Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: High IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder

Translational Psychiatry

Volumn 2, Issue , 2012, Pages

  Frodl, T ^a   Carballedo, A ^a   Hughes, M M ^b,c   Saleh, K ^a   Fagan, A ^d   Skokauskas, N ^c   McLoughlin, D M ^c   Meaney, J ^d   O'Keane, V ^a   Connor, T J ^b  

^a ADELAIDE AND MEATH HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c TRINITY COLLEGE DUBLIN   (Ireland)

^d ST JAMES S HOSPITAL   (Ireland)

Author keywords

Childhood maltreatment; Gene expression; Glucocorticoid; Inflammation; Major depressive disorder; Neuroimaging

Indexed keywords

C REACTIVE PROTEIN; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 6; MESSENGER RNA; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; IMMEDIATE EARLY PROTEIN; PROTEIN SERINE THREONINE KINASE; SERUM GLUCOCORTICOID REGULATED KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; TRANSCRIPTION FACTOR; TSC22D3 PROTEIN, HUMAN;

ADULT; ARTICLE; BRAIN SIZE; CHILD ABUSE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GILZ GENE; HIPPOCAMPUS; HUMAN; MAJOR DEPRESSION; MALE; AMYGDALOID NUCLEUS; BLOOD; CHILD; GENETICS; HEMISPHERIC DOMINANCE; METABOLISM; MIDDLE AGED; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; REFERENCE VALUE; STATISTICS;

ADULT; AMYGDALA; C-REACTIVE PROTEIN; CHILD; CHILD ABUSE; DEPRESSIVE DISORDER, MAJOR; DOMINANCE, CEREBRAL; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERLEUKIN-6; MALE; MIDDLE AGED; ORGAN SIZE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, GLUCOCORTICOID; REFERENCE VALUES; RNA, MESSENGER; STATISTICS AS TOPIC; TRANSCRIPTION FACTORS;

EID: 84858031349     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2012.14     Document Type: Article

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