-
1
-
-
0024109575
-
The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response
-
Arriza, J.L., Simerly, R.B., Swanson, L.W. and Evans, R.M. (1988) The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response. Neuron 1; 887-900.
-
(1988)
Neuron
, vol.1
, pp. 887-900
-
-
Arriza, J.L.1
Simerly, R.B.2
Swanson, L.W.3
Evans, R.M.4
-
2
-
-
0028701846
-
In vitro studies of glucocorticoid effects on neurons and astrocytes
-
Bohn, M.C., O'Banion, M.K., Young, D.A., Giuliano, R., Hussain, S., Dean, D.O. and Cunningham, L.A. (1994) In vitro studies of glucocorticoid effects on neurons and astrocytes. Annl. N.Y. Acad. Sci. 746; 243-259.
-
(1994)
Annl. N.Y. Acad. Sci
, vol.746
, pp. 243-259
-
-
Bohn, M.C.1
O'Banion, M.K.2
Young, D.A.3
Giuliano, R.4
Hussain, S.5
Dean, D.O.6
Cunningham, L.A.7
-
3
-
-
33644867538
-
The proteasome: A utility tool for transcription
-
Collins, G.A. and Tansey, W.P. (2006) The proteasome: A utility tool for transcription? Curr. Opin. Genet. Dev. 16; 197-202.
-
(2006)
Curr. Opin. Genet. Dev
, vol.16
, pp. 197-202
-
-
Collins, G.A.1
Tansey, W.P.2
-
4
-
-
28844441619
-
Fast glucocorticoid actions on brain: Back to the future. Front
-
Dallman, M.F. (2005) Fast glucocorticoid actions on brain: back to the future. Front. Neuroendocrinol. 26; 103-108.
-
(2005)
Neuroendocrinol
, vol.26
, pp. 103-108
-
-
Dallman, M.F.1
-
5
-
-
0029060051
-
The nuclear pore complex
-
Davis, L.I. (1995) The nuclear pore complex. Annu. Rev. Biochem. 64; 865-896.
-
(1995)
Annu. Rev. Biochem
, vol.64
, pp. 865-896
-
-
Davis, L.I.1
-
6
-
-
20044395965
-
Stress and the brain: From adaptation to disease
-
de Kloet, E.R., Joels, M. and Holsboer, F. (2005) Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 6; 463-475.
-
(2005)
Nat. Rev. Neurosci
, vol.6
, pp. 463-475
-
-
de Kloet, E.R.1
Joels, M.2
Holsboer, F.3
-
7
-
-
18044366572
-
Rush hour at the promoter: How the ubiquitin-proteasome pathway polices the traffic flow of nuclear receptor-dependent transcription
-
Dennis, A.P. and O'Malley, B.W. (2005) Rush hour at the promoter: how the ubiquitin-proteasome pathway polices the traffic flow of nuclear receptor-dependent transcription. J. Steroid Biochem. Mol. Biol. 93; 139-151.
-
(2005)
J. Steroid Biochem. Mol. Biol
, vol.93
, pp. 139-151
-
-
Dennis, A.P.1
O'Malley, B.W.2
-
8
-
-
0036261563
-
Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear trafficking
-
Deroo, B.J., Rentsch, C., Sampath, S., Young, J., DeFranco, D.B. and Archer, T.K. (2002) Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear trafficking. Mol. Cell. Biol. 22; 4113-4123.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 4113-4123
-
-
Deroo, B.J.1
Rentsch, C.2
Sampath, S.3
Young, J.4
Defranco, D.B.5
Archer, T.K.6
-
9
-
-
0032539721
-
Subcellualr localization of mineralocorticoid receptors in living cells: Effects of receptor agonists and antagonists
-
Fejes-Toth, G., Pearce, D. and Naray-Fejes-Toth, A. (1998) Subcellualr localization of mineralocorticoid receptors in living cells: effects of receptor agonists and antagonists. Proc. Natl. Acad. Sci. U S A 95; 2973-2978.
-
(1998)
Proc. Natl. Acad. Sci. U S A
, vol.95
, pp. 2973-2978
-
-
Fejes-Toth, G.1
Pearce, D.2
Naray-Fejes-Toth, A.3
-
10
-
-
0029002298
-
Unique response pathways are established by allosteric interactions among nuclear hormone receptors
-
Forman, B.M., Umesono, K., Chen, J. and Evans, R.M. (1995) Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81; 541-550.
-
(1995)
Cell
, vol.81
, pp. 541-550
-
-
Forman, B.M.1
Umesono, K.2
Chen, J.3
Evans, R.M.4
-
11
-
-
0030748889
-
Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development
-
Gould, E., Tanapat, P. and McEwen, B.S. (1997) Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development. Brain Res. Dev. Brain Res. 101; 265-268.
