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Volumn 79, Issue , 2015, Pages 281-291

Hypoxia and free radicals: Role in tumor progression and the use of engineering-based platforms to address these relationships

Author keywords

Angiogenesis; HIF; Hypoxia; Metastasis; ROS; Tumorigenesis

Indexed keywords

FREE RADICAL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; REACTIVE OXYGEN METABOLITE;

EID: 84923222653     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.09.015     Document Type: Review
Times cited : (88)

References (110)
  • 1
    • 34247490186 scopus 로고    scopus 로고
    • Mitochondria, oxidative stress and cell death
    • (913-222)
    • M. Ott Mitochondria, oxidative stress and cell death Apoptosis 12 5 2007 (913-222)
    • (2007) Apoptosis , vol.12 , Issue.5
    • Ott, M.1
  • 2
    • 0036260697 scopus 로고    scopus 로고
    • Cellular response to oxidative stress: Signaling for suicide and survival
    • J.L. Martindale, and N.J. Holbrook Cellular response to oxidative stress: signaling for suicide and survival J. Cell. Physiol. 192 1 2002 1 15
    • (2002) J. Cell. Physiol. , vol.192 , Issue.1 , pp. 1-15
    • Martindale, J.L.1    Holbrook, N.J.2
  • 3
    • 70849093542 scopus 로고    scopus 로고
    • Reactive oxygen species-dependent signaling regulates cancer
    • F. Weinberg, and N.S. Chandel Reactive oxygen species-dependent signaling regulates cancer Cell. Mol. Life Sci. 66 23 2009 3663 3673
    • (2009) Cell. Mol. Life Sci. , vol.66 , Issue.23 , pp. 3663-3673
    • Weinberg, F.1    Chandel, N.S.2
  • 4
    • 77952737658 scopus 로고    scopus 로고
    • Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
    • F. Weinberg Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity Proc. Natl. Acad. Sci. USA 107 19 2010 8788 8793
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , Issue.19 , pp. 8788-8793
    • Weinberg, F.1
  • 5
    • 66649121354 scopus 로고    scopus 로고
    • Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma
    • Q. Ma Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma Proc. Natl. Acad. Sci. USA 106 21 2009 8683 8688
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , Issue.21 , pp. 8683-8688
    • Ma, Q.1
  • 6
    • 43249112094 scopus 로고    scopus 로고
    • ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis
    • K. Ishikawa ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis Science 320 5876 2008 661 664
    • (2008) Science , vol.320 , Issue.5876 , pp. 661-664
    • Ishikawa, K.1
  • 7
    • 64549098628 scopus 로고    scopus 로고
    • A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis
    • J.S. Park A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis Hum. Mol. Genet. 18 9 2009 1578 1589
    • (2009) Hum. Mol. Genet. , vol.18 , Issue.9 , pp. 1578-1589
    • Park, J.S.1
  • 8
    • 41349119625 scopus 로고    scopus 로고
    • Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury
    • V.A. Sardao, S.L. Pereira, and P.J. Oliveira Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury Expert Opin. Drug Saf. 7 2 2008 129 146
    • (2008) Expert Opin. Drug Saf. , vol.7 , Issue.2 , pp. 129-146
    • Sardao, V.A.1    Pereira, S.L.2    Oliveira, P.J.3
  • 9
    • 84888378078 scopus 로고    scopus 로고
    • Cytoplasmic irradiation results in mitochondrial dysfunction and DRP1-dependent mitochondrial fission
    • B. Zhang Cytoplasmic irradiation results in mitochondrial dysfunction and DRP1-dependent mitochondrial fission Cancer Res. 73 22 2013 6700 6710
    • (2013) Cancer Res. , vol.73 , Issue.22 , pp. 6700-6710
    • Zhang, B.1
  • 11
    • 0034682783 scopus 로고    scopus 로고
    • Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    • M.E. Cockman Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein J. Biol. Chem. 275 33 2000 25733 25741
    • (2000) J. Biol. Chem. , vol.275 , Issue.33 , pp. 25733-25741
    • Cockman, M.E.1
  • 12
    • 0035903468 scopus 로고    scopus 로고
    • Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
    • N. Masson Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation EMBO J. 20 18 2001 5197 5206
    • (2001) EMBO J. , vol.20 , Issue.18 , pp. 5197-5206
    • Masson, N.1
  • 13
    • 0033526781 scopus 로고    scopus 로고
    • Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins
    • V. Srinivas Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins Biochem. Biophys. Res. Commun. 260 2 1999 557 561
    • (1999) Biochem. Biophys. Res. Commun. , vol.260 , Issue.2 , pp. 557-561
    • Srinivas, V.1
  • 14
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • P.H. Maxwell The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature 399 6733 1999 271 275
    • (1999) Nature , vol.399 , Issue.6733 , pp. 271-275
