the rat. Am J Physiol Regul lntegr Comp Physiol 292:R291-R307
55. Bonaz B, Taché Y 1994 Induction of Fos immunoreactivity in the rat brain after cold-restraint induced gastric lesions and fecal excretion. Brain Res 652:56-64
56. Martinez V, Wang L, Tache Y 2001 Central TRH receptor 1 antisense blocks cold-induced gastric emptying but not brain c-Fos induction. Peptides 22:81-90
57. Ochi M, Tominaga K, Tanaka F, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T 2008 Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats. Life Sci 82: 862-868
58. Ahren B, Mansson S, Gingerich RL, Havel PJ 1997 Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting. Am J Physiol 273:R113-R120
59. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Morgan PJ, Trayhurn P 1996 Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol 8:733-735
60. Fekete C, Singru PS, Sanchez E, Sarkar S, Christoffolete MA, Riberio RS, Rand WM, Emerson CH, Bianco AC, Lechan RM 2006 Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamicpituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology 147:520-529
61. TachéY 2002 The parasympathetic nervous system in the pathophysiology of the gastrointestinal tract. In: Bolis CL, Licinio J, eds. Handbook of autonomic nervous system in health and diseases. New York: Marcel Dekker, Inc.; 463-503