-
(1997)
Brain Res. Dev. Brain Res
, vol.101
, pp. 265-268
-
-
Gould, E.1
Tanapat, P.2
McEwen, B.S.3
-
12
-
-
0034735864
-
Trafficking of nuclear receptors in living cells
-
Hager, G.L., Lim, C.S., Elbi, C. and Baumann, C.T. (2000) Trafficking of nuclear receptors in living cells. J. Steroid Biochem. Mol. Biol. 74; 249-254.
-
(2000)
J. Steroid Biochem. Mol. Biol
, vol.74
, pp. 249-254
-
-
Hager, G.L.1
Lim, C.S.2
Elbi, C.3
Baumann, C.T.4
-
13
-
-
0031015517
-
Neurocircuitry of stress: Central control of the hypothalamo-pituitary-adrenocortical axis
-
Herman, J.P. and Cullinan, W.E. (1997) Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci. 20; 78-84.
-
(1997)
Trends Neurosci
, vol.20
, pp. 78-84
-
-
Herman, J.P.1
Cullinan, W.E.2
-
14
-
-
67651013632
-
Long-term, high-resolution imaging in the mouse neo-cortex through a chronic cranial window
-
Holtman, A., Bonhoeffer, T., Chow, D.K., Chucjowree, J., Dr Paola, V., Hofer, S.B., Hubener, M., Keck, T., Knott, G., Lee, W-C.A., Mostany, R., Mrsic-Flogel, T.D., Nedivi, E., Portera-Cailliau, C., Svoboda, K., Trachtenberg, J.T. and Wilbrecht, L. (2009) Long-term, high-resolution imaging in the mouse neo-cortex through a chronic cranial window. Nat. Protocol. 4; 1128-1144.
-
(2009)
Nat. Protocol
, vol.4
, pp. 1128-1144
-
-
Holtman, A.1
Bonhoeffer, T.2
Chow, D.K.3
Chucjowree, J.4
Paola, V.5
Hofer, S.B.6
Hubener, M.7
Keck, T.8
Knott, G.9
Lee, W-C.A.10
Mostany, R.11
Mrsic-Flogel, T.D.12
Nedivi, E.13
Portera-Cailliau, C.14
Svoboda, K.15
Trachtenberg, J.T.16
Wilbrecht, L.17
-
15
-
-
0029943273
-
Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera
-
Htun, H., Barsony, J., Renyi, I., Gould, D. and Hager, G.L. (1996) Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera. Proc. Natl. Acad. Sci. U S A 93; 4845-4850.
-
(1996)
Proc. Natl. Acad. Sci. U S A
, vol.93
, pp. 4845-4850
-
-
Htun, H.1
Barsony, J.2
Renyi, I.3
Gould, D.4
Hager, G.L.5
-
16
-
-
0028260545
-
Mineralocorticoid and glucocorticoid receptors in the brain. Implication for ion permeability and transmitter systems
-
Joels, M. and de Kloet, E.R. (1994) Mineralocorticoid and glucocorticoid receptors in the brain. Implication for ion permeability and transmitter systems. Prog. Neurobiol. 43; 1-36.
-
(1994)
Prog. Neurobiol
, vol.43
, pp. 1-36
-
-
Joels, M.1
de Kloet, E.R.2
-
17
-
-
0026592518
-
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signaling
-
Kliewer, S.A., Umesono, K., Mangelsdorf, D.J. and Evans, R.M. (1992) Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signaling. Nature 355; 446-449.
-
(1992)
Nature
, vol.355
, pp. 446-449
-
-
Kliewer, S.A.1
Umesono, K.2
Mangelsdorf, D.J.3
Evans, R.M.4
-
18
-
-
0035384701
-
Resolution of multiple green fluorescent protein color variants and dyes using two-photon microscopy and imaging spectroscopy
-
Lansford, R., Bearman, G. and Fraser, S.E. (2001) Resolution of multiple green fluorescent protein color variants and dyes using two-photon microscopy and imaging spectroscopy. J. Biomed. Opt. 6; 311-318.
-
(2001)
J. Biomed. Opt
, vol.6
, pp. 311-318
-
-
Lansford, R.1
Bearman, G.2
Fraser, S.E.3
-
19
-
-
0029586681
-
Steroid receptor heterodimerization demonstrated in vitro and in vivo
-
Liu, W., Wang, J., Sauter, N.K. and Pearce, D. (1995) Steroid receptor heterodimerization demonstrated in vitro and in vivo. Proc. Natl. Acad. Sci. U S A 92; 12480-12484.