    • Maxwell, P.H.1
  • 15
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • S. Salceda, and J. Caro Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes J. Biol. Chem. 272 36 1997 22642 22647
    • (1997) J. Biol. Chem. , vol.272 , Issue.36 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 16
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
    • L.E. Huang Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit J. Biol. Chem. 271 50 1996 32253 32259
    • (1996) J. Biol. Chem. , vol.271 , Issue.50 , pp. 32253-32259
    • Huang, L.E.1
  • 17
    • 0030914648 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor 1alpha: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor
    • P.J. Kallio Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor Proc. Natl. Acad. Sci. USA 94 11 1997 5667 5672
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , Issue.11 , pp. 5667-5672
    • Kallio, P.J.1
  • 18
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    • D. Lando Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch Science 295 5556 2002 858 861
    • (2002) Science , vol.295 , Issue.5556 , pp. 858-861
    • Lando, D.1
  • 19
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: Pathophysiology and therapeutics
    • G.L. Semenza HIF-1 and tumor progression: pathophysiology and therapeutics Trends Mol. Med. 8 4 Suppl 2002 S62 S67
    • (2002) Trends Mol. Med. , vol.8 , pp. S62-S67
    • Semenza, G.L.1
  • 20
    • 0032578458 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
    • N.S. Chandel Mitochondrial reactive oxygen species trigger hypoxia-induced transcription Proc. Natl. Acad. Sci. USA 95 20 1998 11715 11720
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , Issue.20 , pp. 11715-11720
    • Chandel, N.S.1
  • 21
    • 22744438100 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells
    • H. Sato Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells Cardiovasc. Res. 67 4 2005 714 722
    • (2005) Cardiovasc. Res. , vol.67 , Issue.4 , pp. 714-722
    • Sato, H.1
  • 22
    • 13544254262 scopus 로고    scopus 로고
    • Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia
    • J.M. Lluis Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia J. Biol. Chem. 280 5 2005 3224 3232
    • (2005) J. Biol. Chem. , vol.280 , Issue.5 , pp. 3224-3232
    • Lluis, J.M.1
  • 23
    • 33751329032 scopus 로고    scopus 로고
    • Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
    • Y.J. Peng Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia J. Physiol. 577 Pt 2 2006 705 716
    • (2006) J. Physiol. , vol.577 , pp. 705-716
    • Peng, Y.J.1
  • 24
    • 2942668297 scopus 로고    scopus 로고
    • Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea
    • W. Xu Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea Neuroscience 126 2 2004 313 323
    • (2004) Neuroscience , vol.126 , Issue.2 , pp. 313-323
    • Xu, W.1
  • 25
    • 64149093520 scopus 로고    scopus 로고
    • Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia
    • A. Pawar Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia Am. J. Physiol. Regul. Integr. Comp. Physiol. 296 3 2009 R735 R742
    • (2009) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.296 , Issue.3 , pp. R735-R742
    • Pawar, A.1
  • 26
    • 34247187576 scopus 로고    scopus 로고
    • Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site
    • S. Bonello Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site Arterioscler. Thromb. Vasc. Biol. 27 4 2007 755 761
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , Issue.4 , pp. 755-761
    • Bonello, S.1
  • 27
    • 0034682786 scopus 로고    scopus 로고
    • 2 sensing
    • 2 sensing J. Biol. Chem. 275 33 2000 25130 25138
    • (2000) J. Biol. Chem. , vol.275 , Issue.33 , pp. 25130-25138
    • Chandel, N.S.1
  • 28
    • 24144493814 scopus 로고    scopus 로고
    • Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
    • R.D. Guzy Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing Cell Metab. 1 6 2005 401 408
    • (2005) Cell Metab. , vol.1 , Issue.6 , pp. 401-408
    • Guzy, R.D.1
  • 29
    • 24144444133 scopus 로고    scopus 로고
    • Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
    • J.K. Brunelle Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation Cell Metab. 1 6 2005 409 414
    • (2005) Cell Metab. , vol.1 , Issue.6 , pp. 409-414
    • Brunelle, J.K.1
  • 30
    • 34250745912 scopus 로고    scopus 로고
    • The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
    • E.L. Bell The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production J. Cell Biol. 177 6 2007 1029 1036
    • (2007) J. Cell Biol. , vol.177 , Issue.6 , pp. 1029-1036
    • Bell, E.L.1
  • 31
