Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

Nature Genetics

Volumn 36, Issue 12, 2004, Pages 1319-1325

  Binder, Elisabeth B ^a   Salyakina, Daria ^a   Lichtner, Peter ^b   Wochnik, Gabriele M ^a   Ising, Marcus ^a   Pütz, Benno ^a   Papiol, Sergi ^c   Seaman, Shaun ^a   Lucae, Susanne ^a   Kohli, Martin A ^a   Nickel, Thomas ^a   Künzel, Heike E ^a   Fuchs, Brigitte ^a   Majer, Matthias ^a   Pfennig, Andrea ^a   Kern, Nikola ^a   Brunner, Jürgen ^a   Modell, Sieglinde ^a   Baghai, Thomas ^d   Deiml, Tobias ^d   Zill, Peter ^d   Bondy, Brigitta ^d   Rupprecht, Rainer ^d   Messer, Thomas ^e   Köhnlein, Oliver ^e   Dabitz, Heike ^f   Brückl, Tanja ^a   Müller, Nina ^a   Pfister, Hildegard ^a   Lieb, Roselind ^a   Mueller, Jakob C ^b   Lõhmussaar, Elin ^b   Strom, Tim M ^b   Bettecken, Thomas ^b   Meitinger, Thomas ^b   Uhr, Manfred ^a   Rein, Theo ^a   Holsboer, Florian ^a   Muller Myhsok, Bertram ^a   more..

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF BARCELONA   (Spain)

^d UNIVERSITY OF MUNICH   (Germany)

^e Bezirkskrankenhaus Augsburg   (Germany)

^f KLINIKUM INGOLSTADT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 90; MIRTAZAPINE; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC REGULATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT DISEASE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ANALYSIS OF VARIANCE; ANTIDEPRESSIVE AGENTS; BLOTTING, WESTERN; CORTICOTROPIN-RELEASING HORMONE; DEPRESSION; FLUORESCENCE; GENE FREQUENCY; GENOTYPE; GERMANY; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LYMPHOCYTES; NEUROPHYSINS; PITUITARY-ADRENAL SYSTEM; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN PRECURSORS; RECEPTORS, GLUCOCORTICOID; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VASOPRESSINS;

EID: 9644252785     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1479     Document Type: Article

References (30)

1. Holsboer, F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23, 477-501 (2000),
2. Nemeroff, C.B. & Owens, M.J. Treatment of mood disorders. Nat. Neurosci. 5, 1068-1070 (2002).
3. Holsboer, F. & Barden, N. Antidepressants and hypothalamic-pituitary- adrenocortical regulation. Endocr. Rev. 17, 187-205 (1996).
4. Nemeroff, C.B. The role of corticotropin-releasing factor in the pathogenesis of major depression. Pharmacopsychiatry 21, 76-82 (1988).
5. Nemeroff, C.B. et al. Elevated concentrations of CSF corticotropin- releasing factor-like immunoreactivity in depressed patients. Science 226, 1342-1344 (1984).
6. Nemeroff, C.B., Owens, M.J., Bissette, G., Andorn, A.C. & Stanley, M. Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch. Gen. Psychiatry 45, 577-579 (1988).
7. Purba, J.S., Hoogendijk, W.J., Hofman, M.A. & Swaab, D.F. Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depression. Arch. Gen. Psychiatry 53, 137-143 (1996).
8. Timpl, P. et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor. Nat. Genet. 19, 162-166 (1998).
9. Muller, M.B. et al. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat. Neurosci. 6, 1100-1107 (2003).
10. Pariante, C.M. & Miller, A.H. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 49, 391-404 (2001).
11. Barden, N., Stec, I.S., Montkowski, A., Holsboer, F. & Reul, J.M. Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor. Neuroendocrinology 66, 212-220 (1997).
12. Pratt, W.B. & Toft, D.O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 18, 306-360 (1997).
13. Cheung, J. & Smith, D.F. Molecular chaperone interactions with steroid receptors: an update. Mol. Endocrinol. 14, 939-946 (2000).
14. Schmidt, U. et al. Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor. J. Biol. Chem. 278, 4926-4931 (2003).
15. Freedman, M.L. et al. Assessing the impact of population stratification on genetic association studies. Nat. Genet 36, 388-393 (2004).
16. Schiene-Fischer, C. & Yu, C. Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases. FEBS Lett. 495, 1-6 (2001).
17. Davies, T.H., Ning, Y.M. & Sanchez, E.R. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J. Biol. Chem. 277, 4597-4600 (2002).
18. Denny, W.B., Valentine, D.L., Reynolds, P.D., Smith, D.F. & Scammell, J.G. Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding. Endocrinology 141, 4107-4113 (2000).
19. Reynolds, P.D. et al. Glucocorticoid-resistant B-lymphoblast cell line derived from the Bolivian squirrel monkey (Saimiri boliviensis boliviensis). Lab. Anim. Sci. 48, 364-370 (1998).
20. Scammell, J.G., Denny, W.B., Valentine, D.L. & Smith, D.F. Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates. Gen. Comp. Endocrinol. 124, 152-165 (2001).
21. Vermeer, H., Hendriks-Stegeman, B.I., van der Burg, B., van Buul-Offers, S.C. & Jansen, M. Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability. J. Clin. Endocrinol. Metab. 88, 277-284 (2003).
22. Heuser, I., Yassouridis, A. & Holsboer, F. The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J. Psychiatr. Res, 28, 341-356 (1994).
23. Wittchen, H. et al. Screening for mental disorders: performance of the Composite International Diagnostic - Screener (CID-S). Int. J. Methods Psychiatr. Res. 8, 59-70 (1999).
24. Zobel, A.W., Nickel, T., Sonntag, A., Uhr, M., Holsboer, F. & Ising, M. Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. A prospective study. J. Psychiatr. Res. 35, 83-94 (2001).
25. Fisher, R.A. Statistical Methods for Research Workers (Oliver and Boyd, London, 1932).
26. Dudbridge, F. & Koeleman, B.P. Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. Am. J. Hum. Genet. 75, 424-435 (2004).
27. Neale, B.M. & Sham, P.C. The future of association studies: gene-based analysis and replication. Am. J. Hum. Genet. 75, 353-362 (2004).
28. Devlin, B. & Roeder, K. Genomic control for association studies. Biometrics 55, 997-1004 (1999).
29. Lewontin, R.C. On measures of gametic disequilibrium. Genetics 120, 849-852 (1988).
30. Holsboer, F., Lauer, C.J., Schreiber, W. & Krieg, J.C. Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders. Neuroendocrinology, 62, 340-347 (1995).