Glucocorticoids

Best Practice and Research: Clinical Rheumatology

Volumn 25, Issue 6, 2011, Pages 891-900

  Spies, Cornelia M ^a   Strehl, Cindy ^a   Van Der Goes, Marlies C ^b   Bijlsma, Johannes W J ^b   Buttgereit, Frank ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

11 Beta hydroxysteroid dehydrogenases; Arthritis; Glucocorticoids; Inflammation

Indexed keywords

BOL 303242X; DIPYRIDAMOLE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HORMONE RECEPTOR AFFECTING AGENT; HORMONE RECEPTOR STIMULATING AGENT; MAPRACORAT; METFORMIN; NCB 13739; NITRIC OXIDE; OXIDOREDUCTASE INHIBITOR; PREDNISOLONE; PREDNISONE; UNCLASSIFIED DRUG; ZK 245186;

ANKLE EDEMA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONOTHERAPY; CONTACT ALLERGY; DRUG EFFECT; DRUG MECHANISM; GLAUCOMA; GLUCOSE BLOOD LEVEL; HUMAN; IMMUNOMODULATION; INFLAMMATION; IRRITANT DERMATITIS; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RISK BENEFIT ANALYSIS; SIDE EFFECT;

EID: 84855990974     PISSN: 15216942     EISSN: 15321770     Source Type: Journal    
DOI: 10.1016/j.berh.2011.11.002     Document Type: Review

References (102)

1. G. Bertsias, J.P. Ioannidis, J. Boletis, S. Bombardieri, R. Cervera, and C. Dostal EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics Annals of the Rheumatic Diseases 67 2008 Feb 195 205 (Pubitemid 351183308)
2. G. Hatemi, A. Silman, D. Bang, B. Bodaghi, A.M. Chamberlain, and A. Gul EULAR recommendations for the management of Behcet disease Annals of the Rheumatic Diseases 67 2008 Dec 1656 1662
3. C. Mukhtyar, L. Guillevin, M.C. Cid, B. Dasgupta, K. de Groot, and W. Gross EULAR recommendations for the management of large vessel vasculitis Annals of the Rheumatic Diseases 68 2009 Mar 318 323
4. C. Mukhtyar, L. Guillevin, M.C. Cid, B. Dasgupta, K. de Groot, and W. Gross EULAR recommendations for the management of primary small and medium vessel vasculitis Annals of the Rheumatic Diseases 68 2009 Mar 310 317
5. J.S. Smolen, R. Landewe, F.C. Breedveld, M. Dougados, P. Emery, and C. Gaujoux-Viala EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs Annals of the Rheumatic Diseases 69 2010 Jun 964 975
6. J. Braun, R. van den Berg, X. Baraliakos, H. Boehm, R. Burgos-Vargas, and E. Collantes-Estevez 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis Annals of the Rheumatic Diseases 70 2011 Jun 896 904
7. K.M. Jordan, N.K. Arden, M. Doherty, B. Bannwarth, J.W. Bijlsma, and P. Dieppe EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT) Annals of the Rheumatic Diseases 62 2003 Dec 1145 1155 (Pubitemid 37500619)
8. W. Zhang, M. Doherty, T. Bardin, E. Pascual, V. Barskova, and P. Conaghan EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT) Annals of the Rheumatic Diseases 65 2006 Oct 1312 1324 (Pubitemid 44620440)
9. W. Zhang, M. Doherty, E. Pascual, V. Barskova, P.A. Guerne, and T.L. Jansen EULAR recommendations for calcium pyrophosphate deposition. Part II: management Annals of the Rheumatic Diseases 70 2011 Apr 571 575
10. J.R. Curtis, A.O. Westfall, J. Allison, J.W. Bijlsma, A. Freeman, and V. George Population-based assessment of adverse events associated with long-term glucocorticoid use Arthritis & Rheumatism 55 2006 Jun 15 420 426 (Pubitemid 43887028)