    • 24144447915 scopus 로고    scopus 로고
    • Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation
    • K.D. Mansfield Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation Cell Metab. 1 6 2005 393 399
    • (2005) Cell Metab. , vol.1 , Issue.6 , pp. 393-399
    • Mansfield, K.D.1
  • 32
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • I.C.R. Papandreou, L. Fontana, A.L. Lim, and N.C. Denko HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption Cell Metab. 3 2006 187 197
    • (2006) Cell Metab. , vol.3 , pp. 187-197
    • Papandreou, I.C.R.1    Fontana, L.2    Lim, A.L.3    Denko, N.C.4
  • 33
    • 34547616284 scopus 로고    scopus 로고
    • Dual role of mitochondrial reactive oxygen species in hypoxia signaling: Activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death
    • J.M. Lluis Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death Cancer Res. 67 15 2007 7368 7377
    • (2007) Cancer Res. , vol.67 , Issue.15 , pp. 7368-7377
    • Lluis, J.M.1
  • 34
    • 84868623830 scopus 로고    scopus 로고
    • Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis
    • C.K. Kikani Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis Sci. Signal 5 249 2012 ra80
    • (2012) Sci. Signal , vol.5 , Issue.249 , pp. ra80
    • Kikani, C.K.1
  • 35
    • 0034744949 scopus 로고    scopus 로고
    • NF-kappaB and cell-cycle regulation: The cyclin connection
    • D. Joyce NF-kappaB and cell-cycle regulation: the cyclin connection Cytokine Growth Factor Rev. 12 1 2001 73 90
    • (2001) Cytokine Growth Factor Rev. , vol.12 , Issue.1 , pp. 73-90
    • Joyce, D.1
  • 36
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • S. Huang Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis Oncogene 20 31 2001 4188 4197
    • (2001) Oncogene , vol.20 , Issue.31 , pp. 4188-4197
    • Huang, S.1
  • 37
    • 0142210188 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation
    • M.T. Lin Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation Mol. Pharmacol. 64 5 2003 1029 1036
    • (2003) Mol. Pharmacol. , vol.64 , Issue.5 , pp. 1029-1036
    • Lin, M.T.1
  • 38
    • 0034331239 scopus 로고    scopus 로고
    • Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells
    • W.H. Tong, and T. Rouault Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells EMBO J. 19 21 2000 5692 5700
    • (2000) EMBO J. , vol.19 , Issue.21 , pp. 5692-5700
    • Tong, W.H.1    Rouault, T.2
  • 39
    • 77956402239 scopus 로고    scopus 로고
    • MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU
    • E. Favaro MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU PLoS One 5 4 2010 e10345
    • (2010) PLoS One , vol.5 , Issue.4 , pp. e10345
    • Favaro, E.1
  • 40
    • 84555187316 scopus 로고    scopus 로고
    • Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells
    • Y. Jing Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells Toxicol. Sci. 125 1 2012 10 19
    • (2012) Toxicol. Sci. , vol.125 , Issue.1 , pp. 10-19
    • Jing, Y.1
  • 41
    • 0024273450 scopus 로고
    • Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
    • M.A. Goldberg, S.P. Dunning, and H.F. Bunn Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein Science 242 4884 1988 1412 1415
    • (1988) Science , vol.242 , Issue.4884 , pp. 1412-1415
    • Goldberg, M.A.1    Dunning, S.P.2    Bunn, H.F.3
  • 42
    • 32444432328 scopus 로고    scopus 로고
    • Cobalt chloride, a hypoxia-mimicking agent, modulates redox status and functional parameters of cultured swine granulosa cells
    • F. Grasselli Cobalt chloride, a hypoxia-mimicking agent, modulates redox status and functional parameters of cultured swine granulosa cells Reprod. Fertil. Dev. 17 7 2005 715 720
    • (2005) Reprod. Fertil. Dev. , vol.17 , Issue.7 , pp. 715-720
    • Grasselli, F.1
  • 43
    • 10744229867 scopus 로고    scopus 로고
    • Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: Possible mediation of hypoxia-inducible factor-1alpha
    • Y. Huang Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha Leukemia 17 11 2003 2065 2073
    • (2003) Leukemia , vol.17 , Issue.11 , pp. 2065-2073
    • Huang, Y.1
  • 44
    • 0034658267 scopus 로고    scopus 로고
    • Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells
    • G. Wang Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells Nucleic Acids Res. 28 10 2000 2135 2140
    • (2000) Nucleic Acids Res. , vol.28 , Issue.10 , pp. 2135-2140
    • Wang, G.1
  • 45
    • 34147165621 scopus 로고    scopus 로고
    • Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition
    • S.J. McNally Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition Int. J. Mol. Med 19 1 2007 165 172
    • (2007) Int. J. Mol. Med , vol.19 , Issue.1 , pp. 165-172