-
(1995)
Proc. Natl. Acad. Sci. U S A
, vol.92
, pp. 12480-12484
-
-
Liu, W.1
Wang, J.2
Sauter, N.K.3
Pearce, D.4
-
20
-
-
0033638393
-
The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation
-
Lonard, D.M., Nawaz, Z., Smith, C.L. and O'Malley, B.W. (2000) The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. Mol. Cell 5; 939-948.
-
(2000)
Mol. Cell
, vol.5
, pp. 939-948
-
-
Lonard, D.M.1
Nawaz, Z.2
Smith, C.L.3
O'Malley, B.W.4
-
21
-
-
35148860169
-
Hippocampal formation: Shedding light on the influence of sex and stress on the brain
-
McEween, B.S. (2007) Hippocampal formation: Shedding light on the influence of sex and stress on the brain. Brain Res. Rev. 55; 343-355.
-
(2007)
Brain Res. Rev
, vol.55
, pp. 343-355
-
-
McEween, B.S.1
-
22
-
-
0343415609
-
The glucocorticoid receptor: Rapid exchange with regulatory sites in the living cells
-
McNally, J.G., Muller, W.G., Walker, D., Wolford, R. and Hager, G.L. (2000) The glucocorticoid receptor: Rapid exchange with regulatory sites in the living cells. Science 287; 1262-1265.
-
(2000)
Science
, vol.287
, pp. 1262-1265
-
-
McNally, J.G.1
Muller, W.G.2
Walker, D.3
Wolford, R.4
Hager, G.L.5
-
23
-
-
26944499780
-
Innovations in the imaging of brain functions using fluorescent proteins
-
Miyawaki, A. (2005) Innovations in the imaging of brain functions using fluorescent proteins. Neuron 48; 189-199.
-
(2005)
Neuron
, vol.48
, pp. 189-199
-
-
Miyawaki, A.1
-
24
-
-
1542297619
-
Urban renewal in the nucleus: Is protein turnover by proteasome absolutely required for nuclear receptor-regulated transcription?
-
Nawaz, Z. and O'Malley, B.W. (2004) Urban renewal in the nucleus: Is protein turnover by proteasome absolutely required for nuclear receptor-regulated transcription?. Mol. Endocrinol. 18; 493-499.
-
(2004)
Mol. Endocrinol
, vol.18
, pp. 493-499
-
-
Nawaz, Z.1
O'Malley, B.W.2
-
25
-
-
0033008763
-
Real-time imaging of glucocorticoid receptor dynamics in living neurons and glial cells in comparison with non-neural cells
-
Nishi, M., Takenaka, N., Morita, N., Ito, T., Ozawa, H. and Kawata, M. (1999) Real-time imaging of glucocorticoid receptor dynamics in living neurons and glial cells in comparison with non-neural cells. Eur. J. Neurosci. 11; 1927-1936.
-
(1999)
Eur. J. Neurosci
, vol.11
, pp. 1927-1936
-
-
Nishi, M.1
Takenaka, N.2
Morita, N.3
Ito, T.4
Ozawa, H.5
Kawata, M.6
-
26
-
-
0034973472
-
Dynamic changes in subcellular localization of mineralocorticoid receptor in living cells: In comparison with glucocorticoid receptor using dual-color labeling with green fluorescent protein spectral variants
-
Nishi, M., Ogawa, H., Ito, T., Matsuda, K. and Kawata, M. (2001) Dynamic changes in subcellular localization of mineralocorticoid receptor in living cells: in comparison with glucocorticoid receptor using dual-color labeling with green fluorescent protein spectral variants. Mol. Endocrinol. 15; 1077-1092.
-
(2001)
Mol. Endocrinol
, vol.15
, pp. 1077-1092
-
-
Nishi, M.1
Ogawa, H.2
Ito, T.3
Matsuda, K.4
Kawata, M.5
-
27
-
-
2542510885
-
Visualization of Glucocorticoid receptor and mineralocorticoid receptor interactions in living cells with GFP-based fluorescent resonance energy transfer (FRET)
-
Nishi, M., Tanaka, M., Matsuda, K., Sunaguchi, M. and Kawata, M. (2004) Visualization of Glucocorticoid receptor and mineralocorticoid receptor interactions in living cells with GFP-based fluorescent resonance energy transfer (FRET). J. Neurosci. 24; 4918-4927.