11. J.A. Da Silva, J.W. Jacobs, J.R. Kirwan, M. Boers, K.G. Saag, and L.B. Ines Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data Annals of the Rheumatic Diseases 65 2006 Mar 285 293 (Pubitemid 43268214)
12. J.N. Hoes, J.W. Jacobs, S.M. Verstappen, J.W. Bijlsma, and G.J. Van der Heijden Adverse events of low- to medium-dose oral glucocorticoids in inflammatory diseases: a meta-analysis Annals of the Rheumatic Diseases 68 2009 Dec 1833 1838
13. D. Huscher, K. Thiele, E. Gromnica-Ihle, G. Hein, W. Demary, and R. Dreher Dose-related patterns of glucocorticoid-induced side effects Annals of the Rheumatic Diseases 68 2009 Jul 1119 1124
14. A.K. McDonough, J.R. Curtis, and K.G. Saag The epidemiology of glucocorticoid-associated adverse events Current Opinion in Rheumatology 20 2008 Mar 131 137 (Pubitemid 351339883)
15. F. Buttgereit, R.H. Straub, M. Wehling, and G.R. Burmester Glucocorticoids in the treatment of rheumatic diseases: an update on the mechanisms of action Arthritis & Rheumatism 50 2004 Nov 3408 3417 (Pubitemid 39488664)
16. F. Buttgereit, M. Wehling, and G.R. Burmester A new hypothesis of modular glucocorticoid actions: steroid treatment of rheumatic diseases revisited Arthritis & Rheumatism 41 1998 May 761 767
17. J.D. Croxtall, Q. Choudhury, and R.J. Flower Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism British Journal of Pharmacology 130 2000 May 289 298 (Pubitemid 30261038)
18. T. Rhen, and J.A. Cidlowski Antiinflammatory action of glucocorticoids-new mechanisms for old drugs New England Journal of Medicine 353 2005 Oct 20 1711 1723
19. C. Stahn, and F. Buttgereit Genomic and nongenomic effects of glucocorticoids Nature Clinical Practice Rheumatology 4 2008 Oct 525 533
20. A.E. Coutinho, and K.E. Chapman The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights Molecular and Cellular Endocrinology 335 2011 Mar 15 2 13
21. F. Buttgereit, G.R. Burmester, R.H. Straub, M.J. Seibel, and H. Zhou Exogenous and endogenous glucocorticoids in rheumatic diseases Arthritis & Rheumatism 63 2011 Jan 1 9
22. A.R. Clark Anti-inflammatory functions of glucocorticoid-induced genes Molecular and Cellular Endocrinology 275 2007 Sep 15 79 97 (Pubitemid 47259278)
23. E. Beaulieu, and E.F. Morand Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis Nature Reviews Rheumatology 7 2011 Jun 340 348
24. F. Buttgereit, G.R. Burmester, and B.J. Lipworth Optimised glucocorticoid therapy: the sharpening of an old spear Lancet 365 2005 Feb 26-Mar 4 801 803 (Pubitemid 40311369)
25. A.C. Cato, H. Schacke, W. Sterry, and K. Asadullah The glucocorticoid receptor as target for classic and novel anti-inflammatory therapy Current Drug Targets: Inflammation & Allergy 3 2004 Dec 347 353 (Pubitemid 39534771)
26. H. Schacke, W.D. Docke, and K. Asadullah Mechanisms involved in the side effects of glucocorticoids Pharmacology & Therapeutics 96 2002 Oct 23 43 (Pubitemid 35346616)
27. Schacke H, Hennekes H, Schottelius A, Jaroch S, Lehmann M, Schmees N, et al. SEGRAs: a novel class of anti-inflammatory compounds. Ernst Schering Res Found Workshop 2002:357-71.