    • McNally, S.J.1
  • 46
    • 19944406777 scopus 로고    scopus 로고
    • Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: The effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma
    • N.S. Brown Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma Br. J. Cancer 92 9 2005 1696 1701
    • (2005) Br. J. Cancer , vol.92 , Issue.9 , pp. 1696-1701
    • Brown, N.S.1
  • 47
    • 37849022071 scopus 로고    scopus 로고
    • Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis
    • R.D. Guzy Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis Mol. Cell. Biol. 28 2 2008 718 731
    • (2008) Mol. Cell. Biol. , vol.28 , Issue.2 , pp. 718-731
    • Guzy, R.D.1
  • 48
    • 33846189403 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas
    • E.A. Griffiths Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas Br. J. Cancer 96 1 2007 95 103
    • (2007) Br. J. Cancer , vol.96 , Issue.1 , pp. 95-103
    • Griffiths, E.A.1
  • 49
    • 77957792289 scopus 로고    scopus 로고
    • VEGF secretion during hypoxia depends on free radicals-induced Fyn kinase activity in mast cells
    • J. Garcia-Roman VEGF secretion during hypoxia depends on free radicals-induced Fyn kinase activity in mast cells Biochem. Biophys. Res. Commun. 401 2 2010 262 267
    • (2010) Biochem. Biophys. Res. Commun. , vol.401 , Issue.2 , pp. 262-267
    • Garcia-Roman, J.1
  • 50
    • 84894044753 scopus 로고    scopus 로고
    • Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment
    • M. Kondoh Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment PLoS One 8 11 2013 e80349
    • (2013) PLoS One , vol.8 , Issue.11 , pp. e80349
    • Kondoh, M.1
  • 51
    • 84880306518 scopus 로고    scopus 로고
    • Repression of miR-143 mediates Cr (VI)-induced tumor angiogenesis via IGF-IR/IRS1/ERK/IL-8 pathway
    • J. He Repression of miR-143 mediates Cr (VI)-induced tumor angiogenesis via IGF-IR/IRS1/ERK/IL-8 pathway Toxicol. Sci. 134 1 2013 26 38
    • (2013) Toxicol. Sci. , vol.134 , Issue.1 , pp. 26-38
    • He, J.1
  • 52
    • 84895128766 scopus 로고    scopus 로고
    • Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1alpha/COX-2 pathway
    • J. He Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1alpha/COX-2 pathway Environ. Health Perspect. 122 3 2014 255 261
    • (2014) Environ. Health Perspect. , vol.122 , Issue.3 , pp. 255-261
    • He, J.1
  • 53
    • 84923228595 scopus 로고    scopus 로고
    • Hexavalent chromium-induced ROS Formation, subsequent Akt, NF-κB, and MAPK activation, and TNF-α, and IL-1α production in keratinocytes, which might facilitate the progression of chromium hypersensitivity
    • B.-J.S. Wang, Hamm-Min, Yue-Liang Guo, Yu-Hsuan Lee, Ching-Shu Lai, Min-Hsiung Pan, and Ying-Jan Wang Hexavalent chromium-induced ROS Formation, subsequent Akt, NF-κB, and MAPK activation, and TNF-α, and IL-1α production in keratinocytes, which might facilitate the progression of chromium hypersensitivity Epidemiology 22 2011 S290
    • (2011) Epidemiology , vol.22 , pp. S290
    • Wang, B.-J.S.1    Hamm-Min2    Guo, Y.-L.3    Lee, Y.-H.4    Lai, C.-S.5    Pan, M.-H.6    Wang, Y.-J.7
  • 54
    • 0034282388 scopus 로고    scopus 로고
    • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells
    • D.E. Richard, E. Berra, and J. Pouyssegur Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells J. Biol. Chem. 275 35 2000 26765 26771
    • (2000) J. Biol. Chem. , vol.275 , Issue.35 , pp. 26765-26771
    • Richard, D.E.1    Berra, E.2    Pouyssegur, J.3
  • 55
    • 60849136310 scopus 로고    scopus 로고
    • P53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway
    • N.V. Khromova p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway Cancer Lett. 276 2 2009 143 151
    • (2009) Cancer Lett. , vol.276 , Issue.2 , pp. 143-151
    • Khromova, N.V.1
  • 56
    • 36348938884 scopus 로고    scopus 로고
    • Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor
    • C. Xia Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor Cancer Res. 67 22 2007 10823 10830
    • (2007) Cancer Res. , vol.67 , Issue.22 , pp. 10823-10830
    • Xia, C.1
  • 57
    • 79960983027 scopus 로고    scopus 로고
    • Unforeseen decreases in dissolved oxygen levels affect tube formation kinetics in collagen gels
    • H.E. Abaci Unforeseen decreases in dissolved oxygen levels affect tube formation kinetics in collagen gels Am. J. Physiol. Cell Physiol 301 2 2011 C431 C440
    • (2011) Am. J. Physiol. Cell Physiol , vol.301 , Issue.2 , pp. C431-C440
    • Abaci, H.E.1
  • 58
    • 84875071763 scopus 로고    scopus 로고
    • Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells
    • Y. Shimojo Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells Clin. Exp. Metastasis 30 2 2013 143 154
