Sexually dimorphic actions of glucocorticoids provide a link to inflammatory diseases with gender differences in prevalence

Science Signaling

Volumn 3, Issue 143, 2010, Pages

  Duma, Danielle ^a   Collins, Jennifer B ^a   Chou, Jeff W ^b   Cidlowski, John A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; ANTIINFLAMMATORY AGENT; LIPOPOLYSACCHARIDE; MESSENGER RNA; SEX HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; FEMALE; GENE CONTROL; GENE EXPRESSION; LIVER; MALE; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; RAT; SEPSIS; SEX DIFFERENCE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; ADRENALECTOMY; ANIMAL; APOPTOSIS; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; INFLAMMATION; METABOLISM; OVARIECTOMY; PATHOPHYSIOLOGY; PHYSIOLOGY; SEXUAL DEVELOPMENT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

MAMMALIA; RATTUS;

ADRENALECTOMY; ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; DEXAMETHASONE; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GLUCOCORTICOIDS; GONADAL STEROID HORMONES; INFLAMMATION; LIPOPOLYSACCHARIDES; LIVER; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARIECTOMY; PREVALENCE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 79952116875     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001077     Document Type: Article

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49. Acknowledgments: We thank J. Revollo for discussion and assistance with data analysis, R. Oakley for discussion and assistance with manuscript preparation, and D. Andrews and H. Harris for technical assistance. Funding: This research was supported by the Intramural Research Program of the NIH National Institute of Environmental Health Sciences. Author contributions: D.D. designed and performed the experiments, analyzed the data, and wrote the manuscript. J.B.C. and J.W.C. performed microarray analysis. J.A.C. designed the experiments, analyzed the data, and wrote the manuscript. Competing interests: The authors declare that they have no competing interests. Accession numbers: The microarray data have been deposited in the Gene Expression Omnibus Database (http://www.ncbi.nlm.nih.gov/geo) under accession numbers GSE13461, GSE24255, and GSE24256.