28. H. Schacke, A. Schottelius, W.D. Docke, P. Strehlke, S. Jaroch, and N. Schmees Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects Proceedings of the National Academy of Sciences of the United States of America 101 2004 Jan 6 227 232 (Pubitemid 38084232)
29. H. Schacke, T.M. Zollner, W.D. Docke, H. Rehwinkel, S. Jaroch, and W. Skuballa Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases British Journal of Pharmacology 158 2009 Oct 1088 1103
30. A. Shafiee, C. Bucolo, E. Budzynski, K.W. Ward, and F.J. Lopez In vivo ocular efficacy profile of mapracorat, a novel selective glucocorticoid receptor agonist, in rabbit models of ocular disease Investigative Ophthalmology & Visual Science 52 2011 Mar 1422 1430
31. A. Kleiman, and J.P. Tuckermann Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice Molecular and Cellular Endocrinology 275 2007 Sep 15 98 108 (Pubitemid 47259279)
32. A. Rauch, V. Gossye, D. Bracke, E. Gevaert, P. Jacques, and K. Van Beneden An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation FASEB Journal 25 2011 Apr 1323 1332
33. E. Joanny, Q. Ding, L. Gong, P. Kong, J. Saklatvala, and A.R. Clark Anti-inflammatory effects of selective glucocorticoid receptor modulators (SGRMs) are partially dependent on upregulation of dual specificity phosphatase 1 (DUSP1) British Journal of Pharmacology 2011 Jun 30
34. A.W. Krug, L.H. Pojoga, G.H. Williams, and G.K. Adler Cell membrane-associated mineralocorticoid receptors? New evidence Hypertension 57 2011 Jun 1019 1025
35. A. Wendler, and M. Wehling Translational research on rapid steroid actions Steroids 75 2010 Aug-Sep 619 623
36. B. Bartholome, C.M. Spies, T. Gaber, S. Schuchmann, T. Berki, and D. Kunkel Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis FASEB Journal 18 2004 Jan 70 80 (Pubitemid 38076467)
37. M.W. Harr, Y. Rong, M.D. Bootman, H.L. Roderick, and C.W. Distelhorst Glucocorticoid-mediated inhibition of Lck modulates the pattern of T cell receptor-induced calcium signals by down-regulating inositol 1,4,5-trisphosphate receptors Journal of Biological Chemistry 284 2009 Nov 13 31860 31871
38. M. Lowenberg, C. Stahn, D.W. Hommes, and F. Buttgereit Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands Steroids 2007 Dec 14
39. M. Lowenberg, A.P. Verhaar, J. Bilderbeek, J. Marle, F. Buttgereit, and M.P. Peppelenbosch Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN EMBO Reports 7 2006 Oct 1023 1029 (Pubitemid 44480518)
40. A. Wanner, G. Horvath, J.L. Brieva, S.D. Kumar, and E.S. Mendes Nongenomic actions of glucocorticosteroids on the airway vasculature in asthma Proceedings of the American Thoracic Society 1 2004 235 238
41. J.M. van den Hoven, S.R. Van Tomme, J.M. Metselaar, B. Nuijen, J.H. Beijnen, and G. Storm Liposomal drug formulations in the treatment of rheumatoid arthritis Molecular Pharmaceutics 2011 Jun 17
42. J.M. Metselaar, W.B. van den Berg, A.E. Holthuysen, M.H. Wauben, G. Storm, and P.L. van Lent Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis Annals of the Rheumatic Diseases 63 2004 Apr 348 353 (Pubitemid 38453298)
43. J.M. Metselaar, M.H. Wauben, J.P. Wagenaar-Hilbers, O.C. Boerman, and G. Storm Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes Arthritis & Rheumatism 48 2003 Jul 2059 2066 (Pubitemid 36828702)
44. U. Rauchhaus, R.W. Kinne, D. Pohlers, S. Wiegand, A. Wolfert, and M. Gajda Targeted delivery of liposomal dexamethasone phosphate to the spleen provides a persistent therapeutic effect in rat antigen-induced arthritis Annals of the Rheumatic Diseases 68 2009 Dec 1933 1934
45. U. Rauchhaus, F.W. Schwaiger, and S. Panzner Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment Arthritis Research & Therapy 11 2009 R190
46. P. Barrera, A. Blom, P.L. van Lent, L. van Bloois, J.H. Beijnen, and N. van Rooijen Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis Arthritis & Rheumatism 43 2000 Sep 1951 1959