-
(2004)
J. Neurosci
, vol.24
, pp. 4918-4927
-
-
Nishi, M.1
Tanaka, M.2
Matsuda, K.3
Sunaguchi, M.4
Kawata, M.5
-
28
-
-
33646705636
-
Brain corticosteroid receptor dynamics and trafficking: Implications from live cell imaging
-
Nishi, M. and Kawata, M. (2006) Brain corticosteroid receptor dynamics and trafficking: implications from live cell imaging. Neuroscientist 12; 119-133.
-
(2006)
Neuroscientist
, vol.12
, pp. 119-133
-
-
Nishi, M.1
Kawata, M.2
-
29
-
-
0026773781
-
New insights into activation of the steroid hormone receptor super-family
-
Power, R.F., Conneely, O.M. and O'Malley, B.W. (1992) New insights into activation of the steroid hormone receptor super-family. Trends Pharmacol. Sci. 13; 318-323.
-
(1992)
Trends Pharmacol. Sci
, vol.13
, pp. 318-323
-
-
Power, R.F.1
Conneely, O.M.2
O'Malley, B.W.3
-
30
-
-
0037351881
-
Cyclic, proteasome-mediated turnover of unliganded and ligand-ed ERalpha on responsive promoters is an integral feature of estrogen signaling
-
Reid, G., Hübner, M.R., Métivier, R., Brand, H., Denger, S., Manu, D., Beaudouin, J., Ellenberg, J. and Gannon, F. (2003) Cyclic, proteasome-mediated turnover of unliganded and ligand-ed ERalpha on responsive promoters is an integral feature of estrogen signaling. Mol. Cell 11; 695-707.
-
(2003)
Mol. Cell
, vol.11
, pp. 695-707
-
-
Reid, G.1
Hübner, M.R.2
Métivier, R.3
Brand, H.4
Denger, S.5
Manu, D.6
Beaudouin, J.7
Ellenberg, J.8
Gannon, F.9
-
31
-
-
0022383620
-
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
-
Reul, J.M. and de Kloet, E.R. (1985) Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 117; 2505-2511.
-
(1985)
Endocrinology
, vol.117
, pp. 2505-2511
-
-
Reul, J.M.1
de Kloet, E.R.2
-
32
-
-
0027527215
-
Pharmacological and functional characterization of human mineralo-corticoid and glucocorticoid receptor ligands
-
Rupprecht, R., Reul, J.M., van Steensel, B., Spengler, D., Soder, M., Berning, B., Holsboer, F. and Damm, K. (1993) Pharmacological and functional characterization of human mineralo-corticoid and glucocorticoid receptor ligands. Eur. J. Pharmacol. 247; 145-154.
-
(1993)
Eur. J. Pharmacol
, vol.247
, pp. 145-154
-
-
Rupprecht, R.1
Reul, J.M.2
van Steensel, B.3
Spengler, D.4
Soder, M.5
Berning, B.6
Holsboer, F.7
Damm, K.8
-
33
-
-
0034625631
-
Kinesin superfamily motor protein KIF 17 and mLin-10 in NMDA receptor-containing vesicle transport
-
Setou, M., Nakagawa, T., Seog, D-H. and Hirokawa, N. (2000) Kinesin superfamily motor protein KIF 17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288; 1796-1802.
-
(2000)
Science
, vol.288
, pp. 1796-1802
-
-
Setou, M.1
Nakagawa, T.2
Seog, D.-H.3
Hirokawa, N.4
-
34
-
-
0034675275
-
Inhibiting proteasomes in human HepG2 and LNCaP cells increases endogenous androgen receptor levels
-
Sheflin, L., Keegan, B., Zhang, W. and Spaulding, S.W. (2000) Inhibiting proteasomes in human HepG2 and LNCaP cells increases endogenous androgen receptor levels. Biochem. Biophys. Res. Commun. 276; 144-150.
-
(2000)
Biochem. Biophys. Res. Commun
, vol.276
, pp. 144-150
-
-
Sheflin, L.1
Keegan, B.2
Zhang, W.3
Spaulding, S.W.4
-
35
-
-
12144290835
-
Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes
-
Stavreva, D.A., Müller, W.G., Hager, G.L., Smith, C.L. and McNally, J.G. (2004) Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes. Mol. Cell. Biol. 24; 2682-2697.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 2682-2697
-
-
Stavreva, D.A.1
Müller, W.G.2
Hager, G.L.3
Smith, C.L.4
McNally, J.G.5
-
36
-
-
0035141041
-
FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent
-
Stenoien, D.L., Patel, K., Mancini, M.G., Dutertre, M., Smith, C.L., O'Malley, B.W. and Mancini, M.A. (2001) FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent. Nat. Cell Biol. 3; 15-23.