    • (2013) Clin. Exp. Metastasis , vol.30 , Issue.2 , pp. 143-154
    • Shimojo, Y.1
  • 59
    • 57349164238 scopus 로고    scopus 로고
    • Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells
    • S. Cannito Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells Carcinogenesis 29 12 2008 2267 2278
    • (2008) Carcinogenesis , vol.29 , Issue.12 , pp. 2267-2278
    • Cannito, S.1
  • 60
    • 84880822964 scopus 로고    scopus 로고
    • Mitochondrial dysfunction promotes breast cancer cell migration and invasion through HIF1alpha accumulation via increased production of reactive oxygen species
    • J. Ma Mitochondrial dysfunction promotes breast cancer cell migration and invasion through HIF1alpha accumulation via increased production of reactive oxygen species PLoS One 8 7 2013 e69485
    • (2013) PLoS One , vol.8 , Issue.7 , pp. e69485
    • Ma, J.1
  • 61
    • 77951233373 scopus 로고    scopus 로고
    • Cancer associated fibroblasts (CAFs) in tumor microenvironment
    • F. Xing, J. Saidou, and K. Watabe Cancer associated fibroblasts (CAFs) in tumor microenvironment Front. Biosci. (Landmark Ed.) 15 2010 166 179
    • (2010) Front. Biosci. (Landmark Ed.) , vol.15 , pp. 166-179
    • Xing, F.1    Saidou, J.2    Watabe, K.3
  • 62
    • 79957532451 scopus 로고    scopus 로고
    • Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness
    • E. Giannoni Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness Antioxid. Redox Signal. 14 12 2011 2361 2371
    • (2011) Antioxid. Redox Signal. , vol.14 , Issue.12 , pp. 2361-2371
    • Giannoni, E.1
  • 63
    • 84873735398 scopus 로고    scopus 로고
    • Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer
    • Y. Ino Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer PLoS One 8 2 2013 e55146
    • (2013) PLoS One , vol.8 , Issue.2 , pp. e55146
    • Ino, Y.1
  • 64
    • 84868147963 scopus 로고    scopus 로고
    • Time-dependent stabilization of hypoxia inducible factor-1alpha by different intracellular sources of reactive oxygen species
    • M. Calvani Time-dependent stabilization of hypoxia inducible factor-1alpha by different intracellular sources of reactive oxygen species PLoS One 7 10 2012 e38388
    • (2012) PLoS One , vol.7 , Issue.10 , pp. e38388
    • Calvani, M.1
  • 65
    • 78649396776 scopus 로고    scopus 로고
    • Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity
    • C.H. Hsieh Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity Oncol. Rep. 24 6 2010 1629 1636
    • (2010) Oncol. Rep. , vol.24 , Issue.6 , pp. 1629-1636
    • Hsieh, C.H.1
  • 66
    • 0038626211 scopus 로고    scopus 로고
    • Tumor response to radiotherapy regulated by endothelial cell apoptosis
    • M. Garcia-Barros Tumor response to radiotherapy regulated by endothelial cell apoptosis Science 300 5622 2003 1155 1159
    • (2003) Science , vol.300 , Issue.5622 , pp. 1155-1159
    • Garcia-Barros, M.1
  • 67
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
    • B.J. Moeller Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules Cancer Cell 5 5 2004 429 441
    • (2004) Cancer Cell , vol.5 , Issue.5 , pp. 429-441
    • Moeller, B.J.1
  • 68
    • 84886018696 scopus 로고    scopus 로고
    • Tumor cells upregulate normoxic HIF-1alpha in response to doxorubicin
    • Y. Cao Tumor cells upregulate normoxic HIF-1alpha in response to doxorubicin Cancer Res. 73 20 2013 6230 6242
    • (2013) Cancer Res. , vol.73 , Issue.20 , pp. 6230-6242
    • Cao, Y.1
  • 69
    • 0026453418 scopus 로고
    • Peroxynitrite formation from macrophage-derived nitric oxide
    • H. Ischiropoulos, L. Zhu, and J.S. Beckman Peroxynitrite formation from macrophage-derived nitric oxide Arch. Biochem. Biophys. 298 2 1992 446 451
    • (1992) Arch. Biochem. Biophys. , vol.298 , Issue.2 , pp. 446-451
    • Ischiropoulos, H.1    Zhu, L.2    Beckman, J.S.3
  • 70
    • 0026522884 scopus 로고
    • DNA damage and mutation in human cells exposed to nitric oxide in vitro
    • T. Nguyen DNA damage and mutation in human cells exposed to nitric oxide in vitro Proc. Natl. Acad. Sci. USA 89 7 1992 3030 3034
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , Issue.7 , pp. 3030-3034
    • Nguyen, T.1
  • 71
    • 0026321495 scopus 로고
    • DNA deaminating ability and genotoxicity of nitric oxide and its progenitors
    • D.A. Wink DNA deaminating ability and genotoxicity of nitric oxide and its progenitors Science 254 5034 1991 1001 1003
    • (1991) Science , vol.254 , Issue.5034 , pp. 1001-1003
    • Wink, D.A.1
  • 72
    • 69549084529 scopus 로고    scopus 로고
    • Environmental toxins and Parkinson's disease: What have we learned from pesticide-induced animal models?