47. M.S. Oliveira, O.B.E. de, S. Zamuner, A.L. Pires, T.P. Ferreira, and R.S. Cordeiro Suppressive effects of nitric oxide-releasing prednisolone NCX-1015 on the allergic pleural eosinophil recruitment in rats Clinical & Experimental Allergy 38 2008 Nov 1830 1837
48. M.J. Paul-Clark, F. Roviezzo, R.J. Flower, G. Cirino, P.D. Soldato, and I.M. Adcock Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands Journal of Immunology 171 2003 Sep 15 3245 3252 (Pubitemid 37093551)
49. G.R. Zimmermann, W. Avery, A.L. Finelli, M. Farwell, C.C. Fraser, and A.A. Borisy Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination drug Arthritis Research & Therapy 11 2009 R12
50. F. Buttgereit, G. Doering, A. Schaeffler, S. Witte, S. Sierakowski, and E. Gromnica-Ihle Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): A double-blind, randomised controlled trial Lancet 371 2008 Jan 19 205 214
51. R. Alten, G. Doring, M. Cutolo, E. Gromnica-Ihle, S. Witte, and R. Straub Hypothalamus-pituitary-adrenal axis function in patients with rheumatoid arthritis treated with nighttime-release prednisone Journal of Rheumatology 37 2010 Oct 2025 2031
52. F. Buttgereit, G. Doering, A. Schaeffler, S. Witte, S. Sierakowski, and E. Gromnica-Ihle Targeting pathophysiological rhythms: prednisone chronotherapy shows sustained efficacy in rheumatoid arthritis Annals of the Rheumatic Diseases 69 2010 Jul 1275 1280
53. R.H. Straub, F.S. Dhabhar, J.W. Bijlsma, and M. Cutolo How psychological stress via hormones and nerve fibers may exacerbate rheumatoid arthritis Arthritis & Rheumatism 52 2005 Jan 16 26 (Pubitemid 40129228)
54. M.G. Frank, Z.D. Miguel, L.R. Watkins, and S.F. Maier Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide Brain, Behavior, and Immunity 24 2010 Jan 19 30
55. L.C. Loram, F.R. Taylor, K.A. Strand, M.G. Frank, P. Sholar, and J.A. Harrison Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation Brain, Behavior, and Immunity 2011 Apr 23
56. A.E. Barber, S.M. Coyle, M.A. Marano, E. Fischer, S.E. Calvano, and Y. Fong Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man Journal of Immunology 150 1993 Mar 1 1999 2006 (Pubitemid 23129678)
57. G.J. Wiegers, M.S. Labeur, I.E. Stec, W.E. Klinkert, F. Holsboer, and J.M. Reul Glucocorticoids accelerate anti-T cell receptor-induced T cell growth Journal of Immunology 155 1995 Aug 15 1893 1902
58. G.J. Wiegers, I.E. Stec, W.E. Klinkert, and J.M. Reul Glucocorticoids regulate TCR-induced elevation of CD4: functional implications Journal of Immunology 164 2000 Jun 15 6213 6220 (Pubitemid 30408800)
59. E. Broug-Holub, and G. Kraal Dose- and time-dependent activation of rat alveolar macrophages by glucocorticoids Clinical and Experimental Immunology 104 1996 May 332 336 (Pubitemid 26139780)
60. H.Y. Lim, N. Muller, M.J. Herold, J. van den Brandt, and H.M. Reichardt Glucocorticoids exert opposing effects on macrophage function dependent on their concentration Immunology 122 2007 Sep 47 53 (Pubitemid 47222594)
61. T. Calandra, J. Bernhagen, C.N. Metz, L.A. Spiegel, M. Bacher, and T. Donnelly MIF as a glucocorticoid-induced modulator of cytokine production Nature 377 1995 Sep 7 68 71
62. F. Gebauer, D. Ottendorfer, R. Kunze, and H.J. Maasch Influence of a co-stimulation of human leucocytes with an Escherichia coli preparation and fixed immunoglobulins on cytokine release in the presence of hydrocortisone Arzneimittelforschung 51 2001 Feb 180 187 (Pubitemid 32176252)
63. F.S. Dhabhar, A.H. Miller, B.S. McEwen, and R.L. Spencer Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms Journal of Immunology 154 1995 May 15 5511 5527
64. F.S. Dhabhar, and B.S. McEwen Enhancing versus suppressive effects of stress hormones on skin immune function Proceedings of the National Academy of Sciences of the United States of America 96 1999 Feb 2 1059 1064 (Pubitemid 29072183)
