Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions

Nature Neuroscience

Volumn 16, Issue 1, 2013, Pages 33-41

  Klengel, Torsten ^a   Mehta, Divya ^a   Anacker, Christoph ^b   Rex Haffner, Monika ^a   Pruessner, Jens C ^c   Pariante, Carmine M ^b   Pace, Thaddeus W W ^d   Mercer, Kristina B ^e   Mayberg, Helen S ^d   Bradley, Bekh ^d,f   Nemeroff, Charles B ^g   Holsboer, Florian ^a   Heim, Christine M ^d,h   Ressler, Kerry J ^d,e,i   Rein, Theo ^a   Binder, Elisabeth B ^a,d  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c MCGILL UNIVERSITY   (Canada)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f ATLANTA VA MEDICAL CENTER   (United States)

^g UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^h CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

ⁱ EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STRESS HORMONE;

ADULT; ALLELE; ARTICLE; BRAIN REGION; CHILDHOOD INJURY; CHROMATIN; DNA METHYLATION; FEMALE; FK506 BINDING PROTEIN 5 GENE; GENE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; MAJOR CLINICAL STUDY; MALE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL;

ADULT; CELL LINE; CHILD; CHILD ABUSE; COHORT STUDIES; DEXAMETHASONE; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUCOCORTICOIDS; HEK293 CELLS; HIPPOCAMPUS; HUMANS; HYDROCORTISONE; INTRONS; LOGISTIC MODELS; MALE; MIDDLE AGED; MODELS, MOLECULAR; NEUROIMAGING; NEURONS; ORGANOPHOSPHATES; PEPTIDE ELONGATION FACTOR 1; POLYMORPHISM, SINGLE NUCLEOTIDE; SIGNAL TRANSDUCTION; STRESS DISORDERS, POST-TRAUMATIC; TACROLIMUS BINDING PROTEINS; TRANSFECTION; YOUNG ADULT;

EID: 84871717397     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3275     Document Type: Article

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