    • F. Cicchetti, J. Drouin-Ouellet, and R.E. Gross Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models? Trends Pharmacol. Sci. 30 9 2009 475 483
    • (2009) Trends Pharmacol. Sci. , vol.30 , Issue.9 , pp. 475-483
    • Cicchetti, F.1    Drouin-Ouellet, J.2    Gross, R.E.3
  • 73
    • 70350053122 scopus 로고    scopus 로고
    • The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca(2+) pump
    • T. Tazzeo, F. Worek, and L. Janssen The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca(2+) pump Br. J. Pharmacol. 158 3 2009 790 796
    • (2009) Br. J. Pharmacol. , vol.158 , Issue.3 , pp. 790-796
    • Tazzeo, T.1    Worek, F.2    Janssen, L.3
  • 74
    • 84893383175 scopus 로고    scopus 로고
    • Resveratrol suppresses cancer cell glucose uptake by targeting reactive oxygen species-mediated hypoxia-inducible factor-1alpha activation
    • K.H. Jung Resveratrol suppresses cancer cell glucose uptake by targeting reactive oxygen species-mediated hypoxia-inducible factor-1alpha activation J. Nucl. Med 54 12 2013 2161 2167
    • (2013) J. Nucl. Med , vol.54 , Issue.12 , pp. 2161-2167
    • Jung, K.H.1
  • 75
    • 77951241278 scopus 로고    scopus 로고
    • Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing
    • H.J. Jung Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing J. Biol. Chem. 285 15 2010 11584 11595
    • (2010) J. Biol. Chem. , vol.285 , Issue.15 , pp. 11584-11595
    • Jung, H.J.1
  • 76
    • 84885000571 scopus 로고    scopus 로고
    • USP2a alters chemotherapeutic response by modulating redox
    • B. Benassi USP2a alters chemotherapeutic response by modulating redox Cell Death Dis. 4 2013 e812
    • (2013) Cell Death Dis. , vol.4 , pp. e812
    • Benassi, B.1
  • 77
    • 0033847986 scopus 로고    scopus 로고
    • Dietary antioxidants during cancer chemotherapy: Impact on chemotherapeutic effectiveness and development of side effects
    • K.A. Conklin Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects Nutr. Cancer 37 1 2000 1 18
    • (2000) Nutr. Cancer , vol.37 , Issue.1 , pp. 1-18
    • Conklin, K.A.1
  • 78
    • 0037926836 scopus 로고    scopus 로고
    • Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents
    • Y. Zhou Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents Blood 101 10 2003 4098 4104
    • (2003) Blood , vol.101 , Issue.10 , pp. 4098-4104
    • Zhou, Y.1
  • 79
    • 84866173741 scopus 로고    scopus 로고
    • Drug-induced oxidative stress and toxicity
    • D.G. Deavall Drug-induced oxidative stress and toxicity J. Toxicol. 2012 2012 645460
    • (2012) J. Toxicol. , vol.2012 , pp. 645460
    • Deavall, D.G.1
  • 80
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?
    • D. Trachootham, J. Alexandre, and P. Huang Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat. Rev. Drug Discov. 8 7 2009 579 591
    • (2009) Nat. Rev. Drug Discov. , vol.8 , Issue.7 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 81
    • 35848959463 scopus 로고    scopus 로고
    • Engineering tumors with 3D scaffolds
    • C. Fischbach Engineering tumors with 3D scaffolds Nat. Methods 4 10 2007 855 860
    • (2007) Nat. Methods , vol.4 , Issue.10 , pp. 855-860
    • Fischbach, C.1
  • 82
    • 58849121351 scopus 로고    scopus 로고
    • Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement
    • C. Fischbach Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement Proc. Natl. Acad. Sci. USA 106 2 2009 399 404
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , Issue.2 , pp. 399-404
    • Fischbach, C.1
  • 83
    • 77950254571 scopus 로고    scopus 로고
    • Inhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three-dimensional lung cancer xenograft model
    • X. Xu, and G.D. Prestwich Inhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three-dimensional lung cancer xenograft model Cancer 116 7 2010 1739 1750
    • (2010) Cancer , vol.116 , Issue.7 , pp. 1739-1750
    • Xu, X.1    Prestwich, G.D.2
  • 84
    • 64049095782 scopus 로고    scopus 로고
    • Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates
    • D. Yamazaki, S. Kurisu, and T. Takenawa Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates Oncogene 28 13 2009 1570 1583
    • (2009) Oncogene , vol.28 , Issue.13 , pp. 1570-1583
    • Yamazaki, D.1    Kurisu, S.2    Takenawa, T.3
  • 85
    • 67649446995 scopus 로고    scopus 로고
    • Extracellular matrix molecules: Potential targets in pharmacotherapy
    • H. Jarvelainen Extracellular matrix molecules: potential targets in pharmacotherapy Pharmacol. Rev. 61 2 2009 198 223
    • (2009) Pharmacol. Rev. , vol.61 , Issue.2 , pp. 198-223
    • Jarvelainen, H.1
  • 86
    • 84905674530 scopus 로고    scopus 로고
    • Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment
    • Herrmann, D., et al., Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment. Carcinogenesis, 2014.