65. D. Franchimont Overview of the actions of glucocorticoids on the immune response: a good model to characterize new pathways of immunosuppression for new treatment strategies Annals of the New York Academy of Sciences 1024 2004 Jun 124 137 (Pubitemid 38879597)
66. G. Cox Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes Journal of Immunology 154 1995 May 1 4719 4725
67. W.C. Liles, D.C. Dale, and S.J. Klebanoff Glucocorticoids inhibit apoptosis of human neutrophils Blood 86 1995 Oct 15 3181 3188
68. H.J. Strausbaugh, and S.D. Rosen A potential role for annexin 1 as a physiologic mediator of glucocorticoid-induced L-selectin shedding from myeloid cells Journal of Immunology 166 2001 May 15 6294 6300 (Pubitemid 32440762)
69. L. Piemonti, P. Monti, P. Allavena, B.E. Leone, A. Caputo, and V. Di Carlo Glucocorticoids increase the endocytic activity of human dendritic cells International Immunology 11 1999 Sep 1519 1526 (Pubitemid 29425743)
70. N. Draper, and P.M. Stewart 11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action Journal of Endocrinological 186 2005 Aug 251 271 (Pubitemid 41167396)
71. P.M. Stewart, and Z.S. Krozowski 11 beta-Hydroxysteroid dehydrogenase Vitamins & Hormones 57 1999 249 324
72. M.S. Cooper, and P.M. Stewart 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation Journal of Clinical Endocrinology and Metabolism 94 2009 Dec 4645 4654
73. J.R. Seckl 11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action Current Opinion in Pharmacology 4 2004 Dec 597 602 (Pubitemid 40267874)
74. T.Q. Cai, B. Wong, S.S. Mundt, R. Thieringer, S.D. Wright, and A. Hermanowski-Vosatka Induction of 11beta-hydroxysteroid dehydrogenase type 1 but not -2 in human aortic smooth muscle cells by inflammatory stimuli Journal of Steroid Biochemistry and Molecular Biology 77 2001 May 117 122 (Pubitemid 32476819)
75. R.S. Hardy, A. Filer, M.S. Cooper, G. Parsonage, K. Raza, and D.L. Hardie Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation Arthritis Research & Therapy 8 2006 R108
76. R. Thieringer, C.B. Le Grand, L. Carbin, T.Q. Cai, B. Wong, and S.D. Wright 11 Beta-hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages Journal of Immunology 167 2001 Jul 1 30 35 (Pubitemid 32567757)
77. J.W. Tomlinson, J. Moore, M.S. Cooper, I. Bujalska, M. Shahmanesh, and C. Burt Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines Endocrinology 142 2001 May 1982 1989 (Pubitemid 32405956)
78. J.W. Tomlinson, E.A. Walker, I.J. Bujalska, N. Draper, G.G. Lavery, and M.S. Cooper 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response Endocrine Reviews 25 2004 Oct 831 866 (Pubitemid 39366049)
79. A.A. Tahrani, C.J. Bailey, S. Del Prato, and A.H. Barnett Management of type 2 diabetes: new and future developments in treatment Lancet 2011 Jun 24
80. P.M. Stewart, Z.S. Krozowski, A. Gupta, D.V. Milford, A.J. Howie, and M.C. Sheppard Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11 beta-hydroxysteroid dehydrogenase type 2 gene Lancet 347 1996 Jan 13 88 91 (Pubitemid 26017854)
81. L.L. Gathercole, and P.M. Stewart Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes Journal of Steroid Biochemistry and Molecular Biology 122 2010 Oct 21 27
82. J. Rosenstock, S. Banarer, V.A. Fonseca, S.E. Inzucchi, W. Sun, and W. Yao The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy Diabetes Care 33 2010 Jul 1516 1522
83. S.A. Morgan, and J.W. Tomlinson 11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes Expert Opinion on Investigational Drugs 19 2010 Sep 1067 1076
84. M. Wang Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 in antidiabetic therapy Handbook of Experimental Pharmacology 2011 127 146
85. M.S. Cooper, E.H. Rabbitt, P.E. Goddard, W.A. Bartlett, M. Hewison, and P.M. Stewart Osteoblastic 11beta-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure Journal of Bone and Mineral Research 17 2002 Jun 979 986 (Pubitemid 34535135)
