Loss of glucocorticoid receptor function in the pituitary results in early postnatal lethality

Endocrinology

Volumn 149, Issue 7, 2008, Pages 3446-3451

  Erdmann, Gitta ^a   Schütz, Günther ^a   Berger, Stefan ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; PROTEIN KINASE (CALCIUM,CALMODULIN) II;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; HETEROZYGOSITY; HISTOPATHOLOGY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROENDOCRINE SYSTEM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CORTICOSTERONE; GLUCOCORTICOIDS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTEGRASES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PITUITARY GLAND; PITUITARY-ADRENAL SYSTEM; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID;

EID: 45549089720     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1786     Document Type: Article

References (25)

1. De Kloet ER, Vreugdenhil E, Oitzl MS, Joels M 1998 Brain corticosteroid receptor balance in health and disease. Endocr Rev 19:269-301
2. McEwen BS, Sapolsky RM 1995 Stress and cognitive function. Curr Opin Neurobiol 5:205-216
3. Herbert J, Goodyer IM, Grossman AB, Hastings MH, de Kloet ER, Lightman SL, Lupien SJ, Roozendaal B, Seckl JR 2006 Do corticosteroids damage the brain? J Neuroendocrinol 18:393-411
4. Herman JP, Figueiredo H, Mueller NK, Ulrich-Lai Y, Ostrander MM, Choi DC, Cullinan WE 2003 Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol 24:151-180
5. Jacobson L, Sapolsky R 1991 The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr Rev 12:118-134
6. Tronche F, Kellendonk C, Reichardt HM, Schutz G 1998 Genetic dissection of glucocorticoid receptor function in mice. Curr Opin Genet Dev 8:532-538
7. Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC, Bock R, Klein R, Schutz G 1999 Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23:99-103
8. Nagy A 2000 Cre recombinase: the universal reagent for genome tailoring. Genesis 26:99-109
9. Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K 1994 Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting. Science 265:103-106
10. Boyle MP, Brewer JA, Funatsu M, Wozniak DF, Tsien JZ, Izumi Y, Muglia LJ 2005 Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proc Natl Acad Sci USA 102:473-478
11. Boyle MP, Kolber BJ, Vogt SK, Wozniak DF, Muglia LJ 2006 Forebrain glucocorticoid receptors modulate anxiety-associated locomotor activation and adrenal responsiveness. J Neurosci 26:1971-1978
12. Casanova E, Fehsenfeld S, Mantamadiotis T, Lemberger T, Greiner E, Stewart AF, Schutz G 2001 A CamKIIα iCre BAC allows brain-specific gene inactivation. Genesis 31:37-42
13. Schaeren-Wiemers N, Gerfin-Moser A 1993 A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry 100:431-440
14. Minichiello L, Korte M, Wolfer D, Kuhn R, Unsicker K, Cestari V, Rossi-Arnaud C, Lipp HP, Bonhoeffer T, Klein R 1999 Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24:401-414
15. Tsien JZ, Chen DF, Gerber D, Tom C, Mercer EH, Anderson DJ, Mayford M, Kandel ER, Tonegawa S 1996 Subregion- and cell type-restricted gene knockout in mouse brain. Cell 87:1317-1326
16. Belz T, Liu HK, Bock D, Takacs A, Vogt M, Wintermantel T, Brandwein C, Gass P, Greiner E, Schutz G 2007 Inactivation of the gene for the nuclear receptor tailless in the brain preserving its function in the eye. Eur J Neurosci 26:2222-2227
17. Erdmann G, Schutz G, Berger S 2007 Inducible gene inactivation in neurons of the adult mouse forebrain. BMC Neurosci 8:63
18. Soriano P 1999 Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71
19. Reichardt HM, Schutz G 1996 Feedback control of glucocorticoid production is established during fetal development. Mol Med 2:735-744
20. Berger S, Wolfer DP, Selbach O, Alter H, Erdmann G, Reichardt HM, Chepkova AN, Welzl H, Haas HL, Lipp HP, Schutz G 2006 Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc Natl Acad Sci USA 103:195-200
21. Savage JJ, Yaden BC, Kiratipranon P, Rhodes SJ 2003 Transcriptional control during mammalian anterior pituitary development. Gene 319:1-19
22. Kawamura K, Kouki T, Kawahara G, Kikuyama S 2002 Hypophyseal development in vertebrates from amphibians to mammals. Gen Comp Endocrinol 126:130-135
23. Sloop KW, Parker GE, Rhodes SJ 2001 Transcriptional regulation in mammalian pituitary development and disease. Curr Genomics 2:379-397
24. Kovalovsky D, Refojo D, Liberman AC, Hochbaum D, Pereda MP, Coso OA, Stalla GK, Holsboer F, Arzt E 2002 Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways. Mol Endocrinol 16:1638-1651
25. Schmidt M, Enthoven L, van der Mark M, Levine S, de Kloet ER, Oitzl MS 2003 The postnatal development of the hypothalamic-pituitary-adrenal axis in the mouse. Int J Dev Neurosci 21:125-132