    • (2014) Carcinogenesis
    • Herrmann, D.1
  • 87
    • 84864538442 scopus 로고    scopus 로고
    • Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols
    • L.M. Hyman, and K.J. Franz Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols Coord. Chem. Rev. 256 19-20 2012 2333 2356
    • (2012) Coord. Chem. Rev. , vol.256 , Issue.1920 , pp. 2333-2356
    • Hyman, L.M.1    Franz, K.J.2
  • 88
    • 78650387484 scopus 로고    scopus 로고
    • Imaging cycling tumor hypoxia
    • S. Matsumoto Imaging cycling tumor hypoxia Cancer Res. 70 24 2010 10019 10023
    • (2010) Cancer Res. , vol.70 , Issue.24 , pp. 10019-10023
    • Matsumoto, S.1
  • 89
    • 84902260291 scopus 로고    scopus 로고
    • Hypoxia-inducible hydrogels
    • K.M. Park, and S. Gerecht Hypoxia-inducible hydrogels Nat. Commun. 5 2014 4075
    • (2014) Nat. Commun. , vol.5 , pp. 4075
    • Park, K.M.1    Gerecht, S.2
  • 90
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: A dynamic niche in cancer progression
    • P. Lu, V.M. Weaver, and Z. Werb The extracellular matrix: a dynamic niche in cancer progression J. Cell Biol. 196 4 2012 395 406
    • (2012) J. Cell Biol. , vol.196 , Issue.4 , pp. 395-406
    • Lu, P.1    Weaver, V.M.2    Werb, Z.3
  • 91
    • 84859719473 scopus 로고    scopus 로고
    • Endothelial cell responses to micropillar substrates of varying dimensions and stiffness
    • L.E. Dickinson Endothelial cell responses to micropillar substrates of varying dimensions and stiffness J. Biomed. Mater. Res. A 100 6 2012 1457 1466
    • (2012) J. Biomed. Mater. Res. A , vol.100 , Issue.6 , pp. 1457-1466
    • Dickinson, L.E.1
  • 92
    • 80055118448 scopus 로고    scopus 로고
    • Micropatterned surfaces to study hyaluronic acid interactions with cancer cells
    • L.E. Dickinson, and S. Gerecht Micropatterned surfaces to study hyaluronic acid interactions with cancer cells J. Vis. Exp 46 2010
    • (2010) J. Vis. Exp , Issue.46
    • Dickinson, L.E.1    Gerecht, S.2
  • 93
    • 79958791174 scopus 로고    scopus 로고
    • A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels
    • Q. Tseng A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels Lab Chip 11 13 2011 2231 2240
    • (2011) Lab Chip , vol.11 , Issue.13 , pp. 2231-2240
    • Tseng, Q.1
  • 94
    • 84904090132 scopus 로고    scopus 로고
    • Robust and flexible fabrication of chemical micropatterns for tumor spheroid preparation
    • T. Liu Robust and flexible fabrication of chemical micropatterns for tumor spheroid preparation ACS Appl. Mater. Interfaces 6 13 2014 10162 10171
    • (2014) ACS Appl. Mater. Interfaces , vol.6 , Issue.13 , pp. 10162-10171
    • Liu, T.1
  • 95
    • 84884709908 scopus 로고    scopus 로고
    • Extracellular matrix components in breast cancer progression and metastasis
    • T. Oskarsson Extracellular matrix components in breast cancer progression and metastasis Breast 22 Suppl 2 2013 S66 S72
    • (2013) Breast , vol.22 , pp. S66-S72
    • Oskarsson, T.1
  • 96
    • 79960993177 scopus 로고    scopus 로고
    • Fibronectin and tenascin-C: Accomplices in vascular morphogenesis during development and tumor growth
    • E. Van Obberghen-Schilling Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth Int. J. Dev. Biol. 55 4-5 2011 511 525
    • (2011) Int. J. Dev. Biol. , vol.55 , Issue.45 , pp. 511-525
    • Van Obberghen-Schilling, E.1
  • 97
    • 0032933778 scopus 로고    scopus 로고
    • Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast
    • L.F. Brown Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast Clin. Cancer Res. 5 5 1999 1041 1056
    • (1999) Clin. Cancer Res. , vol.5 , Issue.5 , pp. 1041-1056
    • Brown, L.F.1
  • 98
    • 12144286892 scopus 로고    scopus 로고
    • Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis
    • X. Hao Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis Cancer 100 6 2004 1110 1122
    • (2004) Cancer , vol.100 , Issue.6 , pp. 1110-1122
    • Hao, X.1
  • 99
    • 76349090894 scopus 로고    scopus 로고
    • Gene expression profiling identifies Fibronectin 1 and CXCL9 as candidate biomarkers for breast cancer screening
    • E. Ruiz-Garcia Gene expression profiling identifies Fibronectin 1 and CXCL9 as candidate biomarkers for breast cancer screening Br. J. Cancer 102 3 2010 462 468
    • (2010) Br. J. Cancer , vol.102 , Issue.3 , pp. 462-468
    • Ruiz-Garcia, E.1
  • 100
    • 33847220047 scopus 로고    scopus 로고
    • Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species