86. T.C. Sandeep, J.L. Yau, A.M. MacLullich, J. Noble, I.J. Deary, and B.R. Walker 11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics Proceedings of the National Academy of Sciences of the United States of America 101 2004 Apr 27 6734 6739 (Pubitemid 38586043)
87. M.S. Cooper, I. Bujalska, E. Rabbitt, E.A. Walker, R. Bland, and M.C. Sheppard Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation Journal of Bone and Mineral Research 16 2001 Jun 1037 1044 (Pubitemid 32467147)
88. R. Hardy, E.H. Rabbitt, A. Filer, P. Emery, M. Hewison, and P.M. Stewart Local and systemic glucocorticoid metabolism in inflammatory arthritis Annals of the Rheumatic Diseases 67 2008 Sep 1204 1210
89. J.S. Gilmour, A.E. Coutinho, J.F. Cailhier, T.Y. Man, M. Clay, and G. Thomas Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes Journal of Immunology 176 2006 Jun 15 7605 7611 (Pubitemid 43853055)
90. N. Olsen, T. Sokka, C.L. Seehorn, B. Kraft, K. Maas, and J. Moore A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells Annals of the Rheumatic Diseases 63 2004 Nov 1387 1392 (Pubitemid 39433940)
91. C. Saldanha, G. Tougas, and E. Grace Evidence for anti-inflammatory effect of normal circulating plasma cortisol Clinical & Experimental Rheumatology 4 1986 Oct-Dec 365 366 (Pubitemid 17223176)
92. P. Ergang, P. Leden, K. Vagnerova, P. Klusonova, I. Miksik, and J. Jurcovicova Local metabolism of glucocorticoids and its role in rat adjuvant arthritis Molecular and Cellular Endocrinology 323 2010 Jul 29 155 160
93. F. Buttgereit, H. Zhou, R. Kalak, T. Gaber, C.M. Spies, and D. Huscher Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo Arthritis & Rheumatism 60 2009 Jul 1998 2007
94. E. Ferrer Emerging therapeutic strategies for chronic inflammatory diseases Drug News & Perspectives 19 2006 Jul-Aug 353 358 (Pubitemid 44409886)
95. T. Wilckens, and A. Volkmann Cortisol metabolism by 11 beta-hydroxysteroid dehydrogenase as a novel target in the treatment of inflammation- or immune-mediated bone loss: comment on the article by Makrygiannakis et al Arthritis & Rheumatism 56 2007 Jan 387 388 (Pubitemid 46106217)
96. J.K. Kim, S.M. Oh, H.S. Kwon, Y.S. Oh, S.S. Lim, and H.K. Shin Anti-inflammatory effect of roasted licorice extracts on lipopolysaccharide- induced inflammatory responses in murine macrophages Biochemical and Biophysical Research Communications 345 2006 Jul 7 1215 1223 (Pubitemid 44218790)
97. P. Ferrari The role of 11beta-hydroxysteroid dehydrogenase type 2 in human hypertension Biochimica et Biophysica Acta 1802 2010 Dec 1178 1187
98. K.R. Kim, C.K. Jeong, K.K. Park, J.H. Choi, J.H. Park, and S.S. Lim Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice Journal of Biomedicine and Biotechnology 2010 2010 709378
99. D.V. Kratschmar, A. Vuorinen, T. Da Cunha, G. Wolber, D. Classen-Houben, and O. Doblhoff Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11beta-hydroxysteroid dehydrogenase type 2 Journal of Steroid Biochemistry and Molecular Biology 125 2011 May 129 142
100. J.N. Hoes, J.W. Jacobs, M. Boers, D. Boumpas, F. Buttgereit, and N. Caeyers EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases Annals of the Rheumatic Diseases 66 2007 Dec 1560 1567 (Pubitemid 350205441)
101. M.C. Van der Goes, J.W. Jacobs, M. Boers, T. Andrews, M.A. Blom-Bakkers, and F. Buttgereit Patients' and rheumatologists' perspectives on glucocorticoids an exercise to improve the implementation of the EULAR recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases Annals of the Rheumatic Diseases 2009 Sep 17
102. M.C. van der Goes, J.W. Jacobs, M. Boers, T. Andrews, M.A. Blom-Bakkers, and F. Buttgereit Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice Annals of the Rheumatic Diseases 69 2010 Nov 1913 1919