-
(2001)
Nat. Cell Biol
, vol.3
, pp. 15-23
-
-
Stenoien, D.L.1
Patel, K.2
Mancini, M.G.3
Dutertre, M.4
Smith, C.L.5
O'Malley, B.W.6
Mancini, M.A.7
-
37
-
-
0042922480
-
Nuclear import of glucocorticoid receptor in association with importin α and importin β: Analysis with real-time fluorescence imaging and fluorescence resonance energy transfer in living cells
-
Tanaka, M., Nishi, M., Morimoto, M. and Kawata, M. (2003) Nuclear import of glucocorticoid receptor in association with importin α and importin β: Analysis with real-time fluorescence imaging and fluorescence resonance energy transfer in living cells. Endocrinology 144; 4070-4079.
-
(2003)
Endocrinology
, vol.144
, pp. 4070-4079
-
-
Tanaka, M.1
Nishi, M.2
Morimoto, M.3
Kawata, M.4
-
38
-
-
0029881118
-
Heterodimerization between mineralocorticoid and glucocorticoid receptors increases the functional diversity of corticosteroid action
-
Trapp, T. and Holsber, F. (1996) Heterodimerization between mineralocorticoid and glucocorticoid receptors increases the functional diversity of corticosteroid action. Trends Pharmacol. Sci. 17; 145-149.
-
(1996)
Trends Pharmacol. Sci
, vol.17
, pp. 145-149
-
-
Trapp, T.1
Holsber, F.2
-
39
-
-
0031725138
-
Mechanisms of progesterone receptor export from nuclei: Role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate
-
Tyagi, R.K., Amazit, L., Lescop, P., Milgrom, E. and Guiochon-Mantel, A. (1998) Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate. Mol. Endocrinol. 12; 1684-1695.
-
(1998)
Mol. Endocrinol
, vol.12
, pp. 1684-1695
-
-
Tyagi, R.K.1
Amazit, L.2
Lescop, P.3
Milgrom, E.4
Guiochon-Mantel, A.5
-
40
-
-
26244468935
-
Visualization of glucocorticoid receptor in the brain of green fluorescent protein-glucocorticoid receptor knockin mice
-
Usuku, T., Nishi, M., Morimoto, M., Sugimoto, T., Brewer, J., Muglia, L. and Kawata, M. (2005) Visualization of glucocorticoid receptor in the brain of green fluorescent protein-glucocorticoid receptor knockin mice. Neuroscience 135; 1119-1128.
-
(2005)
Neuroscience
, vol.135
, pp. 1119-1128
-
-
Usuku, T.1
Nishi, M.2
Morimoto, M.3
Sugimoto, T.4
Brewer, J.5
Muglia, L.6
Kawata, M.7
-
41
-
-
0029935163
-
Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampal neurons
-
van Steensel, B., van Binnendijk, E.P., Hornsby, C., van der Voort, T.M., Krozowski, Z.S. and de Kloet, E.R. (1996) Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampal neurons. J. Cell Sci. 109; 787-792.
-
(1996)
J. Cell Sci
, vol.109
, pp. 787-792
-
-
van Steensel, B.1
van Binnendijk, E.P.2
Hornsby, C.3
van der Voort, T.M.4
Krozowski, Z.S.5
de Kloet, E.R.6
-
42
-
-
0035900780
-
Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids
-
Wallace, A.D. and Cidlowski, J.A. (2001) Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids. J. Biol. Chem. 276; 42714-42721.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 42714-42721
-
-
Wallace, A.D.1
Cidlowski, J.A.2
-
43
-
-
0036718782
-
Gluco-corticoid receptors in hippocampal neurons that do not engage proteasomes escape from hormone-dependent down-regulation but maintain transactivation activity
-
Wang, X., Pongrac, J.L. and DeFranco, D.B. (2000) Gluco-corticoid receptors in hippocampal neurons that do not engage proteasomes escape from hormone-dependent down-regulation but maintain transactivation activity. Mol. Endocrinol. 16; 1987-1998.
-
(2000)
Mol. Endocrinol
, vol.16
, pp. 1987-1998
-
-
Wang, X.1
Pongrac, J.L.2
Defranco, D.B.3
-
44
-
-
0036591883
-
Nucleocytoplasmic transport: Cargo trafficking across the border
-
Weis, K. (2002) Nucleocytoplasmic transport: cargo trafficking across the border. Curr. Opin. Cell Biol. 14; 328-335.
-
(2002)
Curr. Opin. Cell Biol
, vol.14
, pp. 328-335
-
-
Weis, K.1
|