    • M.L. Taddei Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species Antioxid. Redox Signal. 9 4 2007 469 481
    • (2007) Antioxid. Redox Signal. , vol.9 , Issue.4 , pp. 469-481
    • Taddei, M.L.1
  • 101
    • 0027458093 scopus 로고
    • Low oxygen tension increases mRNA levels of alpha 1 (I) procollagen in human dermal fibroblasts
    • V. Falanga Low oxygen tension increases mRNA levels of alpha 1 (I) procollagen in human dermal fibroblasts J. Cell. Physiol. 157 2 1993 408 412
    • (1993) J. Cell. Physiol. , vol.157 , Issue.2 , pp. 408-412
    • Falanga, V.1
  • 102
    • 0037111104 scopus 로고    scopus 로고
    • Prolonged hypoxia accelerates the posttranscriptional process of collagen synthesis in cultured fibroblasts
    • Y. Horino Prolonged hypoxia accelerates the posttranscriptional process of collagen synthesis in cultured fibroblasts Life Sci. 71 26 2002 3031 3045
    • (2002) Life Sci. , vol.71 , Issue.26 , pp. 3031-3045
    • Horino, Y.1
  • 103
    • 0031105176 scopus 로고    scopus 로고
    • Stimulation of collagen synthesis in rat cardiac fibroblasts by exposure to hypoxic culture conditions and suppression of the effect by natriuretic peptides
    • M. Tamamori Stimulation of collagen synthesis in rat cardiac fibroblasts by exposure to hypoxic culture conditions and suppression of the effect by natriuretic peptides Cell Biol. Int. 21 3 1997 175 180
    • (1997) Cell Biol. Int. , vol.21 , Issue.3 , pp. 175-180
    • Tamamori, M.1
  • 104
    • 49849106100 scopus 로고    scopus 로고
    • Type i collagen induces tissue factor expression and matrix metalloproteinase 9 production in human primary monocytes through a redox-sensitive pathway
    • S. Poitevin Type I collagen induces tissue factor expression and matrix metalloproteinase 9 production in human primary monocytes through a redox-sensitive pathway J. Thromb. Haemost. 6 9 2008 1586 1594
    • (2008) J. Thromb. Haemost. , vol.6 , Issue.9 , pp. 1586-1594
    • Poitevin, S.1
  • 105
    • 79956340393 scopus 로고    scopus 로고
    • Production of reactive oxygen species in endothelial cells under different pulsatile shear stresses and glucose concentrations
    • L.K. Chin Production of reactive oxygen species in endothelial cells under different pulsatile shear stresses and glucose concentrations Lab Chip 11 11 2011 1856 1863
    • (2011) Lab Chip , vol.11 , Issue.11 , pp. 1856-1863
    • Chin, L.K.1
  • 106
    • 84901611469 scopus 로고    scopus 로고
    • A microfluidic coculture and multiphoton FAD analysis assay provides insight into the influence of the bone microenvironment on prostate cancer cells
    • L.L. Bischel A microfluidic coculture and multiphoton FAD analysis assay provides insight into the influence of the bone microenvironment on prostate cancer cells Integr. Biol. (Camb.) 6 6 2014 627 635
    • (2014) Integr. Biol. (Camb.) , vol.6 , Issue.6 , pp. 627-635
    • Bischel, L.L.1
  • 107
    • 84891445487 scopus 로고    scopus 로고
    • Effects of shear stresses and antioxidant concentrations on the production of reactive oxygen species in lung cancer cells
    • K.Y. Lo Effects of shear stresses and antioxidant concentrations on the production of reactive oxygen species in lung cancer cells Biomicrofluidics 7 6 2013 64108
    • (2013) Biomicrofluidics , vol.7 , Issue.6 , pp. 64108
    • Lo, K.Y.1
  • 108
    • 84857790715 scopus 로고    scopus 로고
    • Design and development of microbioreactors for long-term cell culture in controlled oxygen microenvironments
    • H.E. Abaci Design and development of microbioreactors for long-term cell culture in controlled oxygen microenvironments Biomed. Microdevices 14 1 2012 145 152
    • (2012) Biomed. Microdevices , vol.14 , Issue.1 , pp. 145-152
    • Abaci, H.E.1
  • 109
    • 84923257288 scopus 로고    scopus 로고
    • Co-culture microdevice with oxygen gradient for tumor microenvironment model and metastasis imaging
    • H.U. Takahiro Shiwa, and Kosuke Tsukada Co-culture microdevice with oxygen gradient for tumor microenvironment model and metastasis imaging Am. J. Biomed. Eng. 2 2012 175 180
    • (2012) Am. J. Biomed. Eng. , vol.2 , pp. 175-180
    • Takahiro Shiwa, H.U.1    Tsukada, K.2
  • 110
    • 62749175785 scopus 로고    scopus 로고
    • Cell migration into scaffolds under co-culture conditions in a microfluidic platform
    • S. Chung Cell migration into scaffolds under co-culture conditions in a microfluidic platform Lab Chip 9 2 2009 269 275
    • (2009) Lab Chip , vol.9 , Issue.2 , pp. 269-275
    • Chung, S.1


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